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The map label for this gene is xdhB [H]

Identifier: 186475478

GI number: 186475478

Start: 801704

End: 803242

Strand: Reverse

Name: xdhB [H]

Synonym: Bphy_0713

Alternate gene names: 186475478

Gene position: 803242-801704 (Counterclockwise)

Preceding gene: 186475479

Following gene: 186475477

Centisome position: 23.09

GC content: 67.19

Gene sequence:

>1539_bases
GTGACAACGCAAACCATCCGCTTCTATCACCAGGGGACCGTCCGCGAGGTCGGCGGCGTGCCCGCCTCGCGCACCGTGCT
CCAGCACCTGCGCGACGACCTGCACTGCACGGGCACCAAGGAAGGCTGCGCCGAAGGCGATTGCGGCGCGTGCACCGTCG
TGGTCGGTGAAGCCACTTCCGGCGGTCAGTTGATGCTCAAGGCCGTCAACGCATGCATCCAGTTGCTGCCGACGCTCGAC
GGCAAAGCCCTCTTCACTGTCGAAGACCTGCGCTCGGCGGGCGGCAGGCTGCACCCGGTGCAGCAAGCGATGGTCGATTG
CCACGGTTCGCAATGCGGCTTCTGCACGCCCGGTTTCGTGATGTCGATGTGGGCGCTCTACGAGAACCAGCCCGAAGGCG
CCCGCCTGCCGACGCGCGACGAGATCAACACCGCGCTGTCCGGCAATCTGTGCCGCTGCACCGGCTACCGGCCGATCGTC
GAAGCATCGCAGAAGATGTTCGACGAACAGCAGTATCCACGCGTCGCCCTCGACCGCGCCGCCGTCGTCACAGCGCTCCA
GTCGATCCAGCGCAGCGGCACCTTCGAATACATCGCGCCCGACGCACGCGGCGCCGCGTTCGGCTCGCCGACGTTCTACG
CGCCCGTCACACTCGACGCTTTCGCCAGGCTGCGCGCGCAACATCCGCAAGCCCGGCTGCTCGCGGGCAGCACCGACGTC
GGCCTGTGGGTGACGAAGCAGTTTCGCGATCTCGGCGACATTCTGTACATCGGCAATGTCGCCGAGCTGAAGACCATCGA
ACGCGACGCGCAGACACTGACGATCGGCGCGGCCGCCTCGCTCGAAGACGCGTACGCCGCCCTCGCCGTCGACTATCCCG
AACTGGCTGAACTGTGGACGCGTTTCGCGTCGCTGCCGATCCGCAATGCGGGCACGCTCGGCGGCAATGTCGCGAACGGC
TCGCCCATCGGCGATTCGATGCCTGCGCTGATCGCGCTCGATGCGCTCGTCGTGCTGCAGCGCGAGCGCAAGACGCGCAT
GCTGCCGCTCGATGCGCTCTACGTCGGGTACCAGAAGACCGCGCTCGAAGCCGGCGAATTCGTCGCGGCGATCCGCGTGC
CGCGTCCAGCGCCCGATTTGCGCTTTCGCACGTACAAGGTCTCGAAGCGCTACGACCAGGACATCTCGGCCGTATGCGGC
GCGTTTGCGCTGCGCATCGCAGACGGCATAATCGCGGACGCACGCATCGCGTTCGGCGGCATGGCCGCAACGCCGAAGCG
CGCGCAGCAGGCTGAAGCCGCGCTCAAAGGCGCGCCCTGGGACGCCGCCACGGCACAACGCGCAATGACGGCGCTCGCCG
CCGATTACCAGCCGCTCACCGACATGCGCGCGTCGAGTGCGTACCGGCTGAAAGTTGCGTGCAATCTGCTGTGGCGCTTC
CATCTGGAAACGCGCGACGCCGCTCCGCTCGCGCTGTGCGACGTCAATGCATTCGCCTTTGACGCAGCCACGCTGCAGGC
TGCGCAGGAGTCGACGTGA

Upstream 100 bases:

>100_bases
TTATGTTCGGGCATGGATGGCGATCTACGTGCGCGAGGCCGGCTACGGCGCGACCCCAAGCGTAACGCGCGCCTGGTCCG
CAATGTCTTCAGGATTCGCC

Downstream 100 bases:

>100_bases
TGAACAGGCAAACCGATGCGTTCCTTCATCGCGCAGAGCTGACGCAAGCCGCCGCAGACGAGACGCCGACCGCGATCGGC
GTGCCGCTGCCGCACGAGTC

Product: xanthine dehydrogenase small subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 512; Mature: 511

Protein sequence:

>512_residues
MTTQTIRFYHQGTVREVGGVPASRTVLQHLRDDLHCTGTKEGCAEGDCGACTVVVGEATSGGQLMLKAVNACIQLLPTLD
GKALFTVEDLRSAGGRLHPVQQAMVDCHGSQCGFCTPGFVMSMWALYENQPEGARLPTRDEINTALSGNLCRCTGYRPIV
EASQKMFDEQQYPRVALDRAAVVTALQSIQRSGTFEYIAPDARGAAFGSPTFYAPVTLDAFARLRAQHPQARLLAGSTDV
GLWVTKQFRDLGDILYIGNVAELKTIERDAQTLTIGAAASLEDAYAALAVDYPELAELWTRFASLPIRNAGTLGGNVANG
SPIGDSMPALIALDALVVLQRERKTRMLPLDALYVGYQKTALEAGEFVAAIRVPRPAPDLRFRTYKVSKRYDQDISAVCG
AFALRIADGIIADARIAFGGMAATPKRAQQAEAALKGAPWDAATAQRAMTALAADYQPLTDMRASSAYRLKVACNLLWRF
HLETRDAAPLALCDVNAFAFDAATLQAAQEST

Sequences:

>Translated_512_residues
MTTQTIRFYHQGTVREVGGVPASRTVLQHLRDDLHCTGTKEGCAEGDCGACTVVVGEATSGGQLMLKAVNACIQLLPTLD
GKALFTVEDLRSAGGRLHPVQQAMVDCHGSQCGFCTPGFVMSMWALYENQPEGARLPTRDEINTALSGNLCRCTGYRPIV
EASQKMFDEQQYPRVALDRAAVVTALQSIQRSGTFEYIAPDARGAAFGSPTFYAPVTLDAFARLRAQHPQARLLAGSTDV
GLWVTKQFRDLGDILYIGNVAELKTIERDAQTLTIGAAASLEDAYAALAVDYPELAELWTRFASLPIRNAGTLGGNVANG
SPIGDSMPALIALDALVVLQRERKTRMLPLDALYVGYQKTALEAGEFVAAIRVPRPAPDLRFRTYKVSKRYDQDISAVCG
AFALRIADGIIADARIAFGGMAATPKRAQQAEAALKGAPWDAATAQRAMTALAADYQPLTDMRASSAYRLKVACNLLWRF
HLETRDAAPLALCDVNAFAFDAATLQAAQEST
>Mature_511_residues
TTQTIRFYHQGTVREVGGVPASRTVLQHLRDDLHCTGTKEGCAEGDCGACTVVVGEATSGGQLMLKAVNACIQLLPTLDG
KALFTVEDLRSAGGRLHPVQQAMVDCHGSQCGFCTPGFVMSMWALYENQPEGARLPTRDEINTALSGNLCRCTGYRPIVE
ASQKMFDEQQYPRVALDRAAVVTALQSIQRSGTFEYIAPDARGAAFGSPTFYAPVTLDAFARLRAQHPQARLLAGSTDVG
LWVTKQFRDLGDILYIGNVAELKTIERDAQTLTIGAAASLEDAYAALAVDYPELAELWTRFASLPIRNAGTLGGNVANGS
PIGDSMPALIALDALVVLQRERKTRMLPLDALYVGYQKTALEAGEFVAAIRVPRPAPDLRFRTYKVSKRYDQDISAVCGA
FALRIADGIIADARIAFGGMAATPKRAQQAEAALKGAPWDAATAQRAMTALAADYQPLTDMRASSAYRLKVACNLLWRFH
LETRDAAPLALCDVNAFAFDAATLQAAQEST

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG4630

COG function: function code F; Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=526, Percent_Identity=29.467680608365, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI71773480, Length=468, Percent_Identity=27.5641025641026, Blast_Score=161, Evalue=1e-39,
Organism=Escherichia coli, GI1789231, Length=273, Percent_Identity=31.5018315018315, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1786480, Length=149, Percent_Identity=38.255033557047, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1789232, Length=121, Percent_Identity=42.1487603305785, Blast_Score=86, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17540638, Length=156, Percent_Identity=50, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI32566215, Length=139, Percent_Identity=48.2014388489209, Blast_Score=128, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17539860, Length=139, Percent_Identity=48.2014388489209, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI17737937, Length=536, Percent_Identity=32.4626865671642, Blast_Score=241, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24647197, Length=514, Percent_Identity=30.7392996108949, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24647193, Length=508, Percent_Identity=29.9212598425197, Blast_Score=174, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24647201, Length=489, Percent_Identity=27.8118609406953, Blast_Score=168, Evalue=9e-42,
Organism=Drosophila melanogaster, GI24647199, Length=510, Percent_Identity=29.8039215686275, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24647195, Length=511, Percent_Identity=29.3542074363992, Blast_Score=162, Evalue=4e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005107
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR002346 [H]

Pfam domain/function: PF03450 CO_deh_flav_C; PF00941 FAD_binding_5 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 55117; Mature: 54986

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTQTIRFYHQGTVREVGGVPASRTVLQHLRDDLHCTGTKEGCAEGDCGACTVVVGEATS
CCCCEEEEEECCCHHHHCCCCHHHHHHHHHHHCCEECCCCCCCCCCCCCEEEEEEECCCC
GGQLMLKAVNACIQLLPTLDGKALFTVEDLRSAGGRLHPVQQAMVDCHGSQCGFCTPGFV
CCHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCHHHH
MSMWALYENQPEGARLPTRDEINTALSGNLCRCTGYRPIVEASQKMFDEQQYPRVALDRA
HHHHHHHCCCCCCCCCCCHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHCCCHHHHHHH
AVVTALQSIQRSGTFEYIAPDARGAAFGSPTFYAPVTLDAFARLRAQHPQARLLAGSTDV
HHHHHHHHHHHCCCEEEECCCCCCCCCCCCCEEECCHHHHHHHHHHCCCCCEEEECCCCC
GLWVTKQFRDLGDILYIGNVAELKTIERDAQTLTIGAAASLEDAYAALAVDYPELAELWT
CEEEEHHHHCCCCEEEECCHHHHHHHHHCCCEEEEECHHHHHHHHHHEECCCHHHHHHHH
RFASLPIRNAGTLGGNVANGSPIGDSMPALIALDALVVLQRERKTRMLPLDALYVGYQKT
HHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHCHHHH
ALEAGEFVAAIRVPRPAPDLRFRTYKVSKRYDQDISAVCGAFALRIADGIIADARIAFGG
HHHHHHEEEEEECCCCCCCCEEEEEEHHHHHCHHHHHHHHHHHHHHHHCHHCCCHHCCCC
MAATPKRAQQAEAALKGAPWDAATAQRAMTALAADYQPLTDMRASSAYRLKVACNLLWRF
CCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEEEEEEHHEE
HLETRDAAPLALCDVNAFAFDAATLQAAQEST
EECCCCCCCEEEEECCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTQTIRFYHQGTVREVGGVPASRTVLQHLRDDLHCTGTKEGCAEGDCGACTVVVGEATS
CCCEEEEEECCCHHHHCCCCHHHHHHHHHHHCCEECCCCCCCCCCCCCEEEEEEECCCC
GGQLMLKAVNACIQLLPTLDGKALFTVEDLRSAGGRLHPVQQAMVDCHGSQCGFCTPGFV
CCHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCHHHH
MSMWALYENQPEGARLPTRDEINTALSGNLCRCTGYRPIVEASQKMFDEQQYPRVALDRA
HHHHHHHCCCCCCCCCCCHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHCCCHHHHHHH
AVVTALQSIQRSGTFEYIAPDARGAAFGSPTFYAPVTLDAFARLRAQHPQARLLAGSTDV
HHHHHHHHHHHCCCEEEECCCCCCCCCCCCCEEECCHHHHHHHHHHCCCCCEEEECCCCC
GLWVTKQFRDLGDILYIGNVAELKTIERDAQTLTIGAAASLEDAYAALAVDYPELAELWT
CEEEEHHHHCCCCEEEECCHHHHHHHHHCCCEEEEECHHHHHHHHHHEECCCHHHHHHHH
RFASLPIRNAGTLGGNVANGSPIGDSMPALIALDALVVLQRERKTRMLPLDALYVGYQKT
HHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHCHHHH
ALEAGEFVAAIRVPRPAPDLRFRTYKVSKRYDQDISAVCGAFALRIADGIIADARIAFGG
HHHHHHEEEEEECCCCCCCCEEEEEEHHHHHCHHHHHHHHHHHHHHHHCHHCCCHHCCCC
MAATPKRAQQAEAALKGAPWDAATAQRAMTALAADYQPLTDMRASSAYRLKVACNLLWRF
CCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEEEEEEHHEE
HLETRDAAPLALCDVNAFAFDAATLQAAQEST
EECCCCCCCEEEEECCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]