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The map label for this gene is luxQ [H]

Identifier: 186475757

GI number: 186475757

Start: 1110609

End: 1112600

Strand: Direct

Name: luxQ [H]

Synonym: Bphy_0992

Alternate gene names: 186475757

Gene position: 1110609-1112600 (Clockwise)

Preceding gene: 186475756

Following gene: 186475763

Centisome position: 31.92

GC content: 66.16

Gene sequence:

>1992_bases
ATGACAGAACACGCATTCACGGCACCCGCAGCCCTCGTGCTCGTCGTCGACGACGACGAAGGCATCTTGCGCCTCGCACG
CAAGTCGCTGGAGCGCGCAGGCTGCCGGGTCGAACTGAGCAGCAGCGTCGAGGCCGCGCATCGCTCGATCGTCGCGAGTC
CGCCGGATCTGATCGTGCTCGACTACCAGCTCGACGGCGCCGAGACGGGGCTCGATTTTTTCCGGCGTCTGCGCGGCGAA
GGCGTGCGCATTCCCGCGATTCTCGTCACCGGCTTCACCGACGAGTCGCGCGTGATCGAAGCGTTGCGCGCGGGTGTGTC
CGACGTGGTGCCGAAAGCGGGCGACTATCTCGACTATCTGCCCGAAGCCGTCGAACGGGTGCTGTCGCAAATGCGGCTGC
AGCGCGAGTCCGCGGAAGCGCTGTGGCTGCGCGAGCGCGAGGCGCATTACCGGATGCTGTCGGAGGCGCTGCCACACCTC
GTCTTCACGTGCAGTGCGAATGGCGATTGCGATTTCGTCTCGAAGCAATGGATCGAATACACGGGGCTGGACGGCTCGAA
CGCGCTGGGTCTCGCGTGGCTCGACGCCGTGCATCCCGACGAGCGCGAAGACACGCGGCGCAGTTGGCTCAGGACCGCGC
GCGGCGACGGCAGCGACTTTCGCAGCGAAATCCGGATCCGGCGGCGCGACGGAATGTACCGATGGTTCGACGTGCGCATT
GCCGCGGTGCGCGATGCGGGCGGCGTCATCAGCAAGTGGTTAGGCAATTGCACGGACATCCAATCGCAACGCGAAGCCAT
CGAGGAGCGCGAGCGCCTGCTCGCCTCCGAGCAGGCCGCACGTCAAGCGGCCGAAGAAGCGAACCGCGCAAAGGACCGCT
TTCTCGCGATGCTGTCGCACGAACTGCGCACGCCGCTCACGCCCGTGCTGGCGGGCGCGCGCATGCTCGAAATCATGCCG
GATCTGCCCGAGCCGGTGCGCGCGGGCGTCGTCATGATCCGCCGCAACGTCGAACTCGAAGCGCGGCTGATCGACGATCT
GCTCGATCTCACGCGGGTGGCGAACGGCAAGCTGCGGCTGTCGCTGGAAACCGTCGACGTGCACGAGGTGATCGGCAGCG
TGCTCGAACTGTTTCGTAGCGAGATTCAGACCAAGCAGCAGGACGTGCACGTCGACACGCGCGCGCAGCATCATTTCGTG
CTCGCCGATCGCGCGCGGCTGCAGCAGATGCTATGGAACCTCATCCGCAATGCCGCGAAGTTTACGCCGGACGGCGGTCA
TATCTACGTGCGCACGCGTGACGAACGGATGCATGTGCAGATTTCGATCGAAGATACGGGCGTCGGAATCGAGCCGGAGC
AGATCGGCAAGCTCTTCAATGCGTTCGAGCAGGGCAGTCAGAACATGTCGCGGCAGTTCGGCGGCCTGGGCCTCGGGCTC
GCGATCACGAAGGCGCTCACCGACGCGCACGGCGGCACCGTGACGGCACAAAGCCCAGGCGCGCACTGCGGCGCGACGTT
CACGATCACACTACCCACGGCCGAGGAGCCGCTCGCCGAACGGGCCGCGCCCGAGGCGGCGAGCGTGCAGTCGGCGGGGG
GGCTGACCATCCTCCTGATTGAAGACCACGCGGACACGGCCGAAGTGATGTCGCAACTCATGCGCGCGCTCGGCCACGAA
GTGACGGTGGTTGGGCGCGTGGCCGATGCGCTCGCCGCGACGCAAAGCGCCGGGTTCGATCTGATCGTCAGCGACGTCGG
GCTGCCCGACGGCACGGGCCTCGATTTCATCAAGGCGTTCCGCGAAAGCGACGATGCGCCCGCCGTCGCGCTGACGGGCT
TCGGCAGCGAAGAGGACATCCGGCGTTGCCTCGAAGCGGGCTTCACCTCGCATCTGACCAAGCCTGTGAATTTCTCGCAG
CTCGAGCAGGTGATCGAGGGTGCAGCCGTCGCCAAGTTGCAGAAAGGGGCAGGCAAGGCACGGACGGGTTAG

Upstream 100 bases:

>100_bases
GCGCTATGGGCCCGCCTGAGCACCGAGGTTCGTGCCGACAGTTCACGCAGCCGGTGCACCACTGAAGTCCTCGTCCGTCC
CATTGAACTGATTATCTGGC

Downstream 100 bases:

>100_bases
CGGGCGCACCGTCCGCGTTGGGTGAAAACGACAAGGGCGTGTCGATCGGCAGGCCCTGGTGTCATTCGGGGGCGGCGCCT
CGCCCATGCCGCCTCAGTGT

Product: PAS/PAC sensor hybrid histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 663; Mature: 662

Protein sequence:

>663_residues
MTEHAFTAPAALVLVVDDDEGILRLARKSLERAGCRVELSSSVEAAHRSIVASPPDLIVLDYQLDGAETGLDFFRRLRGE
GVRIPAILVTGFTDESRVIEALRAGVSDVVPKAGDYLDYLPEAVERVLSQMRLQRESAEALWLREREAHYRMLSEALPHL
VFTCSANGDCDFVSKQWIEYTGLDGSNALGLAWLDAVHPDEREDTRRSWLRTARGDGSDFRSEIRIRRRDGMYRWFDVRI
AAVRDAGGVISKWLGNCTDIQSQREAIEERERLLASEQAARQAAEEANRAKDRFLAMLSHELRTPLTPVLAGARMLEIMP
DLPEPVRAGVVMIRRNVELEARLIDDLLDLTRVANGKLRLSLETVDVHEVIGSVLELFRSEIQTKQQDVHVDTRAQHHFV
LADRARLQQMLWNLIRNAAKFTPDGGHIYVRTRDERMHVQISIEDTGVGIEPEQIGKLFNAFEQGSQNMSRQFGGLGLGL
AITKALTDAHGGTVTAQSPGAHCGATFTITLPTAEEPLAERAAPEAASVQSAGGLTILLIEDHADTAEVMSQLMRALGHE
VTVVGRVADALAATQSAGFDLIVSDVGLPDGTGLDFIKAFRESDDAPAVALTGFGSEEDIRRCLEAGFTSHLTKPVNFSQ
LEQVIEGAAVAKLQKGAGKARTG

Sequences:

>Translated_663_residues
MTEHAFTAPAALVLVVDDDEGILRLARKSLERAGCRVELSSSVEAAHRSIVASPPDLIVLDYQLDGAETGLDFFRRLRGE
GVRIPAILVTGFTDESRVIEALRAGVSDVVPKAGDYLDYLPEAVERVLSQMRLQRESAEALWLREREAHYRMLSEALPHL
VFTCSANGDCDFVSKQWIEYTGLDGSNALGLAWLDAVHPDEREDTRRSWLRTARGDGSDFRSEIRIRRRDGMYRWFDVRI
AAVRDAGGVISKWLGNCTDIQSQREAIEERERLLASEQAARQAAEEANRAKDRFLAMLSHELRTPLTPVLAGARMLEIMP
DLPEPVRAGVVMIRRNVELEARLIDDLLDLTRVANGKLRLSLETVDVHEVIGSVLELFRSEIQTKQQDVHVDTRAQHHFV
LADRARLQQMLWNLIRNAAKFTPDGGHIYVRTRDERMHVQISIEDTGVGIEPEQIGKLFNAFEQGSQNMSRQFGGLGLGL
AITKALTDAHGGTVTAQSPGAHCGATFTITLPTAEEPLAERAAPEAASVQSAGGLTILLIEDHADTAEVMSQLMRALGHE
VTVVGRVADALAATQSAGFDLIVSDVGLPDGTGLDFIKAFRESDDAPAVALTGFGSEEDIRRCLEAGFTSHLTKPVNFSQ
LEQVIEGAAVAKLQKGAGKARTG
>Mature_662_residues
TEHAFTAPAALVLVVDDDEGILRLARKSLERAGCRVELSSSVEAAHRSIVASPPDLIVLDYQLDGAETGLDFFRRLRGEG
VRIPAILVTGFTDESRVIEALRAGVSDVVPKAGDYLDYLPEAVERVLSQMRLQRESAEALWLREREAHYRMLSEALPHLV
FTCSANGDCDFVSKQWIEYTGLDGSNALGLAWLDAVHPDEREDTRRSWLRTARGDGSDFRSEIRIRRRDGMYRWFDVRIA
AVRDAGGVISKWLGNCTDIQSQREAIEERERLLASEQAARQAAEEANRAKDRFLAMLSHELRTPLTPVLAGARMLEIMPD
LPEPVRAGVVMIRRNVELEARLIDDLLDLTRVANGKLRLSLETVDVHEVIGSVLELFRSEIQTKQQDVHVDTRAQHHFVL
ADRARLQQMLWNLIRNAAKFTPDGGHIYVRTRDERMHVQISIEDTGVGIEPEQIGKLFNAFEQGSQNMSRQFGGLGLGLA
ITKALTDAHGGTVTAQSPGAHCGATFTITLPTAEEPLAERAAPEAASVQSAGGLTILLIEDHADTAEVMSQLMRALGHEV
TVVGRVADALAATQSAGFDLIVSDVGLPDGTGLDFIKAFRESDDAPAVALTGFGSEEDIRRCLEAGFTSHLTKPVNFSQL
EQVIEGAAVAKLQKGAGKARTG

Specific function: At low cell density, in absence of AI-2 (autoinducer 2), luxQ has a kinase activity and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is t

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI48994928, Length=542, Percent_Identity=26.3837638376384, Blast_Score=148, Evalue=1e-36,
Organism=Escherichia coli, GI87081816, Length=389, Percent_Identity=30.3341902313625, Blast_Score=141, Evalue=2e-34,
Organism=Escherichia coli, GI1788713, Length=397, Percent_Identity=27.455919395466, Blast_Score=128, Evalue=1e-30,
Organism=Escherichia coli, GI145693157, Length=248, Percent_Identity=32.6612903225806, Blast_Score=125, Evalue=1e-29,
Organism=Escherichia coli, GI1789149, Length=325, Percent_Identity=29.5384615384615, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1786912, Length=250, Percent_Identity=32.8, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1786600, Length=227, Percent_Identity=33.920704845815, Blast_Score=91, Evalue=3e-19,
Organism=Escherichia coli, GI1786783, Length=272, Percent_Identity=27.9411764705882, Blast_Score=90, Evalue=5e-19,
Organism=Escherichia coli, GI1788393, Length=234, Percent_Identity=30.3418803418803, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI1788279, Length=220, Percent_Identity=30.9090909090909, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1790436, Length=241, Percent_Identity=27.3858921161826, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1790346, Length=234, Percent_Identity=28.2051282051282, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1790861, Length=210, Percent_Identity=29.0476190476191, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87082128, Length=230, Percent_Identity=27.8260869565217, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1789808, Length=211, Percent_Identity=31.2796208530806, Blast_Score=70, Evalue=6e-13,
Organism=Escherichia coli, GI1790551, Length=207, Percent_Identity=28.9855072463768, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1788549, Length=244, Percent_Identity=26.6393442622951, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1790300, Length=259, Percent_Identity=29.7297297297297, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1787894, Length=239, Percent_Identity=28.0334728033473, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322044, Length=89, Percent_Identity=41.5730337078652, Blast_Score=68, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 72739; Mature: 72608

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEHAFTAPAALVLVVDDDEGILRLARKSLERAGCRVELSSSVEAAHRSIVASPPDLIVL
CCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHCCCEEEECHHHHHHHHHHCCCCCCEEEE
DYQLDGAETGLDFFRRLRGEGVRIPAILVTGFTDESRVIEALRAGVSDVVPKAGDYLDYL
EEEECCHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHCCHHHHCCCCCCHHHHH
PEAVERVLSQMRLQRESAEALWLREREAHYRMLSEALPHLVFTCSANGDCDFVSKQWIEY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHC
TGLDGSNALGLAWLDAVHPDEREDTRRSWLRTARGDGSDFRSEIRIRRRDGMYRWFDVRI
CCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEEEE
AAVRDAGGVISKWLGNCTDIQSQREAIEERERLLASEQAARQAAEEANRAKDRFLAMLSH
EEECCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELRTPLTPVLAGARMLEIMPDLPEPVRAGVVMIRRNVELEARLIDDLLDLTRVANGKLRL
HHHCCHHHHHHHHHHHHHCCCCCCHHHHCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEE
SLETVDVHEVIGSVLELFRSEIQTKQQDVHVDTRAQHHFVLADRARLQQMLWNLIRNAAK
EEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHH
FTPDGGHIYVRTRDERMHVQISIEDTGVGIEPEQIGKLFNAFEQGSQNMSRQFGGLGLGL
CCCCCCEEEEEEECCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
AITKALTDAHGGTVTAQSPGAHCGATFTITLPTAEEPLAERAAPEAASVQSAGGLTILLI
HHHHHHHCCCCCEEEECCCCCCCCEEEEEEECCCCCHHHHHCCCCHHHHHCCCCEEEEEE
EDHADTAEVMSQLMRALGHEVTVVGRVADALAATQSAGFDLIVSDVGLPDGTGLDFIKAF
ECCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHH
RESDDAPAVALTGFGSEEDIRRCLEAGFTSHLTKPVNFSQLEQVIEGAAVAKLQKGAGKA
HCCCCCCEEEEECCCCHHHHHHHHHHCHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
RTG
CCC
>Mature Secondary Structure 
TEHAFTAPAALVLVVDDDEGILRLARKSLERAGCRVELSSSVEAAHRSIVASPPDLIVL
CCCCCCCCEEEEEEEECCCHHHHHHHHHHHHCCCEEEECHHHHHHHHHHCCCCCCEEEE
DYQLDGAETGLDFFRRLRGEGVRIPAILVTGFTDESRVIEALRAGVSDVVPKAGDYLDYL
EEEECCHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHCCHHHHCCCCCCHHHHH
PEAVERVLSQMRLQRESAEALWLREREAHYRMLSEALPHLVFTCSANGDCDFVSKQWIEY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHC
TGLDGSNALGLAWLDAVHPDEREDTRRSWLRTARGDGSDFRSEIRIRRRDGMYRWFDVRI
CCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEEEE
AAVRDAGGVISKWLGNCTDIQSQREAIEERERLLASEQAARQAAEEANRAKDRFLAMLSH
EEECCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELRTPLTPVLAGARMLEIMPDLPEPVRAGVVMIRRNVELEARLIDDLLDLTRVANGKLRL
HHHCCHHHHHHHHHHHHHCCCCCCHHHHCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEE
SLETVDVHEVIGSVLELFRSEIQTKQQDVHVDTRAQHHFVLADRARLQQMLWNLIRNAAK
EEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHH
FTPDGGHIYVRTRDERMHVQISIEDTGVGIEPEQIGKLFNAFEQGSQNMSRQFGGLGLGL
CCCCCCEEEEEEECCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
AITKALTDAHGGTVTAQSPGAHCGATFTITLPTAEEPLAERAAPEAASVQSAGGLTILLI
HHHHHHHCCCCCEEEECCCCCCCCEEEEEEECCCCCHHHHHCCCCHHHHHCCCCEEEEEE
EDHADTAEVMSQLMRALGHEVTVVGRVADALAATQSAGFDLIVSDVGLPDGTGLDFIKAF
ECCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHH
RESDDAPAVALTGFGSEEDIRRCLEAGFTSHLTKPVNFSQLEQVIEGAAVAKLQKGAGKA
HCCCCCCEEEEECCCCHHHHHHHHHHCHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
RTG
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301; 12176318 [H]