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The map label for this gene is lon [H]

Identifier: 186475778

GI number: 186475778

Start: 1136002

End: 1138419

Strand: Direct

Name: lon [H]

Synonym: Bphy_1013

Alternate gene names: 186475778

Gene position: 1136002-1138419 (Clockwise)

Preceding gene: 186475777

Following gene: 186475779

Centisome position: 32.65

GC content: 61.0

Gene sequence:

>2418_bases
ATGTCAGGAACCCAACTCCTCCCGCCGGAACGCGTCACACTTCCGCTGCTCCCGCTGCGCGACGTAGTCGTTTTCCCTCA
CATGGTGATCCCGCTCTTCGTGGGGCGCCCAAAGTCGATCAAAGCGTTGGAAGCCGCGATGGAAGGCGGCAAGCACATCA
TGCTTGTTGCCCAGAAAACGGCGGCCAAAGACGAGCCGACCGAAAAGGACATGTATGAGGTTGGCTGTATCGCCAACATC
CTGCAGATGCTCAAGCTGCCCGACGGCACGGTGAAGGTGCTGGTCGAAGGTCTGCAGCGTGCGAAGACGCTGTCGATCGA
AGAGCAGGAAACGCAATTCTCGTGCGAAGTCATGCCGCTCGAGCCCGATCACGCCGATAGCGCTGAAACGGAAGCGCTGC
GCCGGGCGATCGTCTCGCAGTTCGACCAGTACGTGAAACTGAACAAGAAGATTCCGCCGGAGATCCTGACCTCGCTGTCG
GGCATCGACGAGGCCGGTCGTCTTGCCGACACCATCGCCGCGCATTTGCCGCTCAAGCTCGACCAGAAGCAGCAGATTCT
TGAAATGTTCCCGGTCATCGAGCGCCTCGAGCATCTGCTCGCGCAACTCGAAGCCGAGATCGACATCCTGCAGGTTGAAA
AACGCATCCGCGGACGCGTCAAGCGTCAGATGGAGAAGAGCCAGCGCGAGTACTACCTGAACGAACAGGTCAAGGCGATC
CAGAAGGAACTGGGCGAAGGCGAAGAAGGTGCCGATCTCGAAGAACTCGAGAAACGCATCGCCGCCGCGCGCATGCCGAA
GGAAGCCAAGAAGAAGGCCGACGCCGAGCTGAAGAAGCTCAAGCTGATGTCGCCGATGTCGGCGGAAGCGACGGTCGTGC
GCAACTACATCGACACGCTGATCGGCCTGCCGTGGCGCAAGAAGAGCAAGGTCAACAACGACCTCTCGAATGCGGAGCGC
GTGCTGGACGAAGACCATTTCGGTCTCGAGAAGGTCAAGGAGCGCATTCTCGAGTACCTCGCGGTTCAACAGCGCGTGGA
CAAGGTGAAGGCGCCGATCCTGTGCCTCGTCGGGCCTCCGGGCGTTGGTAAGACGTCGCTGGGCCAGTCGATTGCACGCG
CAACGAATCGCAAGTTCGTGCGCATGGCGCTGGGGGGCGTGCGTGATGAAGCGGAGATCCGCGGCCACCGTCGTACGTAC
ATCGGTTCGATGCCGGGCAAGATCCTGCAGAGCCTGACCAAGGTCGGCGTGCGCAATCCACTCTTCCTGCTCGACGAAGT
TGACAAGATGGGCATGGATTTCCGCGGCGATCCGTCATCGGCGCTGCTCGAAGTGCTCGATCCGGAACAGAACCACACGT
TCGCCGACCATTACGTCGAAGTCGACTTCGACCTGTCGGACGTGATGTTCGTCGCGACGTCGAACTCGCTGAACATTCCG
CCGCCGCTGCTCGACCGGATGGAAGTGATCCGTCTGTCGGGCTACACGGAAGACGAGAAGGTCAGCATCGCGCAACGTTA
TCTGCTGCCGAAGCAGAAGAAGAACAACGGCCTGAAGGAAGGCGAGATCGAGGTCACGGAAGCAGCGATCCGCGACATCA
TTCGCTACTACACGCGTGAAGCGGGTGTGCGTTCGCTCGAGCGTGAAGTGTCGAAGATCTGCCGCAAGGTCGTGAAGATG
CTTCTGTTGAAGAAGGCGGACAAGGCGGTGACGGTCGACGGCAACAACCTCGACACGTTCCTCGGCGTGCGCAAGTATGA
CTTCGGTCTGGCCGCGAAGGAGAACCAGACCGGTCAGGTCACGGGTCTCGCATGGACGGAAGTCGGCGGCGATCTGCTGA
CGATCGAAGCGGCCGTGATGCCGGGCAAGGGCAATGTGATCCGCACGGGTTCGCTTGGCGACGTGATGAAGGAATCCGTC
GAAGCCGCGCGCTCGGTGGTGCGTTCGCGTTCGCGCCGTCTCGGTATCAAGGACGAAGCGTTCGAGAAGCAGGACATCCA
CATCCACGTGCCGGAAGGAGCGACACCGAAGGACGGCCCGTCCGCCGGCATCGCGATGACGACGGCGCTGGTGTCGGTGC
TCACGGGCATCCCCGTGCGAGCTGACGTCGCGATGACGGGCGAGATCACGCTGCGCGGCGAAGTGTTGCCGATCGGCGGG
CTGAAAGAGAAGCTGCTGGCAGCGCATCGCGGCGGCATCAAGCTCGTGCTGATTCCGGAGGAAAACGTCAAGGATCTGAC
GGAGATTCCGGACAACGTGAAGAACGCGATTGAGATCGTTCCGGTTCGCTGGATCGACAAGGTGCTGGAGCTGGCGCTCG
AAAGGGCGCCGTCGGCACTGCCGGAAGAGGAGCCGAAGGCGGCTGCGCCCGTCAGTGAATCGAAAGAGTCTGGCGCAAGC
GACGTAGTGAAACACTAA

Upstream 100 bases:

>100_bases
TTTTCTGGAGTCACTGAACTTTTCCCACACGCGAAGGCTTGCAATCTTTTTTGGCGGCCTCAACTATCGAACAAACTGAT
TCCACTCATGGGGAAATGAA

Downstream 100 bases:

>100_bases
ACGCCTTGCACGCATCGCTGAGTTCGCTCGGTCGGTAGCCATCAAAAACCCGCGGCTTTGCCCGCGGGTTTTTTTGTTCA
CGCGATGCAAACGTTTGCTC

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 805; Mature: 804

Protein sequence:

>805_residues
MSGTQLLPPERVTLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMEGGKHIMLVAQKTAAKDEPTEKDMYEVGCIANI
LQMLKLPDGTVKVLVEGLQRAKTLSIEEQETQFSCEVMPLEPDHADSAETEALRRAIVSQFDQYVKLNKKIPPEILTSLS
GIDEAGRLADTIAAHLPLKLDQKQQILEMFPVIERLEHLLAQLEAEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
QKELGEGEEGADLEELEKRIAAARMPKEAKKKADAELKKLKLMSPMSAEATVVRNYIDTLIGLPWRKKSKVNNDLSNAER
VLDEDHFGLEKVKERILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSIARATNRKFVRMALGGVRDEAEIRGHRRTY
IGSMPGKILQSLTKVGVRNPLFLLDEVDKMGMDFRGDPSSALLEVLDPEQNHTFADHYVEVDFDLSDVMFVATSNSLNIP
PPLLDRMEVIRLSGYTEDEKVSIAQRYLLPKQKKNNGLKEGEIEVTEAAIRDIIRYYTREAGVRSLEREVSKICRKVVKM
LLLKKADKAVTVDGNNLDTFLGVRKYDFGLAAKENQTGQVTGLAWTEVGGDLLTIEAAVMPGKGNVIRTGSLGDVMKESV
EAARSVVRSRSRRLGIKDEAFEKQDIHIHVPEGATPKDGPSAGIAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG
LKEKLLAAHRGGIKLVLIPEENVKDLTEIPDNVKNAIEIVPVRWIDKVLELALERAPSALPEEEPKAAAPVSESKESGAS
DVVKH

Sequences:

>Translated_805_residues
MSGTQLLPPERVTLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMEGGKHIMLVAQKTAAKDEPTEKDMYEVGCIANI
LQMLKLPDGTVKVLVEGLQRAKTLSIEEQETQFSCEVMPLEPDHADSAETEALRRAIVSQFDQYVKLNKKIPPEILTSLS
GIDEAGRLADTIAAHLPLKLDQKQQILEMFPVIERLEHLLAQLEAEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
QKELGEGEEGADLEELEKRIAAARMPKEAKKKADAELKKLKLMSPMSAEATVVRNYIDTLIGLPWRKKSKVNNDLSNAER
VLDEDHFGLEKVKERILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSIARATNRKFVRMALGGVRDEAEIRGHRRTY
IGSMPGKILQSLTKVGVRNPLFLLDEVDKMGMDFRGDPSSALLEVLDPEQNHTFADHYVEVDFDLSDVMFVATSNSLNIP
PPLLDRMEVIRLSGYTEDEKVSIAQRYLLPKQKKNNGLKEGEIEVTEAAIRDIIRYYTREAGVRSLEREVSKICRKVVKM
LLLKKADKAVTVDGNNLDTFLGVRKYDFGLAAKENQTGQVTGLAWTEVGGDLLTIEAAVMPGKGNVIRTGSLGDVMKESV
EAARSVVRSRSRRLGIKDEAFEKQDIHIHVPEGATPKDGPSAGIAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG
LKEKLLAAHRGGIKLVLIPEENVKDLTEIPDNVKNAIEIVPVRWIDKVLELALERAPSALPEEEPKAAAPVSESKESGAS
DVVKH
>Mature_804_residues
SGTQLLPPERVTLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMEGGKHIMLVAQKTAAKDEPTEKDMYEVGCIANIL
QMLKLPDGTVKVLVEGLQRAKTLSIEEQETQFSCEVMPLEPDHADSAETEALRRAIVSQFDQYVKLNKKIPPEILTSLSG
IDEAGRLADTIAAHLPLKLDQKQQILEMFPVIERLEHLLAQLEAEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAIQ
KELGEGEEGADLEELEKRIAAARMPKEAKKKADAELKKLKLMSPMSAEATVVRNYIDTLIGLPWRKKSKVNNDLSNAERV
LDEDHFGLEKVKERILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSIARATNRKFVRMALGGVRDEAEIRGHRRTYI
GSMPGKILQSLTKVGVRNPLFLLDEVDKMGMDFRGDPSSALLEVLDPEQNHTFADHYVEVDFDLSDVMFVATSNSLNIPP
PLLDRMEVIRLSGYTEDEKVSIAQRYLLPKQKKNNGLKEGEIEVTEAAIRDIIRYYTREAGVRSLEREVSKICRKVVKML
LLKKADKAVTVDGNNLDTFLGVRKYDFGLAAKENQTGQVTGLAWTEVGGDLLTIEAAVMPGKGNVIRTGSLGDVMKESVE
AARSVVRSRSRRLGIKDEAFEKQDIHIHVPEGATPKDGPSAGIAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGGL
KEKLLAAHRGGIKLVLIPEENVKDLTEIPDNVKNAIEIVPVRWIDKVLELALERAPSALPEEEPKAAAPVSESKESGASD
VVKH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=564, Percent_Identity=46.6312056737589, Blast_Score=521, Evalue=1e-147,
Organism=Homo sapiens, GI21396489, Length=683, Percent_Identity=40.4099560761347, Blast_Score=501, Evalue=1e-141,
Organism=Escherichia coli, GI1786643, Length=772, Percent_Identity=70.0777202072539, Blast_Score=1090, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=692, Percent_Identity=39.1618497109827, Blast_Score=476, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI17556486, Length=540, Percent_Identity=40.3703703703704, Blast_Score=430, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6319449, Length=720, Percent_Identity=41.1111111111111, Blast_Score=519, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24666867, Length=704, Percent_Identity=41.3352272727273, Blast_Score=513, Evalue=1e-145,
Organism=Drosophila melanogaster, GI221513036, Length=704, Percent_Identity=41.3352272727273, Blast_Score=513, Evalue=1e-145,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 89103; Mature: 88971

Theoretical pI: Translated: 6.49; Mature: 6.49

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGTQLLPPERVTLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMEGGKHIMLVAQKT
CCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEECC
AAKDEPTEKDMYEVGCIANILQMLKLPDGTVKVLVEGLQRAKTLSIEEQETQFSCEVMPL
CCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHCCCEEEEEEEC
EPDHADSAETEALRRAIVSQFDQYVKLNKKIPPEILTSLSGIDEAGRLADTIAAHLPLKL
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCC
DQKQQILEMFPVIERLEHLLAQLEAEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKELGEGEEGADLEELEKRIAAARMPKEAKKKADAELKKLKLMSPMSAEATVVRNYIDTL
HHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
IGLPWRKKSKVNNDLSNAERVLDEDHFGLEKVKERILEYLAVQQRVDKVKAPILCLVGPP
HCCCCCHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
GVGKTSLGQSIARATNRKFVRMALGGVRDEAEIRGHRRTYIGSMPGKILQSLTKVGVRNP
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCHHHHHHHHHHHCCCCC
LFLLDEVDKMGMDFRGDPSSALLEVLDPEQNHTFADHYVEVDFDLSDVMFVATSNSLNIP
CHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCEEECCEEEEEECCCCEEEEEECCCCCCC
PPLLDRMEVIRLSGYTEDEKVSIAQRYLLPKQKKNNGLKEGEIEVTEAAIRDIIRYYTRE
CHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
AGVRSLEREVSKICRKVVKMLLLKKADKAVTVDGNNLDTFLGVRKYDFGLAAKENQTGQV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHCCHHHCCCCCCCCCCCCCE
TGLAWTEVGGDLLTIEAAVMPGKGNVIRTGSLGDVMKESVEAARSVVRSRSRRLGIKDEA
EEEEHHHCCCCEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCHHC
FEKQDIHIHVPEGATPKDGPSAGIAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG
CCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEECEEEECEEEEECEEEECCC
LKEKLLAAHRGGIKLVLIPEENVKDLTEIPDNVKNAIEIVPVRWIDKVLELALERAPSAL
HHHHHHHHHCCCEEEEEECCCCHHHHHHCCHHHHHHHEEECHHHHHHHHHHHHHHCCCCC
PEEEPKAAAPVSESKESGASDVVKH
CCCCCCCCCCCCCCCCCCCHHHHCC
>Mature Secondary Structure 
SGTQLLPPERVTLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMEGGKHIMLVAQKT
CCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEECC
AAKDEPTEKDMYEVGCIANILQMLKLPDGTVKVLVEGLQRAKTLSIEEQETQFSCEVMPL
CCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHCCCEEEEEEEC
EPDHADSAETEALRRAIVSQFDQYVKLNKKIPPEILTSLSGIDEAGRLADTIAAHLPLKL
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCC
DQKQQILEMFPVIERLEHLLAQLEAEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKELGEGEEGADLEELEKRIAAARMPKEAKKKADAELKKLKLMSPMSAEATVVRNYIDTL
HHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
IGLPWRKKSKVNNDLSNAERVLDEDHFGLEKVKERILEYLAVQQRVDKVKAPILCLVGPP
HCCCCCHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
GVGKTSLGQSIARATNRKFVRMALGGVRDEAEIRGHRRTYIGSMPGKILQSLTKVGVRNP
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCHHHHHHHHHHHCCCCC
LFLLDEVDKMGMDFRGDPSSALLEVLDPEQNHTFADHYVEVDFDLSDVMFVATSNSLNIP
CHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCEEECCEEEEEECCCCEEEEEECCCCCCC
PPLLDRMEVIRLSGYTEDEKVSIAQRYLLPKQKKNNGLKEGEIEVTEAAIRDIIRYYTRE
CHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
AGVRSLEREVSKICRKVVKMLLLKKADKAVTVDGNNLDTFLGVRKYDFGLAAKENQTGQV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHCCHHHCCCCCCCCCCCCCE
TGLAWTEVGGDLLTIEAAVMPGKGNVIRTGSLGDVMKESVEAARSVVRSRSRRLGIKDEA
EEEEHHHCCCCEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCHHC
FEKQDIHIHVPEGATPKDGPSAGIAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG
CCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEECEEEECEEEEECEEEECCC
LKEKLLAAHRGGIKLVLIPEENVKDLTEIPDNVKNAIEIVPVRWIDKVLELALERAPSAL
HHHHHHHHHCCCEEEEEECCCCHHHHHHCCHHHHHHHEEECHHHHHHHHHHHHHHCCCCC
PEEEPKAAAPVSESKESGASDVVKH
CCCCCCCCCCCCCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8981986; 12620739 [H]