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The map label for this gene is ispD

Identifier: 186475763

GI number: 186475763

Start: 1120787

End: 1121497

Strand: Direct

Name: ispD

Synonym: Bphy_0998

Alternate gene names: 186475763

Gene position: 1120787-1121497 (Clockwise)

Preceding gene: 186475757

Following gene: 186475764

Centisome position: 32.21

GC content: 68.5

Gene sequence:

>711_bases
GTGACTTCCCGCCTCTTTGCACTGATTCCCTGCGCCGGCACCGGCAGCCGTTCGGGCGCTCCGATGCCCAAGCAATATCG
CACCGTCGCGGGCCGCGACATGCTGCATTATTCGCTGGCCGCGTTCGACGCCTGCAGCGAGTTCGCGCAGACGCTCGTCG
TGATCGCGCCCGACGACCAGCACTTCGACGCGCGCCGCTTTGGCGGCCTGCGCTTTGCCGTGCAACGCTGCGGCGGCGCA
TCGCGGCAGGCGTCGGTGCTCAACGGTCTGCACGCGCTCGCCGGCTTTGGTGCACACGACGACGACTGGGTGCTCGTGCA
CGACGCGGCGCGGCCCGGCATCACGCCCGCGCTGATACGCGCGCTGGTCGGCGCGCTGAAGGACGACGCCGTGGGCGGCA
TCATGGCGTTGCCCGTGGCCGACACGCTCAAGCGCGTGGCGCCCGGCACCGACAACCGCATCGATCACACCGAACCGCGC
GACGGCCTGTGGCAGGCGCAAACGCCGCAGATGTTCCGCATCGGCATGTTGCGCGACGCGATTCTGCGCGCGCAAAGCGA
CGGGCACGATCTCACCGACGAAGCCAGCGCCATCGAATGGAGCGGGCACGCACCCAGACTGGTTCAGGGCAGCTTGCGCA
ATTTCAAGGTTACCTATCCGGAAGACTTCGATCTGGCCGAAGCTATCCTCGGACGCGGCGCGGCGGGCTGA

Upstream 100 bases:

>100_bases
CATCGACAGGCAATCGACAAGTTTAAGCGTGCCGGGGCGTGCGTGCCGAAGACCTATTATAAAATCCGTCCTTCACTTTG
ACCTGCAACGCGCCCGTTCT

Downstream 100 bases:

>100_bases
CTCACGCGCTCATCGCGTCGGCTTCGCGCCGACCATAACGCTTTCACGAAACAACGGAACCTCACGCATATGGATTTGAG
AATCGGACAAGGCTATGACG

Product: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Products: NA

Alternate protein names: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MTSRLFALIPCAGTGSRSGAPMPKQYRTVAGRDMLHYSLAAFDACSEFAQTLVVIAPDDQHFDARRFGGLRFAVQRCGGA
SRQASVLNGLHALAGFGAHDDDWVLVHDAARPGITPALIRALVGALKDDAVGGIMALPVADTLKRVAPGTDNRIDHTEPR
DGLWQAQTPQMFRIGMLRDAILRAQSDGHDLTDEASAIEWSGHAPRLVQGSLRNFKVTYPEDFDLAEAILGRGAAG

Sequences:

>Translated_236_residues
MTSRLFALIPCAGTGSRSGAPMPKQYRTVAGRDMLHYSLAAFDACSEFAQTLVVIAPDDQHFDARRFGGLRFAVQRCGGA
SRQASVLNGLHALAGFGAHDDDWVLVHDAARPGITPALIRALVGALKDDAVGGIMALPVADTLKRVAPGTDNRIDHTEPR
DGLWQAQTPQMFRIGMLRDAILRAQSDGHDLTDEASAIEWSGHAPRLVQGSLRNFKVTYPEDFDLAEAILGRGAAG
>Mature_235_residues
TSRLFALIPCAGTGSRSGAPMPKQYRTVAGRDMLHYSLAAFDACSEFAQTLVVIAPDDQHFDARRFGGLRFAVQRCGGAS
RQASVLNGLHALAGFGAHDDDWVLVHDAARPGITPALIRALVGALKDDAVGGIMALPVADTLKRVAPGTDNRIDHTEPRD
GLWQAQTPQMFRIGMLRDAILRAQSDGHDLTDEASAIEWSGHAPRLVQGSLRNFKVTYPEDFDLAEAILGRGAAG

Specific function: Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)

COG id: COG1211

COG function: function code I; 4-diphosphocytidyl-2-methyl-D-erithritol synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispD family

Homologues:

Organism=Homo sapiens, GI157412259, Length=238, Percent_Identity=25.6302521008403, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1789104, Length=226, Percent_Identity=41.5929203539823, Blast_Score=153, Evalue=8e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ISPD_BURP8 (B2JGK2)

Other databases:

- EMBL:   CP001043
- RefSeq:   YP_001857233.1
- GeneID:   6242496
- GenomeReviews:   CP001043_GR
- KEGG:   bph:Bphy_0998
- HOGENOM:   HBG672839
- OMA:   FPQGAIL
- ProtClustDB:   PRK00155
- HAMAP:   MF_00108
- InterPro:   IPR001228
- InterPro:   IPR018294
- TIGRFAMs:   TIGR00453

Pfam domain/function: PF01128 IspD

EC number: =2.7.7.60

Molecular weight: Translated: 25299; Mature: 25168

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS01295 ISPD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSRLFALIPCAGTGSRSGAPMPKQYRTVAGRDMLHYSLAAFDACSEFAQTLVVIAPDDQ
CCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCC
HFDARRFGGLRFAVQRCGGASRQASVLNGLHALAGFGAHDDDWVLVHDAARPGITPALIR
CCCHHHHCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHH
ALVGALKDDAVGGIMALPVADTLKRVAPGTDNRIDHTEPRDGLWQAQTPQMFRIGMLRDA
HHHHHHHHCCCCCEEEECHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
ILRAQSDGHDLTDEASAIEWSGHAPRLVQGSLRNFKVTYPEDFDLAEAILGRGAAG
HHHHCCCCCCCCCCCCEEEECCCCCHHHHCCCCCEEEECCCCCCHHHHHHCCCCCC
>Mature Secondary Structure 
TSRLFALIPCAGTGSRSGAPMPKQYRTVAGRDMLHYSLAAFDACSEFAQTLVVIAPDDQ
CCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCC
HFDARRFGGLRFAVQRCGGASRQASVLNGLHALAGFGAHDDDWVLVHDAARPGITPALIR
CCCHHHHCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHH
ALVGALKDDAVGGIMALPVADTLKRVAPGTDNRIDHTEPRDGLWQAQTPQMFRIGMLRDA
HHHHHHHHCCCCCEEEECHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
ILRAQSDGHDLTDEASAIEWSGHAPRLVQGSLRNFKVTYPEDFDLAEAILGRGAAG
HHHHCCCCCCCCCCCCEEEECCCCCHHHHCCCCCEEEECCCCCCHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA