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The map label for this gene is envZ [H]

Identifier: 186475767

GI number: 186475767

Start: 1123538

End: 1124887

Strand: Reverse

Name: envZ [H]

Synonym: Bphy_1002

Alternate gene names: 186475767

Gene position: 1124887-1123538 (Counterclockwise)

Preceding gene: 186475768

Following gene: 186475766

Centisome position: 32.33

GC content: 63.19

Gene sequence:

>1350_bases
ATGCGGATCGACCGGCGCCTACTGACGCTCGCATTCGGCGGTCTGTTCTGGCGAACGTTCCTGCTGATCGCGCTCCTGAT
CGCGGTCAGTCTCGCCGCATGGTTTCAGAGCTTCCGGGTGATCGAGCGCGAGCCGCGCGCGCAGCGTGTCGCGCTGCAAC
TCGTCGCGATCGTGAAGCTCACGCGCACCGCACTCCTCTATTCCGATCCCGACCTGCGGCGCGCGCTGCTGCAGGACCTG
GAAAGCAACGAAGGCGTGCGCGTGTACCCGCGCGAAACCACTGACAAATACAAACTTCAGCCCGACGAATCGCTCAATCG
TTTGATCGAGCATGACATACGCGGGCGTCTCGGCGACGACACCATCATCGCGCAGTCGGTCAACGACATTCCCGGCGTAT
GGATCAGCTTCAAGATCGACGACGATGACTACTGGGTCGCGCTCGACCGCGATCAACTCGACAGTGTGACGGGCCTGCAA
TGGGCCGGCTGGGGTATTTTTGCGCTGGCGCTGTCGCTGTTCGGCGCAGCGTTCATCACGAGCCTGGTGAACCGGCCGTT
CGCGCGCCTCGCGATGGCCGCGCGCAAAGTCGGTTCTGGTCAGGCGCCCGAGAAATTGCCCGAACGCGGCATGGGCGTTG
CCGCCGAAACCAACCGAAGCTTCAACCAGATGGTGCAGGATCTCGAGCAGCTCGATGCGGACCGAGCGTTGATGCTCGCG
GGCATTTCGCACGATCTGCGCACGCCGCTTGCCCGCCTGCGTCTGGAAACGGAAATGAGTCCGTCGGACCAGGCGACCAA
GGACGCGATGATCGACGACATCGAACAGATGGACATGATCATCGGGCGCTTCCTCGATTACGCGCGTCCGGTACAGAGAA
ATCCGGAACCTGTCGACCTTTCAGTGATCGCAGGAGAACTGGCTGCGCGCATGTCGAGCGAAGACGGCATGCGGCTGGTC
ACGCGGCTTGCTCCATCTGCAGTGATCGAGGCAGACGAAACGGATATCCGGCGCGTCGTCGGCAATCTGATCGAGAACGC
GCGCAAGTACGGCTTGTCCGAGGCCGACGGCATTCCGCATGTCATCCTGGAAACGCGCGTGTCGCATTCGCGCGTCGAGC
TGTCGGTGGTCGACGAAGGTCCCGGCATTCCGGAAGACCAGCTTCCGCTCGTCACGCGCCCGTTTTATCGCGTGAATTCG
GCGCGCACGCAGGCGAACGGCACCGGGCTCGGCATGGCGATCGTGCAGCGGCTCGTCGGGCGTTATCGCGGCGCGCTCCG
TCTGCGCAACCGCACACCGCTGCCCGGCCTGGAAGTGACGATCGAGTTTCCACTGGCGAAGAGCATCTGA

Upstream 100 bases:

>100_bases
TTCATCCAGACGGTGTGGGGTCTCGGCTACGTGTTCATTCCCGACGGCGCCGCCTGAGTTTGCCGTTCCAGTTGTCTCTC
TTTTTTGACACGAAGGCCGC

Downstream 100 bases:

>100_bases
CGGGCTCATCGCACGTTCGAAACACCACTGCGATTTCGGCATTTTTTTCTCCCATTTCGCGCAGACGAATATTCATAAAC
TGCAATATCGACCTATTTGA

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MRIDRRLLTLAFGGLFWRTFLLIALLIAVSLAAWFQSFRVIEREPRAQRVALQLVAIVKLTRTALLYSDPDLRRALLQDL
ESNEGVRVYPRETTDKYKLQPDESLNRLIEHDIRGRLGDDTIIAQSVNDIPGVWISFKIDDDDYWVALDRDQLDSVTGLQ
WAGWGIFALALSLFGAAFITSLVNRPFARLAMAARKVGSGQAPEKLPERGMGVAAETNRSFNQMVQDLEQLDADRALMLA
GISHDLRTPLARLRLETEMSPSDQATKDAMIDDIEQMDMIIGRFLDYARPVQRNPEPVDLSVIAGELAARMSSEDGMRLV
TRLAPSAVIEADETDIRRVVGNLIENARKYGLSEADGIPHVILETRVSHSRVELSVVDEGPGIPEDQLPLVTRPFYRVNS
ARTQANGTGLGMAIVQRLVGRYRGALRLRNRTPLPGLEVTIEFPLAKSI

Sequences:

>Translated_449_residues
MRIDRRLLTLAFGGLFWRTFLLIALLIAVSLAAWFQSFRVIEREPRAQRVALQLVAIVKLTRTALLYSDPDLRRALLQDL
ESNEGVRVYPRETTDKYKLQPDESLNRLIEHDIRGRLGDDTIIAQSVNDIPGVWISFKIDDDDYWVALDRDQLDSVTGLQ
WAGWGIFALALSLFGAAFITSLVNRPFARLAMAARKVGSGQAPEKLPERGMGVAAETNRSFNQMVQDLEQLDADRALMLA
GISHDLRTPLARLRLETEMSPSDQATKDAMIDDIEQMDMIIGRFLDYARPVQRNPEPVDLSVIAGELAARMSSEDGMRLV
TRLAPSAVIEADETDIRRVVGNLIENARKYGLSEADGIPHVILETRVSHSRVELSVVDEGPGIPEDQLPLVTRPFYRVNS
ARTQANGTGLGMAIVQRLVGRYRGALRLRNRTPLPGLEVTIEFPLAKSI
>Mature_449_residues
MRIDRRLLTLAFGGLFWRTFLLIALLIAVSLAAWFQSFRVIEREPRAQRVALQLVAIVKLTRTALLYSDPDLRRALLQDL
ESNEGVRVYPRETTDKYKLQPDESLNRLIEHDIRGRLGDDTIIAQSVNDIPGVWISFKIDDDDYWVALDRDQLDSVTGLQ
WAGWGIFALALSLFGAAFITSLVNRPFARLAMAARKVGSGQAPEKLPERGMGVAAETNRSFNQMVQDLEQLDADRALMLA
GISHDLRTPLARLRLETEMSPSDQATKDAMIDDIEQMDMIIGRFLDYARPVQRNPEPVDLSVIAGELAARMSSEDGMRLV
TRLAPSAVIEADETDIRRVVGNLIENARKYGLSEADGIPHVILETRVSHSRVELSVVDEGPGIPEDQLPLVTRPFYRVNS
ARTQANGTGLGMAIVQRLVGRYRGALRLRNRTPLPGLEVTIEFPLAKSI

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=425, Percent_Identity=32, Blast_Score=171, Evalue=9e-44,
Organism=Escherichia coli, GI1788393, Length=284, Percent_Identity=28.5211267605634, Blast_Score=98, Evalue=9e-22,
Organism=Escherichia coli, GI1790346, Length=281, Percent_Identity=29.1814946619217, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1787894, Length=273, Percent_Identity=29.6703296703297, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1786600, Length=218, Percent_Identity=28.8990825688073, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1790551, Length=293, Percent_Identity=27.6450511945392, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI145693157, Length=242, Percent_Identity=24.3801652892562, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI87082128, Length=320, Percent_Identity=25.3125, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI48994928, Length=221, Percent_Identity=29.4117647058824, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1786912, Length=224, Percent_Identity=29.4642857142857, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87081816, Length=240, Percent_Identity=28.3333333333333, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1786783, Length=227, Percent_Identity=27.7533039647577, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1788713, Length=233, Percent_Identity=24.8927038626609, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790861, Length=282, Percent_Identity=26.241134751773, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790436, Length=208, Percent_Identity=25.4807692307692, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788549, Length=222, Percent_Identity=26.5765765765766, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1789149, Length=217, Percent_Identity=26.7281105990783, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50160; Mature: 50160

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIDRRLLTLAFGGLFWRTFLLIALLIAVSLAAWFQSFRVIEREPRAQRVALQLVAIVKL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
TRTALLYSDPDLRRALLQDLESNEGVRVYPRETTDKYKLQPDESLNRLIEHDIRGRLGDD
HHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCCCEECCCHHHHHHHHHHHHCCCCCCC
TIIAQSVNDIPGVWISFKIDDDDYWVALDRDQLDSVTGLQWAGWGIFALALSLFGAAFIT
HHHHHHHCCCCCEEEEEEECCCCEEEEECHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
SLVNRPFARLAMAARKVGSGQAPEKLPERGMGVAAETNRSFNQMVQDLEQLDADRALMLA
HHHHCHHHHHHHHHHHHCCCCCCHHHHHCCCCCEECCCCHHHHHHHHHHHHCCCCEEHHH
GISHDLRTPLARLRLETEMSPSDQATKDAMIDDIEQMDMIIGRFLDYARPVQRNPEPVDL
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCCCCCH
SVIAGELAARMSSEDGMRLVTRLAPSAVIEADETDIRRVVGNLIENARKYGLSEADGIPH
HHHHHHHHHHHCCCCHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCE
VILETRVSHSRVELSVVDEGPGIPEDQLPLVTRPFYRVNSARTQANGTGLGMAIVQRLVG
EHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHCCHHHCCCCCCHHHHHHHHHHH
RYRGALRLRNRTPLPGLEVTIEFPLAKSI
HHHHHEEECCCCCCCCCEEEEECCCCCCC
>Mature Secondary Structure
MRIDRRLLTLAFGGLFWRTFLLIALLIAVSLAAWFQSFRVIEREPRAQRVALQLVAIVKL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
TRTALLYSDPDLRRALLQDLESNEGVRVYPRETTDKYKLQPDESLNRLIEHDIRGRLGDD
HHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCCCEECCCHHHHHHHHHHHHCCCCCCC
TIIAQSVNDIPGVWISFKIDDDDYWVALDRDQLDSVTGLQWAGWGIFALALSLFGAAFIT
HHHHHHHCCCCCEEEEEEECCCCEEEEECHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
SLVNRPFARLAMAARKVGSGQAPEKLPERGMGVAAETNRSFNQMVQDLEQLDADRALMLA
HHHHCHHHHHHHHHHHHCCCCCCHHHHHCCCCCEECCCCHHHHHHHHHHHHCCCCEEHHH
GISHDLRTPLARLRLETEMSPSDQATKDAMIDDIEQMDMIIGRFLDYARPVQRNPEPVDL
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCCCCCH
SVIAGELAARMSSEDGMRLVTRLAPSAVIEADETDIRRVVGNLIENARKYGLSEADGIPH
HHHHHHHHHHHCCCCHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCE
VILETRVSHSRVELSVVDEGPGIPEDQLPLVTRPFYRVNSARTQANGTGLGMAIVQRLVG
EHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHCCHHHCCCCCCHHHHHHHHHHH
RYRGALRLRNRTPLPGLEVTIEFPLAKSI
HHHHHEEECCCCCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]