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The map label for this gene is hutU [H]

Identifier: 186476570

GI number: 186476570

Start: 2071261

End: 2072949

Strand: Reverse

Name: hutU [H]

Synonym: Bphy_1812

Alternate gene names: 186476570

Gene position: 2072949-2071261 (Counterclockwise)

Preceding gene: 186476571

Following gene: 186476569

Centisome position: 59.58

GC content: 64.42

Gene sequence:

>1689_bases
ATGAACAACCCGAAGCACATCGACCCGCGTCTCGACCCATCCCGCACGATCCGCGCGCCGCGCGGCAGCGAGAAAACCTG
CAAGACCTGGATCGCGGAAGCCGCGTACCGGATGATCCAGAACAACCTGGATCCCGAAGTGGCCGAGCATCCGCATGCGC
TGGTGGTCTACGGCGGCATCGGCCGCGCGGCGCGCAACTGGGATTGCTACGACCAGATCCTCGCGTCGCTGAAGAACCTC
GAAGAAAACGAGACGCTGCTGATCCAGTCGGGCAAGCCCGTCGGCGTGTTCCGCACGCATGCCGATGCGCCGCGCGTGCT
GCTCGCGAATTCGAACCTCGTGCCGCACTGGGCGAACTGGGATCACTTCCACGAGCTCGACCGCAAGGGCCTGATGATGT
ACGGCCAGATGACGGCGGGCAGCTGGATCTATATCGGCAGCCAGGGGATCGTGCAGGGCACGTATGAAACGTTCTTCTCG
GTGGCAAACCAGCACTTCAACGGCGATCCGAAGGGCCGCTGGATCCTGACGGGCGGTCTCGGCGGCATGGGCGGCGCGCA
GCCGCTCGCGGCGACGATGGCGGGCTTTTCGATGATCGCCGTCGAATGCGACGAGACGCGCATCGACTTCCGTCTGAAGA
CGCGTTACGTTGACAAGAAGGCGAAGACGCTCGACGAAGCGCTCGCGATGATCGACGAAGCGAAGAAGACGGGCAACCCC
GTGTCAGTCGGCCTGCTCGGCAATGCCGCCGACGTGTTCGCGGAACTGGTGACGCGCAATATCACGCCGGACTGCGTGAC
CGACCAGACGAGCGCGCACGATCCGATTCACGGTTATCTGCCGCAAGGCTGGAAGATCGAAGACTGGCGCGAGCGTCAGA
AGACGGACCCGCAAAGCATCGTGACGCCCGCGAAGCAGTCGATGGCCAAACAGGTTCAGGCGATGCTCACGCTGCAGGAA
CGCGGCGCGGCCACACTCGACTACGGCAACAACATCCGTCAGATGGCGCTGGAAATGGGCGTGCAGAACGCGTTCGATTT
CCCGGGCTTCGTGCCCGCGTATATCCGGCCGCTTTTCTGCGAAGGCAAGGGCCCGTTCCGCTGGGTCGCGCTGTCGGGCG
ATCCCGAAGACATCTACAAGACGGATGCGAAGGTCAAGGAACTGATTCCCGACGATTCGCACCTGCACAACTGGCTCGAC
ATGGCGCGCGAACGCATTGCGTTCCAGGGGCTGCCGGCGCGTATCTGCTGGGTCGGCGTGAAGGATCGCTATCGCCTCGG
CCAGGCATTCAACGAGATGGTCAGGAAGGGCGAGCTGAAAGCGCCCATCGTGATCGGTCGCGATCACCTGGACACGGGTT
CGGTGGCGAGCCCGAACCGCGAAACGGAATCGATGAAAGACGGCTCGGATGCTGTCAGCGACTGGCCGCTGCTCAACGCA
CTGCTGAACACGGCAGGCGGTGCGTCGTGGGTATCGCTGCATCACGGCGGCGGCGTCGGCATGGGCTTCTCGCAGCACTC
GGGCGTCGTGATCGTCGCTGACGGAACGGACGCCGCGCATGAGCGCCTCGGCCGCGTGCTCTTCAACGATCCCGCGACGG
GCGTGATGCGTCACGCGGACGCCGGCTACGAACTCGCGCAGCAGACGGCGCGCGAAGCCGGTCTCAAGCTGCCCATGCTG
GGCCGCTGA

Upstream 100 bases:

>100_bases
CCCGGCAACCGTTACCGGTTCACCGGCCACTTCTGATTCCGTTTTCGTTTCCGTTCAATCTTCGACTCATCACCGAGTTA
TCTGCGATTCCGAGGGCATC

Downstream 100 bases:

>100_bases
GCATGACGACGGGCGCGGCAACGACGACGGTCATGCGCGGCGCGGAACTCGTGGCGTCGCCGTGGAAGAACGGCGGCGGC
GTCACGCGCGAAGTCGCCGT

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 562; Mature: 562

Protein sequence:

>562_residues
MNNPKHIDPRLDPSRTIRAPRGSEKTCKTWIAEAAYRMIQNNLDPEVAEHPHALVVYGGIGRAARNWDCYDQILASLKNL
EENETLLIQSGKPVGVFRTHADAPRVLLANSNLVPHWANWDHFHELDRKGLMMYGQMTAGSWIYIGSQGIVQGTYETFFS
VANQHFNGDPKGRWILTGGLGGMGGAQPLAATMAGFSMIAVECDETRIDFRLKTRYVDKKAKTLDEALAMIDEAKKTGNP
VSVGLLGNAADVFAELVTRNITPDCVTDQTSAHDPIHGYLPQGWKIEDWRERQKTDPQSIVTPAKQSMAKQVQAMLTLQE
RGAATLDYGNNIRQMALEMGVQNAFDFPGFVPAYIRPLFCEGKGPFRWVALSGDPEDIYKTDAKVKELIPDDSHLHNWLD
MARERIAFQGLPARICWVGVKDRYRLGQAFNEMVRKGELKAPIVIGRDHLDTGSVASPNRETESMKDGSDAVSDWPLLNA
LLNTAGGASWVSLHHGGGVGMGFSQHSGVVIVADGTDAAHERLGRVLFNDPATGVMRHADAGYELAQQTAREAGLKLPML
GR

Sequences:

>Translated_562_residues
MNNPKHIDPRLDPSRTIRAPRGSEKTCKTWIAEAAYRMIQNNLDPEVAEHPHALVVYGGIGRAARNWDCYDQILASLKNL
EENETLLIQSGKPVGVFRTHADAPRVLLANSNLVPHWANWDHFHELDRKGLMMYGQMTAGSWIYIGSQGIVQGTYETFFS
VANQHFNGDPKGRWILTGGLGGMGGAQPLAATMAGFSMIAVECDETRIDFRLKTRYVDKKAKTLDEALAMIDEAKKTGNP
VSVGLLGNAADVFAELVTRNITPDCVTDQTSAHDPIHGYLPQGWKIEDWRERQKTDPQSIVTPAKQSMAKQVQAMLTLQE
RGAATLDYGNNIRQMALEMGVQNAFDFPGFVPAYIRPLFCEGKGPFRWVALSGDPEDIYKTDAKVKELIPDDSHLHNWLD
MARERIAFQGLPARICWVGVKDRYRLGQAFNEMVRKGELKAPIVIGRDHLDTGSVASPNRETESMKDGSDAVSDWPLLNA
LLNTAGGASWVSLHHGGGVGMGFSQHSGVVIVADGTDAAHERLGRVLFNDPATGVMRHADAGYELAQQTAREAGLKLPML
GR
>Mature_562_residues
MNNPKHIDPRLDPSRTIRAPRGSEKTCKTWIAEAAYRMIQNNLDPEVAEHPHALVVYGGIGRAARNWDCYDQILASLKNL
EENETLLIQSGKPVGVFRTHADAPRVLLANSNLVPHWANWDHFHELDRKGLMMYGQMTAGSWIYIGSQGIVQGTYETFFS
VANQHFNGDPKGRWILTGGLGGMGGAQPLAATMAGFSMIAVECDETRIDFRLKTRYVDKKAKTLDEALAMIDEAKKTGNP
VSVGLLGNAADVFAELVTRNITPDCVTDQTSAHDPIHGYLPQGWKIEDWRERQKTDPQSIVTPAKQSMAKQVQAMLTLQE
RGAATLDYGNNIRQMALEMGVQNAFDFPGFVPAYIRPLFCEGKGPFRWVALSGDPEDIYKTDAKVKELIPDDSHLHNWLD
MARERIAFQGLPARICWVGVKDRYRLGQAFNEMVRKGELKAPIVIGRDHLDTGSVASPNRETESMKDGSDAVSDWPLLNA
LLNTAGGASWVSLHHGGGVGMGFSQHSGVVIVADGTDAAHERLGRVLFNDPATGVMRHADAGYELAQQTAREAGLKLPML
GR

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=576, Percent_Identity=33.8541666666667, Blast_Score=306, Evalue=4e-83,
Organism=Homo sapiens, GI260306182, Length=352, Percent_Identity=32.3863636363636, Blast_Score=157, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71997891, Length=581, Percent_Identity=33.5628227194492, Blast_Score=306, Evalue=2e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 61903; Mature: 61903

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNPKHIDPRLDPSRTIRAPRGSEKTCKTWIAEAAYRMIQNNLDPEVAEHPHALVVYGGI
CCCCCCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHCCCCEEEEECCC
GRAARNWDCYDQILASLKNLEENETLLIQSGKPVGVFRTHADAPRVLLANSNLVPHWANW
CCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCCCCEEEEECCCCCCCCCCC
DHFHELDRKGLMMYGQMTAGSWIYIGSQGIVQGTYETFFSVANQHFNGDPKGRWILTGGL
HHHHHHCCCCEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCC
GGMGGAQPLAATMAGFSMIAVECDETRIDFRLKTRYVDKKAKTLDEALAMIDEAKKTGNP
CCCCCCHHHHHHHCCCEEEEEEECCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCC
VSVGLLGNAADVFAELVTRNITPDCVTDQTSAHDPIHGYLPQGWKIEDWRERQKTDPQSI
EEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCHHHH
VTPAKQSMAKQVQAMLTLQERGAATLDYGNNIRQMALEMGVQNAFDFPGFVPAYIRPLFC
HCHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCHHHHCEEEE
EGKGPFRWVALSGDPEDIYKTDAKVKELIPDDSHLHNWLDMARERIAFQGLPARICWVGV
CCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECC
KDRYRLGQAFNEMVRKGELKAPIVIGRDHLDTGSVASPNRETESMKDGSDAVSDWPLLNA
HHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHH
LLNTAGGASWVSLHHGGGVGMGFSQHSGVVIVADGTDAAHERLGRVLFNDPATGVMRHAD
HHHCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHCHHHCCCCCHHHHHHCC
AGYELAQQTAREAGLKLPMLGR
CCHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MNNPKHIDPRLDPSRTIRAPRGSEKTCKTWIAEAAYRMIQNNLDPEVAEHPHALVVYGGI
CCCCCCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHCCCCEEEEECCC
GRAARNWDCYDQILASLKNLEENETLLIQSGKPVGVFRTHADAPRVLLANSNLVPHWANW
CCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCCCCEEEEECCCCCCCCCCC
DHFHELDRKGLMMYGQMTAGSWIYIGSQGIVQGTYETFFSVANQHFNGDPKGRWILTGGL
HHHHHHCCCCEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCC
GGMGGAQPLAATMAGFSMIAVECDETRIDFRLKTRYVDKKAKTLDEALAMIDEAKKTGNP
CCCCCCHHHHHHHCCCEEEEEEECCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCC
VSVGLLGNAADVFAELVTRNITPDCVTDQTSAHDPIHGYLPQGWKIEDWRERQKTDPQSI
EEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCHHHH
VTPAKQSMAKQVQAMLTLQERGAATLDYGNNIRQMALEMGVQNAFDFPGFVPAYIRPLFC
HCHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCHHHHCEEEE
EGKGPFRWVALSGDPEDIYKTDAKVKELIPDDSHLHNWLDMARERIAFQGLPARICWVGV
CCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECC
KDRYRLGQAFNEMVRKGELKAPIVIGRDHLDTGSVASPNRETESMKDGSDAVSDWPLLNA
HHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHH
LLNTAGGASWVSLHHGGGVGMGFSQHSGVVIVADGTDAAHERLGRVLFNDPATGVMRHAD
HHHCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHCHHHCCCCCHHHHHHCC
AGYELAQQTAREAGLKLPMLGR
CCHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14500782 [H]