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The map label for this gene is purE [H]

Identifier: 186475231

GI number: 186475231

Start: 525932

End: 526441

Strand: Direct

Name: purE [H]

Synonym: Bphy_0463

Alternate gene names: 186475231

Gene position: 525932-526441 (Clockwise)

Preceding gene: 186475230

Following gene: 186475232

Centisome position: 15.12

GC content: 66.08

Gene sequence:

>510_bases
ATGAGTGAAGCACACGCGCACAGCGCGCCCGTCGTTGGCGTGCTGATGGGTTCCAGCTCCGACTGGGAAGTGATGAAGAA
CGCGGTCGCGATCCTGCAGGAATTCGGCGTGCCGTACGAAGCGAAGGTTGTGTCCGCGCACCGTATGCCGGACGAGATGT
TCGCCTATGCTGAAAGTGCGCGCGAGCGCGGCATCCGCGCGATCATCGCGGGCGCGGGCGGCGCGGCGCATCTGCCTGGC
ATGCTTGCCGCGAAGACGACGGTGCCCGTGCTAGGTGTGCCCGTCGCAAGCAAGTACCTGAAGGGCGTCGATTCGCTGCA
TTCGATCGTTCAGATGCCGAAGGGCGTGCCCGTCGCGACGTTCGCGATCGGCGAAGCGGGCGCGGCGAATGCGGCGCTGT
TTGCGGTGTCGCTGCTCTCCGGCACGTCGGCGGAATATGCGGAGAAGCTCGCCGCGTTCCGTGTGCGCCAGAACCAGGCC
GCTCACGCGATGACGCTGCCGCCACTGTAA

Upstream 100 bases:

>100_bases
CGACGAAGTCGTCACGAAGACGGCCGAAAAGTATCAGGAAGCGCTCGAACGCCTCACGGGACAGAAGCTCGACTGAGCGC
CACGTACACGGAAAGACAAC

Downstream 100 bases:

>100_bases
AAGCTGGCGGTTCCGCTTCGCCGTTCGATGTTTCACCCGGCCGACTCTCACGTCGGCCGCGACCGACCACCAAGATGAAT
CCAGACAACACTCCCGTTTC

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 169; Mature: 168

Protein sequence:

>169_residues
MSEAHAHSAPVVGVLMGSSSDWEVMKNAVAILQEFGVPYEAKVVSAHRMPDEMFAYAESARERGIRAIIAGAGGAAHLPG
MLAAKTTVPVLGVPVASKYLKGVDSLHSIVQMPKGVPVATFAIGEAGAANAALFAVSLLSGTSAEYAEKLAAFRVRQNQA
AHAMTLPPL

Sequences:

>Translated_169_residues
MSEAHAHSAPVVGVLMGSSSDWEVMKNAVAILQEFGVPYEAKVVSAHRMPDEMFAYAESARERGIRAIIAGAGGAAHLPG
MLAAKTTVPVLGVPVASKYLKGVDSLHSIVQMPKGVPVATFAIGEAGAANAALFAVSLLSGTSAEYAEKLAAFRVRQNQA
AHAMTLPPL
>Mature_168_residues
SEAHAHSAPVVGVLMGSSSDWEVMKNAVAILQEFGVPYEAKVVSAHRMPDEMFAYAESARERGIRAIIAGAGGAAHLPGM
LAAKTTVPVLGVPVASKYLKGVDSLHSIVQMPKGVPVATFAIGEAGAANAALFAVSLLSGTSAEYAEKLAAFRVRQNQAA
HAMTLPPL

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=110, Percent_Identity=63.6363636363636, Blast_Score=147, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6324702, Length=150, Percent_Identity=59.3333333333333, Blast_Score=178, Evalue=5e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17478; Mature: 17347

Theoretical pI: Translated: 7.93; Mature: 7.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEAHAHSAPVVGVLMGSSSDWEVMKNAVAILQEFGVPYEAKVVSAHRMPDEMFAYAESA
CCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHH
RERGIRAIIAGAGGAAHLPGMLAAKTTVPVLGVPVASKYLKGVDSLHSIVQMPKGVPVAT
HHCCCEEEEECCCCHHHCCCHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHCCCCCCEEE
FAIGEAGAANAALFAVSLLSGTSAEYAEKLAAFRVRQNQAAHAMTLPPL
EECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEECCCC
>Mature Secondary Structure 
SEAHAHSAPVVGVLMGSSSDWEVMKNAVAILQEFGVPYEAKVVSAHRMPDEMFAYAESA
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHH
RERGIRAIIAGAGGAAHLPGMLAAKTTVPVLGVPVASKYLKGVDSLHSIVQMPKGVPVAT
HHCCCEEEEECCCCHHHCCCHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHCCCCCCEEE
FAIGEAGAANAALFAVSLLSGTSAEYAEKLAAFRVRQNQAAHAMTLPPL
EECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3036807; 9384377 [H]