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The map label for this gene is tpm [H]

Identifier: 186475147

GI number: 186475147

Start: 429512

End: 430153

Strand: Direct

Name: tpm [H]

Synonym: Bphy_0378

Alternate gene names: 186475147

Gene position: 429512-430153 (Clockwise)

Preceding gene: 186475146

Following gene: 186475148

Centisome position: 12.35

GC content: 66.04

Gene sequence:

>642_bases
ATGAGTGACAAGAGGCCGTCCGTTCCCCCTTCGGCGCCGGACTTCGAAAACCGCGATCCGAATGCGCCCGGCTTTTGGGA
CGAGCGTTTTGGGCGTGGCTTCACACCGTGGGATCAGGCGGGCGTGCCGCCCGCGTTCAAGGCGTTCGTCGAGCGGCATT
CGCCAGTGCCCGTGCTGATTCCGGGTTGCGGGAGCGCGTACGAAGCCCGGTGGCTCGCGGAAAAGGGCTGGACCGTCCGC
GCGATCGACTTTGCGCCGAACGCCGTCGAGGCCGCGCGTGCGCAACTCGGCTCGCATGCCAGCCTCGTGCACGAGGCGGA
TTTCTTCACTTATCGGCCGCCTTTCGATCCCGGCTGGATCTACGAACGAGCGTTCCTGTGCGCGCTGCCGCCCGCACGCC
GCTCGGACTGGGTTGCGCGGATGGCGCAACTCCTGTCGCCCGGCGGACTGCTCGCCGGTTTCTTTTTTATCGGCGCGACC
GAGAAAGGCCCGCCGTTCGGCATCGAGCGCGCGGAACTCGATGCGCTCATGTCGCCCGATTTCACACTGGTCGAAGATGA
ACCCGTAGACGATTCGATCGCTGTGTTTGCCGGACGGGAACGCTGGCTCACGTGGCGTCGACGCGGCGCAGCAAGGGGTT
GA

Upstream 100 bases:

>100_bases
TTGATGTTCGGTGTAGCAGTGGGCGTGGGCGCGGTGCTGGCGCGCGCGTGGCTCGCCATCGCGTACGGCGGCTATTGAGC
GCATTCCACGAGGGTGTTCC

Downstream 100 bases:

>100_bases
TCTTCGGCTTGCGCGCCCCCATCTGCTAGCGCGGCCGGGATGCCGGCCGTTTCCCTCGAATTCGAGGGCCGGCCATCGTT
TGCGGCTATAATTCAAGGCT

Product: thiopurine S-methyltransferase

Products: NA

Alternate protein names: Thiopurine methyltransferase [H]

Number of amino acids: Translated: 213; Mature: 212

Protein sequence:

>213_residues
MSDKRPSVPPSAPDFENRDPNAPGFWDERFGRGFTPWDQAGVPPAFKAFVERHSPVPVLIPGCGSAYEARWLAEKGWTVR
AIDFAPNAVEAARAQLGSHASLVHEADFFTYRPPFDPGWIYERAFLCALPPARRSDWVARMAQLLSPGGLLAGFFFIGAT
EKGPPFGIERAELDALMSPDFTLVEDEPVDDSIAVFAGRERWLTWRRRGAARG

Sequences:

>Translated_213_residues
MSDKRPSVPPSAPDFENRDPNAPGFWDERFGRGFTPWDQAGVPPAFKAFVERHSPVPVLIPGCGSAYEARWLAEKGWTVR
AIDFAPNAVEAARAQLGSHASLVHEADFFTYRPPFDPGWIYERAFLCALPPARRSDWVARMAQLLSPGGLLAGFFFIGAT
EKGPPFGIERAELDALMSPDFTLVEDEPVDDSIAVFAGRERWLTWRRRGAARG
>Mature_212_residues
SDKRPSVPPSAPDFENRDPNAPGFWDERFGRGFTPWDQAGVPPAFKAFVERHSPVPVLIPGCGSAYEARWLAEKGWTVRA
IDFAPNAVEAARAQLGSHASLVHEADFFTYRPPFDPGWIYERAFLCALPPARRSDWVARMAQLLSPGGLLAGFFFIGATE
KGPPFGIERAELDALMSPDFTLVEDEPVDDSIAVFAGRERWLTWRRRGAARG

Specific function: Unknown

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. TPMT family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022474
- InterPro:   IPR008854
- InterPro:   IPR016822 [H]

Pfam domain/function: PF05724 TPMT [H]

EC number: =2.1.1.67 [H]

Molecular weight: Translated: 23632; Mature: 23501

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDKRPSVPPSAPDFENRDPNAPGFWDERFGRGFTPWDQAGVPPAFKAFVERHSPVPVLI
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCHHHCCCCHHHHHHHHHCCCCCEEE
PGCGSAYEARWLAEKGWTVRAIDFAPNAVEAARAQLGSHASLVHEADFFTYRPPFDPGWI
CCCCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCHHHHHHHCCCEEECCCCCCCHH
YERAFLCALPPARRSDWVARMAQLLSPGGLLAGFFFIGATEKGPPFGIERAELDALMSPD
HHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHEECCCCCCCCCCCHHHHHHHCCCC
FTLVEDEPVDDSIAVFAGRERWLTWRRRGAARG
EEEECCCCCCCCEEEEECCHHHHHHHHHCCCCC
>Mature Secondary Structure 
SDKRPSVPPSAPDFENRDPNAPGFWDERFGRGFTPWDQAGVPPAFKAFVERHSPVPVLI
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCHHHCCCCHHHHHHHHHCCCCCEEE
PGCGSAYEARWLAEKGWTVRAIDFAPNAVEAARAQLGSHASLVHEADFFTYRPPFDPGWI
CCCCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCHHHHHHHCCCEEECCCCCCCHH
YERAFLCALPPARRSDWVARMAQLLSPGGLLAGFFFIGATEKGPPFGIERAELDALMSPD
HHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHEECCCCCCCCCCCHHHHHHHCCCC
FTLVEDEPVDDSIAVFAGRERWLTWRRRGAARG
EEEECCCCCCCCEEEEECCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA