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The map label for this gene is luxQ [H]

Identifier: 186474904

GI number: 186474904

Start: 142340

End: 143983

Strand: Direct

Name: luxQ [H]

Synonym: Bphy_0134

Alternate gene names: 186474904

Gene position: 142340-143983 (Clockwise)

Preceding gene: 186474903

Following gene: 186474905

Centisome position: 4.09

GC content: 66.06

Gene sequence:

>1644_bases
ATGACGGTTGCCGCTCCGCTGATTTTGAACGTCGACGACAACGACGGCGCGCGTTATGCGAAAACGCGCGTGCTCGTGCA
TGCCGGTTTCGATGTGGTCGAGGCGGCGACGGGCCAGGGCGCGCTCGATCAGGTGCGCACGCACAACCCCGCGATCGTGC
TGCTCGATGTGAAGCTGCCCGATATCAGCGGCATCGAGGTCTGTTCGATTCTCAAGCGCGATCCGCAGACGCGATCGACG
CTCATCCTGCAAACGTCAGCGGCCGCTGTGCAATCGTTCGACAAGGTTCGCGCGCTCGACGGCGGAGCGGACAGCTATCT
GACCGAGCCGATCGAGCCCGCCGAACTCGTCGCCAACGTGCGCGCGCTGCTGCGGCTGCATCGCGCGGAAGAAGCGCTGC
GCGACGCCGACCGCCGCAAGGACCAGTTTCTCGCGACGCTCGCACACGAACTGCGCAATCCGCTCGCGCCGATCCGCAAT
GCGGTCGAACTGATGGATCCGCGCTATCACGCGGCCGAAGACGCCGTGTGTCATGCGCGCATGATCGCGCGCCGTCAGGT
CGAACATCTGAGCCGGCTGGTCGACGATCTGCTCGACGTGTCGCGCATCACGCACGGCAAGATCGCGCTGCAGCGCGAAT
GCGTTCATCTCGATGCTGCCGTCGCGACGGCCGTCGAAGCGAACCAGCCGTTCATCGCGACGAAACAGCACACATTGCGC
GTCAATGTGCCCAAGAGCGCCTGCATGATTTACGGTGATCCGATCCGCGTCGCGCAGGTGATCAGCAATCTTTTGTCGAA
TGCGGCGAAGTACACGCCGGAGGGCGGCGTGATCGAACTGGACGTGAGCGCCGCCGACGGCAGCGTGACGGTTCGCGTGC
GCGACAACGGCATCGGCATTCCACCGAACGAACTGGCGGATGTGTTCAACCTGTTCATGCAGTCAGAAGATTCGCTGGCG
CGCTCCGAAGGCGGTCTCGGCATTGGGCTGTCGCTCGCGAAGACCCTCACCGAACTGCATGGCGGAACGATCGAAGCATT
TTCAGGAGGACTCGGGATGGGCTCAGAATTCGTCGTGACGCTGCCGATGGTGGTCGAACAAAGCGCTGGCAAGCCCTGTG
ACGCATCGCCGGACACGTCGGCGGCGGCTGACGGAGAGCCCGCTGCCAGGCAGCCCGCGGGCGAAGCCACGCCCGCAACA
CGACGGCGCGTGATGGTGGTCGACGACAGCGTCGATGGCGCGGAGTCGATGTCGATCCTGCTCGAGATGCTCGGCCACGA
GGTGCGCGTGATGTACGACGGCGCAGCGGCGATCGCGGCCGCGAGCGAATTCAAGCCGGAGGTCGTGCTGCTCGATATCG
GCTTGCCGGGCGTCGACGGCTACCAGGTGGCGCGCGCGTTGCGCGCCGAGCCGGCCACGGCGGGCGCGCTGCTGATCGCG
CTGACGGGCTACGGACAGGACACCGACCGCCAGCGTACGCGCGACGCGGGCTTCGATCACCACCTCGTGAAGCCGGCTTC
GCTCGACGACATCGAGCGCGTGATCGCGGCGGACGGCGCAAGCGGAGCGCCGCGCAATCCCGGCACGACGCTGCGGCCGG
ACGCGAACTGCTCTGACGCGACCCGTTCCGATGTGACGGAGTGA

Upstream 100 bases:

>100_bases
GCTCGACCTTCTACCTGACGCTGCCCCTCGAGGCCAAGGCTGCAGCCGGCCCGGACGTGCGATGGGCGGACGGCTCGTCC
ATCGCACACGGAGGCGCCTC

Downstream 100 bases:

>100_bases
ATGCATCGGATGAAACACGGCGAGTAGCGAACCCAGGCGAGCGCAGCACACATAAAGCCATCGCAAGGCCGGTAAGGGCC
GCGTGGGCGACAGCGATACG

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MTVAAPLILNVDDNDGARYAKTRVLVHAGFDVVEAATGQGALDQVRTHNPAIVLLDVKLPDISGIEVCSILKRDPQTRST
LILQTSAAAVQSFDKVRALDGGADSYLTEPIEPAELVANVRALLRLHRAEEALRDADRRKDQFLATLAHELRNPLAPIRN
AVELMDPRYHAAEDAVCHARMIARRQVEHLSRLVDDLLDVSRITHGKIALQRECVHLDAAVATAVEANQPFIATKQHTLR
VNVPKSACMIYGDPIRVAQVISNLLSNAAKYTPEGGVIELDVSAADGSVTVRVRDNGIGIPPNELADVFNLFMQSEDSLA
RSEGGLGIGLSLAKTLTELHGGTIEAFSGGLGMGSEFVVTLPMVVEQSAGKPCDASPDTSAAADGEPAARQPAGEATPAT
RRRVMVVDDSVDGAESMSILLEMLGHEVRVMYDGAAAIAAASEFKPEVVLLDIGLPGVDGYQVARALRAEPATAGALLIA
LTGYGQDTDRQRTRDAGFDHHLVKPASLDDIERVIAADGASGAPRNPGTTLRPDANCSDATRSDVTE

Sequences:

>Translated_547_residues
MTVAAPLILNVDDNDGARYAKTRVLVHAGFDVVEAATGQGALDQVRTHNPAIVLLDVKLPDISGIEVCSILKRDPQTRST
LILQTSAAAVQSFDKVRALDGGADSYLTEPIEPAELVANVRALLRLHRAEEALRDADRRKDQFLATLAHELRNPLAPIRN
AVELMDPRYHAAEDAVCHARMIARRQVEHLSRLVDDLLDVSRITHGKIALQRECVHLDAAVATAVEANQPFIATKQHTLR
VNVPKSACMIYGDPIRVAQVISNLLSNAAKYTPEGGVIELDVSAADGSVTVRVRDNGIGIPPNELADVFNLFMQSEDSLA
RSEGGLGIGLSLAKTLTELHGGTIEAFSGGLGMGSEFVVTLPMVVEQSAGKPCDASPDTSAAADGEPAARQPAGEATPAT
RRRVMVVDDSVDGAESMSILLEMLGHEVRVMYDGAAAIAAASEFKPEVVLLDIGLPGVDGYQVARALRAEPATAGALLIA
LTGYGQDTDRQRTRDAGFDHHLVKPASLDDIERVIAADGASGAPRNPGTTLRPDANCSDATRSDVTE
>Mature_546_residues
TVAAPLILNVDDNDGARYAKTRVLVHAGFDVVEAATGQGALDQVRTHNPAIVLLDVKLPDISGIEVCSILKRDPQTRSTL
ILQTSAAAVQSFDKVRALDGGADSYLTEPIEPAELVANVRALLRLHRAEEALRDADRRKDQFLATLAHELRNPLAPIRNA
VELMDPRYHAAEDAVCHARMIARRQVEHLSRLVDDLLDVSRITHGKIALQRECVHLDAAVATAVEANQPFIATKQHTLRV
NVPKSACMIYGDPIRVAQVISNLLSNAAKYTPEGGVIELDVSAADGSVTVRVRDNGIGIPPNELADVFNLFMQSEDSLAR
SEGGLGIGLSLAKTLTELHGGTIEAFSGGLGMGSEFVVTLPMVVEQSAGKPCDASPDTSAAADGEPAARQPAGEATPATR
RRVMVVDDSVDGAESMSILLEMLGHEVRVMYDGAAAIAAASEFKPEVVLLDIGLPGVDGYQVARALRAEPATAGALLIAL
TGYGQDTDRQRTRDAGFDHHLVKPASLDDIERVIAADGASGAPRNPGTTLRPDANCSDATRSDVTE

Specific function: At low cell density, in absence of AI-2 (autoinducer 2), luxQ has a kinase activity and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is t

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788713, Length=376, Percent_Identity=27.6595744680851, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI48994928, Length=393, Percent_Identity=30.2798982188295, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1786912, Length=252, Percent_Identity=32.5396825396825, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI145693157, Length=260, Percent_Identity=33.4615384615385, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1788393, Length=234, Percent_Identity=31.6239316239316, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI87081816, Length=388, Percent_Identity=28.8659793814433, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1789149, Length=268, Percent_Identity=31.7164179104478, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786783, Length=257, Percent_Identity=27.6264591439689, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1790436, Length=257, Percent_Identity=29.5719844357977, Blast_Score=99, Evalue=9e-22,
Organism=Escherichia coli, GI1788279, Length=307, Percent_Identity=28.0130293159609, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1790346, Length=227, Percent_Identity=27.3127753303965, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1786600, Length=314, Percent_Identity=24.8407643312102, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87082128, Length=228, Percent_Identity=32.0175438596491, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1786599, Length=118, Percent_Identity=38.9830508474576, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1790861, Length=232, Percent_Identity=30.1724137931034, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1787894, Length=224, Percent_Identity=27.2321428571429, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1790551, Length=203, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1788549, Length=231, Percent_Identity=25.974025974026, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1790300, Length=233, Percent_Identity=31.3304721030043, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1790860, Length=118, Percent_Identity=35.5932203389831, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1786911, Length=125, Percent_Identity=36.8, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87082012, Length=122, Percent_Identity=34.4262295081967, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 58106; Mature: 57975

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVAAPLILNVDDNDGARYAKTRVLVHAGFDVVEAATGQGALDQVRTHNPAIVLLDVKLP
CCEECEEEEEECCCCCCCCHHEEEEEEECCHHHHHCCCCCHHHHHHCCCCEEEEEEEECC
DISGIEVCSILKRDPQTRSTLILQTSAAAVQSFDKVRALDGGADSYLTEPIEPAELVANV
CCCCHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHH
RALLRLHRAEEALRDADRRKDQFLATLAHELRNPLAPIRNAVELMDPRYHAAEDAVCHAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHH
MIARRQVEHLSRLVDDLLDVSRITHGKIALQRECVHLDAAVATAVEANQPFIATKQHTLR
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEEEE
VNVPKSACMIYGDPIRVAQVISNLLSNAAKYTPEGGVIELDVSAADGSVTVRVRDNGIGI
EECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEEECCCCCC
PPNELADVFNLFMQSEDSLARSEGGLGIGLSLAKTLTELHGGTIEAFSGGLGMGSEFVVT
CHHHHHHHHHHHHCCCHHHHHCCCCCEEHHHHHHHHHHHCCCEEEECCCCCCCCCCEEEE
LPMVVEQSAGKPCDASPDTSAAADGEPAARQPAGEATPATRRRVMVVDDSVDGAESMSIL
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHH
LEMLGHEVRVMYDGAAAIAAASEFKPEVVLLDIGLPGVDGYQVARALRAEPATAGALLIA
HHHHCCCEEEEECCHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCCEEEEE
LTGYGQDTDRQRTRDAGFDHHLVKPASLDDIERVIAADGASGAPRNPGTTLRPDANCSDA
EECCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
TRSDVTE
CCCCCCC
>Mature Secondary Structure 
TVAAPLILNVDDNDGARYAKTRVLVHAGFDVVEAATGQGALDQVRTHNPAIVLLDVKLP
CEECEEEEEECCCCCCCCHHEEEEEEECCHHHHHCCCCCHHHHHHCCCCEEEEEEEECC
DISGIEVCSILKRDPQTRSTLILQTSAAAVQSFDKVRALDGGADSYLTEPIEPAELVANV
CCCCHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHH
RALLRLHRAEEALRDADRRKDQFLATLAHELRNPLAPIRNAVELMDPRYHAAEDAVCHAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHH
MIARRQVEHLSRLVDDLLDVSRITHGKIALQRECVHLDAAVATAVEANQPFIATKQHTLR
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEEEE
VNVPKSACMIYGDPIRVAQVISNLLSNAAKYTPEGGVIELDVSAADGSVTVRVRDNGIGI
EECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEEECCCCCC
PPNELADVFNLFMQSEDSLARSEGGLGIGLSLAKTLTELHGGTIEAFSGGLGMGSEFVVT
CHHHHHHHHHHHHCCCHHHHHCCCCCEEHHHHHHHHHHHCCCEEEECCCCCCCCCCEEEE
LPMVVEQSAGKPCDASPDTSAAADGEPAARQPAGEATPATRRRVMVVDDSVDGAESMSIL
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHH
LEMLGHEVRVMYDGAAAIAAASEFKPEVVLLDIGLPGVDGYQVARALRAEPATAGALLIA
HHHHCCCEEEEECCHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCCEEEEE
LTGYGQDTDRQRTRDAGFDHHLVKPASLDDIERVIAADGASGAPRNPGTTLRPDANCSDA
EECCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
TRSDVTE
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301; 12176318 [H]