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The map label for this gene is rcsC [C]

Identifier: 186474903

GI number: 186474903

Start: 140895

End: 142343

Strand: Direct

Name: rcsC [C]

Synonym: Bphy_0133

Alternate gene names: 186474903

Gene position: 140895-142343 (Clockwise)

Preceding gene: 186474902

Following gene: 186474904

Centisome position: 4.05

GC content: 63.84

Gene sequence:

>1449_bases
ATGACGACCCCTATCCTGCGCATCCGGCTCGGCGCCGAAGAAGATGTCGTGGCGGCGCGCCGCAAGGCTCGTGCGATCGC
CGCGGGCTTTGGCTTCTCTTCGCTCGATCAGACGCGCATCGCGAGCGCCGTGTCGGAGATCGCGCGCAACGCGTTCGAGT
ATGCGCACGGCGGCGAAGTGACGTTCACGTTCGACGCCGCAGCTAAGCCGCAAGCGCTGCTCATCGACGTGCGCGACAAG
GGGCCCGGCATCCGGAATCTTGAATCGGTGCTGGAAGGCACGTACCGCTCGCCGACGGGCATGGGCTGCGGCATCGCCGG
CAGCCGTCGCCTGATGGACCGTTGCGAGATCCAATCGTCTGCAGAACAGGGCACGGTCGTGTCGATGGCGCGCTTTCTGC
CGAACGACCGGCCCGAGATGGCGCTCACCGGCATCGACGCGATCATGCGCAGCCTCGTGCAGCAAAACCCGACGAGCGCG
CGTATGCACAGTGAAACCAACGACGAAACAGCGCGCCGTTCGATGGACGAACTGCACGAACAGAACCGCGAACTGCTGTC
GACGCTGACGGAATTGCGCGACCGTCAGGACGAACTTTCGCGTCTCACCCAGGAACTCGAAGCGACTAATCGCGGCGTCG
TCGCGCTATACGCGGAACTCGACGAGCGCGCGGACGAGCTGCGCCGCGCCGACGCGATGAAATCGCGCTTCCTGTCGAAC
ATGAGCCACGAGCTGCGTACGCCGCTCAGTTCGATACGCGCGCTTTCGAACTTGCTGCTCAATCGTCTCGATGGCGATCT
TTCCGGCGAGCAGGAACGCCAGGTGCTACTTATCCGCAAATCGGCCGAGGACCTGTCCGAGATCGTTAACGACCTCCTCG
ATCTGGCCAAGATCGAAGCGGGCCGTACAGATGTGACGCCCGTCTGGTTCAAGGCTGCGGGGCTATTCGCGGCGCTGCGC
GCGATGCTCACGCCTCTCCTGACCGATCCGGCGGTGAAGCTGATCTTCGAGGACACACACGGTTTGCCATCCATCTTCGC
CGACGAAGCGAAACTCACGCAGATACTGCGTAACTTTGTCTCGAACGCGCTCAAATTTACCGAGCGCGGGGAAATACGCG
TCGGTGCGCACCTTGAGCCGGATGGCCAGCACGTCACATTTGCCGTGGTCGACACGGGAATTGGCATCGCGGAGGAACAC
CAGCAAGTGATCTTCGAGGAATTCGGCCAGGTGCAGAACCATCTGCAGCAGCGCGTGAAGGGAACGGGGCTCGGCTTGCC
GCTATGCCGCAAGCTCGCCGCGCTGCTCGGCGGCCATGCAGGCGTCGACAGCAAACCGGGCGTCGGCTCGACCTTCTACC
TGACGCTGCCCCTCGAGGCCAAGGCTGCAGCCGGCCCGGACGTGCGATGGGCGGACGGCTCGTCCATCGCACACGGAGGC
GCCTCATGA

Upstream 100 bases:

>100_bases
AGGGATCGGAGTAGGGCGCCAACTCCCACCGACAGCTTTGCATGGGGCGGGAGCAAGGCGCTAAAGCGCCAACTCCCACC
GACAGGAGTAAATTTCACGC

Downstream 100 bases:

>100_bases
CGGTTGCCGCTCCGCTGATTTTGAACGTCGACGACAACGACGGCGCGCGTTATGCGAAAACGCGCGTGCTCGTGCATGCC
GGTTTCGATGTGGTCGAGGC

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 482; Mature: 481

Protein sequence:

>482_residues
MTTPILRIRLGAEEDVVAARRKARAIAAGFGFSSLDQTRIASAVSEIARNAFEYAHGGEVTFTFDAAAKPQALLIDVRDK
GPGIRNLESVLEGTYRSPTGMGCGIAGSRRLMDRCEIQSSAEQGTVVSMARFLPNDRPEMALTGIDAIMRSLVQQNPTSA
RMHSETNDETARRSMDELHEQNRELLSTLTELRDRQDELSRLTQELEATNRGVVALYAELDERADELRRADAMKSRFLSN
MSHELRTPLSSIRALSNLLLNRLDGDLSGEQERQVLLIRKSAEDLSEIVNDLLDLAKIEAGRTDVTPVWFKAAGLFAALR
AMLTPLLTDPAVKLIFEDTHGLPSIFADEAKLTQILRNFVSNALKFTERGEIRVGAHLEPDGQHVTFAVVDTGIGIAEEH
QQVIFEEFGQVQNHLQQRVKGTGLGLPLCRKLAALLGGHAGVDSKPGVGSTFYLTLPLEAKAAAGPDVRWADGSSIAHGG
AS

Sequences:

>Translated_482_residues
MTTPILRIRLGAEEDVVAARRKARAIAAGFGFSSLDQTRIASAVSEIARNAFEYAHGGEVTFTFDAAAKPQALLIDVRDK
GPGIRNLESVLEGTYRSPTGMGCGIAGSRRLMDRCEIQSSAEQGTVVSMARFLPNDRPEMALTGIDAIMRSLVQQNPTSA
RMHSETNDETARRSMDELHEQNRELLSTLTELRDRQDELSRLTQELEATNRGVVALYAELDERADELRRADAMKSRFLSN
MSHELRTPLSSIRALSNLLLNRLDGDLSGEQERQVLLIRKSAEDLSEIVNDLLDLAKIEAGRTDVTPVWFKAAGLFAALR
AMLTPLLTDPAVKLIFEDTHGLPSIFADEAKLTQILRNFVSNALKFTERGEIRVGAHLEPDGQHVTFAVVDTGIGIAEEH
QQVIFEEFGQVQNHLQQRVKGTGLGLPLCRKLAALLGGHAGVDSKPGVGSTFYLTLPLEAKAAAGPDVRWADGSSIAHGG
AS
>Mature_481_residues
TTPILRIRLGAEEDVVAARRKARAIAAGFGFSSLDQTRIASAVSEIARNAFEYAHGGEVTFTFDAAAKPQALLIDVRDKG
PGIRNLESVLEGTYRSPTGMGCGIAGSRRLMDRCEIQSSAEQGTVVSMARFLPNDRPEMALTGIDAIMRSLVQQNPTSAR
MHSETNDETARRSMDELHEQNRELLSTLTELRDRQDELSRLTQELEATNRGVVALYAELDERADELRRADAMKSRFLSNM
SHELRTPLSSIRALSNLLLNRLDGDLSGEQERQVLLIRKSAEDLSEIVNDLLDLAKIEAGRTDVTPVWFKAAGLFAALRA
MLTPLLTDPAVKLIFEDTHGLPSIFADEAKLTQILRNFVSNALKFTERGEIRVGAHLEPDGQHVTFAVVDTGIGIAEEHQ
QVIFEEFGQVQNHLQQRVKGTGLGLPLCRKLAALLGGHAGVDSKPGVGSTFYLTLPLEAKAAAGPDVRWADGSSIAHGGA
S

Specific function: Member Of The Two-Component Regulatory System rcsC/rcsB Involved In The Regulation Of The Expression Of Genes Involved In Colanic Acid Capsule Synthesis. rcsC Probably Functions As A Membrane-Associated Protein Kinase That Phosphorylates rcsB In Response

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAC (PAS-associated C-terminal) domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=285, Percent_Identity=32.280701754386, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI48994928, Length=236, Percent_Identity=38.5593220338983, Blast_Score=135, Evalue=7e-33,
Organism=Escherichia coli, GI1789149, Length=292, Percent_Identity=31.5068493150685, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1788713, Length=238, Percent_Identity=32.3529411764706, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI87081816, Length=266, Percent_Identity=34.2105263157895, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1786912, Length=238, Percent_Identity=29.4117647058824, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1790436, Length=240, Percent_Identity=30.8333333333333, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI87082128, Length=236, Percent_Identity=27.5423728813559, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI1788549, Length=281, Percent_Identity=27.4021352313167, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1790346, Length=276, Percent_Identity=28.2608695652174, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1788393, Length=272, Percent_Identity=24.6323529411765, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1786600, Length=236, Percent_Identity=27.1186440677966, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1790861, Length=204, Percent_Identity=29.9019607843137, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1787894, Length=246, Percent_Identity=26.4227642276423, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR001610
- InterPro:   IPR000700
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52570; Mature: 52439

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPILRIRLGAEEDVVAARRKARAIAAGFGFSSLDQTRIASAVSEIARNAFEYAHGGEV
CCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCE
TFTFDAAAKPQALLIDVRDKGPGIRNLESVLEGTYRSPTGMGCGIAGSRRLMDRCEIQSS
EEEECCCCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCC
AEQGTVVSMARFLPNDRPEMALTGIDAIMRSLVQQNPTSARMHSETNDETARRSMDELHE
CCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHH
QNRELLSTLTELRDRQDELSRLTQELEATNRGVVALYAELDERADELRRADAMKSRFLSN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHH
MSHELRTPLSSIRALSNLLLNRLDGDLSGEQERQVLLIRKSAEDLSEIVNDLLDLAKIEA
HHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCC
GRTDVTPVWFKAAGLFAALRAMLTPLLTDPAVKLIFEDTHGLPSIFADEAKLTQILRNFV
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHEEEECCCCCCCHHHHHHHHHHHHHHHHH
SNALKFTERGEIRVGAHLEPDGQHVTFAVVDTGIGIAEEHQQVIFEEFGQVQNHLQQRVK
HHHHHHCCCCCEEECCEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHC
GTGLGLPLCRKLAALLGGHAGVDSKPGVGSTFYLTLPLEAKAAAGPDVRWADGSSIAHGG
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCEECCCCCCCCCC
AS
CC
>Mature Secondary Structure 
TTPILRIRLGAEEDVVAARRKARAIAAGFGFSSLDQTRIASAVSEIARNAFEYAHGGEV
CCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCE
TFTFDAAAKPQALLIDVRDKGPGIRNLESVLEGTYRSPTGMGCGIAGSRRLMDRCEIQSS
EEEECCCCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCC
AEQGTVVSMARFLPNDRPEMALTGIDAIMRSLVQQNPTSARMHSETNDETARRSMDELHE
CCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHH
QNRELLSTLTELRDRQDELSRLTQELEATNRGVVALYAELDERADELRRADAMKSRFLSN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHH
MSHELRTPLSSIRALSNLLLNRLDGDLSGEQERQVLLIRKSAEDLSEIVNDLLDLAKIEA
HHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCC
GRTDVTPVWFKAAGLFAALRAMLTPLLTDPAVKLIFEDTHGLPSIFADEAKLTQILRNFV
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHEEEECCCCCCCHHHHHHHHHHHHHHHHH
SNALKFTERGEIRVGAHLEPDGQHVTFAVVDTGIGIAEEHQQVIFEEFGQVQNHLQQRVK
HHHHHHCCCCCEEECCEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHC
GTGLGLPLCRKLAALLGGHAGVDSKPGVGSTFYLTLPLEAKAAAGPDVRWADGSSIAHGG
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCEECCCCCCCCCC
AS
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430; 7756693 [H]