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The map label for this gene is uppS [H]

Identifier: 186476092

GI number: 186476092

Start: 1494132

End: 1494914

Strand: Reverse

Name: uppS [H]

Synonym: Bphy_1334

Alternate gene names: 186476092

Gene position: 1494914-1494132 (Counterclockwise)

Preceding gene: 186476093

Following gene: 186476091

Centisome position: 42.97

GC content: 64.11

Gene sequence:

>783_bases
ATGACCTATACAAGCTCAACCGTTCGCGTACCTGACGTGTCAGCCGTACCGCGTCACATCGCGATCATCATGGACGGCAA
TGGCCGTTGGGCGACTCAACGCCGTCTTCCGCGCGTCGCGGGCCATACCCGCGGGGTCGATGCCGTGCGCGCGGCTGTCG
AAGCCTGTGCGCGCCAGGGTGTCGAATATCTGACGCTGTTCGCCTTCAGTTCGGAAAACTGGCGTCGTCCGACCGACGAA
GTGTCGTTCCTGATGCGCCTGTTCGTCACCGCGCTCGAGCGCGAAATCGGCAAGCTGCACGCCAACGGCATCCGCTTGCG
CGTCGTGGGCGATCTGTCGATGTTCGACAAGAAGATCCAGGATCTGATCACCCGCGCCGAAACCAAGACGGCGAAGAACA
CGCGCCTCACGCTCACCATCGCCGCGAACTACGGCGGCCGCTGGGACATCATGCAGGCTACGCGCAAGCTGGTCGAGCAG
TCCGTGCAAGCGGGCCGCCCGGTCGAGATCAGCGAGGAAGCGTTCGCCGAACACCTCGCGATGGCTTACGCACCCGAGCC
GGACCTGTTCATCCGCACGGGCGGCGAGCAGCGCATCAGCAACTTCCTGCTGTGGCAGCTGGCGTACACCGAGTTCTATT
TCACCGACACCTACTGGCCGGATTTCGACGCCGACGCGCTTGGCCGCGCGATGGCCTCGTACACCGGACGCGAGCGCCGC
TTCGGCCGGACCAGCGCGCAGCTCGAGCCGCAATCGCAAAACGTCGATTCGCTTCCATGCTAA

Upstream 100 bases:

>100_bases
CCAAGGAAGGCGAGATCATGACGGTTTGACGGTCTGGCGCAAACCAGACATGCAGACTTTCACTGATCATTGTTCCTTTC
TCTAGCTTTACCCGACGGCC

Downstream 100 bases:

>100_bases
AAACCCGTGTCATCACGGCGATCGTTCTGCTGGCTATTCTTCTGCCTGTCACGCTGTGGGCGCCGATCGGCGGCTTCGGC
GCGCTGATCGCCTTCGTCGT

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MTYTSSTVRVPDVSAVPRHIAIIMDGNGRWATQRRLPRVAGHTRGVDAVRAAVEACARQGVEYLTLFAFSSENWRRPTDE
VSFLMRLFVTALEREIGKLHANGIRLRVVGDLSMFDKKIQDLITRAETKTAKNTRLTLTIAANYGGRWDIMQATRKLVEQ
SVQAGRPVEISEEAFAEHLAMAYAPEPDLFIRTGGEQRISNFLLWQLAYTEFYFTDTYWPDFDADALGRAMASYTGRERR
FGRTSAQLEPQSQNVDSLPC

Sequences:

>Translated_260_residues
MTYTSSTVRVPDVSAVPRHIAIIMDGNGRWATQRRLPRVAGHTRGVDAVRAAVEACARQGVEYLTLFAFSSENWRRPTDE
VSFLMRLFVTALEREIGKLHANGIRLRVVGDLSMFDKKIQDLITRAETKTAKNTRLTLTIAANYGGRWDIMQATRKLVEQ
SVQAGRPVEISEEAFAEHLAMAYAPEPDLFIRTGGEQRISNFLLWQLAYTEFYFTDTYWPDFDADALGRAMASYTGRERR
FGRTSAQLEPQSQNVDSLPC
>Mature_259_residues
TYTSSTVRVPDVSAVPRHIAIIMDGNGRWATQRRLPRVAGHTRGVDAVRAAVEACARQGVEYLTLFAFSSENWRRPTDEV
SFLMRLFVTALEREIGKLHANGIRLRVVGDLSMFDKKIQDLITRAETKTAKNTRLTLTIAANYGGRWDIMQATRKLVEQS
VQAGRPVEISEEAFAEHLAMAYAPEPDLFIRTGGEQRISNFLLWQLAYTEFYFTDTYWPDFDADALGRAMASYTGRERRF
GRTSAQLEPQSQNVDSLPC

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=213, Percent_Identity=35.6807511737089, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI45580742, Length=213, Percent_Identity=35.6807511737089, Blast_Score=139, Evalue=3e-33,
Organism=Escherichia coli, GI1786371, Length=229, Percent_Identity=55.4585152838428, Blast_Score=258, Evalue=3e-70,
Organism=Caenorhabditis elegans, GI71993029, Length=226, Percent_Identity=34.070796460177, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6323748, Length=223, Percent_Identity=34.5291479820628, Blast_Score=129, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6319474, Length=226, Percent_Identity=37.1681415929204, Blast_Score=122, Evalue=5e-29,
Organism=Drosophila melanogaster, GI18857969, Length=209, Percent_Identity=36.3636363636364, Blast_Score=150, Evalue=6e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 29402; Mature: 29270

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYTSSTVRVPDVSAVPRHIAIIMDGNGRWATQRRLPRVAGHTRGVDAVRAAVEACARQG
CCCCCCEEECCCCCCCCCEEEEEECCCCCCHHHHHCHHHHCCCCCHHHHHHHHHHHHHCC
VEYLTLFAFSSENWRRPTDEVSFLMRLFVTALEREIGKLHANGIRLRVVGDLSMFDKKIQ
CCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHH
DLITRAETKTAKNTRLTLTIAANYGGRWDIMQATRKLVEQSVQAGRPVEISEEAFAEHLA
HHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
MAYAPEPDLFIRTGGEQRISNFLLWQLAYTEFYFTDTYWPDFDADALGRAMASYTGRERR
HHCCCCCCEEEECCCHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHCCHHHH
FGRTSAQLEPQSQNVDSLPC
CCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TYTSSTVRVPDVSAVPRHIAIIMDGNGRWATQRRLPRVAGHTRGVDAVRAAVEACARQG
CCCCCEEECCCCCCCCCEEEEEECCCCCCHHHHHCHHHHCCCCCHHHHHHHHHHHHHCC
VEYLTLFAFSSENWRRPTDEVSFLMRLFVTALEREIGKLHANGIRLRVVGDLSMFDKKIQ
CCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHH
DLITRAETKTAKNTRLTLTIAANYGGRWDIMQATRKLVEQSVQAGRPVEISEEAFAEHLA
HHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
MAYAPEPDLFIRTGGEQRISNFLLWQLAYTEFYFTDTYWPDFDADALGRAMASYTGRERR
HHCCCCCCEEEECCCHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHCCHHHH
FGRTSAQLEPQSQNVDSLPC
CCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]