Click here to switch to the map view.

The map label for this gene is yeiA [H]

Identifier: 186476292

GI number: 186476292

Start: 1732257

End: 1733567

Strand: Reverse

Name: yeiA [H]

Synonym: Bphy_1534

Alternate gene names: 186476292

Gene position: 1733567-1732257 (Counterclockwise)

Preceding gene: 186476293

Following gene: 186476291

Centisome position: 49.83

GC content: 62.32

Gene sequence:

>1311_bases
ATGGCCGATCTACGCTGCACGATAGCCGGCATCACGTCGCCGAATCCTTTCTGGCTCGCATCCGCGCCGCCCACTGACAA
AGCCTATAACGTGAACCGCGCATTCGAAGCGGGCTGGGGCGGCGTCGTGTGGAAGACGCTCGGGCTGGATCCGCATGTGG
TCAACGTCAGCTCGCGTTACGGCGCGGTGCAATGGAACGGCCAACGCATCGCAGGGCTGAACAATATCGAACTGATCACC
GACCGGCCGCTCGACGTCAATCTGCGCGAGATCGCCCAGGTCAAGCGCGACTGGCCCGATCGCGCGTTGATCGTATCGCT
GATGGTGCCTTGCAACGAACGCGACTGGAAATGGATCCTGCCGCTCGTCGAAGACACGGGTGCCGATGCCGTCGAACTGA
ACTTTGGTTGTCCGCATGGCATGAGCGAGCGCGGTATGGGCTCGGCTGTCGGCCAGGTCCCGGAATACGTGGAGATGGTC
ACGCGCTGGGTGAAGGAAGGCACGAAGCTGCCATGCCTCGTGAAGCTCACGCCCAACATCAGCGACATCCGCATGGGGTC
GCGCGCCGCCTGGAAGGGCGGCGCGGACGGCGTGTCGCTGATCAACACGATCAATTCGATCGTCGCCGTCGATCTCGATC
AGATGGCGCCGATGCCAACTGTCGACGGCAAGGGCACGCATGGCGGCTACTGCGGTCCCGCTGTGAAGCCGATCGCGCTG
AACATGGTCGCCGAAATCGCGCGCGATCCGGAAACGCCGGGTCTGCCGATCTCCGGCATCGGCGGCATTTCGTCGTGGCG
CGACGCCGCCGAGTTCATGGTGCTCGGCGCGGGCAGTGTACAGGTCTGCACGGCGGCCATGCATTACGGCTTTCGCATCG
TGTCCGACATGGCGGACGGCCTGTCGAACTGGATGGATGAGAAGGGCTATGCGACGCTCGAGGATATCCGTGGCCGTGCC
GTGCCGAACGTCACGGACTGGAAATACCTGAACCTGAAGTACGACATCAAGGCACGCATCGATCAGCACAAGTGCATTCA
ATGCGGCCTCTGCCATATTGCCTGTGAGGACACTTCGCATCAGGCCATCACACGCGAGAAGGACGGCAAGCGCCACTTTG
AAGTGATCGATGCGCAATGCGTCGGGTGCAATCTTTGCATGCATGTGTGTCCCGTTGAGCAATGCATCACGATGGAGCGC
GTCGATAGCGGCGAGTACGCGAACTGGACCACCCATCCGAACAATCCCGCACGTGTCGTGGCGGACGCGCCTGAAACGGC
AGACGCACGGCACCCCGCCAAGGCAGCCTGA

Upstream 100 bases:

>100_bases
GCGGCATCGATCGACGCGGCGTTCGCATTGGCCGCAGTGAAGGCGGCCTGAACGCGCCGCCCGATATCCAAGGATAAAAC
CGAACCCCACGGAGCCGAAC

Downstream 100 bases:

>100_bases
AAAAAGCACGCTGATAAGGGCACCCCAGTCAACGAGCGGTCAAGTGGAGAACCATCGATGAAGCAGACAGCGCAATCCGC
CGACGCGTCTTACGCGGCCG

Product: dihydropyrimidine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MADLRCTIAGITSPNPFWLASAPPTDKAYNVNRAFEAGWGGVVWKTLGLDPHVVNVSSRYGAVQWNGQRIAGLNNIELIT
DRPLDVNLREIAQVKRDWPDRALIVSLMVPCNERDWKWILPLVEDTGADAVELNFGCPHGMSERGMGSAVGQVPEYVEMV
TRWVKEGTKLPCLVKLTPNISDIRMGSRAAWKGGADGVSLINTINSIVAVDLDQMAPMPTVDGKGTHGGYCGPAVKPIAL
NMVAEIARDPETPGLPISGIGGISSWRDAAEFMVLGAGSVQVCTAAMHYGFRIVSDMADGLSNWMDEKGYATLEDIRGRA
VPNVTDWKYLNLKYDIKARIDQHKCIQCGLCHIACEDTSHQAITREKDGKRHFEVIDAQCVGCNLCMHVCPVEQCITMER
VDSGEYANWTTHPNNPARVVADAPETADARHPAKAA

Sequences:

>Translated_436_residues
MADLRCTIAGITSPNPFWLASAPPTDKAYNVNRAFEAGWGGVVWKTLGLDPHVVNVSSRYGAVQWNGQRIAGLNNIELIT
DRPLDVNLREIAQVKRDWPDRALIVSLMVPCNERDWKWILPLVEDTGADAVELNFGCPHGMSERGMGSAVGQVPEYVEMV
TRWVKEGTKLPCLVKLTPNISDIRMGSRAAWKGGADGVSLINTINSIVAVDLDQMAPMPTVDGKGTHGGYCGPAVKPIAL
NMVAEIARDPETPGLPISGIGGISSWRDAAEFMVLGAGSVQVCTAAMHYGFRIVSDMADGLSNWMDEKGYATLEDIRGRA
VPNVTDWKYLNLKYDIKARIDQHKCIQCGLCHIACEDTSHQAITREKDGKRHFEVIDAQCVGCNLCMHVCPVEQCITMER
VDSGEYANWTTHPNNPARVVADAPETADARHPAKAA
>Mature_435_residues
ADLRCTIAGITSPNPFWLASAPPTDKAYNVNRAFEAGWGGVVWKTLGLDPHVVNVSSRYGAVQWNGQRIAGLNNIELITD
RPLDVNLREIAQVKRDWPDRALIVSLMVPCNERDWKWILPLVEDTGADAVELNFGCPHGMSERGMGSAVGQVPEYVEMVT
RWVKEGTKLPCLVKLTPNISDIRMGSRAAWKGGADGVSLINTINSIVAVDLDQMAPMPTVDGKGTHGGYCGPAVKPIALN
MVAEIARDPETPGLPISGIGGISSWRDAAEFMVLGAGSVQVCTAAMHYGFRIVSDMADGLSNWMDEKGYATLEDIRGRAV
PNVTDWKYLNLKYDIKARIDQHKCIQCGLCHIACEDTSHQAITREKDGKRHFEVIDAQCVGCNLCMHVCPVEQCITMERV
DSGEYANWTTHPNNPARVVADAPETADARHPAKAA

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=336, Percent_Identity=39.2857142857143, Blast_Score=233, Evalue=2e-61,
Organism=Escherichia coli, GI87082059, Length=401, Percent_Identity=44.6384039900249, Blast_Score=338, Evalue=5e-94,
Organism=Caenorhabditis elegans, GI71984108, Length=326, Percent_Identity=40.1840490797546, Blast_Score=226, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6322633, Length=323, Percent_Identity=25.077399380805, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24640763, Length=310, Percent_Identity=43.2258064516129, Blast_Score=244, Evalue=6e-65,
Organism=Drosophila melanogaster, GI18858217, Length=310, Percent_Identity=43.2258064516129, Blast_Score=244, Evalue=6e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR012285 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: NA

Molecular weight: Translated: 47546; Mature: 47415

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADLRCTIAGITSPNPFWLASAPPTDKAYNVNRAFEAGWGGVVWKTLGLDPHVVNVSSRY
CCCCEEEEEECCCCCCEEEECCCCCCCCEECCCHHHCCCCCEEEEECCCCCEEEEECCCC
GAVQWNGQRIAGLNNIELITDRPLDVNLREIAQVKRDWPDRALIVSLMVPCNERDWKWIL
CEEEECCEEEECCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEE
PLVEDTGADAVELNFGCPHGMSERGMGSAVGQVPEYVEMVTRWVKEGTKLPCLVKLTPNI
EEEECCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCH
SDIRMGSRAAWKGGADGVSLINTINSIVAVDLDQMAPMPTVDGKGTHGGYCGPAVKPIAL
HHHCCCCCCCCCCCCCHHHHHHHHHHHHEEEHHHCCCCCCCCCCCCCCCCCCCCCCHHHH
NMVAEIARDPETPGLPISGIGGISSWRDAAEFMVLGAGSVQVCTAAMHYGFRIVSDMADG
HHHHHHHCCCCCCCCCCCCCCCCHHHHHHCEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
LSNWMDEKGYATLEDIRGRAVPNVTDWKYLNLKYDIKARIDQHKCIQCGLCHIACEDTSH
HHHHHHCCCCEEHHHHCCCCCCCCCCEEEEEEEEEEEECCCCHHHHHCCEEEEEECCCCC
QAITREKDGKRHFEVIDAQCVGCNLCMHVCPVEQCITMERVDSGEYANWTTHPNNPARVV
CHHHCCCCCCEEEEEEECCHHCCHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEE
ADAPETADARHPAKAA
ECCCCCCCCCCCCCCC
>Mature Secondary Structure 
ADLRCTIAGITSPNPFWLASAPPTDKAYNVNRAFEAGWGGVVWKTLGLDPHVVNVSSRY
CCCEEEEEECCCCCCEEEECCCCCCCCEECCCHHHCCCCCEEEEECCCCCEEEEECCCC
GAVQWNGQRIAGLNNIELITDRPLDVNLREIAQVKRDWPDRALIVSLMVPCNERDWKWIL
CEEEECCEEEECCCCEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEE
PLVEDTGADAVELNFGCPHGMSERGMGSAVGQVPEYVEMVTRWVKEGTKLPCLVKLTPNI
EEEECCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCH
SDIRMGSRAAWKGGADGVSLINTINSIVAVDLDQMAPMPTVDGKGTHGGYCGPAVKPIAL
HHHCCCCCCCCCCCCCHHHHHHHHHHHHEEEHHHCCCCCCCCCCCCCCCCCCCCCCHHHH
NMVAEIARDPETPGLPISGIGGISSWRDAAEFMVLGAGSVQVCTAAMHYGFRIVSDMADG
HHHHHHHCCCCCCCCCCCCCCCCHHHHHHCEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
LSNWMDEKGYATLEDIRGRAVPNVTDWKYLNLKYDIKARIDQHKCIQCGLCHIACEDTSH
HHHHHHCCCCEEHHHHCCCCCCCCCCEEEEEEEEEEEECCCCHHHHHCCEEEEEECCCCC
QAITREKDGKRHFEVIDAQCVGCNLCMHVCPVEQCITMERVDSGEYANWTTHPNNPARVV
CHHHCCCCCCEEEEEEECCHHCCHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEE
ADAPETADARHPAKAA
ECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 1719366 [H]