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The map label for this gene is moeA [H]

Identifier: 186475698

GI number: 186475698

Start: 1037419

End: 1038714

Strand: Direct

Name: moeA [H]

Synonym: Bphy_0933

Alternate gene names: 186475698

Gene position: 1037419-1038714 (Clockwise)

Preceding gene: 186475697

Following gene: 186475699

Centisome position: 29.82

GC content: 67.44

Gene sequence:

>1296_bases
ATGATGTCCACACCCACGCCTCCGACGCCTCCGGAACAGGCAGCGCCCCGCGCGCCCATGCTCTCGACGGCAGATGCGCT
CGCGACACTGCTCGGCGCCGCCGTGCAGATCCACGGCACCGAAACGCTGCCGACCCTCGATGCGACCAACCGCGTGCTGG
CCGCCAACGTCGTCTCGCCGCTCGATGTGCCGCCAATGAATACGAGTTCGATGGACGGCTACGCGGTGCGCGTCGCTGAA
CTGTCGCAGGGTGAGCGGCGTCTGATCATTTCCCAGCGGATTCCGGCGGGCCACGCACCGCAACCGCTCGCCGAGGGCAC
GGCCGCGCGCATTTTCACGGGAGCGACGGTGCCAGCCGGTGCCGATGCCATCGTGATGCAGGAACAGACGGAAGCGGCTG
GCGACCAGGTGACCATCCTGCACACACCGAAGACGGGCGAGTGGATCACTCAACAGGGCGCCGACATCCGCAAAGGCGCG
ACGATCCTGCCCGCCGGCACGCGGCTCTCGCCGCAGGCGCTCGGGCTGGCGGCGTCCGTCGGCTGTGCACATCTCGAAGT
CGTGCGGCGGGTGAAAGTCGCCGTGTTTTTCACGGGCGACGAACTGACGATGCCCGGCGCGCCGCTCAAGCCGGGCGCCA
TCTACAACTCAAACCGCTTCACGTTGACGGGTTTGCTGCACAAGCTCGGCTGCGATGTGACCGACTACGGCATCGTGCCC
GACAAGCTCGACGCGACGCGCGACACGCTGCGCGAAGCCGCGCAGGCGCACGACCTGATCCTGACCTGCGGGGGCGTCTC
CGTAGGCGAGGAAGATCACGTGAAGCCCGCTGTCGAGGCGGAAGGGCGGCTGTCGATGTGGCAGATCGCCATGAAGCCGG
GCAAGCCGCTCGCATTCGGCGCGGTTCGCCGTGCGGCCACACAGGGCGACGCCGGCACGCCGGGCAATGCCGGCGAAACG
TTCTTCATCGGTCTGCCGGGCAACCCCGTGTCGACGTTCGTCACGTTTCTGCTGTTCGTGCGGCCATTTCTGCTGCGGCT
CGCGGGCGTCCGCACAGTCACGCCGCGCGCGCTGTCGCTGCGCGCTGATTTCACGCAGCAGAAGGGCGACCGCCGCAATG
AATTCCTGCGCGCACGCGTGAATGCCGCCGGAGGCCTCGACCTGTTCCCGAACCAGAGTTCGGCGGTGCTGACGTCGACC
GTCTGGGGCGACGGGCTGATCGATAATCCGCCGAATCATACGATCAGCGCCGGCGAGACCGTGCGCTTCATCCCGTTCTC
CGAACTGCTGAACTGA

Upstream 100 bases:

>100_bases
CCGCGCGCACCGCGCAGGCGCACGAAAACCCGAAACCGCGCCCACCGCCAAAGGGCCCCCCTCCCGTTACAATGATTCTT
TCCGAATCGCTCCGGATCGA

Downstream 100 bases:

>100_bases
ATGTGCAGTCACACGCGAGCCGCGATTGAACCTGATTAAACGCCTTTGAGGCCGCTACCGACGATGAAGATTCAGTTGAA
ATATTTTGCGAGCGTGCGCG

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MMSTPTPPTPPEQAAPRAPMLSTADALATLLGAAVQIHGTETLPTLDATNRVLAANVVSPLDVPPMNTSSMDGYAVRVAE
LSQGERRLIISQRIPAGHAPQPLAEGTAARIFTGATVPAGADAIVMQEQTEAAGDQVTILHTPKTGEWITQQGADIRKGA
TILPAGTRLSPQALGLAASVGCAHLEVVRRVKVAVFFTGDELTMPGAPLKPGAIYNSNRFTLTGLLHKLGCDVTDYGIVP
DKLDATRDTLREAAQAHDLILTCGGVSVGEEDHVKPAVEAEGRLSMWQIAMKPGKPLAFGAVRRAATQGDAGTPGNAGET
FFIGLPGNPVSTFVTFLLFVRPFLLRLAGVRTVTPRALSLRADFTQQKGDRRNEFLRARVNAAGGLDLFPNQSSAVLTST
VWGDGLIDNPPNHTISAGETVRFIPFSELLN

Sequences:

>Translated_431_residues
MMSTPTPPTPPEQAAPRAPMLSTADALATLLGAAVQIHGTETLPTLDATNRVLAANVVSPLDVPPMNTSSMDGYAVRVAE
LSQGERRLIISQRIPAGHAPQPLAEGTAARIFTGATVPAGADAIVMQEQTEAAGDQVTILHTPKTGEWITQQGADIRKGA
TILPAGTRLSPQALGLAASVGCAHLEVVRRVKVAVFFTGDELTMPGAPLKPGAIYNSNRFTLTGLLHKLGCDVTDYGIVP
DKLDATRDTLREAAQAHDLILTCGGVSVGEEDHVKPAVEAEGRLSMWQIAMKPGKPLAFGAVRRAATQGDAGTPGNAGET
FFIGLPGNPVSTFVTFLLFVRPFLLRLAGVRTVTPRALSLRADFTQQKGDRRNEFLRARVNAAGGLDLFPNQSSAVLTST
VWGDGLIDNPPNHTISAGETVRFIPFSELLN
>Mature_431_residues
MMSTPTPPTPPEQAAPRAPMLSTADALATLLGAAVQIHGTETLPTLDATNRVLAANVVSPLDVPPMNTSSMDGYAVRVAE
LSQGERRLIISQRIPAGHAPQPLAEGTAARIFTGATVPAGADAIVMQEQTEAAGDQVTILHTPKTGEWITQQGADIRKGA
TILPAGTRLSPQALGLAASVGCAHLEVVRRVKVAVFFTGDELTMPGAPLKPGAIYNSNRFTLTGLLHKLGCDVTDYGIVP
DKLDATRDTLREAAQAHDLILTCGGVSVGEEDHVKPAVEAEGRLSMWQIAMKPGKPLAFGAVRRAATQGDAGTPGNAGET
FFIGLPGNPVSTFVTFLLFVRPFLLRLAGVRTVTPRALSLRADFTQQKGDRRNEFLRARVNAAGGLDLFPNQSSAVLTST
VWGDGLIDNPPNHTISAGETVRFIPFSELLN

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=411, Percent_Identity=34.0632603406326, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI66932975, Length=411, Percent_Identity=34.0632603406326, Blast_Score=177, Evalue=1e-44,
Organism=Escherichia coli, GI1787049, Length=396, Percent_Identity=39.3939393939394, Blast_Score=258, Evalue=6e-70,
Organism=Caenorhabditis elegans, GI25147659, Length=351, Percent_Identity=31.6239316239316, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17562606, Length=391, Percent_Identity=25.3196930946292, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17136978, Length=413, Percent_Identity=32.6876513317191, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24638841, Length=413, Percent_Identity=32.6876513317191, Blast_Score=160, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 45419; Mature: 45419

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSTPTPPTPPEQAAPRAPMLSTADALATLLGAAVQIHGTETLPTLDATNRVLAANVVSP
CCCCCCCCCCCHHCCCCCCCHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCEEEECCCCC
LDVPPMNTSSMDGYAVRVAELSQGERRLIISQRIPAGHAPQPLAEGTAARIFTGATVPAG
CCCCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCCCCCCCHHCCCCEEEEECCCCCCC
ADAIVMQEQTEAAGDQVTILHTPKTGEWITQQGADIRKGATILPAGTRLSPQALGLAASV
CCEEEEECCHHCCCCEEEEEECCCCCCHHHHCCCCHHCCCEEECCCCCCCHHHHHHHHHH
GCAHLEVVRRVKVAVFFTGDELTMPGAPLKPGAIYNSNRFTLTGLLHKLGCDVTDYGIVP
HHHHHHHHHEEEEEEEEECCCEECCCCCCCCCEEECCCCEEHHHHHHHHCCCCCCCCCCC
DKLDATRDTLREAAQAHDLILTCGGVSVGEEDHVKPAVEAEGRLSMWQIAMKPGKPLAFG
CCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCHHHH
AVRRAATQGDAGTPGNAGETFFIGLPGNPVSTFVTFLLFVRPFLLRLAGVRTVTPRALSL
HHHHHHCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
RADFTQQKGDRRNEFLRARVNAAGGLDLFPNQSSAVLTSTVWGDGLIDNPPNHTISAGET
ECHHHHHCCCHHHHHHHHHHCCCCCCEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCCE
VRFIPFSELLN
EEEEEHHHHCC
>Mature Secondary Structure
MMSTPTPPTPPEQAAPRAPMLSTADALATLLGAAVQIHGTETLPTLDATNRVLAANVVSP
CCCCCCCCCCCHHCCCCCCCHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCEEEECCCCC
LDVPPMNTSSMDGYAVRVAELSQGERRLIISQRIPAGHAPQPLAEGTAARIFTGATVPAG
CCCCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCCCCCCCHHCCCCEEEEECCCCCCC
ADAIVMQEQTEAAGDQVTILHTPKTGEWITQQGADIRKGATILPAGTRLSPQALGLAASV
CCEEEEECCHHCCCCEEEEEECCCCCCHHHHCCCCHHCCCEEECCCCCCCHHHHHHHHHH
GCAHLEVVRRVKVAVFFTGDELTMPGAPLKPGAIYNSNRFTLTGLLHKLGCDVTDYGIVP
HHHHHHHHHEEEEEEEEECCCEECCCCCCCCCEEECCCCEEHHHHHHHHCCCCCCCCCCC
DKLDATRDTLREAAQAHDLILTCGGVSVGEEDHVKPAVEAEGRLSMWQIAMKPGKPLAFG
CCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCHHHH
AVRRAATQGDAGTPGNAGETFFIGLPGNPVSTFVTFLLFVRPFLLRLAGVRTVTPRALSL
HHHHHHCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
RADFTQQKGDRRNEFLRARVNAAGGLDLFPNQSSAVLTSTVWGDGLIDNPPNHTISAGET
ECHHHHHCCCHHHHHHHHHHCCCCCCEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCCE
VRFIPFSELLN
EEEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]