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The map label for this gene is ytpA [H]

Identifier: 186475523

GI number: 186475523

Start: 854634

End: 855581

Strand: Reverse

Name: ytpA [H]

Synonym: Bphy_0758

Alternate gene names: 186475523

Gene position: 855581-854634 (Counterclockwise)

Preceding gene: 186475530

Following gene: 186475520

Centisome position: 24.59

GC content: 67.19

Gene sequence:

>948_bases
ATGGCACGGACTCCCCGTGCCGCTATGATCGGGCGCATCTCGATAAAGAGCGGGCGATTGCCGATGCAGACTTCACAGGC
CAACTTTGCTTCGGCGACACCGCCTTTCGAGTACTCGCGGATCACCACGCGCGACGCTCTCGCGCTGCCGCTTTATCGCT
GGCATGTCGCGGGGCCGCGCCGTGCGACGATCGCCCTCATTCACGGCCTGGCCGAACACGCGCGTCGATATGCAACGCTT
GCCCATACGCTGACTGCGCACGGCATCGAGCTGGTCGCTGTCGATCTGCGCGGCCACGGTAACGCGCCGGGCCGGCGCGC
GTGGGTCGAACGTTTCGACGACTACCTGCTGGATGCGCATGCGCTCGTCGCCGAGGCAGCCCGCAACGGCGGCCCGCTGT
TCCTGATGGGCCACAGCATGGGCGGAGCAATCGCGGCGCTGCACGCGATCGAACGGCACGCGGACGACGCGCGCGATCTG
AGCGGCCTGATCCTGTCGAGTCCCGCACTCGCGCCCGGCCGCGACGTGCCGCGCTGGATGCTCGCGTTGAGCCAAAAGAT
CAGCCTGGTATGGCCGCGTTTCCCCGCCATGAAGATCGATGCAACGCTGCTGTCGCGCGATCAACACGTGGTCGCGGCCA
ACCGCAACGATCCCCTCGTGCATCACGGCGCGATTCCCGCGCGCACGGGCGCCGAGCTCCTGCTGGCGATGCAGCGCATC
GAACTGGGTCGCGCCCGTCTGCGCACGCCGCTTCTCATCTGGCACGGCAGCGCCGACAAGCTCACAGAACCGCAAGGCAG
CCGCGACTTCGGCGCGCATGCCGGCTCGCCCGACAAAACGCTGACGCTCTACGACGGCAGTTATCACGAGACGATGAACG
ACCTCGACCGCGAACGCGTGATCGACGCACTCGTCGCGTGGATAGTGGCGCGTTCGGAGCGAGGCTGA

Upstream 100 bases:

>100_bases
GAACGCGCGATTTTACCGCAGCCCGGTCATATCCTTTAATAATCAATTCGGCAACTTTCATAACGCAAAGGAATTAGAGG
ATCGCTGACGTGAAGGGACA

Downstream 100 bases:

>100_bases
TGGACGCGTTCAGCCGCCCCGCGCGGGTTTCCAGTCGGGCGGCCGCTTGTCGATGAACGCCTGCACGCCTTCGAGCGCCG
ACTCGTCCATCATGTTGCAC

Product: alpha/beta hydrolase fold protein

Products: NA

Alternate protein names: Bacilysocin biosynthesis protein ytpA [H]

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MARTPRAAMIGRISIKSGRLPMQTSQANFASATPPFEYSRITTRDALALPLYRWHVAGPRRATIALIHGLAEHARRYATL
AHTLTAHGIELVAVDLRGHGNAPGRRAWVERFDDYLLDAHALVAEAARNGGPLFLMGHSMGGAIAALHAIERHADDARDL
SGLILSSPALAPGRDVPRWMLALSQKISLVWPRFPAMKIDATLLSRDQHVVAANRNDPLVHHGAIPARTGAELLLAMQRI
ELGRARLRTPLLIWHGSADKLTEPQGSRDFGAHAGSPDKTLTLYDGSYHETMNDLDRERVIDALVAWIVARSERG

Sequences:

>Translated_315_residues
MARTPRAAMIGRISIKSGRLPMQTSQANFASATPPFEYSRITTRDALALPLYRWHVAGPRRATIALIHGLAEHARRYATL
AHTLTAHGIELVAVDLRGHGNAPGRRAWVERFDDYLLDAHALVAEAARNGGPLFLMGHSMGGAIAALHAIERHADDARDL
SGLILSSPALAPGRDVPRWMLALSQKISLVWPRFPAMKIDATLLSRDQHVVAANRNDPLVHHGAIPARTGAELLLAMQRI
ELGRARLRTPLLIWHGSADKLTEPQGSRDFGAHAGSPDKTLTLYDGSYHETMNDLDRERVIDALVAWIVARSERG
>Mature_314_residues
ARTPRAAMIGRISIKSGRLPMQTSQANFASATPPFEYSRITTRDALALPLYRWHVAGPRRATIALIHGLAEHARRYATLA
HTLTAHGIELVAVDLRGHGNAPGRRAWVERFDDYLLDAHALVAEAARNGGPLFLMGHSMGGAIAALHAIERHADDARDLS
GLILSSPALAPGRDVPRWMLALSQKISLVWPRFPAMKIDATLLSRDQHVVAANRNDPLVHHGAIPARTGAELLLAMQRIE
LGRARLRTPLLIWHGSADKLTEPQGSRDFGAHAGSPDKTLTLYDGSYHETMNDLDRERVIDALVAWIVARSERG

Specific function: Phospholipase involved in the biosynthesis of the antibiotic bacilysocin. It probably catalyzes the hydrolysis of the 2-sn-acyl moiety of phosphatidylglycerol to produce bacilysocin (lysophosphatidylglycerol). Is also able to catalyze the hydrolysis react

COG id: COG2267

COG function: function code I; Lysophospholipase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily [H]

Homologues:

Organism=Homo sapiens, GI51242953, Length=298, Percent_Identity=31.2080536912752, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI6005786, Length=298, Percent_Identity=31.2080536912752, Blast_Score=135, Evalue=4e-32,
Organism=Escherichia coli, GI1787678, Length=277, Percent_Identity=27.0758122743682, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR022742 [H]

Pfam domain/function: PF12146 Hydrolase_4 [H]

EC number: NA

Molecular weight: Translated: 34497; Mature: 34366

Theoretical pI: Translated: 10.46; Mature: 10.46

Prosite motif: PS00120 LIPASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARTPRAAMIGRISIKSGRLPMQTSQANFASATPPFEYSRITTRDALALPLYRWHVAGPR
CCCCCCCHHEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEECCCCHHCCCCEEEECCCCC
RATIALIHGLAEHARRYATLAHTLTAHGIELVAVDLRGHGNAPGRRAWVERFDDYLLDAH
HHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
ALVAEAARNGGPLFLMGHSMGGAIAALHAIERHADDARDLSGLILSSPALAPGRDVPRWM
HHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCHHHH
LALSQKISLVWPRFPAMKIDATLLSRDQHVVAANRNDPLVHHGAIPARTGAELLLAMQRI
HHHHHHHEEECCCCCCEEECHHHHCCCCEEEEECCCCCEEECCCCCCCCHHHHHHHHHHH
ELGRARLRTPLLIWHGSADKLTEPQGSRDFGAHAGSPDKTLTLYDGSYHETMNDLDRERV
HHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHH
IDALVAWIVARSERG
HHHHHHHHHHHCCCC
>Mature Secondary Structure 
ARTPRAAMIGRISIKSGRLPMQTSQANFASATPPFEYSRITTRDALALPLYRWHVAGPR
CCCCCCHHEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEECCCCHHCCCCEEEECCCCC
RATIALIHGLAEHARRYATLAHTLTAHGIELVAVDLRGHGNAPGRRAWVERFDDYLLDAH
HHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
ALVAEAARNGGPLFLMGHSMGGAIAALHAIERHADDARDLSGLILSSPALAPGRDVPRWM
HHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCHHHH
LALSQKISLVWPRFPAMKIDATLLSRDQHVVAANRNDPLVHHGAIPARTGAELLLAMQRI
HHHHHHHEEECCCCCCEEECHHHHCCCCEEEEECCCCCEEECCCCCCCCHHHHHHHHHHH
ELGRARLRTPLLIWHGSADKLTEPQGSRDFGAHAGSPDKTLTLYDGSYHETMNDLDRERV
HHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHH
IDALVAWIVARSERG
HHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]