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The map label for this gene is aroP [H]

Identifier: 186475368

GI number: 186475368

Start: 678209

End: 679609

Strand: Direct

Name: aroP [H]

Synonym: Bphy_0601

Alternate gene names: 186475368

Gene position: 678209-679609 (Clockwise)

Preceding gene: 186475364

Following gene: 186475370

Centisome position: 19.49

GC content: 61.6

Gene sequence:

>1401_bases
TTGAGTAACGCAGGAAACAACGGACAGCAGCATGACGGCCTGAAGCGTGGGCTGAAGAACCGCCATATTCAGCTGATCGC
GCTGGGCGGCGCGATCGGCACGGGCCTCTTCCTGGGATCGGCGGGGGTATTGAAGTCGGCGGGACCGTCGATGATTCTGG
GCTACGCGATCGGCGGCTTCATCGCGTTTCTGATCATGCGGCAACTCGGCGAAATGGTTGCACAGGAGCCTGTCGCGGGC
TCGTTCAGCCACTTCGCGTACAAGTATTGGGGCGATTTTCCGGGCTTTCTGTCGGGCTGGAACTACTGGGTGCTGTACGT
GCTCGTGAGCATGGCCGAACTGACGGCTGTCGGCACTTATGTGCACTTCTGGTGGCCCGGCGTGCCGGCGTGGCTATCGG
CGCTCGTGTGCTTCGTCGTGATCAACGCCATCAACCTCGCAAATGTGAAGGCGTACGGCGAGACAGAGTTCTGGTTCGCG
ATCGTCAAGGTCGTGGCTGTGATGGGCATGATCGTGTTCGGCGGCTACCTGCTGCTGAGCGGCCACGGCGGTCCGCAGGC
ATCCATCTCCAATCTGTGGAGCCAGGGCGGCTTCTTTCCGCATGGCGTCCACGGTCTTTTCATGATGCTCGCCGTGATCA
TGTTCTCGTTTGGCGGGCTGGAGCTGATCGGTATCACGGCTGCCGAAGCCGACGATCCGCAGAAGAGCATTCCGAAGGCC
GTGAACCAGGTGATCTACCGGATTCTGATTTTCTACATCTGCTCGCTGATCGTGCTGCTGTCGCTGTATCCGTGGAATCA
GGTTGCGGAAGGCGGCAGCCCGTTCGTGATGATTTTTTCGCAGATCGGCGCTGGGTTGACGGCGAATGTGCTGAACGTCG
TCGTGCTGACGGCGGCGCTGTCCGTGTACAACAGCGGTGTCTATGCGAATAGCCGCATGCTGTACGGTCTCGCCGAGCAG
GGCAATGCGCCGCGCGCGCTGCTGGAGGTGGATCGCCGGGGCGTGCCCTATATGGCGATCGGTTTGTCGGCGGTCGCGAC
GTTTGCTTGTGTGATCATCAATTACCTGATGCCCGCGAAGGCGCTCGACGTGCTGATGGCGCTCGTCGTCGCGGCGCTGG
TGCTGAACTGGTCGCTGATCAGCCTGACGCATCTGAAGTCGCGTCGCGCGATGCTCGCGCAGGGCGACACGCTCGTCTTC
AAGTCGCTGTGGTTCCCGCTCGGCAACTGGGTTTGTCTGGCGTTCATGGCGCTGATTCTCGTGATTCTCGCGCTGACGCC
GGGACTCAACGTGTCGGTGCTGCTGGTGCCCGTGTGGCTCTTCGTCATGTGGATCGGGTACGTGGTGAAGCGGCGGCGCG
CCACGGCACATCAGTTGGCGGGTGCGACGGGCGGGCGTTAA

Upstream 100 bases:

>100_bases
GCGCCGAAGCGTACAATTTATGGTTTTTCCGCGCGGGTTCTATTGGCGATTGGCGATTGGCGCGGCGCATCTTCAGTTGA
GTGCAGTGGGGTGAGACATC

Downstream 100 bases:

>100_bases
GGTTCGTGCAGAGTTGAAGCGTTTGATGCAGTCGAGCCGGATCAGCCGTGAGGCGATCCGGCTTTTGTTTTTTTCGGCAC
CAGCGCGCAGCCGCCGAATG

Product: amino acid permease-associated protein

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: General aromatic amino acid permease [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MSNAGNNGQQHDGLKRGLKNRHIQLIALGGAIGTGLFLGSAGVLKSAGPSMILGYAIGGFIAFLIMRQLGEMVAQEPVAG
SFSHFAYKYWGDFPGFLSGWNYWVLYVLVSMAELTAVGTYVHFWWPGVPAWLSALVCFVVINAINLANVKAYGETEFWFA
IVKVVAVMGMIVFGGYLLLSGHGGPQASISNLWSQGGFFPHGVHGLFMMLAVIMFSFGGLELIGITAAEADDPQKSIPKA
VNQVIYRILIFYICSLIVLLSLYPWNQVAEGGSPFVMIFSQIGAGLTANVLNVVVLTAALSVYNSGVYANSRMLYGLAEQ
GNAPRALLEVDRRGVPYMAIGLSAVATFACVIINYLMPAKALDVLMALVVAALVLNWSLISLTHLKSRRAMLAQGDTLVF
KSLWFPLGNWVCLAFMALILVILALTPGLNVSVLLVPVWLFVMWIGYVVKRRRATAHQLAGATGGR

Sequences:

>Translated_466_residues
MSNAGNNGQQHDGLKRGLKNRHIQLIALGGAIGTGLFLGSAGVLKSAGPSMILGYAIGGFIAFLIMRQLGEMVAQEPVAG
SFSHFAYKYWGDFPGFLSGWNYWVLYVLVSMAELTAVGTYVHFWWPGVPAWLSALVCFVVINAINLANVKAYGETEFWFA
IVKVVAVMGMIVFGGYLLLSGHGGPQASISNLWSQGGFFPHGVHGLFMMLAVIMFSFGGLELIGITAAEADDPQKSIPKA
VNQVIYRILIFYICSLIVLLSLYPWNQVAEGGSPFVMIFSQIGAGLTANVLNVVVLTAALSVYNSGVYANSRMLYGLAEQ
GNAPRALLEVDRRGVPYMAIGLSAVATFACVIINYLMPAKALDVLMALVVAALVLNWSLISLTHLKSRRAMLAQGDTLVF
KSLWFPLGNWVCLAFMALILVILALTPGLNVSVLLVPVWLFVMWIGYVVKRRRATAHQLAGATGGR
>Mature_465_residues
SNAGNNGQQHDGLKRGLKNRHIQLIALGGAIGTGLFLGSAGVLKSAGPSMILGYAIGGFIAFLIMRQLGEMVAQEPVAGS
FSHFAYKYWGDFPGFLSGWNYWVLYVLVSMAELTAVGTYVHFWWPGVPAWLSALVCFVVINAINLANVKAYGETEFWFAI
VKVVAVMGMIVFGGYLLLSGHGGPQASISNLWSQGGFFPHGVHGLFMMLAVIMFSFGGLELIGITAAEADDPQKSIPKAV
NQVIYRILIFYICSLIVLLSLYPWNQVAEGGSPFVMIFSQIGAGLTANVLNVVVLTAALSVYNSGVYANSRMLYGLAEQG
NAPRALLEVDRRGVPYMAIGLSAVATFACVIINYLMPAKALDVLMALVVAALVLNWSLISLTHLKSRRAMLAQGDTLVFK
SLWFPLGNWVCLAFMALILVILALTPGLNVSVLLVPVWLFVMWIGYVVKRRRATAHQLAGATGGR

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan) [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=338, Percent_Identity=24.8520710059172, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI114326544, Length=483, Percent_Identity=22.1532091097308, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI114326550, Length=483, Percent_Identity=22.1532091097308, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI258614005, Length=414, Percent_Identity=22.2222222222222, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI258614003, Length=414, Percent_Identity=21.9806763285024, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI4507047, Length=374, Percent_Identity=23.2620320855615, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI258645169, Length=414, Percent_Identity=22.2222222222222, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI181337167, Length=428, Percent_Identity=23.3644859813084, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1786302, Length=451, Percent_Identity=70.2882483370288, Blast_Score=647, Evalue=0.0,
Organism=Escherichia coli, GI1786789, Length=445, Percent_Identity=61.123595505618, Blast_Score=558, Evalue=1e-160,
Organism=Escherichia coli, GI1790653, Length=465, Percent_Identity=38.7096774193548, Blast_Score=349, Evalue=2e-97,
Organism=Escherichia coli, GI1786602, Length=459, Percent_Identity=43.5729847494553, Blast_Score=343, Evalue=1e-95,
Organism=Escherichia coli, GI48994972, Length=458, Percent_Identity=41.0480349344978, Blast_Score=336, Evalue=2e-93,
Organism=Escherichia coli, GI87081915, Length=458, Percent_Identity=35.3711790393013, Blast_Score=300, Evalue=2e-82,
Organism=Escherichia coli, GI1789017, Length=432, Percent_Identity=35.6481481481481, Blast_Score=290, Evalue=2e-79,
Organism=Escherichia coli, GI87081708, Length=410, Percent_Identity=34.8780487804878, Blast_Score=264, Evalue=1e-71,
Organism=Escherichia coli, GI1788480, Length=462, Percent_Identity=33.5497835497836, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI87081869, Length=331, Percent_Identity=23.5649546827795, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI87082023, Length=354, Percent_Identity=23.4463276836158, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=363, Percent_Identity=25.6198347107438, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17531343, Length=344, Percent_Identity=23.8372093023256, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17540018, Length=476, Percent_Identity=21.4285714285714, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17533459, Length=344, Percent_Identity=24.7093023255814, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6324061, Length=440, Percent_Identity=34.0909090909091, Blast_Score=227, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6320772, Length=466, Percent_Identity=33.0472103004292, Blast_Score=226, Evalue=5e-60,
Organism=Saccharomyces cerevisiae, GI6322892, Length=493, Percent_Identity=33.4685598377282, Blast_Score=217, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6324924, Length=496, Percent_Identity=30.8467741935484, Blast_Score=215, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6319824, Length=437, Percent_Identity=32.4942791762014, Blast_Score=207, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6324059, Length=449, Percent_Identity=33.8530066815145, Blast_Score=202, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6321053, Length=425, Percent_Identity=31.0588235294118, Blast_Score=196, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6320251, Length=486, Percent_Identity=29.2181069958848, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6324990, Length=417, Percent_Identity=31.89448441247, Blast_Score=189, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6320717, Length=405, Percent_Identity=30.1234567901235, Blast_Score=186, Evalue=8e-48,
Organism=Saccharomyces cerevisiae, GI6319543, Length=409, Percent_Identity=30.8068459657702, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6324553, Length=394, Percent_Identity=32.2335025380711, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6319542, Length=479, Percent_Identity=29.6450939457203, Blast_Score=179, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6321629, Length=444, Percent_Identity=29.0540540540541, Blast_Score=177, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6319608, Length=410, Percent_Identity=29.5121951219512, Blast_Score=173, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6322967, Length=412, Percent_Identity=30.5825242718447, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6324981, Length=411, Percent_Identity=29.1970802919708, Blast_Score=147, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6320364, Length=481, Percent_Identity=24.7401247401247, Blast_Score=116, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24667468, Length=329, Percent_Identity=25.8358662613982, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24666159, Length=335, Percent_Identity=23.2835820895522, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI221512776, Length=335, Percent_Identity=23.2835820895522, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI161077963, Length=399, Percent_Identity=24.812030075188, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50262; Mature: 50131

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNAGNNGQQHDGLKRGLKNRHIQLIALGGAIGTGLFLGSAGVLKSAGPSMILGYAIGGF
CCCCCCCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHCCCCHHHCCCCHHHHHHHHHHH
IAFLIMRQLGEMVAQEPVAGSFSHFAYKYWGDFPGFLSGWNYWVLYVLVSMAELTAVGTY
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHH
VHFWWPGVPAWLSALVCFVVINAINLANVKAYGETEFWFAIVKVVAVMGMIVFGGYLLLS
HEEECCCHHHHHHHHHHHHHHHHHHHHCEEECCCHHHHHHHHHHHHHHHHHHHCCEEEEE
GHGGPQASISNLWSQGGFFPHGVHGLFMMLAVIMFSFGGLELIGITAAEADDPQKSIPKA
CCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHH
VNQVIYRILIFYICSLIVLLSLYPWNQVAEGGSPFVMIFSQIGAGLTANVLNVVVLTAAL
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHH
SVYNSGVYANSRMLYGLAEQGNAPRALLEVDRRGVPYMAIGLSAVATFACVIINYLMPAK
HHHHCCCEECCCEEEEECCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHH
ALDVLMALVVAALVLNWSLISLTHLKSRRAMLAQGDTLVFKSLWFPLGNWVCLAFMALIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
VILALTPGLNVSVLLVPVWLFVMWIGYVVKRRRATAHQLAGATGGR
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SNAGNNGQQHDGLKRGLKNRHIQLIALGGAIGTGLFLGSAGVLKSAGPSMILGYAIGGF
CCCCCCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHCCCCHHHCCCCHHHHHHHHHHH
IAFLIMRQLGEMVAQEPVAGSFSHFAYKYWGDFPGFLSGWNYWVLYVLVSMAELTAVGTY
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHH
VHFWWPGVPAWLSALVCFVVINAINLANVKAYGETEFWFAIVKVVAVMGMIVFGGYLLLS
HEEECCCHHHHHHHHHHHHHHHHHHHHCEEECCCHHHHHHHHHHHHHHHHHHHCCEEEEE
GHGGPQASISNLWSQGGFFPHGVHGLFMMLAVIMFSFGGLELIGITAAEADDPQKSIPKA
CCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHH
VNQVIYRILIFYICSLIVLLSLYPWNQVAEGGSPFVMIFSQIGAGLTANVLNVVVLTAAL
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHH
SVYNSGVYANSRMLYGLAEQGNAPRALLEVDRRGVPYMAIGLSAVATFACVIINYLMPAK
HHHHCCCEECCCEEEEECCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHH
ALDVLMALVVAALVLNWSLISLTHLKSRRAMLAQGDTLVFKSLWFPLGNWVCLAFMALIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
VILALTPGLNVSVLLVPVWLFVMWIGYVVKRRRATAHQLAGATGGR
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]