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The map label for this gene is atoC [H]

Identifier: 186474813

GI number: 186474813

Start: 50024

End: 50713

Strand: Direct

Name: atoC [H]

Synonym: Bphy_0042

Alternate gene names: 186474813

Gene position: 50024-50713 (Clockwise)

Preceding gene: 186474812

Following gene: 186474814

Centisome position: 1.44

GC content: 64.06

Gene sequence:

>690_bases
ATGGCAACCATCCTGGTGGTAGATGATGAAATGGGCATCCGGGAATTGCTCTCGGAGATCCTGAGCGACGAAGGGCATGT
CGTGGAGGTCGCGGAGAACGCGCAGGAGGCGCGCGATTACCGGCAACGCCTGGCACCCGATCTGGTGTTGCTCGACATCT
GGATGCCCGATACCGATGGCGTCACCTTGCTCAAAGAGTGGGCGGCACAAGGCACGTTGACGATGCCCGTTATCATGATG
TCGGGCCACGCGACCATCGATACGGCTGTTGAAGCAACGAAGATCGGTGCGCTCAACTTCCTCGAAAAGCCGATCGCGCT
TCAGAAGCTGCTGAAGGCCGTCGAGCAGGGGCTCGCACGCGGCAGCGCGGCACCCGCGGCGGGCGGCATGGCAGCCAAGC
CCCCGATGGCGGCGAACGCGTCCGCAGTCGCGTCGGCGGCGGCGCTGCCGATGATGTCCGCGGATAGTCTGGGCGGCGGC
ATGCTGTCCGCGCAGACAGCGTCGATTTCGTTCGACATCCCGCTGCGCGATGCGCGCGACGCATTCGAGCGCGCCTACTT
CGAATATCACCTCGCGCGCGAGAACGGCAGCATGACGCGCGTCGCGGAGAAGACGGGGCTCGAACGGACTCACCTGTATC
GCAAGCTCAAGCAGCTCGGCGTCGATCTCGGCAAGAACAAGGGCGAGTGA

Upstream 100 bases:

>100_bases
CAAGGCTGCGGCGCCCGGAAGCGGGCCGCAGGCGGCGCATGACAGCAGCGGCACGTCGCAGGGAAAGACAAAAGCAACAG
TGCAGACAAGGGCAGCTTAA

Downstream 100 bases:

>100_bases
CGCCGGGTGAATGAACGTCATTGAAGTTTTTTTCGCGAAGGGCTTGAGGAACGCAAAACTGCTTGCTATACTCTCGCTTC
TTCGTTGGCCCGGTAGCTCA

Product: two component Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 229; Mature: 228

Protein sequence:

>229_residues
MATILVVDDEMGIRELLSEILSDEGHVVEVAENAQEARDYRQRLAPDLVLLDIWMPDTDGVTLLKEWAAQGTLTMPVIMM
SGHATIDTAVEATKIGALNFLEKPIALQKLLKAVEQGLARGSAAPAAGGMAAKPPMAANASAVASAAALPMMSADSLGGG
MLSAQTASISFDIPLRDARDAFERAYFEYHLARENGSMTRVAEKTGLERTHLYRKLKQLGVDLGKNKGE

Sequences:

>Translated_229_residues
MATILVVDDEMGIRELLSEILSDEGHVVEVAENAQEARDYRQRLAPDLVLLDIWMPDTDGVTLLKEWAAQGTLTMPVIMM
SGHATIDTAVEATKIGALNFLEKPIALQKLLKAVEQGLARGSAAPAAGGMAAKPPMAANASAVASAAALPMMSADSLGGG
MLSAQTASISFDIPLRDARDAFERAYFEYHLARENGSMTRVAEKTGLERTHLYRKLKQLGVDLGKNKGE
>Mature_228_residues
ATILVVDDEMGIRELLSEILSDEGHVVEVAENAQEARDYRQRLAPDLVLLDIWMPDTDGVTLLKEWAAQGTLTMPVIMMS
GHATIDTAVEATKIGALNFLEKPIALQKLLKAVEQGLARGSAAPAAGGMAAKPPMAANASAVASAAALPMMSADSLGGGM
LSAQTASISFDIPLRDARDAFERAYFEYHLARENGSMTRVAEKTGLERTHLYRKLKQLGVDLGKNKGE

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=115, Percent_Identity=40, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1790437, Length=174, Percent_Identity=32.7586206896552, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1787375, Length=138, Percent_Identity=27.536231884058, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790299, Length=116, Percent_Identity=35.3448275862069, Blast_Score=70, Evalue=8e-14,
Organism=Escherichia coli, GI1786784, Length=124, Percent_Identity=33.8709677419355, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1786911, Length=129, Percent_Identity=32.5581395348837, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789809, Length=117, Percent_Identity=30.7692307692308, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1788905, Length=123, Percent_Identity=35.7723577235772, Blast_Score=61, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 24506; Mature: 24375

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATILVVDDEMGIRELLSEILSDEGHVVEVAENAQEARDYRQRLAPDLVLLDIWMPDTDG
CEEEEEEECCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHCCCCEEEEEEECCCCCC
VTLLKEWAAQGTLTMPVIMMSGHATIDTAVEATKIGALNFLEKPIALQKLLKAVEQGLAR
HHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHC
GSAAPAAGGMAAKPPMAANASAVASAAALPMMSADSLGGGMLSAQTASISFDIPLRDARD
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECCCHHHHH
AFERAYFEYHLARENGSMTRVAEKTGLERTHLYRKLKQLGVDLGKNKGE
HHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
ATILVVDDEMGIRELLSEILSDEGHVVEVAENAQEARDYRQRLAPDLVLLDIWMPDTDG
EEEEEEECCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHCCCCEEEEEEECCCCCC
VTLLKEWAAQGTLTMPVIMMSGHATIDTAVEATKIGALNFLEKPIALQKLLKAVEQGLAR
HHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHC
GSAAPAAGGMAAKPPMAANASAVASAAALPMMSADSLGGGMLSAQTASISFDIPLRDARD
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEEEECCCHHHHH
AFERAYFEYHLARENGSMTRVAEKTGLERTHLYRKLKQLGVDLGKNKGE
HHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]