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The map label for this gene is nadC [H]

Identifier: 186475348

GI number: 186475348

Start: 659827

End: 660729

Strand: Direct

Name: nadC [H]

Synonym: Bphy_0581

Alternate gene names: 186475348

Gene position: 659827-660729 (Clockwise)

Preceding gene: 186475347

Following gene: 186475353

Centisome position: 18.96

GC content: 65.01

Gene sequence:

>903_bases
ATGGGCGTGAACGAACCGCTGGAGTTCAAGGACGCCGTGTCGCCGCTTTTCGCGGAAATTCAGGAACAGTACGGCGAAGC
GTTCGCGGCGGCGATCGCGCGCAACGTGGCCGATGCGCTTGCGGAAGACGTGGGTAGCGGTGATCTTACGGGCCTTCTCG
TTCCCGCCGATGAGATGCGCGATGCACGCATCATCGTGCGCGAAGAGGCGGTGCTGTGTGGCGTACCGTGGTTCAACGAA
GTGATGCGTCGAGTGGATCCGCGCATTGAGGCGCAATGGCGTTATCGCGAAGGCGATCGTATGACGGCCGACTCGGTGGT
GTGTACGCTGCGTGGTCCGGCGCGCGCGCTGTTGACGGCCGAGCGTAACGGGCTCAACTTCTTGCAGATGCTGTCGGGCG
TCGCGAGTGCGACGCGCAAGTTCGCCGACGCGATCGCACACACCCGCGCGCGCGTACTCGATACGCGCAAGACGCTCCCC
GGCCTGCGACTCGCGCAAAAGTACGCGGTGCGCGTTGGCGGCGGTGCGAACCAGCGCCTCGCACTCTACGACGGCATCCT
GATCAAGGAGAACCACATCGCGGCGGCAGGCGGCGTCGGCGCGGCGATGCAGGCTGCGATCGCGCTGAACGCGGGCGTGT
CGATCCAGATCGAGGTCGAAACGCTTGGACAGCTTGAGTCGGCGCTTGCGCACGGTGCGCAGTCGGTTCTGCTCGACAAC
TTCTCGTTCGACATGATGCGCGACGCGGTGCGGATCACGGCAGGGCGCGCGGTACTCGAAGTGTCCGGCGGCGTGAACCT
CGACACGATCCGGCTGATCGCCGAGACGGGCGTCGATCGTGTGTCGGTTGGCTCGCTGACCAAAGACGTGCGCGCGACCG
ATTTTTCGATGCGCATCGTCTGA

Upstream 100 bases:

>100_bases
ATCGCATGCTCGATTTCGCAGCGCGTCACAAGAAGCGCGTGCAGGCGAGCGGCGATCTCGCGCACGACACCGCGTTGTTC
TCGAACGTTGGAGCGGCTTG

Downstream 100 bases:

>100_bases
TCGAATTGTGTAGCGGTTCAAGGAAAAGGCCATCGACAGTCGCACTGTCCATGGCCTTTTTCATATGCAGCGCGAACCGG
CTACACGTTCCGGTTCGGTA

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MGVNEPLEFKDAVSPLFAEIQEQYGEAFAAAIARNVADALAEDVGSGDLTGLLVPADEMRDARIIVREEAVLCGVPWFNE
VMRRVDPRIEAQWRYREGDRMTADSVVCTLRGPARALLTAERNGLNFLQMLSGVASATRKFADAIAHTRARVLDTRKTLP
GLRLAQKYAVRVGGGANQRLALYDGILIKENHIAAAGGVGAAMQAAIALNAGVSIQIEVETLGQLESALAHGAQSVLLDN
FSFDMMRDAVRITAGRAVLEVSGGVNLDTIRLIAETGVDRVSVGSLTKDVRATDFSMRIV

Sequences:

>Translated_300_residues
MGVNEPLEFKDAVSPLFAEIQEQYGEAFAAAIARNVADALAEDVGSGDLTGLLVPADEMRDARIIVREEAVLCGVPWFNE
VMRRVDPRIEAQWRYREGDRMTADSVVCTLRGPARALLTAERNGLNFLQMLSGVASATRKFADAIAHTRARVLDTRKTLP
GLRLAQKYAVRVGGGANQRLALYDGILIKENHIAAAGGVGAAMQAAIALNAGVSIQIEVETLGQLESALAHGAQSVLLDN
FSFDMMRDAVRITAGRAVLEVSGGVNLDTIRLIAETGVDRVSVGSLTKDVRATDFSMRIV
>Mature_299_residues
GVNEPLEFKDAVSPLFAEIQEQYGEAFAAAIARNVADALAEDVGSGDLTGLLVPADEMRDARIIVREEAVLCGVPWFNEV
MRRVDPRIEAQWRYREGDRMTADSVVCTLRGPARALLTAERNGLNFLQMLSGVASATRKFADAIAHTRARVLDTRKTLPG
LRLAQKYAVRVGGGANQRLALYDGILIKENHIAAAGGVGAAMQAAIALNAGVSIQIEVETLGQLESALAHGAQSVLLDNF
SFDMMRDAVRITAGRAVLEVSGGVNLDTIRLIAETGVDRVSVGSLTKDVRATDFSMRIV

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=244, Percent_Identity=33.6065573770492, Blast_Score=126, Evalue=2e-29,
Organism=Escherichia coli, GI1786299, Length=270, Percent_Identity=48.1481481481481, Blast_Score=222, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6321162, Length=285, Percent_Identity=32.9824561403509, Blast_Score=151, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 32204; Mature: 32073

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVNEPLEFKDAVSPLFAEIQEQYGEAFAAAIARNVADALAEDVGSGDLTGLLVPADEMR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHCC
DARIIVREEAVLCGVPWFNEVMRRVDPRIEAQWRYREGDRMTADSVVCTLRGPARALLTA
CCEEEEEECEEEECCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEECCCHHEEEEE
ERNGLNFLQMLSGVASATRKFADAIAHTRARVLDTRKTLPGLRLAQKYAVRVGGGANQRL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHEEECCCCCCEE
ALYDGILIKENHIAAAGGVGAAMQAAIALNAGVSIQIEVETLGQLESALAHGAQSVLLDN
EEECCEEEECCCEEECCCHHHHHHHHHEECCCCEEEEEHHHHHHHHHHHHHCHHHHHHCC
FSFDMMRDAVRITAGRAVLEVSGGVNLDTIRLIAETGVDRVSVGSLTKDVRATDFSMRIV
CCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCEEECCHHHHHHHHCCEEEEEC
>Mature Secondary Structure 
GVNEPLEFKDAVSPLFAEIQEQYGEAFAAAIARNVADALAEDVGSGDLTGLLVPADEMR
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHCC
DARIIVREEAVLCGVPWFNEVMRRVDPRIEAQWRYREGDRMTADSVVCTLRGPARALLTA
CCEEEEEECEEEECCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEECCCHHEEEEE
ERNGLNFLQMLSGVASATRKFADAIAHTRARVLDTRKTLPGLRLAQKYAVRVGGGANQRL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHEEECCCCCCEE
ALYDGILIKENHIAAAGGVGAAMQAAIALNAGVSIQIEVETLGQLESALAHGAQSVLLDN
EEECCEEEECCCEEECCCHHHHHHHHHEECCCCEEEEEHHHHHHHHHHHHHCHHHHHHCC
FSFDMMRDAVRITAGRAVLEVSGGVNLDTIRLIAETGVDRVSVGSLTKDVRATDFSMRIV
CCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCEEECCHHHHHHHHCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 2430961; 8419294 [H]