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The map label for this gene is phbA [H]

Identifier: 186475735

GI number: 186475735

Start: 1084301

End: 1085482

Strand: Direct

Name: phbA [H]

Synonym: Bphy_0970

Alternate gene names: 186475735

Gene position: 1084301-1085482 (Clockwise)

Preceding gene: 186475734

Following gene: 186475736

Centisome position: 31.17

GC content: 66.16

Gene sequence:

>1182_bases
ATGACTGACGTAGTGATCGTATCGGCGGCCCGTACGGCTGTCGGCAAATTCGGTGGGTCGCTGGCGAAGATTGCGGCGCC
GGAACTGGGCGCCACGGTGATCCGTGCCGTGCTGGAGCGCTCGGGCCTGAAGCCCGAGCAGGTGAGCGAAGTCATTCTGG
GCCAGGTGCTCGCGGCAGGCTCGGGCCAGAACCCGGCGCGTCAATCGCTGATCAAGGCCGGTCTGCCGATGGCGGTGCCG
GGTATGACCATCAACAAGGTGTGCGGCTCTGGCCTGAAGGCGGTGATGCTCGCCGCCAACGCGATCATCGCGGGCGACGC
GGACATCGTCGTTGCGGGCGGCCAGGAAAACATGAGCGCCGCGCCGCACGTGCTGCCGGGCTCGCGCGACGGCTTCCGCA
TGGGCGACGCGAAGCTGATCGACACGATGATCGTCGACGGCCTGTGGGACGTGTACAACCAGTACCACATGGGCGTGACG
GCCGAGAACGTCGCGAAGGAATACGGCATCACGCGCGAAGATCAGGACGCGTTCGCCGCGCTTTCGCAGAATAAGGCGGA
AGCCGCACAGAAGGCCGGGCGCTTCGATGATGAAATCGTGCCGGTCCAGATTCCGCAGAAGAAGGGCGACCCGCTGTCGT
TCGCGACGGACGAATTCGTGCGCCACGGCGTCACGGCCGAAGCGCTCGCTGGACTGAAGCCGGCATTCTCGAAGGAAGGT
ACGGTGACGGCGGCCAACGCGTCGGGCATCAACGACGGCGCGGCGGCTGTCGTCGTGATGTCGGCGAAAAAGGCCGAGGC
GCTGGGGCTCACGCCGCTCGCGCGCATCAAGGCTTACGCGAACGCGGGCGTCGATCCGAAAGTGATGGGCATGGGACCCG
TGCCGGCATCGCGCCGCTGTCTGGAGCGTGCAGGCTGGAGCGTGAACGACCTCGACCTGATGGAAATCAACGAGGCATTC
GCGGCGCAGGCGTTGGCGGTGCACAAGCAGATGGGCTGGGATCAGTCGAAGATCAACGTGAACGGCGGCGCGATCGCGAT
CGGCCACCCGATCGGCGCATCCGGTTGCCGGATTCTCGTCACGCTGCTGCACGAAATGCAGAAGCGCGACGCGAAGAAGG
GCCTGGCGTCGCTGTGCATCGGCGGCGGCATGGGCGTGGCGCTCGCAGTCGAGCGTCCGTAA

Upstream 100 bases:

>100_bases
AGTGAGACAGACGCTGTATCGCAGTAAAGCTGACTTGACCGGATCAACAACTTGACGGGCTACTGTGGAGCATGTCGCCG
CAGCCCCGGAGGAAACTCAA

Downstream 100 bases:

>100_bases
GAGGACGTTTCACGAGGAGGCCGTCACGCGGCTGGTGTCCCATCGAGGGCGATCGGCAGCGTGACGCGGTCCGGTGCGCG
TCGCGTGAGCGAGCGAGCGG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MTDVVIVSAARTAVGKFGGSLAKIAAPELGATVIRAVLERSGLKPEQVSEVILGQVLAAGSGQNPARQSLIKAGLPMAVP
GMTINKVCGSGLKAVMLAANAIIAGDADIVVAGGQENMSAAPHVLPGSRDGFRMGDAKLIDTMIVDGLWDVYNQYHMGVT
AENVAKEYGITREDQDAFAALSQNKAEAAQKAGRFDDEIVPVQIPQKKGDPLSFATDEFVRHGVTAEALAGLKPAFSKEG
TVTAANASGINDGAAAVVVMSAKKAEALGLTPLARIKAYANAGVDPKVMGMGPVPASRRCLERAGWSVNDLDLMEINEAF
AAQALAVHKQMGWDQSKINVNGGAIAIGHPIGASGCRILVTLLHEMQKRDAKKGLASLCIGGGMGVALAVERP

Sequences:

>Translated_393_residues
MTDVVIVSAARTAVGKFGGSLAKIAAPELGATVIRAVLERSGLKPEQVSEVILGQVLAAGSGQNPARQSLIKAGLPMAVP
GMTINKVCGSGLKAVMLAANAIIAGDADIVVAGGQENMSAAPHVLPGSRDGFRMGDAKLIDTMIVDGLWDVYNQYHMGVT
AENVAKEYGITREDQDAFAALSQNKAEAAQKAGRFDDEIVPVQIPQKKGDPLSFATDEFVRHGVTAEALAGLKPAFSKEG
TVTAANASGINDGAAAVVVMSAKKAEALGLTPLARIKAYANAGVDPKVMGMGPVPASRRCLERAGWSVNDLDLMEINEAF
AAQALAVHKQMGWDQSKINVNGGAIAIGHPIGASGCRILVTLLHEMQKRDAKKGLASLCIGGGMGVALAVERP
>Mature_392_residues
TDVVIVSAARTAVGKFGGSLAKIAAPELGATVIRAVLERSGLKPEQVSEVILGQVLAAGSGQNPARQSLIKAGLPMAVPG
MTINKVCGSGLKAVMLAANAIIAGDADIVVAGGQENMSAAPHVLPGSRDGFRMGDAKLIDTMIVDGLWDVYNQYHMGVTA
ENVAKEYGITREDQDAFAALSQNKAEAAQKAGRFDDEIVPVQIPQKKGDPLSFATDEFVRHGVTAEALAGLKPAFSKEGT
VTAANASGINDGAAAVVVMSAKKAEALGLTPLARIKAYANAGVDPKVMGMGPVPASRRCLERAGWSVNDLDLMEINEAFA
AQALAVHKQMGWDQSKINVNGGAIAIGHPIGASGCRILVTLLHEMQKRDAKKGLASLCIGGGMGVALAVERP

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=56.2659846547315, Blast_Score=446, Evalue=1e-125,
Organism=Homo sapiens, GI4557237, Length=393, Percent_Identity=44.529262086514, Blast_Score=324, Evalue=1e-88,
Organism=Homo sapiens, GI167614485, Length=390, Percent_Identity=43.5897435897436, Blast_Score=318, Evalue=5e-87,
Organism=Homo sapiens, GI4501853, Length=397, Percent_Identity=42.0654911838791, Blast_Score=275, Evalue=5e-74,
Organism=Homo sapiens, GI4504327, Length=424, Percent_Identity=31.6037735849057, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI194353979, Length=394, Percent_Identity=31.2182741116751, Blast_Score=164, Evalue=1e-40,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=62.7551020408163, Blast_Score=493, Evalue=1e-141,
Organism=Escherichia coli, GI1788554, Length=393, Percent_Identity=60.8142493638677, Blast_Score=450, Evalue=1e-128,
Organism=Escherichia coli, GI1787663, Length=404, Percent_Identity=46.5346534653465, Blast_Score=332, Evalue=2e-92,
Organism=Escherichia coli, GI48994986, Length=399, Percent_Identity=42.1052631578947, Blast_Score=271, Evalue=4e-74,
Organism=Escherichia coli, GI1788683, Length=409, Percent_Identity=33.9853300733496, Blast_Score=200, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI133906874, Length=390, Percent_Identity=45.3846153846154, Blast_Score=330, Evalue=5e-91,
Organism=Caenorhabditis elegans, GI25147385, Length=387, Percent_Identity=42.8940568475452, Blast_Score=304, Evalue=4e-83,
Organism=Caenorhabditis elegans, GI17535921, Length=396, Percent_Identity=41.1616161616162, Blast_Score=279, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17535917, Length=392, Percent_Identity=32.1428571428571, Blast_Score=188, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17551802, Length=428, Percent_Identity=31.5420560747664, Blast_Score=186, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6325229, Length=397, Percent_Identity=43.8287153652393, Blast_Score=299, Evalue=4e-82,
Organism=Saccharomyces cerevisiae, GI6322031, Length=399, Percent_Identity=39.3483709273183, Blast_Score=239, Evalue=4e-64,
Organism=Drosophila melanogaster, GI24655093, Length=392, Percent_Identity=56.3775510204082, Blast_Score=449, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24640423, Length=393, Percent_Identity=46.3104325699746, Blast_Score=325, Evalue=2e-89,
Organism=Drosophila melanogaster, GI17648125, Length=390, Percent_Identity=45.3846153846154, Blast_Score=319, Evalue=2e-87,
Organism=Drosophila melanogaster, GI17137578, Length=425, Percent_Identity=31.0588235294118, Blast_Score=180, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40577; Mature: 40446

Theoretical pI: Translated: 7.54; Mature: 7.54

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDVVIVSAARTAVGKFGGSLAKIAAPELGATVIRAVLERSGLKPEQVSEVILGQVLAAG
CCCEEEEEHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
SGQNPARQSLIKAGLPMAVPGMTINKVCGSGLKAVMLAANAIIAGDADIVVAGGQENMSA
CCCCHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHCEEEECCCCEEEECCCCCCCC
APHVLPGSRDGFRMGDAKLIDTMIVDGLWDVYNQYHMGVTAENVAKEYGITREDQDAFAA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHH
LSQNKAEAAQKAGRFDDEIVPVQIPQKKGDPLSFATDEFVRHGVTAEALAGLKPAFSKEG
HHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCHHHHHCCCCCCCCCC
TVTAANASGINDGAAAVVVMSAKKAEALGLTPLARIKAYANAGVDPKVMGMGPVPASRRC
CEEECCCCCCCCCCEEEEEEECCCCHHCCCCHHHHHHHHHCCCCCCEEEECCCCCHHHHH
LERAGWSVNDLDLMEINEAFAAQALAVHKQMGWDQSKINVNGGAIAIGHPIGASGCRILV
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEECCCCCCCHHHHHH
TLLHEMQKRDAKKGLASLCIGGGMGVALAVERP
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
>Mature Secondary Structure 
TDVVIVSAARTAVGKFGGSLAKIAAPELGATVIRAVLERSGLKPEQVSEVILGQVLAAG
CCEEEEEHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
SGQNPARQSLIKAGLPMAVPGMTINKVCGSGLKAVMLAANAIIAGDADIVVAGGQENMSA
CCCCHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHCEEEECCCCEEEECCCCCCCC
APHVLPGSRDGFRMGDAKLIDTMIVDGLWDVYNQYHMGVTAENVAKEYGITREDQDAFAA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHH
LSQNKAEAAQKAGRFDDEIVPVQIPQKKGDPLSFATDEFVRHGVTAEALAGLKPAFSKEG
HHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCHHHHHCCCCCCCCCC
TVTAANASGINDGAAAVVVMSAKKAEALGLTPLARIKAYANAGVDPKVMGMGPVPASRRC
CEEECCCCCCCCCCEEEEEEECCCCHHCCCCHHHHHHHHHCCCCCCEEEECCCCCHHHHH
LERAGWSVNDLDLMEINEAFAAQALAVHKQMGWDQSKINVNGGAIAIGHPIGASGCRILV
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEECCCCCCCHHHHHH
TLLHEMQKRDAKKGLASLCIGGGMGVALAVERP
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2670935; 2670936 [H]