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The map label for this gene is atoC [H]

Identifier: 186475612

GI number: 186475612

Start: 945728

End: 947110

Strand: Reverse

Name: atoC [H]

Synonym: Bphy_0847

Alternate gene names: 186475612

Gene position: 947110-945728 (Counterclockwise)

Preceding gene: 186475613

Following gene: 186475589

Centisome position: 27.22

GC content: 66.88

Gene sequence:

>1383_bases
ATGCCACATGCCCTGATTGTCGAAGACGATCCCAATAGCCTGTCAGGCCTGTCCGCGATTCTGGCCGCCGACGGTTTTTC
CGTCGACACCGCGATCACGCTCTCCGAAGCGCGCGCAGCCCTGACACGCTTCATTCCCGACGTCGTGCTGGTCGATCTGA
ATCTGCCCGACGGCAGCGGGCTGGACCTGCTTCAGCATCTGCCCGCGCAGCCGCCGGGCGGTGCGCTGCCCGTTATCGTG
ATGACGGGCAATGCGACCGTGGAGAGCGCGATCGAAGGCTTGCGGCACGGAATCTGGGACTACCTGCTCAAGCCCGTGAA
CATTCCCCGTCTGCGCAGCCTGCTGGCACGCATTCCGCGTCCGTACGAACTGACGGAGGAAGTGCAGACGCTGCGCGCGA
AGCTGCGCCGCATGGGCCGTTTCGGGCCGATGATCGGCCGCAGCGGCGCGATCCAGCATATCTACGATTCGATCGAGCAC
ATCGCCCCGACGGAAGCCGCCGTGCTGATTTCCGGCGAAGCCGGAACGGGTAAGGAAGTCGCAGCGCGCACGCTGCATGA
AATGAGCCGCCGACGCAAAGGGCCGTTCGTCGTGCTCGACTGCCGCTCGGCGCAGGCCGTCGCGGGCGGCCGGCCGCTCG
ACAGCCTGCTGTTCGGTCACGAGCGCGGCGCGTTCGGTGGCGCGGAGCAGCGCGAGCCCGGCCTGTTCGAGCAGGCGAGC
GGCGGCACACTCTTCATCGACGAGATTACGTTGTTGCCGCGTCCGCAGCAGGAAGCGCTGCTGAGCGCACTCGATTCACA
GACCTTCATGCGCGTCGGCGGCACGAACCAGGTCGCGACCGACTTCCGGCTGATCGCGTCGACGCGCAAGGCGCCGCGGG
CGGCTCTCGCGGATGGCACGCTGCATCAGGATCTGGGGCTGCGTCTCGAAGCAGCCGCGCTGTCGCTGCCGCCGCTGCGC
GAACGCGGCGACGACCCTGCCCTCTTCGCGCAGGTGATCGTCGACGAACTGAACGACGAAGCGAACGCCCGCGGCGTCGC
CGACGCGACGAAGCTGGTCGGACCGAATTTCGTCCGCGAATGCCTCGCGTATGAGTGGCCGGGCAATGTGCGTGAATTGC
AGGACCGCGTGCGGCGCGCCTATCACGCTTCCGGCGACGTGCTAGAGACGTTGCGCGCCGACGAGAGCAACGGCGCAGGT
GGCCGCGACCTGAACGGCGGCCGCGTGCAGGTGACGGTCGGCACGCCGCTCGCCGATGTCGAGGAAATGCTGATTCGTGC
GACCCTCGATGCCGTGGGCGGCACACGTCATCGCGCGGCTTCGCTGCTCGGCATCAGTCCAAAGACGCTGTACAACAAAT
TGCAACGGATGCGGCTGAACTGA

Upstream 100 bases:

>100_bases
ATTGGCCGCTCACCCCGATCATCAAGCGTCCGCGCGCACGGCGCCGCCCCGGCGGGCCGCGCACGTCGGACACCCGTCCA
TCTGAACAATTGCGCTCGTT

Downstream 100 bases:

>100_bases
TCGGCTGCTTGCCGGCAAAACAAAAGGACGGGCTCGATCGAGACCCGTCCTTTCTTATTGCTACTGCAGCGCGAAGATCA
CGCAGCGAAAGTCTCGCGCA

Product: two component, sigma54 specific, Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MPHALIVEDDPNSLSGLSAILAADGFSVDTAITLSEARAALTRFIPDVVLVDLNLPDGSGLDLLQHLPAQPPGGALPVIV
MTGNATVESAIEGLRHGIWDYLLKPVNIPRLRSLLARIPRPYELTEEVQTLRAKLRRMGRFGPMIGRSGAIQHIYDSIEH
IAPTEAAVLISGEAGTGKEVAARTLHEMSRRRKGPFVVLDCRSAQAVAGGRPLDSLLFGHERGAFGGAEQREPGLFEQAS
GGTLFIDEITLLPRPQQEALLSALDSQTFMRVGGTNQVATDFRLIASTRKAPRAALADGTLHQDLGLRLEAAALSLPPLR
ERGDDPALFAQVIVDELNDEANARGVADATKLVGPNFVRECLAYEWPGNVRELQDRVRRAYHASGDVLETLRADESNGAG
GRDLNGGRVQVTVGTPLADVEEMLIRATLDAVGGTRHRAASLLGISPKTLYNKLQRMRLN

Sequences:

>Translated_460_residues
MPHALIVEDDPNSLSGLSAILAADGFSVDTAITLSEARAALTRFIPDVVLVDLNLPDGSGLDLLQHLPAQPPGGALPVIV
MTGNATVESAIEGLRHGIWDYLLKPVNIPRLRSLLARIPRPYELTEEVQTLRAKLRRMGRFGPMIGRSGAIQHIYDSIEH
IAPTEAAVLISGEAGTGKEVAARTLHEMSRRRKGPFVVLDCRSAQAVAGGRPLDSLLFGHERGAFGGAEQREPGLFEQAS
GGTLFIDEITLLPRPQQEALLSALDSQTFMRVGGTNQVATDFRLIASTRKAPRAALADGTLHQDLGLRLEAAALSLPPLR
ERGDDPALFAQVIVDELNDEANARGVADATKLVGPNFVRECLAYEWPGNVRELQDRVRRAYHASGDVLETLRADESNGAG
GRDLNGGRVQVTVGTPLADVEEMLIRATLDAVGGTRHRAASLLGISPKTLYNKLQRMRLN
>Mature_459_residues
PHALIVEDDPNSLSGLSAILAADGFSVDTAITLSEARAALTRFIPDVVLVDLNLPDGSGLDLLQHLPAQPPGGALPVIVM
TGNATVESAIEGLRHGIWDYLLKPVNIPRLRSLLARIPRPYELTEEVQTLRAKLRRMGRFGPMIGRSGAIQHIYDSIEHI
APTEAAVLISGEAGTGKEVAARTLHEMSRRRKGPFVVLDCRSAQAVAGGRPLDSLLFGHERGAFGGAEQREPGLFEQASG
GTLFIDEITLLPRPQQEALLSALDSQTFMRVGGTNQVATDFRLIASTRKAPRAALADGTLHQDLGLRLEAAALSLPPLRE
RGDDPALFAQVIVDELNDEANARGVADATKLVGPNFVRECLAYEWPGNVRELQDRVRRAYHASGDVLETLRADESNGAGG
RDLNGGRVQVTVGTPLADVEEMLIRATLDAVGGTRHRAASLLGISPKTLYNKLQRMRLN

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=461, Percent_Identity=36.2255965292842, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI1790437, Length=458, Percent_Identity=35.589519650655, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI1790299, Length=479, Percent_Identity=33.6116910229645, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1788905, Length=381, Percent_Identity=30.7086614173228, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI87081872, Length=247, Percent_Identity=40.080971659919, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI87082117, Length=352, Percent_Identity=33.5227272727273, Blast_Score=165, Evalue=7e-42,
Organism=Escherichia coli, GI1789087, Length=252, Percent_Identity=38.8888888888889, Blast_Score=161, Evalue=8e-41,
Organism=Escherichia coli, GI1789233, Length=328, Percent_Identity=30.4878048780488, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI87082152, Length=239, Percent_Identity=39.7489539748954, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1786524, Length=263, Percent_Identity=37.6425855513308, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI1787583, Length=269, Percent_Identity=33.457249070632, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1789828, Length=265, Percent_Identity=33.9622641509434, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI87081858, Length=298, Percent_Identity=25.503355704698, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786838, Length=137, Percent_Identity=33.5766423357664, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 49502; Mature: 49371

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00676 SIGMA54_INTERACT_2 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHALIVEDDPNSLSGLSAILAADGFSVDTAITLSEARAALTRFIPDVVLVDLNLPDGSG
CCCEEEEECCCCCHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHCCCEEEEEEECCCCCC
LDLLQHLPAQPPGGALPVIVMTGNATVESAIEGLRHGIWDYLLKPVNIPRLRSLLARIPR
HHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCC
PYELTEEVQTLRAKLRRMGRFGPMIGRSGAIQHIYDSIEHIAPTEAAVLISGEAGTGKEV
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCHHH
AARTLHEMSRRRKGPFVVLDCRSAQAVAGGRPLDSLLFGHERGAFGGAEQREPGLFEQAS
HHHHHHHHHHHCCCCEEEEECCCCCHHCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCC
GGTLFIDEITLLPRPQQEALLSALDSQTFMRVGGTNQVATDFRLIASTRKAPRAALADGT
CCEEEEEEEEECCCCHHHHHHHHHCCHHHEEECCCCHHHHHHHHHHHHCCCCHHHHCCCC
LHQDLGLRLEAAALSLPPLRERGDDPALFAQVIVDELNDEANARGVADATKLVGPNFVRE
HHHHHCCEEEEHHCCCCCHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHH
CLAYEWPGNVRELQDRVRRAYHASGDVLETLRADESNGAGGRDLNGGRVQVTVGTPLADV
HHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCHHHH
EEMLIRATLDAVGGTRHRAASLLGISPKTLYNKLQRMRLN
HHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
PHALIVEDDPNSLSGLSAILAADGFSVDTAITLSEARAALTRFIPDVVLVDLNLPDGSG
CCEEEEECCCCCHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHCCCEEEEEEECCCCCC
LDLLQHLPAQPPGGALPVIVMTGNATVESAIEGLRHGIWDYLLKPVNIPRLRSLLARIPR
HHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCC
PYELTEEVQTLRAKLRRMGRFGPMIGRSGAIQHIYDSIEHIAPTEAAVLISGEAGTGKEV
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCHHH
AARTLHEMSRRRKGPFVVLDCRSAQAVAGGRPLDSLLFGHERGAFGGAEQREPGLFEQAS
HHHHHHHHHHHCCCCEEEEECCCCCHHCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCC
GGTLFIDEITLLPRPQQEALLSALDSQTFMRVGGTNQVATDFRLIASTRKAPRAALADGT
CCEEEEEEEEECCCCHHHHHHHHHCCHHHEEECCCCHHHHHHHHHHHHCCCCHHHHCCCC
LHQDLGLRLEAAALSLPPLRERGDDPALFAQVIVDELNDEANARGVADATKLVGPNFVRE
HHHHHCCEEEEHHCCCCCHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHH
CLAYEWPGNVRELQDRVRRAYHASGDVLETLRADESNGAGGRDLNGGRVQVTVGTPLADV
HHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCHHHH
EEMLIRATLDAVGGTRHRAASLLGISPKTLYNKLQRMRLN
HHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]