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The map label for this gene is ggt [H]

Identifier: 186476374

GI number: 186476374

Start: 1836724

End: 1838502

Strand: Reverse

Name: ggt [H]

Synonym: Bphy_1616

Alternate gene names: 186476374

Gene position: 1838502-1836724 (Counterclockwise)

Preceding gene: 186476377

Following gene: 186476373

Centisome position: 52.84

GC content: 64.53

Gene sequence:

>1779_bases
ATGCATGTCGAAACGCATGCGGGCGCCCATGTCCGTTCACGTTCCGCCCACCATCGCTTGCCCGCCGCTCGCGGATGGGC
GCGTGTTGCCGCGACGCTGGCGCTCACGGGCATGCTGCTCGCGAGCTTCGTCGCGTCGCCCGCAGCCAATGCGAAAACGC
CTCAACCGAAGCCGATGCTCGACGCATCCGCGGTCGCCGTGCCCGACCGGTACGCCGCCGATGCCGCGCAGCAGATCTTC
GCCGCGGGCGGCAATGCCGTCGATGCCGCCGTCGCGGTTTCATTCACGCTCGCCGTCACGTACCCGGATGCAGGCAACAT
CGGCGGCGGCGGGTTCATGACGGTCTATATGGACGGCAAGCCGTACTTCCTCGACTACCGGGAAAAGGCGCCGCAGAGCG
CAACACGCGACATGTACCTCGACGACAAGGGCAACGTGATCAAGGGCATGAGCCTCGTCGGGCATCGCGCGGTGGCCGTG
CCAGGCACGGTCGAGGGCATGTGGGAGGCCCAGAAGCGCTTCGGCAAGCTCAAATGGAAGCAGGTGCTTGCGCCCGCGAT
CAAGTACGCGACGGACGGCTTCACGGTCCAGCCATGGCTGCAGCAGCGCCGTGAATTCGCGTCGAAGAACTTCGGTGGCA
AGACCAATTTCGATGCGTATTTCTCGAACCTGAAGGCGGGAGCGATGTTCCGTCAGCCCGAGCTCGCGCAAACGCTGACG
CGGATCGCGTCCGACGGCGGCCGCGAGTTCTACGAAGGCCAGACGGCCGACCTGATCGCGCAGCAAATGTACGGCCACGG
GCTGATCACGAAGACAGATCTGTTGCAGTACAAGGCTGTGTGGCGTGAGCCCGTGACGGCGAGCTGGAACGGTTACCAGA
TCGTGACCGCGCCGCCGCCGAGTTCGGGCGGCGTCGGGCTGATCCAGTTGCTGAAGATGAAGGCGGACCTGAAGCCGCAG
TTCGATGGCGTGGCGCTCAATTCGGAGCCCTACATCCATCTGATCGCGCAGATGGAGGACCGCGTGTTCGCCGATCGCCA
GCAATATTTAGGCGACCCCGATTCGTACCGCGTGCCCGTCGACAAGCTGATCGACGACGCGTACCTCGCAAAGCGCGCAG
AAGGCATCACGCCGGATGAAGTGCCGGGCGCTGCGCCCGTGAAGCCGGGTCTCGGCGACTCGATGCCGGAAAAGGCACAG
ACGACGCATTTCTCCGTGGTCGACAAATGGGGCAATGCCGTGTCGAACACCTACACACTGAACGGGCCGTTCGGTTCGGG
CGTGGTGGTGGACGGGGGAGGGTTCGTGCTCAACGACGAGATGGACGACTTCGAGGCGAAGGCGGGTGTCCAGAACCAGT
TCGGCGTGACGAGCGGCGACGTGAATACGATCGCGCCGGGCCGCCGGCCGTTGTCGTCGATGACGCCGACCATCCTGCTG
AAGGACGGCAAGGTCTCGCTCGTGATCGGCACGCCGGGCGGCTCGCGCATCTTCACATCGATCTTCCAGGTGATGACGAA
TCTGTACGACTTCAACATGCCGCCCGCCGATGCACTCTCCGCGATGCGCTTTCACCATCAGTTGCTGCCGCAGAAAACGA
TCTACTGGGAGCCCTATCGCCCGATCGACGGCGAACTGGCCGACCAGCTGAAGGCGCGCGGCTACACGCTGGAGGGTCAG
TTGTTCAACGGCGACGTGCAGATGATCCGCATCGACGGCACGGCGCCGCAACCGGCTGCCGATCCGCGCGGCGTGGGCGT
GGGCCGTGTGATTCAATAG

Upstream 100 bases:

>100_bases
TCTCTCGTGCTGCGCAGGGGCGGGCCCGTCCATCGATCCCGGAGTTCCTCGGATGTTCCTTCCGACATTGCGCGCGCCGC
GCGCGCTTTCTGGTGCCGAT

Downstream 100 bases:

>100_bases
GGCTGGCGGCGCAGCCGCTTTCCATGAACGCATAAACGGGGAATCGAATGGCACTGGAGCAGCAGAGCGTGATCGTGTTG
CCGGGTTATATGAACTCGGG

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 592; Mature: 592

Protein sequence:

>592_residues
MHVETHAGAHVRSRSAHHRLPAARGWARVAATLALTGMLLASFVASPAANAKTPQPKPMLDASAVAVPDRYAADAAQQIF
AAGGNAVDAAVAVSFTLAVTYPDAGNIGGGGFMTVYMDGKPYFLDYREKAPQSATRDMYLDDKGNVIKGMSLVGHRAVAV
PGTVEGMWEAQKRFGKLKWKQVLAPAIKYATDGFTVQPWLQQRREFASKNFGGKTNFDAYFSNLKAGAMFRQPELAQTLT
RIASDGGREFYEGQTADLIAQQMYGHGLITKTDLLQYKAVWREPVTASWNGYQIVTAPPPSSGGVGLIQLLKMKADLKPQ
FDGVALNSEPYIHLIAQMEDRVFADRQQYLGDPDSYRVPVDKLIDDAYLAKRAEGITPDEVPGAAPVKPGLGDSMPEKAQ
TTHFSVVDKWGNAVSNTYTLNGPFGSGVVVDGGGFVLNDEMDDFEAKAGVQNQFGVTSGDVNTIAPGRRPLSSMTPTILL
KDGKVSLVIGTPGGSRIFTSIFQVMTNLYDFNMPPADALSAMRFHHQLLPQKTIYWEPYRPIDGELADQLKARGYTLEGQ
LFNGDVQMIRIDGTAPQPAADPRGVGVGRVIQ

Sequences:

>Translated_592_residues
MHVETHAGAHVRSRSAHHRLPAARGWARVAATLALTGMLLASFVASPAANAKTPQPKPMLDASAVAVPDRYAADAAQQIF
AAGGNAVDAAVAVSFTLAVTYPDAGNIGGGGFMTVYMDGKPYFLDYREKAPQSATRDMYLDDKGNVIKGMSLVGHRAVAV
PGTVEGMWEAQKRFGKLKWKQVLAPAIKYATDGFTVQPWLQQRREFASKNFGGKTNFDAYFSNLKAGAMFRQPELAQTLT
RIASDGGREFYEGQTADLIAQQMYGHGLITKTDLLQYKAVWREPVTASWNGYQIVTAPPPSSGGVGLIQLLKMKADLKPQ
FDGVALNSEPYIHLIAQMEDRVFADRQQYLGDPDSYRVPVDKLIDDAYLAKRAEGITPDEVPGAAPVKPGLGDSMPEKAQ
TTHFSVVDKWGNAVSNTYTLNGPFGSGVVVDGGGFVLNDEMDDFEAKAGVQNQFGVTSGDVNTIAPGRRPLSSMTPTILL
KDGKVSLVIGTPGGSRIFTSIFQVMTNLYDFNMPPADALSAMRFHHQLLPQKTIYWEPYRPIDGELADQLKARGYTLEGQ
LFNGDVQMIRIDGTAPQPAADPRGVGVGRVIQ
>Mature_592_residues
MHVETHAGAHVRSRSAHHRLPAARGWARVAATLALTGMLLASFVASPAANAKTPQPKPMLDASAVAVPDRYAADAAQQIF
AAGGNAVDAAVAVSFTLAVTYPDAGNIGGGGFMTVYMDGKPYFLDYREKAPQSATRDMYLDDKGNVIKGMSLVGHRAVAV
PGTVEGMWEAQKRFGKLKWKQVLAPAIKYATDGFTVQPWLQQRREFASKNFGGKTNFDAYFSNLKAGAMFRQPELAQTLT
RIASDGGREFYEGQTADLIAQQMYGHGLITKTDLLQYKAVWREPVTASWNGYQIVTAPPPSSGGVGLIQLLKMKADLKPQ
FDGVALNSEPYIHLIAQMEDRVFADRQQYLGDPDSYRVPVDKLIDDAYLAKRAEGITPDEVPGAAPVKPGLGDSMPEKAQ
TTHFSVVDKWGNAVSNTYTLNGPFGSGVVVDGGGFVLNDEMDDFEAKAGVQNQFGVTSGDVNTIAPGRRPLSSMTPTILL
KDGKVSLVIGTPGGSRIFTSIFQVMTNLYDFNMPPADALSAMRFHHQLLPQKTIYWEPYRPIDGELADQLKARGYTLEGQ
LFNGDVQMIRIDGTAPQPAADPRGVGVGRVIQ

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=507, Percent_Identity=30.5719921104536, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI73915090, Length=507, Percent_Identity=30.5719921104536, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI73915096, Length=507, Percent_Identity=30.5719921104536, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI73915094, Length=507, Percent_Identity=30.5719921104536, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI113429324, Length=504, Percent_Identity=29.1666666666667, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI109148539, Length=505, Percent_Identity=29.7029702970297, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI113429326, Length=509, Percent_Identity=28.4872298624754, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI153266885, Length=547, Percent_Identity=25.7769652650823, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI153266901, Length=548, Percent_Identity=25.1824817518248, Blast_Score=127, Evalue=4e-29,
Organism=Homo sapiens, GI153266907, Length=545, Percent_Identity=24.954128440367, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI30581157, Length=163, Percent_Identity=41.1042944785276, Blast_Score=107, Evalue=4e-23,
Organism=Homo sapiens, GI30581155, Length=163, Percent_Identity=41.1042944785276, Blast_Score=107, Evalue=4e-23,
Organism=Homo sapiens, GI218505805, Length=177, Percent_Identity=37.2881355932203, Blast_Score=81, Evalue=3e-15,
Organism=Escherichia coli, GI1789856, Length=531, Percent_Identity=43.1261770244821, Blast_Score=388, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17542894, Length=539, Percent_Identity=31.3543599257885, Blast_Score=216, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI72000294, Length=515, Percent_Identity=31.6504854368932, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI212646519, Length=515, Percent_Identity=31.6504854368932, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI193208245, Length=497, Percent_Identity=30.1810865191147, Blast_Score=190, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI193208247, Length=497, Percent_Identity=29.9798792756539, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17506189, Length=566, Percent_Identity=30.0353356890459, Blast_Score=176, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI72001495, Length=218, Percent_Identity=27.5229357798165, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI72001497, Length=218, Percent_Identity=27.5229357798165, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17564448, Length=419, Percent_Identity=25.7756563245823, Blast_Score=90, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6323330, Length=525, Percent_Identity=29.5238095238095, Blast_Score=153, Evalue=1e-37,
Organism=Drosophila melanogaster, GI18859893, Length=538, Percent_Identity=31.2267657992565, Blast_Score=218, Evalue=7e-57,
Organism=Drosophila melanogaster, GI161077496, Length=564, Percent_Identity=30.6737588652482, Blast_Score=206, Evalue=4e-53,
Organism=Drosophila melanogaster, GI161077880, Length=514, Percent_Identity=28.988326848249, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI161077878, Length=514, Percent_Identity=28.988326848249, Blast_Score=163, Evalue=3e-40,
Organism=Drosophila melanogaster, GI45551474, Length=514, Percent_Identity=28.988326848249, Blast_Score=163, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24642670, Length=514, Percent_Identity=28.988326848249, Blast_Score=163, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24642666, Length=514, Percent_Identity=28.988326848249, Blast_Score=163, Evalue=3e-40,
Organism=Drosophila melanogaster, GI18859741, Length=548, Percent_Identity=26.6423357664234, Blast_Score=150, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 64033; Mature: 64033

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHVETHAGAHVRSRSAHHRLPAARGWARVAATLALTGMLLASFVASPAANAKTPQPKPML
CCCCCCCCCHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
DASAVAVPDRYAADAAQQIFAAGGNAVDAAVAVSFTLAVTYPDAGNIGGGGFMTVYMDGK
CCCCEECCCHHHHHHHHHHHHCCCCHHHHEEEEEEEEEEECCCCCCCCCCEEEEEEECCC
PYFLDYREKAPQSATRDMYLDDKGNVIKGMSLVGHRAVAVPGTVEGMWEAQKRFGKLKWK
EEEECCHHCCCCCCCCCEEECCCCCEEECHHHHCCEEEECCCCHHHHHHHHHHHCCHHHH
QVLAPAIKYATDGFTVQPWLQQRREFASKNFGGKTNFDAYFSNLKAGAMFRQPELAQTLT
HHHHHHHHHHCCCCEECHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCEECCCHHHHHHH
RIASDGGREFYEGQTADLIAQQMYGHGLITKTDLLQYKAVWREPVTASWNGYQIVTAPPP
HHHCCCCCHHHCCCHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCCCCCCCCEEEEECCCC
SSGGVGLIQLLKMKADLKPQFDGVALNSEPYIHLIAQMEDRVFADRQQYLGDPDSYRVPV
CCCCHHHHHHHHHHHCCCCCCCCEEECCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCH
DKLIDDAYLAKRAEGITPDEVPGAAPVKPGLGDSMPEKAQTTHFSVVDKWGNAVSNTYTL
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHCCHHHHHHHHHCCHHCCEEEE
NGPFGSGVVVDGGGFVLNDEMDDFEAKAGVQNQFGVTSGDVNTIAPGRRPLSSMTPTILL
CCCCCCCEEECCCCEEECCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCEEEE
KDGKVSLVIGTPGGSRIFTSIFQVMTNLYDFNMPPADALSAMRFHHQLLPQKTIYWEPYR
ECCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEECCCC
PIDGELADQLKARGYTLEGQLFNGDVQMIRIDGTAPQPAADPRGVGVGRVIQ
CCCHHHHHHHHHCCEEEECEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MHVETHAGAHVRSRSAHHRLPAARGWARVAATLALTGMLLASFVASPAANAKTPQPKPML
CCCCCCCCCHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
DASAVAVPDRYAADAAQQIFAAGGNAVDAAVAVSFTLAVTYPDAGNIGGGGFMTVYMDGK
CCCCEECCCHHHHHHHHHHHHCCCCHHHHEEEEEEEEEEECCCCCCCCCCEEEEEEECCC
PYFLDYREKAPQSATRDMYLDDKGNVIKGMSLVGHRAVAVPGTVEGMWEAQKRFGKLKWK
EEEECCHHCCCCCCCCCEEECCCCCEEECHHHHCCEEEECCCCHHHHHHHHHHHCCHHHH
QVLAPAIKYATDGFTVQPWLQQRREFASKNFGGKTNFDAYFSNLKAGAMFRQPELAQTLT
HHHHHHHHHHCCCCEECHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCEECCCHHHHHHH
RIASDGGREFYEGQTADLIAQQMYGHGLITKTDLLQYKAVWREPVTASWNGYQIVTAPPP
HHHCCCCCHHHCCCHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCCCCCCCCEEEEECCCC
SSGGVGLIQLLKMKADLKPQFDGVALNSEPYIHLIAQMEDRVFADRQQYLGDPDSYRVPV
CCCCHHHHHHHHHHHCCCCCCCCEEECCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCH
DKLIDDAYLAKRAEGITPDEVPGAAPVKPGLGDSMPEKAQTTHFSVVDKWGNAVSNTYTL
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHCCHHHHHHHHHCCHHCCEEEE
NGPFGSGVVVDGGGFVLNDEMDDFEAKAGVQNQFGVTSGDVNTIAPGRRPLSSMTPTILL
CCCCCCCEEECCCCEEECCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCEEEE
KDGKVSLVIGTPGGSRIFTSIFQVMTNLYDFNMPPADALSAMRFHHQLLPQKTIYWEPYR
ECCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEECCCC
PIDGELADQLKARGYTLEGQLFNGDVQMIRIDGTAPQPAADPRGVGVGRVIQ
CCCHHHHHHHHHCCEEEECEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]