Click here to switch to the map view.

The map label for this gene is thrC [H]

Identifier: 186475697

GI number: 186475697

Start: 1035698

End: 1037146

Strand: Direct

Name: thrC [H]

Synonym: Bphy_0932

Alternate gene names: 186475697

Gene position: 1035698-1037146 (Clockwise)

Preceding gene: 186475696

Following gene: 186475698

Centisome position: 29.77

GC content: 61.08

Gene sequence:

>1449_bases
ATGAATTACATTTCCACGCGCGGCGCCGGCATCGGCGAGCGCCACACGTTCTCCGACATCCTGCTCGGTGGTCTAGCGAA
GGATGGCGGCCTGTATCTGCCGAACGAATATCCGCAGGTCACGACGGATGAACTCGCCCGCTGGCGCACGCTGCCGTATG
CGGATCTCGCGTTCGAGATTCTGCACAAGTTCAGCGACGACATTCCCGCCGACGACCTGCGCGAGCTGACGCGCCGCACG
TACACGGCGCAGGTGTACTGCAACGTGCGCGACGAGGAGAACGCCGCGCAGATCACGCCGCTCAAGACGCTCGGCGTCGA
AAACGGCGCGCCGCTGTCGCTGCTGGAACTGTCGAATGGTCCGACGCTCGCGTTCAAGGACATGGCGATGCAACTGCTCG
GCAATCTGTTCGAGTACACGCTCGCGAAGCACGGCGAGACGTTGAACATTCTCGGCGCGACGTCGGGCGATACGGGCAGC
GCGGCCGAATACGCGATGCGCGGCAAGAAGGGCATTCGCGTGTTCATGTTGTCGCCGCACAAGAAGATGAGCGCGTTCCA
GACGGCGCAGATGTACAGCCTGCAGGACCCGAACATTTTCAACATCGCCGTCGAAGGCGTTTTCGACGATTGCCAGGACA
TCGTCAAAGCCGTGTCGAACGATCACGCGTTCAAGGCACAGCAGAAGATCGGCACGGTCAACTCGATCAACTGGGCGCGC
GTCGTCGCACAGGTCGTGTACTACTTCAAGGGCTATTTCGCGGCCACGAAGCGTAATGACGAGCGCGTGTCGTTCACGGT
GCCGTCGGGCAACTTCGGCAATGTGTGCGCGGGCCATATCGCGCGCATGATGGGCTTGCCGATTGAAAAGCTGGTCGTCG
CGACCAACGAGAACGACGTGCTCGACGAGTTTTTCCGCACGGGCATTTACCGTGTGCGCAAGTCGTCGGAGACGTATCAC
ACCAGCAGCCCGAGCATGGACATTTCGAAGGCGTCGAACTTCGAGCGCTTCGTGTTCGATCTGCTCGGCCGCGATCCGAA
GCGCGTGCTGCAGCTATTCCGCGATGTCGAAGAGAAGGGCGGTTTCGATCTGCAGGCGAGCGGCGATTTCGCGCGTGTGA
AGGCATTCGGCTTCGTCTCGGGACGTAGTAGCCACGACGATCGCGTCGACACGATCCGCGACGTGTTCCAGCATTACGAC
ACGATGATCGATACGCATACGGCCGATGGTGTGAAGGTCGCGCGTGAGCATCTGCAGGCGGGCGTTCCTATGGTAGTGCT
GGAGACTGCGCAGCCAATCAAGTTCGGCGAGACGATTCGCGAGGCGCTGGAGCGTGAGCCGGAGCGTCCGGCCGCGTTCA
GTGGGATTGAAGATTTGCCGCAGCGGTTCGAAGTGCTGGCGAATGACGCGGAGCGTGTGAAGGCATTCGTTGCTGCGCAT
ACGCGTTGA

Upstream 100 bases:

>100_bases
CGCGAACATCGAGGCGCTGAAGACGGTCGTGTCGAAAGTGACGAAGCTGCGCATGGAAGCGCTGGACTGACGCACCGCAC
ACACGTAAAGAGGCAAGCTC

Downstream 100 bases:

>100_bases
TTTTTGTCTGCGACGCGGTCGCCGTTTTGGTTTTTTGCGGTTTTTTTGCGCTGGCATCCGCGTTTCGTTTCTGGTTTGCC
GGGGTTGCTCCTGTGCGGGG

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MNYISTRGAGIGERHTFSDILLGGLAKDGGLYLPNEYPQVTTDELARWRTLPYADLAFEILHKFSDDIPADDLRELTRRT
YTAQVYCNVRDEENAAQITPLKTLGVENGAPLSLLELSNGPTLAFKDMAMQLLGNLFEYTLAKHGETLNILGATSGDTGS
AAEYAMRGKKGIRVFMLSPHKKMSAFQTAQMYSLQDPNIFNIAVEGVFDDCQDIVKAVSNDHAFKAQQKIGTVNSINWAR
VVAQVVYYFKGYFAATKRNDERVSFTVPSGNFGNVCAGHIARMMGLPIEKLVVATNENDVLDEFFRTGIYRVRKSSETYH
TSSPSMDISKASNFERFVFDLLGRDPKRVLQLFRDVEEKGGFDLQASGDFARVKAFGFVSGRSSHDDRVDTIRDVFQHYD
TMIDTHTADGVKVAREHLQAGVPMVVLETAQPIKFGETIREALEREPERPAAFSGIEDLPQRFEVLANDAERVKAFVAAH
TR

Sequences:

>Translated_482_residues
MNYISTRGAGIGERHTFSDILLGGLAKDGGLYLPNEYPQVTTDELARWRTLPYADLAFEILHKFSDDIPADDLRELTRRT
YTAQVYCNVRDEENAAQITPLKTLGVENGAPLSLLELSNGPTLAFKDMAMQLLGNLFEYTLAKHGETLNILGATSGDTGS
AAEYAMRGKKGIRVFMLSPHKKMSAFQTAQMYSLQDPNIFNIAVEGVFDDCQDIVKAVSNDHAFKAQQKIGTVNSINWAR
VVAQVVYYFKGYFAATKRNDERVSFTVPSGNFGNVCAGHIARMMGLPIEKLVVATNENDVLDEFFRTGIYRVRKSSETYH
TSSPSMDISKASNFERFVFDLLGRDPKRVLQLFRDVEEKGGFDLQASGDFARVKAFGFVSGRSSHDDRVDTIRDVFQHYD
TMIDTHTADGVKVAREHLQAGVPMVVLETAQPIKFGETIREALEREPERPAAFSGIEDLPQRFEVLANDAERVKAFVAAH
TR
>Mature_482_residues
MNYISTRGAGIGERHTFSDILLGGLAKDGGLYLPNEYPQVTTDELARWRTLPYADLAFEILHKFSDDIPADDLRELTRRT
YTAQVYCNVRDEENAAQITPLKTLGVENGAPLSLLELSNGPTLAFKDMAMQLLGNLFEYTLAKHGETLNILGATSGDTGS
AAEYAMRGKKGIRVFMLSPHKKMSAFQTAQMYSLQDPNIFNIAVEGVFDDCQDIVKAVSNDHAFKAQQKIGTVNSINWAR
VVAQVVYYFKGYFAATKRNDERVSFTVPSGNFGNVCAGHIARMMGLPIEKLVVATNENDVLDEFFRTGIYRVRKSSETYH
TSSPSMDISKASNFERFVFDLLGRDPKRVLQLFRDVEEKGGFDLQASGDFARVKAFGFVSGRSSHDDRVDTIRDVFQHYD
TMIDTHTADGVKVAREHLQAGVPMVVLETAQPIKFGETIREALEREPERPAAFSGIEDLPQRFEVLANDAERVKAFVAAH
TR

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=451, Percent_Identity=32.5942350332594, Blast_Score=208, Evalue=7e-54,
Organism=Homo sapiens, GI149193323, Length=475, Percent_Identity=30.9473684210526, Blast_Score=204, Evalue=1e-52,
Organism=Escherichia coli, GI1786185, Length=472, Percent_Identity=27.5423728813559, Blast_Score=179, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6319901, Length=473, Percent_Identity=40.5919661733615, Blast_Score=322, Evalue=8e-89,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 53741; Mature: 53741

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYISTRGAGIGERHTFSDILLGGLAKDGGLYLPNEYPQVTTDELARWRTLPYADLAFEI
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEECCCCCCCCCHHHHHHHCCCCHHHHHHHH
LHKFSDDIPADDLRELTRRTYTAQVYCNVRDEENAAQITPLKTLGVENGAPLSLLELSNG
HHHHCCCCCHHHHHHHHHHCEEEEEEEEECCCCCCCEECCHHHHCCCCCCCEEEEEECCC
PTLAFKDMAMQLLGNLFEYTLAKHGETLNILGATSGDTGSAAEYAMRGKKGIRVFMLSPH
CCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHCCCCCCEEEEECCC
KKMSAFQTAQMYSLQDPNIFNIAVEGVFDDCQDIVKAVSNDHAFKAQQKIGTVNSINWAR
HHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHH
VVAQVVYYFKGYFAATKRNDERVSFTVPSGNFGNVCAGHIARMMGLPIEKLVVATNENDV
HHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCHHHEEEECCCCHH
LDEFFRTGIYRVRKSSETYHTSSPSMDISKASNFERFVFDLLGRDPKRVLQLFRDVEEKG
HHHHHHHHHHHHHCCCCCEECCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHC
GFDLQASGDFARVKAFGFVSGRSSHDDRVDTIRDVFQHYDTMIDTHTADGVKVAREHLQA
CCEEECCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
GVPMVVLETAQPIKFGETIREALEREPERPAAFSGIEDLPQRFEVLANDAERVKAFVAAH
CCCEEEEECCCCCHHHHHHHHHHHCCCCCCCHHCCHHHHHHHHHHHHCCHHHHHHHHHHC
TR
CC
>Mature Secondary Structure
MNYISTRGAGIGERHTFSDILLGGLAKDGGLYLPNEYPQVTTDELARWRTLPYADLAFEI
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEECCCCCCCCCHHHHHHHCCCCHHHHHHHH
LHKFSDDIPADDLRELTRRTYTAQVYCNVRDEENAAQITPLKTLGVENGAPLSLLELSNG
HHHHCCCCCHHHHHHHHHHCEEEEEEEEECCCCCCCEECCHHHHCCCCCCCEEEEEECCC
PTLAFKDMAMQLLGNLFEYTLAKHGETLNILGATSGDTGSAAEYAMRGKKGIRVFMLSPH
CCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHCCCCCCEEEEECCC
KKMSAFQTAQMYSLQDPNIFNIAVEGVFDDCQDIVKAVSNDHAFKAQQKIGTVNSINWAR
HHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHH
VVAQVVYYFKGYFAATKRNDERVSFTVPSGNFGNVCAGHIARMMGLPIEKLVVATNENDV
HHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCHHHEEEECCCCHH
LDEFFRTGIYRVRKSSETYHTSSPSMDISKASNFERFVFDLLGRDPKRVLQLFRDVEEKG
HHHHHHHHHHHHHCCCCCEECCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHC
GFDLQASGDFARVKAFGFVSGRSSHDDRVDTIRDVFQHYDTMIDTHTADGVKVAREHLQA
CCEEECCCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
GVPMVVLETAQPIKFGETIREALEREPERPAAFSGIEDLPQRFEVLANDAERVKAFVAAH
CCCEEEEECCCCCHHHHHHHHHHHCCCCCCCHHCCHHHHHHHHHHHHCCHHHHHHHHHHC
TR
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8117070 [H]