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The map label for this gene is lpxH [H]

Identifier: 186476152

GI number: 186476152

Start: 1566355

End: 1567155

Strand: Direct

Name: lpxH [H]

Synonym: Bphy_1394

Alternate gene names: 186476152

Gene position: 1566355-1567155 (Clockwise)

Preceding gene: 186476151

Following gene: 186476155

Centisome position: 45.02

GC content: 63.42

Gene sequence:

>801_bases
ATGCTGCAAGAAACGCCGCTGCGAAGCGTCGCTGCGGGCGTGCCTGGCGAGGGCAAACGCCCTCACGCGGCGCGCCCGTT
TTTCTTTATCGCCGACCTTCACCTGAGCGAGGCGATCCCGCAAACGGTCGCCGCGTTCGAGCATTTCGTCATGGTGACGG
CCGAGCACGCGGATTCCGTCTTCATTCTCGGCGACCTGTTCGAATACTGGATCGGCGACGATATGCTCGCTGAACCCTTC
GCTGCCCGCATGGCCAAGCTGATGCACACACTGTCGGAGCGCGGCATCGCGCTCTACATCATGCACGGCAACCGCGACTT
CCTCTTGGGCAAACGCTTCATGAAAGCGGCGGGCGCGATCTGGCTACCCGATCCGTTCGTCATTACCGCGTTCGGCACCA
AAATCGCGCTCACGCATGGCGACGCGCAGTGCACGCTGGACCGCGGCTACCAGCGCTTTCGCGGCTTTGCGCGCAATCGT
ATCGCGCAGTGGCTGTTTCTGGCATGGCCGTATCGCTGGCGCAAGGCGCTGGCCGAAAAGATGCGCAGAACGAGCGAAGC
CGGACGTGCACGCCCGGTGACGCCGCGCTATGACGTGACGTCGGAAGGCGTCGCTGCGCTCTTCAAGAAGACGAAGACGG
CTACGATGATTCACGGTCATACGCACCGGCCCGCGCTGCATCACGAGAAAGGCGGCATGCGCTGGGTACTGCCCGATTGG
GATCTCGACCACGGCGAGCGCCGGGGCGGTTACGTGCGTATCGATTCCGAGGGGATCAAGGCGCTGCGGCTCGACAAATA
G

Upstream 100 bases:

>100_bases
CGTCATCATCGAAAAGGCCGTCGTGGTTGAGTAAGAACATTACTCGACCGAAAGGCCTATTCTTTAAGAAGCGCTGAAAA
ACTAAGAGAAGCACACTTCA

Downstream 100 bases:

>100_bases
ATAGCCGCTTGCAAGCTCGCTCGCCCGTCGACGCGTCGGCGCAGCACCACCACTGCTGACGCAACCTTAGCGCGACCTTA
GCGCGTCGTTTCCTCGACCT

Product: UDP-2,3-diacylglucosamine hydrolase

Products: 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1; UMP [C]

Alternate protein names: NA

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MLQETPLRSVAAGVPGEGKRPHAARPFFFIADLHLSEAIPQTVAAFEHFVMVTAEHADSVFILGDLFEYWIGDDMLAEPF
AARMAKLMHTLSERGIALYIMHGNRDFLLGKRFMKAAGAIWLPDPFVITAFGTKIALTHGDAQCTLDRGYQRFRGFARNR
IAQWLFLAWPYRWRKALAEKMRRTSEAGRARPVTPRYDVTSEGVAALFKKTKTATMIHGHTHRPALHHEKGGMRWVLPDW
DLDHGERRGGYVRIDSEGIKALRLDK

Sequences:

>Translated_266_residues
MLQETPLRSVAAGVPGEGKRPHAARPFFFIADLHLSEAIPQTVAAFEHFVMVTAEHADSVFILGDLFEYWIGDDMLAEPF
AARMAKLMHTLSERGIALYIMHGNRDFLLGKRFMKAAGAIWLPDPFVITAFGTKIALTHGDAQCTLDRGYQRFRGFARNR
IAQWLFLAWPYRWRKALAEKMRRTSEAGRARPVTPRYDVTSEGVAALFKKTKTATMIHGHTHRPALHHEKGGMRWVLPDW
DLDHGERRGGYVRIDSEGIKALRLDK
>Mature_266_residues
MLQETPLRSVAAGVPGEGKRPHAARPFFFIADLHLSEAIPQTVAAFEHFVMVTAEHADSVFILGDLFEYWIGDDMLAEPF
AARMAKLMHTLSERGIALYIMHGNRDFLLGKRFMKAAGAIWLPDPFVITAFGTKIALTHGDAQCTLDRGYQRFRGFARNR
IAQWLFLAWPYRWRKALAEKMRRTSEAGRARPVTPRYDVTSEGVAALFKKTKTATMIHGHTHRPALHHEKGGMRWVLPDW
DLDHGERRGGYVRIDSEGIKALRLDK

Specific function: Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP [H]

COG id: COG2908

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxH family [H]

Homologues:

Organism=Escherichia coli, GI1786735, Length=239, Percent_Identity=39.3305439330544, Blast_Score=168, Evalue=3e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004843
- InterPro:   IPR010138 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: NA

Molecular weight: Translated: 30193; Mature: 30193

Theoretical pI: Translated: 10.31; Mature: 10.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQETPLRSVAAGVPGEGKRPHAARPFFFIADLHLSEAIPQTVAAFEHFVMVTAEHADSV
CCCCCCCHHHHCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHEEEEECCCCCE
FILGDLFEYWIGDDMLAEPFAARMAKLMHTLSERGIALYIMHGNRDFLLGKRFMKAAGAI
EEHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHCCCE
WLPDPFVITAFGTKIALTHGDAQCTLDRGYQRFRGFARNRIAQWLFLAWPYRWRKALAEK
ECCCCEEEEEECCEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
MRRTSEAGRARPVTPRYDVTSEGVAALFKKTKTATMIHGHTHRPALHHEKGGMRWVLPDW
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEECCCC
DLDHGERRGGYVRIDSEGIKALRLDK
CCCCCCCCCCEEEECCCCCCEEECCC
>Mature Secondary Structure
MLQETPLRSVAAGVPGEGKRPHAARPFFFIADLHLSEAIPQTVAAFEHFVMVTAEHADSV
CCCCCCCHHHHCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHEEEEECCCCCE
FILGDLFEYWIGDDMLAEPFAARMAKLMHTLSERGIALYIMHGNRDFLLGKRFMKAAGAI
EEHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHCCCE
WLPDPFVITAFGTKIALTHGDAQCTLDRGYQRFRGFARNRIAQWLFLAWPYRWRKALAEK
ECCCCEEEEEECCEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
MRRTSEAGRARPVTPRYDVTSEGVAALFKKTKTATMIHGHTHRPALHHEKGGMRWVLPDW
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEECCCC
DLDHGERRGGYVRIDSEGIKALRLDK
CCCCCCCCCCEEEECCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O; UDP-2,3-bis(3-hydroxymyristoyl)glucosamine [C]

Specific reaction: H2O + UDP-2,3-bis(3-hydroxymyristoyl)glucosamine = 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1 + UMP [C]

General reaction: Lipid A biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]