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The map label for this gene is xdhD [H]

Identifier: 186475477

GI number: 186475477

Start: 799248

End: 801704

Strand: Reverse

Name: xdhD [H]

Synonym: Bphy_0712

Alternate gene names: 186475477

Gene position: 801704-799248 (Counterclockwise)

Preceding gene: 186475478

Following gene: 186475476

Centisome position: 23.04

GC content: 66.59

Gene sequence:

>2457_bases
ATGAACAGGCAAACCGATGCGTTCCTTCATCGCGCAGAGCTGACGCAAGCCGCCGCAGACGAGACGCCGACCGCGATCGG
CGTGCCGCTGCCGCACGAGTCGGCGGCGCTGCATGTGAGCGGCGAAGCGACCTACACCGACGACATTCCCGAACTCCAGC
AGACGCTGCACGCGGCGCTCGGCCTGTCGCGGCATGCACACGCGCGCATCGTGTCGCTCGATCTCGATGCCGTGCGCGCG
ATGCCCGGCGTCGTCGCCGTGCTGACAGCCGAGGACATCCCCGGTGAAAACAATTGCGGCCCCGTGCTGCACGACGACCC
GATTCTCGCCGACGGCGAAGTGCTGTACCTCGGGCAGCCCGTCTTCATCGTCGTCGCGCACAGCCACGAACTTGCGCGGC
GCGCGGCGGCGCTCGCGAAGAGCGACGAGGTCGTGCGCTACGAGCCGCTCGAAGCCGTGCTGACAGCTGCCGAAGCGAAA
GCGAAGAAACAGTATGTGCTGCCGCCGCTGCATCTCAAACGCGGTGCGCCCGCCGAGAAAATCGCCCAGGCGCCGCACCG
GATCGCGGGCACGTTCGAGGTCGGCGGCCAGGAGCAGTTCTATCTGGAAGGCCAGGTTGCGTACGCCGTGCCGAAGGAAA
TGGACGGCATGCTCGTCTACAGTTCGACGCAGCATCCGAGCGAAATGCAGCACGTGGTCGCGCATATGTTCGGCTGGCCG
ACGCACAGCGTGCAGTGCGAATGCCGCCGCATGGGCGGCGGCTTCGGCGGCAAGGAATCGCAGTCGGCGCTCTTTGCCTG
CGCGGCGTCGCTGGCCGCGCACACGCTGCGCCGCCCCGTGAAGCTGCGCGCCGATCGCGACGACGACTTCATGATCACGG
GCAAACGCCACGACGCGATCTACGAGTACGAAGCCGGCTTCGACGACGCCGGCCGCATTCTCGGCGCGCGTGTCGAGATC
GCGCTGCGCGCGGGGTTTTCGGCGGACCTGTCGGGCGCCGTCGCGACGCGCGCCGTGTGCCACTTCGACAATGCGTACTA
CCTGTCGGACGTCGATATCGTTGCGCTGCCGTGCAAGACCAACACGCAGTCGAACACCGCGTTTCGCGGCTTCGGCGGCC
CACAGGGCGCGCTCGTGATGGAAGTGATGATGGACGGCATCGCTCGTGAACTGAAGCGCGATCCCCTCGACGTGCGCCGC
GTAAATTTCTACGGCGTCGGCGAGCGCAATGTCACGCCGTACGGCCAAACGGTCACGGACAACGTGATCGCGCCGCTCAC
TGACGAACTGATCGGATCGAGCGGCTATCGCGCGCGGCGCGAAGCGATTGCAGCGTTCAACGCGACGAGCCCCATACTCA
AGCGCGGCATCGCGTATTCGCCCGTCAAGTTCGGCATCTCGTTCAACGTGCCGTTCCTGAACCAGGCGGGAGCGCTCGTG
CATGTCTATAAGGACGGCTCGGTGCTCGTGAATCATGGCGGCACCGAAATGGGCCAGGGCCTGAACACGAAGGTCGCGCA
AGTCGTCGCGAGCGTGTTCGGCCTGCCGCTTGCTCGCGTGCGCGTGACGGCGACGGATACGTCCAAGGTCGCGAATACGT
CGGCGACGGCCGCCTCGACGGGCAGCGACCTGAACGGCAAGGCCGCCGAAGCCGCCGCACACACGATCCGCGCCCGCCTC
GCCTCGCTCGCCGCGAAAGAGCTCGGCGGCACGCCCGACGAGGTCAGGTTCGAGCATGGCGAAGCCCAGGCGAACGGCGC
GTCGATGCCGTTTGCACAACTCGTCAACGCGGCGTATCTCGCGCGCATCCAGCTGTGGTCCGACGGCTTCTACGCGACGC
CGAAAGTGCATTGGGACGCGAAGACGCTGACGGGTCATCCGTTCTACTACTTCGCGTACGGCGCGGCCGTTTCCGAAGTC
GTGATCGACACGTTGACGGGCGAATGGAAGCTCGTGCGCGCCGACGTGCTGCACGACGCAGGCCAGTCGATCAATCCCGC
CATCGATCTCGGCCAGGTCGAAGGCGCATTCATTCAGGGCATGGGCTGGCTCACGACGGAAGAGCTCTGGTGGAACCGCG
ACGGGCGCCTGATGACGCATGCGCCGTCGACGTACAAGATTCCCGCCGTCAGCGACACGCCCGCTGCGTTCAACGTGAAG
CTGTATCGCAATGAAAACGCCGAGCCGACGGTGTTCCGCTCGAAAGCCGTCGGCGAGCCGCCGTTATTGCTGCCGTTTTC
GGTGTTTCTCGCGATTCGCGATGCCGTGGCGGCCACCGCGCCCGACGCCGCGCCTGCACCGCCGTTGCGTGCGCCCGCGA
CGCCCGAAGCCATTCTCGATGCGATTGAAGCCATCGCCGCGACTGCCGCACTGACGGCTGGCACGCGCGCTGCAACGAGT
GGGGGAACGTCCGGTCCGACTTCGCCTGAACCCGCGGGCGCGGGCACGACGGCATAG

Upstream 100 bases:

>100_bases
TCCATCTGGAAACGCGCGACGCCGCTCCGCTCGCGCTGTGCGACGTCAATGCATTCGCCTTTGACGCAGCCACGCTGCAG
GCTGCGCAGGAGTCGACGTG

Downstream 100 bases:

>100_bases
CACAACCCAGGTGCGGCGCGACACGACCGCGCCGCCCACACGATCAACCGGCTGCGCGGCCAATCCACGCGGCCTTGCAC
GGAGAACAGCCGGATGCACG

Product: xanthine dehydrogenase, molybdopterin binding subunit

Products: urate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 818; Mature: 818

Protein sequence:

>818_residues
MNRQTDAFLHRAELTQAAADETPTAIGVPLPHESAALHVSGEATYTDDIPELQQTLHAALGLSRHAHARIVSLDLDAVRA
MPGVVAVLTAEDIPGENNCGPVLHDDPILADGEVLYLGQPVFIVVAHSHELARRAAALAKSDEVVRYEPLEAVLTAAEAK
AKKQYVLPPLHLKRGAPAEKIAQAPHRIAGTFEVGGQEQFYLEGQVAYAVPKEMDGMLVYSSTQHPSEMQHVVAHMFGWP
THSVQCECRRMGGGFGGKESQSALFACAASLAAHTLRRPVKLRADRDDDFMITGKRHDAIYEYEAGFDDAGRILGARVEI
ALRAGFSADLSGAVATRAVCHFDNAYYLSDVDIVALPCKTNTQSNTAFRGFGGPQGALVMEVMMDGIARELKRDPLDVRR
VNFYGVGERNVTPYGQTVTDNVIAPLTDELIGSSGYRARREAIAAFNATSPILKRGIAYSPVKFGISFNVPFLNQAGALV
HVYKDGSVLVNHGGTEMGQGLNTKVAQVVASVFGLPLARVRVTATDTSKVANTSATAASTGSDLNGKAAEAAAHTIRARL
ASLAAKELGGTPDEVRFEHGEAQANGASMPFAQLVNAAYLARIQLWSDGFYATPKVHWDAKTLTGHPFYYFAYGAAVSEV
VIDTLTGEWKLVRADVLHDAGQSINPAIDLGQVEGAFIQGMGWLTTEELWWNRDGRLMTHAPSTYKIPAVSDTPAAFNVK
LYRNENAEPTVFRSKAVGEPPLLLPFSVFLAIRDAVAATAPDAAPAPPLRAPATPEAILDAIEAIAATAALTAGTRAATS
GGTSGPTSPEPAGAGTTA

Sequences:

>Translated_818_residues
MNRQTDAFLHRAELTQAAADETPTAIGVPLPHESAALHVSGEATYTDDIPELQQTLHAALGLSRHAHARIVSLDLDAVRA
MPGVVAVLTAEDIPGENNCGPVLHDDPILADGEVLYLGQPVFIVVAHSHELARRAAALAKSDEVVRYEPLEAVLTAAEAK
AKKQYVLPPLHLKRGAPAEKIAQAPHRIAGTFEVGGQEQFYLEGQVAYAVPKEMDGMLVYSSTQHPSEMQHVVAHMFGWP
THSVQCECRRMGGGFGGKESQSALFACAASLAAHTLRRPVKLRADRDDDFMITGKRHDAIYEYEAGFDDAGRILGARVEI
ALRAGFSADLSGAVATRAVCHFDNAYYLSDVDIVALPCKTNTQSNTAFRGFGGPQGALVMEVMMDGIARELKRDPLDVRR
VNFYGVGERNVTPYGQTVTDNVIAPLTDELIGSSGYRARREAIAAFNATSPILKRGIAYSPVKFGISFNVPFLNQAGALV
HVYKDGSVLVNHGGTEMGQGLNTKVAQVVASVFGLPLARVRVTATDTSKVANTSATAASTGSDLNGKAAEAAAHTIRARL
ASLAAKELGGTPDEVRFEHGEAQANGASMPFAQLVNAAYLARIQLWSDGFYATPKVHWDAKTLTGHPFYYFAYGAAVSEV
VIDTLTGEWKLVRADVLHDAGQSINPAIDLGQVEGAFIQGMGWLTTEELWWNRDGRLMTHAPSTYKIPAVSDTPAAFNVK
LYRNENAEPTVFRSKAVGEPPLLLPFSVFLAIRDAVAATAPDAAPAPPLRAPATPEAILDAIEAIAATAALTAGTRAATS
GGTSGPTSPEPAGAGTTA
>Mature_818_residues
MNRQTDAFLHRAELTQAAADETPTAIGVPLPHESAALHVSGEATYTDDIPELQQTLHAALGLSRHAHARIVSLDLDAVRA
MPGVVAVLTAEDIPGENNCGPVLHDDPILADGEVLYLGQPVFIVVAHSHELARRAAALAKSDEVVRYEPLEAVLTAAEAK
AKKQYVLPPLHLKRGAPAEKIAQAPHRIAGTFEVGGQEQFYLEGQVAYAVPKEMDGMLVYSSTQHPSEMQHVVAHMFGWP
THSVQCECRRMGGGFGGKESQSALFACAASLAAHTLRRPVKLRADRDDDFMITGKRHDAIYEYEAGFDDAGRILGARVEI
ALRAGFSADLSGAVATRAVCHFDNAYYLSDVDIVALPCKTNTQSNTAFRGFGGPQGALVMEVMMDGIARELKRDPLDVRR
VNFYGVGERNVTPYGQTVTDNVIAPLTDELIGSSGYRARREAIAAFNATSPILKRGIAYSPVKFGISFNVPFLNQAGALV
HVYKDGSVLVNHGGTEMGQGLNTKVAQVVASVFGLPLARVRVTATDTSKVANTSATAASTGSDLNGKAAEAAAHTIRARL
ASLAAKELGGTPDEVRFEHGEAQANGASMPFAQLVNAAYLARIQLWSDGFYATPKVHWDAKTLTGHPFYYFAYGAAVSEV
VIDTLTGEWKLVRADVLHDAGQSINPAIDLGQVEGAFIQGMGWLTTEELWWNRDGRLMTHAPSTYKIPAVSDTPAAFNVK
LYRNENAEPTVFRSKAVGEPPLLLPFSVFLAIRDAVAATAPDAAPAPPLRAPATPEAILDAIEAIAATAALTAGTRAATS
GGTSGPTSPEPAGAGTTA

Specific function: Probably has no xanthine dehydrogenase activity; however deletion results in increased adenine sensitivity, suggesting that this protein contributes to the conversion of adenine to guanine nucleotides during purine salvage [H]

COG id: COG4631

COG function: function code F; Xanthine dehydrogenase, molybdopterin-binding subunit B

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=773, Percent_Identity=41.3971539456662, Blast_Score=586, Evalue=1e-167,
Organism=Homo sapiens, GI71773480, Length=762, Percent_Identity=38.4514435695538, Blast_Score=480, Evalue=1e-135,
Organism=Escherichia coli, GI1789246, Length=860, Percent_Identity=26.6279069767442, Blast_Score=195, Evalue=1e-50,
Organism=Escherichia coli, GI1789230, Length=779, Percent_Identity=25.6739409499358, Blast_Score=170, Evalue=4e-43,
Organism=Escherichia coli, GI1786478, Length=733, Percent_Identity=24.2837653478854, Blast_Score=104, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17540638, Length=786, Percent_Identity=39.3129770992366, Blast_Score=512, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17539860, Length=730, Percent_Identity=33.2876712328767, Blast_Score=346, Evalue=2e-95,
Organism=Caenorhabditis elegans, GI32566215, Length=732, Percent_Identity=31.4207650273224, Blast_Score=343, Evalue=3e-94,
Organism=Drosophila melanogaster, GI17737937, Length=783, Percent_Identity=41.1238825031928, Blast_Score=570, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24647199, Length=763, Percent_Identity=31.7169069462647, Blast_Score=334, Evalue=2e-91,
Organism=Drosophila melanogaster, GI24647193, Length=775, Percent_Identity=31.3548387096774, Blast_Score=320, Evalue=4e-87,
Organism=Drosophila melanogaster, GI24647195, Length=775, Percent_Identity=31.0967741935484, Blast_Score=315, Evalue=1e-85,
Organism=Drosophila melanogaster, GI24647201, Length=785, Percent_Identity=32.1019108280255, Blast_Score=315, Evalue=1e-85,
Organism=Drosophila melanogaster, GI24647197, Length=767, Percent_Identity=31.2907431551499, Blast_Score=313, Evalue=2e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR000674
- InterPro:   IPR008274
- InterPro:   IPR001041
- InterPro:   IPR017699 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2; PF01799 Fer2_2 [H]

EC number: 1.17.1.4

Molecular weight: Translated: 86943; Mature: 86943

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRQTDAFLHRAELTQAAADETPTAIGVPLPHESAALHVSGEATYTDDIPELQQTLHAAL
CCCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHH
GLSRHAHARIVSLDLDAVRAMPGVVAVLTAEDIPGENNCGPVLHDDPILADGEVLYLGQP
CCCCCCCEEEEEECHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCEEECCCEEEECCC
VFIVVAHSHELARRAAALAKSDEVVRYEPLEAVLTAAEAKAKKQYVLPPLHLKRGAPAEK
EEEEEECCHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCCCCCCCHHHCCCCCHHH
IAQAPHRIAGTFEVGGQEQFYLEGQVAYAVPKEMDGMLVYSSTQHPSEMQHVVAHMFGWP
HHHCCHHEEEEEEECCCEEEEECCEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHCCC
THSVQCECRRMGGGFGGKESQSALFACAASLAAHTLRRPVKLRADRDDDFMITGKRHDAI
CCCCEEHHEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEECCCCCEE
YEYEAGFDDAGRILGARVEIALRAGFSADLSGAVATRAVCHFDNAYYLSDVDIVALPCKT
EEECCCCCHHHHHEEEEEEEEEECCCCCCCCHHHHHHHHEECCCEEEEECCEEEEECCCC
NTQSNTAFRGFGGPQGALVMEVMMDGIARELKRDPLDVRRVNFYGVGERNVTPYGQTVTD
CCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCC
NVIAPLTDELIGSSGYRARREAIAAFNATSPILKRGIAYSPVKFGISFNVPFLNQAGALV
CCHHCCHHHHHCCCCCHHHHHHHHHHCCCCHHHHCCCCCCCEEEEEEECCCCCCCCCCEE
HVYKDGSVLVNHGGTEMGQGLNTKVAQVVASVFGLPLARVRVTATDTSKVANTSATAAST
EEEECCCEEEECCCHHHCCCCCHHHHHHHHHHHCCCEEEEEEEECCCHHHCCCCCCCCCC
GSDLNGKAAEAAAHTIRARLASLAAKELGGTPDEVRFEHGEAQANGASMPFAQLVNAAYL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHH
ARIQLWSDGFYATPKVHWDAKTLTGHPFYYFAYGAAVSEVVIDTLTGEWKLVRADVLHDA
EEEEEECCCEEECCEEEECCEECCCCCEEEEEHHHHHHHHHHHHCCCCEEEEEEHHHHHC
GQSINPAIDLGQVEGAFIQGMGWLTTEELWWNRDGRLMTHAPSTYKIPAVSDTPAAFNVK
CCCCCCCEECCCCCCHHHCCCCCCEEHHHHCCCCCCEEEECCCCEECCCCCCCCCEEEEE
LYRNENAEPTVFRSKAVGEPPLLLPFSVFLAIRDAVAATAPDAAPAPPLRAPATPEAILD
EEECCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHH
AIEAIAATAALTAGTRAATSGGTSGPTSPEPAGAGTTA
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNRQTDAFLHRAELTQAAADETPTAIGVPLPHESAALHVSGEATYTDDIPELQQTLHAAL
CCCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHH
GLSRHAHARIVSLDLDAVRAMPGVVAVLTAEDIPGENNCGPVLHDDPILADGEVLYLGQP
CCCCCCCEEEEEECHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCEEECCCEEEECCC
VFIVVAHSHELARRAAALAKSDEVVRYEPLEAVLTAAEAKAKKQYVLPPLHLKRGAPAEK
EEEEEECCHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCCCCCCCHHHCCCCCHHH
IAQAPHRIAGTFEVGGQEQFYLEGQVAYAVPKEMDGMLVYSSTQHPSEMQHVVAHMFGWP
HHHCCHHEEEEEEECCCEEEEECCEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHCCC
THSVQCECRRMGGGFGGKESQSALFACAASLAAHTLRRPVKLRADRDDDFMITGKRHDAI
CCCCEEHHEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEECCCCCEE
YEYEAGFDDAGRILGARVEIALRAGFSADLSGAVATRAVCHFDNAYYLSDVDIVALPCKT
EEECCCCCHHHHHEEEEEEEEEECCCCCCCCHHHHHHHHEECCCEEEEECCEEEEECCCC
NTQSNTAFRGFGGPQGALVMEVMMDGIARELKRDPLDVRRVNFYGVGERNVTPYGQTVTD
CCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCC
NVIAPLTDELIGSSGYRARREAIAAFNATSPILKRGIAYSPVKFGISFNVPFLNQAGALV
CCHHCCHHHHHCCCCCHHHHHHHHHHCCCCHHHHCCCCCCCEEEEEEECCCCCCCCCCEE
HVYKDGSVLVNHGGTEMGQGLNTKVAQVVASVFGLPLARVRVTATDTSKVANTSATAAST
EEEECCCEEEECCCHHHCCCCCHHHHHHHHHHHCCCEEEEEEEECCCHHHCCCCCCCCCC
GSDLNGKAAEAAAHTIRARLASLAAKELGGTPDEVRFEHGEAQANGASMPFAQLVNAAYL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHH
ARIQLWSDGFYATPKVHWDAKTLTGHPFYYFAYGAAVSEVVIDTLTGEWKLVRADVLHDA
EEEEEECCCEEECCEEEECCEECCCCCEEEEEHHHHHHHHHHHHCCCCEEEEEEHHHHHC
GQSINPAIDLGQVEGAFIQGMGWLTTEELWWNRDGRLMTHAPSTYKIPAVSDTPAAFNVK
CCCCCCCEECCCCCCHHHCCCCCCEEHHHHCCCCCCEEEECCCCEECCCCCCCCCEEEEE
LYRNENAEPTVFRSKAVGEPPLLLPFSVFLAIRDAVAATAPDAAPAPPLRAPATPEAILD
EEECCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHH
AIEAIAATAALTAGTRAATSGGTSGPTSPEPAGAGTTA
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: xanthine; NAD+; H2O

Specific reaction: xanthine + NAD+ + H2O = urate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]