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The map label for this gene is cyp18 [H]

Identifier: 186476151

GI number: 186476151

Start: 1565794

End: 1566288

Strand: Direct

Name: cyp18 [H]

Synonym: Bphy_1393

Alternate gene names: 186476151

Gene position: 1565794-1566288 (Clockwise)

Preceding gene: 186476150

Following gene: 186476152

Centisome position: 45.0

GC content: 58.79

Gene sequence:

>495_bases
ATGGTTGAACTACACACGAACCACGGCGTCATCAAGCTCGAACTGGACGCGGAAAAGGCGCCCAAGTCGGTCGAAAACTT
CCTCGCCTATGTGAAGGCCGGCCACTACGACAATACGGTGTTCCACCGCGTGATTGACGGCTTCATGATCCAGGGCGGCG
GCTTCGAACCCGGCATGCAGCAAAAGCCGACGAATGCGCCGATCGCCAACGAAGCAAACAACGGTCTGAAGAACGTGAAG
GGCTCGATCGCCATGGCGCGCACGAACGATCCGCATTCGGCAACGGCCCAGTTCTTCATCAACGTGAACGACAACGACTT
CCTGAACCACTCCTCCCCGACGCCGCAGGGCTGGGGCTATGCAGTGTTCGGCAAGGTCGTCGAAGGCCTCGACGTGGTCG
ATGCGATCCGCAAGGTGAAGACGGGTTCAAAGGGCTTCCACCAGGACGTGCCCGTCGATGACGTCATCATCGAAAAGGCC
GTCGTGGTTGAGTAA

Upstream 100 bases:

>100_bases
ACATGCTGCACCGAAACTAACCATGCCACGGGCGCGGGCCACTCACCGCACAAACGCGATGCCCTGCGCCTTCCACTCAC
TAGACCCAAAGGAAATCATC

Downstream 100 bases:

>100_bases
GAACATTACTCGACCGAAAGGCCTATTCTTTAAGAAGCGCTGAAAAACTAAGAGAAGCACACTTCAATGCTGCAAGAAAC
GCCGCTGCGAAGCGTCGCTG

Product: cyclophilin type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase cyp18; SanCyp18; Rotamase cyp18 [H]

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
MVELHTNHGVIKLELDAEKAPKSVENFLAYVKAGHYDNTVFHRVIDGFMIQGGGFEPGMQQKPTNAPIANEANNGLKNVK
GSIAMARTNDPHSATAQFFINVNDNDFLNHSSPTPQGWGYAVFGKVVEGLDVVDAIRKVKTGSKGFHQDVPVDDVIIEKA
VVVE

Sequences:

>Translated_164_residues
MVELHTNHGVIKLELDAEKAPKSVENFLAYVKAGHYDNTVFHRVIDGFMIQGGGFEPGMQQKPTNAPIANEANNGLKNVK
GSIAMARTNDPHSATAQFFINVNDNDFLNHSSPTPQGWGYAVFGKVVEGLDVVDAIRKVKTGSKGFHQDVPVDDVIIEKA
VVVE
>Mature_164_residues
MVELHTNHGVIKLELDAEKAPKSVENFLAYVKAGHYDNTVFHRVIDGFMIQGGGFEPGMQQKPTNAPIANEANNGLKNVK
GSIAMARTNDPHSATAQFFINVNDNDFLNHSSPTPQGWGYAVFGKVVEGLDVVDAIRKVKTGSKGFHQDVPVDDVIIEKA
VVVE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=163, Percent_Identity=35.5828220858896, Blast_Score=91, Evalue=4e-19,
Organism=Homo sapiens, GI7706339, Length=163, Percent_Identity=33.1288343558282, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI22547212, Length=164, Percent_Identity=32.9268292682927, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI7657473, Length=164, Percent_Identity=32.9268292682927, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI22547215, Length=164, Percent_Identity=32.9268292682927, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI24308049, Length=158, Percent_Identity=33.5443037974684, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI64276486, Length=130, Percent_Identity=36.1538461538462, Blast_Score=70, Evalue=6e-13,
Organism=Homo sapiens, GI310110104, Length=134, Percent_Identity=34.3283582089552, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI5454154, Length=145, Percent_Identity=33.1034482758621, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI10863927, Length=152, Percent_Identity=30.2631578947368, Blast_Score=66, Evalue=1e-11,
Organism=Homo sapiens, GI310129267, Length=134, Percent_Identity=32.8358208955224, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI310120620, Length=134, Percent_Identity=32.8358208955224, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI4758950, Length=162, Percent_Identity=33.9506172839506, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI1786736, Length=164, Percent_Identity=65.8536585365854, Blast_Score=229, Evalue=7e-62,
Organism=Escherichia coli, GI1789763, Length=162, Percent_Identity=59.2592592592593, Blast_Score=184, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI71980590, Length=148, Percent_Identity=35.8108108108108, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71980594, Length=148, Percent_Identity=35.8108108108108, Blast_Score=84, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17532641, Length=167, Percent_Identity=32.9341317365269, Blast_Score=81, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17506311, Length=143, Percent_Identity=31.4685314685315, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17539496, Length=167, Percent_Identity=29.3413173652695, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320510, Length=158, Percent_Identity=35.4430379746835, Blast_Score=65, Evalue=7e-12,
Organism=Drosophila melanogaster, GI19922376, Length=172, Percent_Identity=29.6511627906977, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17986117, Length=166, Percent_Identity=31.9277108433735, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24652460, Length=163, Percent_Identity=30.0613496932515, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI19922912, Length=162, Percent_Identity=34.5679012345679, Blast_Score=70, Evalue=8e-13,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 17841; Mature: 17841

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVELHTNHGVIKLELDAEKAPKSVENFLAYVKAGHYDNTVFHRVIDGFMIQGGGFEPGMQ
CEEEECCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCEEEECCCCCCCCC
QKPTNAPIANEANNGLKNVKGSIAMARTNDPHSATAQFFINVNDNDFLNHSSPTPQGWGY
CCCCCCCCCCCCCCCHHHCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCH
AVFGKVVEGLDVVDAIRKVKTGSKGFHQDVPVDDVIIEKAVVVE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCEEEECC
>Mature Secondary Structure
MVELHTNHGVIKLELDAEKAPKSVENFLAYVKAGHYDNTVFHRVIDGFMIQGGGFEPGMQ
CEEEECCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCEEEECCCCCCCCC
QKPTNAPIANEANNGLKNVKGSIAMARTNDPHSATAQFFINVNDNDFLNHSSPTPQGWGY
CCCCCCCCCCCCCCCHHHCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCH
AVFGKVVEGLDVVDAIRKVKTGSKGFHQDVPVDDVIIEKAVVVE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10400660 [H]