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The map label for this gene is pgi

Identifier: 186475784

GI number: 186475784

Start: 1143453

End: 1145075

Strand: Reverse

Name: pgi

Synonym: Bphy_1019

Alternate gene names: 186475784

Gene position: 1145075-1143453 (Counterclockwise)

Preceding gene: 186475785

Following gene: 186475782

Centisome position: 32.91

GC content: 62.91

Gene sequence:

>1623_bases
ATGACTCTCAACTCGCTCCCCGCCTGGAACTCGCTGCAGACACACTACGGACAGATTCGCGATGCGCGCCTGCGCGACTG
GTTTGCACCCGAGAACGATCCCGCGCCGACCCGCGCCGAACGCTTTACGCTCTCCGGCGGCGGTCTCGCAGCCGATTTTT
CGAAAAACCGCATCACCGACGACACCCTCAAGCTGCTCGTGCAGCTCGCGCGCGAAGCACAGGTCGAGACACGCCGCGAC
GCGATGTTCGCGGGCGAAACCGTCAATCCGACGGAAGGCCGCGCGGTCCTGCACACGGCGCTGCGCGCGAGCAACCCGAC
GTCACCGTTCTACGGCAAGGTGCAGGCCGAGCGCGCAAAAATGGCGGCGTTCGCTGACAAGGTTCGCAGCGGCGAATGGA
CGGGCTATACGGGCAAGCGCATTCGCCATGTCGTGAACATCGGCATCGGCGGGTCCGATCTCGGTCCGAAGATGGTCGTG
CACGCGCTGCAACACCTCGCTACGCCTGAAATTTCTACGCACTTCGTATCAAACGTCGACGGCGCGGACCTCTACCGCGT
GCTTCAACAGATCAATCCCGAAGAAACGCTCGCGATCATCGTGTCGAAGACATTCACGACGCTCGAAACGATGACCAATG
CGAACTCGCTGCGCGACTGGTTCATCCAGAAAGGTTGCCCGGAGAGCGAGCTGGCGAAGCACTTCGTCGGCGTGTCGGCG
AATCCCGCCGAAGTCGTCAAGTTCGGCATCGCTCAGGAGAATGTGTTCGAGATGTGGGACTGGGTTGGCGGGCGTTATTC
GCTGTGGTCGGCCGTCGGTCTGTCGATCGTGATCGCCATCGGTCCGAAGCAGTTCGACGAACTGCTAGCGGGCGCGAACG
AGATGGACGAGCATTTCCGCAGCGCGCCGCTGGAACGCAACCTGCCCGTGCTGATGGGCATGATCGGCATCTGGTATCGC
AACTTCTTCGGCTCGCAGAGCTATCTGGTCGCGCCGTACTCCGAGGCACTCCACTTCCTGCCGTCGTACCTGCAGCAGCT
GGAGATGGAAAGCAACGGCAAGCAGGCATGCCTGGACGGCTCGTTCGTCACCTACGACACGTCGGCCGTCACGTGGGGCG
AGCCCGGCACGAACGGCCAGCATGCGTTCTTTCAGATGTTGCACCAGGGGCCGACCATCGTCCCGATCGACTTCGTCGCC
GTGCTTACGCCCGAGCATCCCCTCGTGTCCCATCATCCGAAGCTACTGGCTAACTGCTTCGCGCAAAGCGAAGCGCTGAT
GCTCGGCCGCACGCGGGAGGAAGCTGAGAAAGTGGCGGGACGGGACAAGCCCGACCTCGTGCCGCACATCATGTTCCCCG
GCAACCGTCCGACCACGACGCTGCTCGTTGACGCCCTCACCGCCCGTTCGCTCGGCGCGCTGATCGCGCTGTACGAACAC
AAGGTGCTCGTGCAAGGCACGGTCTGGAACATCAACTCGTTCGACCAGTGGGGCGTCGAGCTGGGCAAGATTCTCGGCAA
GGTGGTCGAAGCCGATCTGACGGCGGCCACTGTCGATGAAACGAAGCACGACTCGTCCACTTCGGCGTTGATCGCGCGTG
CGCGTGCGGCGCTGAAGCGCTGA

Upstream 100 bases:

>100_bases
CCGGCGACCGGACCGCTCAGCCAACTGCGCGACTGCAGATCACCCCCGGCACGCCCGACGTGCGGCCGGCCATTCGTTTC
CCTTCGTTAGACGGACGGTT

Downstream 100 bases:

>100_bases
TCCGGCGCATCCGCCCATTCAAGCGCTCGAAACCAAACGGGCCTTCGTCACGAAGGCCCGTTTTTTTCGCCTGCAATGCA
CGCTTGGATCTGCTCAGATC

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 540; Mature: 539

Protein sequence:

>540_residues
MTLNSLPAWNSLQTHYGQIRDARLRDWFAPENDPAPTRAERFTLSGGGLAADFSKNRITDDTLKLLVQLAREAQVETRRD
AMFAGETVNPTEGRAVLHTALRASNPTSPFYGKVQAERAKMAAFADKVRSGEWTGYTGKRIRHVVNIGIGGSDLGPKMVV
HALQHLATPEISTHFVSNVDGADLYRVLQQINPEETLAIIVSKTFTTLETMTNANSLRDWFIQKGCPESELAKHFVGVSA
NPAEVVKFGIAQENVFEMWDWVGGRYSLWSAVGLSIVIAIGPKQFDELLAGANEMDEHFRSAPLERNLPVLMGMIGIWYR
NFFGSQSYLVAPYSEALHFLPSYLQQLEMESNGKQACLDGSFVTYDTSAVTWGEPGTNGQHAFFQMLHQGPTIVPIDFVA
VLTPEHPLVSHHPKLLANCFAQSEALMLGRTREEAEKVAGRDKPDLVPHIMFPGNRPTTTLLVDALTARSLGALIALYEH
KVLVQGTVWNINSFDQWGVELGKILGKVVEADLTAATVDETKHDSSTSALIARARAALKR

Sequences:

>Translated_540_residues
MTLNSLPAWNSLQTHYGQIRDARLRDWFAPENDPAPTRAERFTLSGGGLAADFSKNRITDDTLKLLVQLAREAQVETRRD
AMFAGETVNPTEGRAVLHTALRASNPTSPFYGKVQAERAKMAAFADKVRSGEWTGYTGKRIRHVVNIGIGGSDLGPKMVV
HALQHLATPEISTHFVSNVDGADLYRVLQQINPEETLAIIVSKTFTTLETMTNANSLRDWFIQKGCPESELAKHFVGVSA
NPAEVVKFGIAQENVFEMWDWVGGRYSLWSAVGLSIVIAIGPKQFDELLAGANEMDEHFRSAPLERNLPVLMGMIGIWYR
NFFGSQSYLVAPYSEALHFLPSYLQQLEMESNGKQACLDGSFVTYDTSAVTWGEPGTNGQHAFFQMLHQGPTIVPIDFVA
VLTPEHPLVSHHPKLLANCFAQSEALMLGRTREEAEKVAGRDKPDLVPHIMFPGNRPTTTLLVDALTARSLGALIALYEH
KVLVQGTVWNINSFDQWGVELGKILGKVVEADLTAATVDETKHDSSTSALIARARAALKR
>Mature_539_residues
TLNSLPAWNSLQTHYGQIRDARLRDWFAPENDPAPTRAERFTLSGGGLAADFSKNRITDDTLKLLVQLAREAQVETRRDA
MFAGETVNPTEGRAVLHTALRASNPTSPFYGKVQAERAKMAAFADKVRSGEWTGYTGKRIRHVVNIGIGGSDLGPKMVVH
ALQHLATPEISTHFVSNVDGADLYRVLQQINPEETLAIIVSKTFTTLETMTNANSLRDWFIQKGCPESELAKHFVGVSAN
PAEVVKFGIAQENVFEMWDWVGGRYSLWSAVGLSIVIAIGPKQFDELLAGANEMDEHFRSAPLERNLPVLMGMIGIWYRN
FFGSQSYLVAPYSEALHFLPSYLQQLEMESNGKQACLDGSFVTYDTSAVTWGEPGTNGQHAFFQMLHQGPTIVPIDFVAV
LTPEHPLVSHHPKLLANCFAQSEALMLGRTREEAEKVAGRDKPDLVPHIMFPGNRPTTTLLVDALTARSLGALIALYEHK
VLVQGTVWNINSFDQWGVELGKILGKVVEADLTAATVDETKHDSSTSALIARARAALKR

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=544, Percent_Identity=48.8970588235294, Blast_Score=516, Evalue=1e-146,
Organism=Homo sapiens, GI296080693, Length=538, Percent_Identity=44.9814126394052, Blast_Score=457, Evalue=1e-128,
Organism=Escherichia coli, GI1790457, Length=542, Percent_Identity=50.3690036900369, Blast_Score=530, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI71996708, Length=552, Percent_Identity=48.0072463768116, Blast_Score=502, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI71996703, Length=552, Percent_Identity=48.0072463768116, Blast_Score=501, Evalue=1e-142,
Organism=Saccharomyces cerevisiae, GI6319673, Length=544, Percent_Identity=47.7941176470588, Blast_Score=508, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24651916, Length=553, Percent_Identity=47.0162748643761, Blast_Score=506, Evalue=1e-143,
Organism=Drosophila melanogaster, GI24651914, Length=553, Percent_Identity=47.0162748643761, Blast_Score=506, Evalue=1e-143,
Organism=Drosophila melanogaster, GI17737445, Length=553, Percent_Identity=47.0162748643761, Blast_Score=506, Evalue=1e-143,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_BURP8 (B2JGM3)

Other databases:

- EMBL:   CP001043
- RefSeq:   YP_001857254.1
- ProteinModelPortal:   B2JGM3
- SMR:   B2JGM3
- GeneID:   6242517
- GenomeReviews:   CP001043_GR
- KEGG:   bph:Bphy_1019
- HOGENOM:   HBG352954
- OMA:   LGKGVYQ
- ProtClustDB:   PRK00179
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 59520; Mature: 59389

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 381-381 ACT_SITE 503-503

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLNSLPAWNSLQTHYGQIRDARLRDWFAPENDPAPTRAERFTLSGGGLAADFSKNRITD
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHEEEECCCCEEECCCCCCCCH
DTLKLLVQLAREAQVETRRDAMFAGETVNPTEGRAVLHTALRASNPTSPFYGKVQAERAK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHH
MAAFADKVRSGEWTGYTGKRIRHVVNIGIGGSDLGPKMVVHALQHLATPEISTHFVSNVD
HHHHHHHHCCCCCCCCCHHHHHHHHEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHCCCC
GADLYRVLQQINPEETLAIIVSKTFTTLETMTNANSLRDWFIQKGCPESELAKHFVGVSA
HHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHCCCCC
NPAEVVKFGIAQENVFEMWDWVGGRYSLWSAVGLSIVIAIGPKQFDELLAGANEMDEHFR
CHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHCEEEEEEECHHHHHHHHCCCHHHHHHHH
SAPLERNLPVLMGMIGIWYRNFFGSQSYLVAPYSEALHFLPSYLQQLEMESNGKQACLDG
CCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHCCCCCEEEECC
SFVTYDTSAVTWGEPGTNGQHAFFQMLHQGPTIVPIDFVAVLTPEHPLVSHHPKLLANCF
CEEEECCCEEECCCCCCCCHHHHHHHHHCCCCEEEEEEEEEECCCCCCHHCCHHHHHHHH
AQSEALMLGRTREEAEKVAGRDKPDLVPHIMFPGNRPTTTLLVDALTARSLGALIALYEH
HHCCHHHHCCCHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHC
KVLVQGTVWNINSFDQWGVELGKILGKVVEADLTAATVDETKHDSSTSALIARARAALKR
EEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TLNSLPAWNSLQTHYGQIRDARLRDWFAPENDPAPTRAERFTLSGGGLAADFSKNRITD
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHEEEECCCCEEECCCCCCCCH
DTLKLLVQLAREAQVETRRDAMFAGETVNPTEGRAVLHTALRASNPTSPFYGKVQAERAK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHH
MAAFADKVRSGEWTGYTGKRIRHVVNIGIGGSDLGPKMVVHALQHLATPEISTHFVSNVD
HHHHHHHHCCCCCCCCCHHHHHHHHEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHCCCC
GADLYRVLQQINPEETLAIIVSKTFTTLETMTNANSLRDWFIQKGCPESELAKHFVGVSA
HHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHCCCCC
NPAEVVKFGIAQENVFEMWDWVGGRYSLWSAVGLSIVIAIGPKQFDELLAGANEMDEHFR
CHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHCEEEEEEECHHHHHHHHCCCHHHHHHHH
SAPLERNLPVLMGMIGIWYRNFFGSQSYLVAPYSEALHFLPSYLQQLEMESNGKQACLDG
CCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHCCCCCEEEECC
SFVTYDTSAVTWGEPGTNGQHAFFQMLHQGPTIVPIDFVAVLTPEHPLVSHHPKLLANCF
CEEEECCCEEECCCCCCCCHHHHHHHHHCCCCEEEEEEEEEECCCCCCHHCCHHHHHHHH
AQSEALMLGRTREEAEKVAGRDKPDLVPHIMFPGNRPTTTLLVDALTARSLGALIALYEH
HHCCHHHHCCCHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHC
KVLVQGTVWNINSFDQWGVELGKILGKVVEADLTAATVDETKHDSSTSALIARARAALKR
EEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA