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The map label for this gene is aqpZ [H]

Identifier: 186475126

GI number: 186475126

Start: 401854

End: 402597

Strand: Direct

Name: aqpZ [H]

Synonym: Bphy_0357

Alternate gene names: 186475126

Gene position: 401854-402597 (Clockwise)

Preceding gene: 186475125

Following gene: 186475127

Centisome position: 11.55

GC content: 65.32

Gene sequence:

>744_bases
ATGTCAGGGCTGGGAAAGCGATTGATCGTGGAAGGCGCCGGGACGGCGTGGCTCGTGTTCATTGGGTGTGGCACAGCTGC
GCTTAACACGGGCGCGCAAGGCAATAGCATCATCGCCGTGCCGCTCGCCTTCGGCTTTGCGTTGGCTACCGCGACTTACG
TGCTTGGGCGCTTTTCGGGGGCGCACTTCAATCCCGCCGTCACCGTCGCTTTTGTGACAGCGCAACGCTTTTCCGTGCGC
GACCTCGCACCCTATATCGCCGCGCAAGTGCTCGGCGCCGTCGCGGGCGCTGCGCTGCTTGTCTATATCGCCAGCGGCCG
TCCGGGCTTCGAGCTTGCATCGAGCCAGTTCGGCGCGACGGGGTTTGGCGACCATTCTCCCGCCGACTACTCACTGCATT
CCGCGCTGGCGGTCGAAGTCACCCTGTCCTTTGCATTCGTACTGGCGCGCATGCTGATGTCGAGCGGCCGCTCGGCGAAC
CTGATCGGTCCGCTCGTCACGGGTTTGTGGCTGATGCTGAGCTACGTCGTCGCGGCACCCGTCACTAATGCTTCACTGAA
TCCCGCCCGCTCGACGGGCCCGGCACTGCTCGTCGGCGACTGGGCGCTCGACCAGTTGTGGCTTTTTTGGGCGGCTCCGC
TCACGGGAGGTGTGCTCGCCGGCTTGCTGCATTCGCGAGTTTTTGGCCAGCCACGGGATATGTTCGCGGGGCGCCGCGAG
GGCCGTCGCGGCGAGTCGGCGTGA

Upstream 100 bases:

>100_bases
GCCACGTCATTGATTCGCGATGCGAATCAATTGTGACCAGGCGCAACCCTGGAGATCCGTCGCAAAAGATCGTCTGAGCG
GGGTAATTTCCGGAGGATGC

Downstream 100 bases:

>100_bases
GCGCCATCATGCATTGCTTACGCGTCCGGATGCCGTTTCGCGCCCATTCGCTATGTCACACCTCCCGGGTTCTCGTTCGC
GAGGCCTTGATAGCCGGTTT

Product: major intrinsic protein

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 247; Mature: 246

Protein sequence:

>247_residues
MSGLGKRLIVEGAGTAWLVFIGCGTAALNTGAQGNSIIAVPLAFGFALATATYVLGRFSGAHFNPAVTVAFVTAQRFSVR
DLAPYIAAQVLGAVAGAALLVYIASGRPGFELASSQFGATGFGDHSPADYSLHSALAVEVTLSFAFVLARMLMSSGRSAN
LIGPLVTGLWLMLSYVVAAPVTNASLNPARSTGPALLVGDWALDQLWLFWAAPLTGGVLAGLLHSRVFGQPRDMFAGRRE
GRRGESA

Sequences:

>Translated_247_residues
MSGLGKRLIVEGAGTAWLVFIGCGTAALNTGAQGNSIIAVPLAFGFALATATYVLGRFSGAHFNPAVTVAFVTAQRFSVR
DLAPYIAAQVLGAVAGAALLVYIASGRPGFELASSQFGATGFGDHSPADYSLHSALAVEVTLSFAFVLARMLMSSGRSAN
LIGPLVTGLWLMLSYVVAAPVTNASLNPARSTGPALLVGDWALDQLWLFWAAPLTGGVLAGLLHSRVFGQPRDMFAGRRE
GRRGESA
>Mature_246_residues
SGLGKRLIVEGAGTAWLVFIGCGTAALNTGAQGNSIIAVPLAFGFALATATYVLGRFSGAHFNPAVTVAFVTAQRFSVRD
LAPYIAAQVLGAVAGAALLVYIASGRPGFELASSQFGATGFGDHSPADYSLHSALAVEVTLSFAFVLARMLMSSGRSANL
IGPLVTGLWLMLSYVVAAPVTNASLNPARSTGPALLVGDWALDQLWLFWAAPLTGGVLAGLLHSRVFGQPRDMFAGRREG
RRGESA

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI4502181, Length=195, Percent_Identity=33.3333333333333, Blast_Score=104, Evalue=6e-23,
Organism=Homo sapiens, GI4755125, Length=195, Percent_Identity=33.3333333333333, Blast_Score=104, Evalue=7e-23,
Organism=Homo sapiens, GI4502179, Length=258, Percent_Identity=33.3333333333333, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI6912506, Length=222, Percent_Identity=35.1351351351351, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI37694062, Length=238, Percent_Identity=31.5126050420168, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI4502183, Length=222, Percent_Identity=32.8828828828829, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI86792455, Length=235, Percent_Identity=30.2127659574468, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI45446752, Length=206, Percent_Identity=27.6699029126214, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI157266307, Length=276, Percent_Identity=28.6231884057971, Blast_Score=73, Evalue=2e-13,
Organism=Escherichia coli, GI1787101, Length=207, Percent_Identity=44.9275362318841, Blast_Score=170, Evalue=9e-44,
Organism=Escherichia coli, GI1790362, Length=210, Percent_Identity=29.5238095238095, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71993722, Length=241, Percent_Identity=28.2157676348548, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17558372, Length=206, Percent_Identity=29.6116504854369, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24652747, Length=227, Percent_Identity=33.920704845815, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI45551084, Length=227, Percent_Identity=33.920704845815, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI17136672, Length=240, Percent_Identity=33.75, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24652751, Length=257, Percent_Identity=29.5719844357977, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI19922038, Length=227, Percent_Identity=30.8370044052863, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24762344, Length=244, Percent_Identity=29.9180327868852, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24762346, Length=244, Percent_Identity=29.9180327868852, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24762348, Length=244, Percent_Identity=29.9180327868852, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI20130305, Length=244, Percent_Identity=29.9180327868852, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI45550503, Length=248, Percent_Identity=27.8225806451613, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24762342, Length=231, Percent_Identity=29.004329004329, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 25543; Mature: 25412

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGLGKRLIVEGAGTAWLVFIGCGTAALNTGAQGNSIIAVPLAFGFALATATYVLGRFSG
CCCCCCEEEEECCCCEEEEEEECCHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCC
AHFNPAVTVAFVTAQRFSVRDLAPYIAAQVLGAVAGAALLVYIASGRPGFELASSQFGAT
CCCCCCEEEEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHCCCCCC
GFGDHSPADYSLHSALAVEVTLSFAFVLARMLMSSGRSANLIGPLVTGLWLMLSYVVAAP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCC
VTNASLNPARSTGPALLVGDWALDQLWLFWAAPLTGGVLAGLLHSRVFGQPRDMFAGRRE
CCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCC
GRRGESA
CCCCCCC
>Mature Secondary Structure 
SGLGKRLIVEGAGTAWLVFIGCGTAALNTGAQGNSIIAVPLAFGFALATATYVLGRFSG
CCCCCEEEEECCCCEEEEEEECCHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCC
AHFNPAVTVAFVTAQRFSVRDLAPYIAAQVLGAVAGAALLVYIASGRPGFELASSQFGAT
CCCCCCEEEEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHCCCCCC
GFGDHSPADYSLHSALAVEVTLSFAFVLARMLMSSGRSANLIGPLVTGLWLMLSYVVAAP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCC
VTNASLNPARSTGPALLVGDWALDQLWLFWAAPLTGGVLAGLLHSRVFGQPRDMFAGRRE
CCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCC
GRRGESA
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12910271 [H]