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The map label for this gene is uvrY [H]

Identifier: 186475902

GI number: 186475902

Start: 1279121

End: 1279765

Strand: Direct

Name: uvrY [H]

Synonym: Bphy_1137

Alternate gene names: 186475902

Gene position: 1279121-1279765 (Clockwise)

Preceding gene: 186475900

Following gene: 186475903

Centisome position: 36.76

GC content: 59.69

Gene sequence:

>645_bases
ATGATCAAGGTATTGTTGGCCGATGACCATGCGCTCGTACGCGACGGCCTGCGCCACATTCTCCAGAGCGCCAGCGGTTT
CGAAGTGGCCGGCGAAGCATGGGACGGCATCACCACCATCGCGCTCATTCGCTCTACGCCGGCGCAAGTGCTCGTTCTCG
ATCTGACGATGCCGGGCCGCAACGGCATCGAACTGATCCGGCAGATCAAGGACGAGCAGCCCGCGCTGCGCATCCTCGTG
CTGACGATGCATGCCGAGCAGCAGTACGCGGTGCGCGCATTCAAAGCGGGCGCCTCGGGATATCTGACGAAGGAAAGCGC
AAGCGTGGAGCTGGTCAACGCCGTCACGAAGATAGCGGGCGGAGGTGTGTACATCAGCCTGGCGATGGCCGAACGCCTGG
CACAAACCCTGAACGAGCCCGCGGAAGCGTTACCGCATCAGCGGCTCTCGGACCGGGAGTTCGATGTCTTCAGACGAATC
GTCGCCGGCCAGAGCATTACGGAGATCGCTCATGAATTATGTGTGAGCGTAAAGACCGTGAGCACGCACAAGACACGCGT
ACTCGAGAAAATGCAGTTGCCGAATGAGAACGCGCTTGTACGTTACGCGATTCGTTACAAGCTCATCGAGGACGACGAGC
TATAA

Upstream 100 bases:

>100_bases
CGCGTGTCAAGCAACAACGCGTTGTCGTCCGGACCGACGGCCGCTTCGCGAAAACGATCAAGTTTCCCCTGCAATTCGTG
AGCCAGGAAGAAACCCAACC

Downstream 100 bases:

>100_bases
ATAGGCATTCTGACGTCGGCGTTGGTAGGACTATTCCTAGCCTCGCTGCCTCACCTCCTATCTCCGGTTAAAGCACCGCC
GATACCTTTTTGCGATACGA

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MIKVLLADDHALVRDGLRHILQSASGFEVAGEAWDGITTIALIRSTPAQVLVLDLTMPGRNGIELIRQIKDEQPALRILV
LTMHAEQQYAVRAFKAGASGYLTKESASVELVNAVTKIAGGGVYISLAMAERLAQTLNEPAEALPHQRLSDREFDVFRRI
VAGQSITEIAHELCVSVKTVSTHKTRVLEKMQLPNENALVRYAIRYKLIEDDEL

Sequences:

>Translated_214_residues
MIKVLLADDHALVRDGLRHILQSASGFEVAGEAWDGITTIALIRSTPAQVLVLDLTMPGRNGIELIRQIKDEQPALRILV
LTMHAEQQYAVRAFKAGASGYLTKESASVELVNAVTKIAGGGVYISLAMAERLAQTLNEPAEALPHQRLSDREFDVFRRI
VAGQSITEIAHELCVSVKTVSTHKTRVLEKMQLPNENALVRYAIRYKLIEDDEL
>Mature_214_residues
MIKVLLADDHALVRDGLRHILQSASGFEVAGEAWDGITTIALIRSTPAQVLVLDLTMPGRNGIELIRQIKDEQPALRILV
LTMHAEQQYAVRAFKAGASGYLTKESASVELVNAVTKIAGGGVYISLAMAERLAQTLNEPAEALPHQRLSDREFDVFRRI
VAGQSITEIAHELCVSVKTVSTHKTRVLEKMQLPNENALVRYAIRYKLIEDDEL

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=215, Percent_Identity=35.8139534883721, Blast_Score=143, Evalue=8e-36,
Organism=Escherichia coli, GI1786747, Length=219, Percent_Identity=29.6803652968037, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1790102, Length=201, Percent_Identity=32.3383084577114, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1788521, Length=196, Percent_Identity=33.1632653061224, Blast_Score=97, Evalue=6e-22,
Organism=Escherichia coli, GI1788546, Length=207, Percent_Identity=33.3333333333333, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788712, Length=207, Percent_Identity=25.1207729468599, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1787473, Length=182, Percent_Identity=32.4175824175824, Blast_Score=87, Evalue=7e-19,
Organism=Escherichia coli, GI87082052, Length=104, Percent_Identity=35.5769230769231, Blast_Score=68, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23638; Mature: 23638

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKVLLADDHALVRDGLRHILQSASGFEVAGEAWDGITTIALIRSTPAQVLVLDLTMPGR
CEEEEEECCHHHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHCCCCEEEEEEEECCCC
NGIELIRQIKDEQPALRILVLTMHAEQQYAVRAFKAGASGYLTKESASVELVNAVTKIAG
HHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHCC
GGVYISLAMAERLAQTLNEPAEALPHQRLSDREFDVFRRIVAGQSITEIAHELCVSVKTV
CCEEEHHHHHHHHHHHHCCHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHH
STHKTRVLEKMQLPNENALVRYAIRYKLIEDDEL
HHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCCC
>Mature Secondary Structure
MIKVLLADDHALVRDGLRHILQSASGFEVAGEAWDGITTIALIRSTPAQVLVLDLTMPGR
CEEEEEECCHHHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHCCCCEEEEEEEECCCC
NGIELIRQIKDEQPALRILVLTMHAEQQYAVRAFKAGASGYLTKESASVELVNAVTKIAG
HHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHCC
GGVYISLAMAERLAQTLNEPAEALPHQRLSDREFDVFRRIVAGQSITEIAHELCVSVKTV
CCEEEHHHHHHHHHHHHCCHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHH
STHKTRVLEKMQLPNENALVRYAIRYKLIEDDEL
HHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]