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The map label for this gene is ahpC [C]

Identifier: 186475766

GI number: 186475766

Start: 1122737

End: 1123285

Strand: Reverse

Name: ahpC [C]

Synonym: Bphy_1001

Alternate gene names: 186475766

Gene position: 1123285-1122737 (Counterclockwise)

Preceding gene: 186475767

Following gene: 186475765

Centisome position: 32.29

GC content: 58.47

Gene sequence:

>549_bases
ATGAAAACTGTCGGCGATAAACTCGAAGCTTTCACCGTCACCGCTGCCAAGCCGGGTTTCAATCACCACGAAGAGAACGG
CGTGTCGGCGTTCGAAGAAATCACCGAATCGTCGTTCCCGGGCAAGTGGAAAATCATCTATTTCTACCCGAAGGACTTCA
CGTTCGTTTGCCCCACGGAAATCGTCGAATTCGGCAAGCTGGTGAAGGACTTCGAAGAGCGCGATGCCGTTCTGCTCGGC
GGCAGCGTCGACAACGAGTTCGTCAAGCTCGCCTGGCGCCGCGAGCACAAGGACCTGAACAAACTGAACCACTACGCCTT
TGGCGACGTGAAGGGCGAACTGATCGACCAGCTCGGCGTGCGCGACAAGGAAGCAGGCGTCGCACTGCGCGCGACGTTCA
TTGTCGATCCGGACAACACGATCCAGCACGTGTCGGTGAATAACCTGAACGTCGGCCGTAATCCGGAAGAGGTCCTGCGC
ATTCTGGACGGCCTGCAGACGGACGAGCTGTGCCCGTGCAACCGCGCAGTCGGCGGTGCAACGCTGTAA

Upstream 100 bases:

>100_bases
AGTTATAGTTTTCTCGTGTAACGCCTTCGTTACAGCCAGCAGGTAGTGTTGAGCAGGTTGTGCGACGAATCTCATTTGCC
AATTTTCAAGGAGCATGCGC

Downstream 100 bases:

>100_bases
GAATGTGTGGTCGAAAGCCCGCTAGGCTCGAAAGGCAAGCGGGCTTTTTTATCGGCAACCTGATAGGAGATATCGATGGA
ATTCATCGCGACGATTAAGG

Product: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen

Products: NA

Alternate protein names: Peroxiredoxin; Thioredoxin peroxidase [H]

Number of amino acids: Translated: 182; Mature: 182

Protein sequence:

>182_residues
MKTVGDKLEAFTVTAAKPGFNHHEENGVSAFEEITESSFPGKWKIIYFYPKDFTFVCPTEIVEFGKLVKDFEERDAVLLG
GSVDNEFVKLAWRREHKDLNKLNHYAFGDVKGELIDQLGVRDKEAGVALRATFIVDPDNTIQHVSVNNLNVGRNPEEVLR
ILDGLQTDELCPCNRAVGGATL

Sequences:

>Translated_182_residues
MKTVGDKLEAFTVTAAKPGFNHHEENGVSAFEEITESSFPGKWKIIYFYPKDFTFVCPTEIVEFGKLVKDFEERDAVLLG
GSVDNEFVKLAWRREHKDLNKLNHYAFGDVKGELIDQLGVRDKEAGVALRATFIVDPDNTIQHVSVNNLNVGRNPEEVLR
ILDGLQTDELCPCNRAVGGATL
>Mature_182_residues
MKTVGDKLEAFTVTAAKPGFNHHEENGVSAFEEITESSFPGKWKIIYFYPKDFTFVCPTEIVEFGKLVKDFEERDAVLLG
GSVDNEFVKLAWRREHKDLNKLNHYAFGDVKGELIDQLGVRDKEAGVALRATFIVDPDNTIQHVSVNNLNVGRNPEEVLR
ILDGLQTDELCPCNRAVGGATL

Specific function: Together with AhpD, DltA and Lpd constitutes an NADH- dependent peroxidase active against hydrogen and alkyl peroxides as well as serving as a peroxynitrite reductase, thus protecting the bacterium against reactive nitrogen intermediates and oxidative str

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI5802974, Length=151, Percent_Identity=39.0728476821192, Blast_Score=117, Evalue=6e-27,
Organism=Homo sapiens, GI32483377, Length=151, Percent_Identity=39.0728476821192, Blast_Score=117, Evalue=8e-27,
Organism=Homo sapiens, GI32189392, Length=160, Percent_Identity=39.375, Blast_Score=116, Evalue=9e-27,
Organism=Homo sapiens, GI4505591, Length=186, Percent_Identity=32.7956989247312, Blast_Score=109, Evalue=1e-24,
Organism=Homo sapiens, GI32455266, Length=186, Percent_Identity=32.7956989247312, Blast_Score=109, Evalue=1e-24,
Organism=Homo sapiens, GI32455264, Length=186, Percent_Identity=32.7956989247312, Blast_Score=109, Evalue=1e-24,
Organism=Homo sapiens, GI5453549, Length=159, Percent_Identity=33.9622641509434, Blast_Score=103, Evalue=9e-23,
Organism=Homo sapiens, GI33188454, Length=66, Percent_Identity=46.969696969697, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI4758638, Length=136, Percent_Identity=31.6176470588235, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI1786822, Length=174, Percent_Identity=33.9080459770115, Blast_Score=104, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17554494, Length=151, Percent_Identity=37.0860927152318, Blast_Score=119, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI32565831, Length=159, Percent_Identity=34.5911949685535, Blast_Score=115, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI193204376, Length=159, Percent_Identity=34.5911949685535, Blast_Score=115, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI25153706, Length=144, Percent_Identity=28.4722222222222, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323613, Length=159, Percent_Identity=40.8805031446541, Blast_Score=122, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6320661, Length=159, Percent_Identity=40.251572327044, Blast_Score=117, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6319407, Length=135, Percent_Identity=31.8518518518519, Blast_Score=75, Evalue=8e-15,
Organism=Drosophila melanogaster, GI17157991, Length=164, Percent_Identity=37.1951219512195, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24641739, Length=164, Percent_Identity=37.1951219512195, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17738015, Length=153, Percent_Identity=36.6013071895425, Blast_Score=114, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24656348, Length=157, Percent_Identity=33.7579617834395, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI17864676, Length=157, Percent_Identity=33.7579617834395, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21357347, Length=159, Percent_Identity=32.0754716981132, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24581278, Length=158, Percent_Identity=29.1139240506329, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24652434, Length=188, Percent_Identity=27.1276595744681, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24652436, Length=188, Percent_Identity=27.1276595744681, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI17975518, Length=188, Percent_Identity=27.1276595744681, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 20354; Mature: 20354

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVGDKLEAFTVTAAKPGFNHHEENGVSAFEEITESSFPGKWKIIYFYPKDFTFVCPTE
CCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCEEECHHH
IVEFGKLVKDFEERDAVLLGGSVDNEFVKLAWRREHKDLNKLNHYAFGDVKGELIDQLGV
HHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCC
RDKEAGVALRATFIVDPDNTIQHVSVNNLNVGRNPEEVLRILDGLQTDELCPCNRAVGGA
CCCCCCEEEEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCC
TL
CC
>Mature Secondary Structure
MKTVGDKLEAFTVTAAKPGFNHHEENGVSAFEEITESSFPGKWKIIYFYPKDFTFVCPTE
CCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCEEECHHH
IVEFGKLVKDFEERDAVLLGGSVDNEFVKLAWRREHKDLNKLNHYAFGDVKGELIDQLGV
HHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCC
RDKEAGVALRATFIVDPDNTIQHVSVNNLNVGRNPEEVLRILDGLQTDELCPCNRAVGGA
CCCCCCEEEEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCC
TL
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA