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The map label for this gene is acsA

Identifier: 183222790

GI number: 183222790

Start: 3570278

End: 3572242

Strand: Reverse

Name: acsA

Synonym: LEPBI_I3450

Alternate gene names: 183222790

Gene position: 3572242-3570278 (Counterclockwise)

Preceding gene: 183222791

Following gene: 183222788

Centisome position: 99.24

GC content: 44.89

Gene sequence:

>1965_bases
ATGCCGAAAGAAAGAATCGTGGCACCATCCAAAGAATTTGCCAAACTTGCAAACGTTAGCTTAAAAGAATACAAATCCAA
ATACAAAGAATCCATTGAAAAACCAGAGAAATTTTGGGCAGAACAAGCAAAACGCCTAACATGGTTTAAAAAATGGACCA
AAGTTCTGAGACACGACTTTGCAAAAGCAAAAGTAGAATGGTTTGTGGGGGGAAAACTCAATGTCTCTTATAATTGTTTA
GACCGCCACCTTGACTCTCCCTTAAAAAACAAAGCCGCTCTCATATGGGAAGGTGACAATCCCGACGAATCCAAAGTCCT
CACCTATCACGACTTACATAGAGAAGTGAATCACTTTGCCAATGTACTAAAAAAATTCAAAGTGAAGAAAGGAGACCGAG
TTCTCATCTACCTTCCGATGGTCCCAGAACTTGCCATCGCCACACTTGCTTGTACTCGCATCGGGGCCGTGCATTCCGTT
GTCTTTGGGGGATTTTCTCCAGAAGCACTCCTTGGTCGTATCGAAGATTGTAAACCAACTCTTGTCATCACAGCCGATGG
TGGATACCGTGGTGGCAAACCCATCGAACTGAAAAAAAATGTCGATGCTGCCCTCGCTGAAACCAAATTCAAAGTGAATG
ATGTGATTGTCGTCAAACGAACGGGTGATGAAGGCAATCTCAATTGGAAAGAAGGTCGTGACCATTGGTATCACTACCTC
ATGAAAGACCCTGAAGTGAAAAAAGAATGCCCCGCTGTTCCTATGGAATCGGAAGACCCACTCTTCATCCTTTACACATC
TGGTTCCACGGGAAAACCAAAAGGGGTCCTCCATACCACCGCCGGGTATTTGTTAGGTGCCAATCTAACATTCGCTACTA
TCTTTGATTACAAAGACACGGATACATACTGGTGTACGGCAGACATTGGTTGGATCACGGGTCATAGTTATATATTGTAT
GGACCACTCTCCAATGGTGCTACTTCCTTGATGTTCGAAGGGGTTCCGAGTTACCCTGACATGGGTCGATTTTGGGATGT
GATTGATAAATACAAAGTCACCGTATTTTATACCGCACCGACGGCCATTCGGGCACTCATGCGAGAAGGTCTAGAGCATA
TCAAAAAGCGATCACTCGCATCACTGCGGTTACTTGGTTCTGTGGGAGAACCCATTAACCCAGAAGCTTGGGAATGGTAT
TATGCTAATATTGGAAAATCGAAATGCCCGATTGTGGATACATGGTGGCAAACAGAAACTGGATCCATTATGATCTCAGG
GATTCCGGGAGCCATTCCGCAAAAACCAGGATCGGCCAGTTGGCCATTTTATGGAATCCAACCAGTACTTGTGGACAACG
AAGGGGTGGAACTGAAAGGCAAAGGTGAAATTTCAGGCAATCTTTGTATCGCGAAACCTTGGCCTTCGATGATGCGCGGA
GTGTATGGAGATCCGAAACGATTCTTTGATACCTACTTCTCTCAATTCAAAGGCTATTATTTCACAGGGGATGGGGCCAA
TCGTGATAAAGAAGGATACTTTCGCATCACAGGGCGAGTCGATGATGTCCTCAATGTCTCAGGGCATCGGATTGGATCGG
CAGAAGTGGAAAGTGCCCTTGTGGAACACAAATCGGTGGCGGAAGCGGCTGTTGTGGGTTTCCCACATGACATCAAAGGC
CAGGGAATTTATGCCTATGTCACGGTGAAACAAGGGGTTGTCACAAACGACCTACTGAAAAAAGAACTCATTGCGATGGT
GGAAAAGGTGATTGGAAAAATAGCGAGGCCAGATGTGATCCATTGGGCCCCAGGACTTCCTAAAACTCGGTCTGGTAAAA
TCATGCGTCGAATTTTACGGAAGATTGCCAATAACGAATTTGATACGTTAGGTGACATTAGTACACTTGCCGATCCATCC
GTTGTCCAATCGTTAATTGATGATAAGAAGAAATACCATAGTTAA

Upstream 100 bases:

>100_bases
GAACCGGATCGCACTAAGTTCAATTTTTAAATTCTTTTTTTTCGATTCATGCTGGACTTTTTTTTAAAAAAGTTCAGTCT
TTCTCCACTAGAGGGACACA

Downstream 100 bases:

>100_bases
GAGAAATGACAGAGTAGATTGATTTCCTAACTTTGCATTTCTCAAGGCGTTGGTTAGGAAATTTTTTGAATCAGAAGGTA
TAATCAAAAATTACGAATGT

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme

Number of amino acids: Translated: 654; Mature: 653

Protein sequence:

>654_residues
MPKERIVAPSKEFAKLANVSLKEYKSKYKESIEKPEKFWAEQAKRLTWFKKWTKVLRHDFAKAKVEWFVGGKLNVSYNCL
DRHLDSPLKNKAALIWEGDNPDESKVLTYHDLHREVNHFANVLKKFKVKKGDRVLIYLPMVPELAIATLACTRIGAVHSV
VFGGFSPEALLGRIEDCKPTLVITADGGYRGGKPIELKKNVDAALAETKFKVNDVIVVKRTGDEGNLNWKEGRDHWYHYL
MKDPEVKKECPAVPMESEDPLFILYTSGSTGKPKGVLHTTAGYLLGANLTFATIFDYKDTDTYWCTADIGWITGHSYILY
GPLSNGATSLMFEGVPSYPDMGRFWDVIDKYKVTVFYTAPTAIRALMREGLEHIKKRSLASLRLLGSVGEPINPEAWEWY
YANIGKSKCPIVDTWWQTETGSIMISGIPGAIPQKPGSASWPFYGIQPVLVDNEGVELKGKGEISGNLCIAKPWPSMMRG
VYGDPKRFFDTYFSQFKGYYFTGDGANRDKEGYFRITGRVDDVLNVSGHRIGSAEVESALVEHKSVAEAAVVGFPHDIKG
QGIYAYVTVKQGVVTNDLLKKELIAMVEKVIGKIARPDVIHWAPGLPKTRSGKIMRRILRKIANNEFDTLGDISTLADPS
VVQSLIDDKKKYHS

Sequences:

>Translated_654_residues
MPKERIVAPSKEFAKLANVSLKEYKSKYKESIEKPEKFWAEQAKRLTWFKKWTKVLRHDFAKAKVEWFVGGKLNVSYNCL
DRHLDSPLKNKAALIWEGDNPDESKVLTYHDLHREVNHFANVLKKFKVKKGDRVLIYLPMVPELAIATLACTRIGAVHSV
VFGGFSPEALLGRIEDCKPTLVITADGGYRGGKPIELKKNVDAALAETKFKVNDVIVVKRTGDEGNLNWKEGRDHWYHYL
MKDPEVKKECPAVPMESEDPLFILYTSGSTGKPKGVLHTTAGYLLGANLTFATIFDYKDTDTYWCTADIGWITGHSYILY
GPLSNGATSLMFEGVPSYPDMGRFWDVIDKYKVTVFYTAPTAIRALMREGLEHIKKRSLASLRLLGSVGEPINPEAWEWY
YANIGKSKCPIVDTWWQTETGSIMISGIPGAIPQKPGSASWPFYGIQPVLVDNEGVELKGKGEISGNLCIAKPWPSMMRG
VYGDPKRFFDTYFSQFKGYYFTGDGANRDKEGYFRITGRVDDVLNVSGHRIGSAEVESALVEHKSVAEAAVVGFPHDIKG
QGIYAYVTVKQGVVTNDLLKKELIAMVEKVIGKIARPDVIHWAPGLPKTRSGKIMRRILRKIANNEFDTLGDISTLADPS
VVQSLIDDKKKYHS
>Mature_653_residues
PKERIVAPSKEFAKLANVSLKEYKSKYKESIEKPEKFWAEQAKRLTWFKKWTKVLRHDFAKAKVEWFVGGKLNVSYNCLD
RHLDSPLKNKAALIWEGDNPDESKVLTYHDLHREVNHFANVLKKFKVKKGDRVLIYLPMVPELAIATLACTRIGAVHSVV
FGGFSPEALLGRIEDCKPTLVITADGGYRGGKPIELKKNVDAALAETKFKVNDVIVVKRTGDEGNLNWKEGRDHWYHYLM
KDPEVKKECPAVPMESEDPLFILYTSGSTGKPKGVLHTTAGYLLGANLTFATIFDYKDTDTYWCTADIGWITGHSYILYG
PLSNGATSLMFEGVPSYPDMGRFWDVIDKYKVTVFYTAPTAIRALMREGLEHIKKRSLASLRLLGSVGEPINPEAWEWYY
ANIGKSKCPIVDTWWQTETGSIMISGIPGAIPQKPGSASWPFYGIQPVLVDNEGVELKGKGEISGNLCIAKPWPSMMRGV
YGDPKRFFDTYFSQFKGYYFTGDGANRDKEGYFRITGRVDDVLNVSGHRIGSAEVESALVEHKSVAEAAVVGFPHDIKGQ
GIYAYVTVKQGVVTNDLLKKELIAMVEKVIGKIARPDVIHWAPGLPKTRSGKIMRRILRKIANNEFDTLGDISTLADPSV
VQSLIDDKKKYHS

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family

Homologues:

Organism=Homo sapiens, GI8923896, Length=677, Percent_Identity=50.96011816839, Blast_Score=677, Evalue=0.0,
Organism=Homo sapiens, GI253970489, Length=690, Percent_Identity=50, Blast_Score=672, Evalue=0.0,
Organism=Homo sapiens, GI28416953, Length=638, Percent_Identity=48.4326018808777, Blast_Score=605, Evalue=1e-173,
Organism=Homo sapiens, GI13375727, Length=634, Percent_Identity=36.1198738170347, Blast_Score=401, Evalue=1e-111,
Organism=Homo sapiens, GI42544132, Length=575, Percent_Identity=30.2608695652174, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI38505220, Length=526, Percent_Identity=30.6083650190114, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI115511026, Length=535, Percent_Identity=28.2242990654206, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI31982927, Length=621, Percent_Identity=24.7987117552335, Blast_Score=176, Evalue=7e-44,
Organism=Homo sapiens, GI58082049, Length=562, Percent_Identity=27.7580071174377, Blast_Score=169, Evalue=6e-42,
Organism=Homo sapiens, GI122937307, Length=534, Percent_Identity=29.5880149812734, Blast_Score=169, Evalue=1e-41,
Organism=Homo sapiens, GI157311624, Length=560, Percent_Identity=27.5, Blast_Score=159, Evalue=7e-39,
Organism=Homo sapiens, GI157311622, Length=560, Percent_Identity=27.5, Blast_Score=159, Evalue=7e-39,
Organism=Homo sapiens, GI42544134, Length=392, Percent_Identity=27.8061224489796, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI195947378, Length=500, Percent_Identity=23.8, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI187761345, Length=391, Percent_Identity=25.5754475703325, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI187761343, Length=391, Percent_Identity=25.5754475703325, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI156151445, Length=385, Percent_Identity=25.1948051948052, Blast_Score=80, Evalue=8e-15,
Organism=Escherichia coli, GI1790505, Length=635, Percent_Identity=58.2677165354331, Blast_Score=747, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=634, Percent_Identity=38.1703470031546, Blast_Score=417, Evalue=1e-117,
Organism=Escherichia coli, GI221142682, Length=544, Percent_Identity=23.7132352941176, Blast_Score=121, Evalue=2e-28,
Organism=Escherichia coli, GI1786810, Length=527, Percent_Identity=22.7703984819734, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1788107, Length=565, Percent_Identity=23.3628318584071, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI145693145, Length=518, Percent_Identity=22.5868725868726, Blast_Score=101, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71983001, Length=655, Percent_Identity=50.381679389313, Blast_Score=624, Evalue=1e-179,
Organism=Caenorhabditis elegans, GI71982997, Length=664, Percent_Identity=49.6987951807229, Blast_Score=622, Evalue=1e-178,
Organism=Caenorhabditis elegans, GI17569507, Length=627, Percent_Identity=21.5311004784689, Blast_Score=128, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17558820, Length=533, Percent_Identity=24.202626641651, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI32563687, Length=528, Percent_Identity=21.969696969697, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17557194, Length=578, Percent_Identity=24.7404844290657, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17538037, Length=574, Percent_Identity=23.5191637630662, Blast_Score=89, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17559526, Length=548, Percent_Identity=22.8102189781022, Blast_Score=86, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6323182, Length=641, Percent_Identity=49.4539781591264, Blast_Score=625, Evalue=1e-180,
Organism=Saccharomyces cerevisiae, GI6319264, Length=647, Percent_Identity=49.9227202472952, Blast_Score=596, Evalue=1e-171,
Organism=Saccharomyces cerevisiae, GI6319699, Length=367, Percent_Identity=25.8855585831063, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24667955, Length=670, Percent_Identity=53.8805970149254, Blast_Score=692, Evalue=0.0,
Organism=Drosophila melanogaster, GI62472339, Length=566, Percent_Identity=57.9505300353357, Blast_Score=640, Evalue=0.0,
Organism=Drosophila melanogaster, GI24667959, Length=524, Percent_Identity=58.0152671755725, Blast_Score=598, Evalue=1e-171,
Organism=Drosophila melanogaster, GI21355225, Length=628, Percent_Identity=35.5095541401274, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI18859661, Length=534, Percent_Identity=23.7827715355805, Blast_Score=100, Evalue=6e-21,
Organism=Drosophila melanogaster, GI21355181, Length=531, Percent_Identity=25.2354048964218, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24648260, Length=374, Percent_Identity=26.7379679144385, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24656500, Length=522, Percent_Identity=22.2222222222222, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21358303, Length=500, Percent_Identity=22.6, Blast_Score=71, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACSA_LEPBA (B0S8X7)

Other databases:

- EMBL:   CP000777
- RefSeq:   YP_001964376.1
- ProteinModelPortal:   B0S8X7
- SMR:   B0S8X7
- GeneID:   6390134
- GenomeReviews:   CP000777_GR
- KEGG:   lbf:LBF_3332
- HOGENOM:   HBG547964
- OMA:   ILACTRI
- ProtClustDB:   PRK00174
- BioCyc:   LBIF355278:LBF_3332-MONOMER
- HAMAP:   MF_01123
- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873
- TIGRFAMs:   TIGR02188

Pfam domain/function: PF00501 AMP-binding

EC number: =6.2.1.1

Molecular weight: Translated: 73319; Mature: 73188

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: PS00455 AMP_BINDING

Important sites: ACT_SITE 521-521

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKERIVAPSKEFAKLANVSLKEYKSKYKESIEKPEKFWAEQAKRLTWFKKWTKVLRHDF
CCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AKAKVEWFVGGKLNVSYNCLDRHLDSPLKNKAALIWEGDNPDESKVLTYHDLHREVNHFA
HHCEEEEEECCEEEEEHHHHHHHCCCCCCCCEEEEECCCCCCCCCEEEHHHHHHHHHHHH
NVLKKFKVKKGDRVLIYLPMVPELAIATLACTRIGAVHSVVFGGFSPEALLGRIEDCKPT
HHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCE
LVITADGGYRGGKPIELKKNVDAALAETKFKVNDVIVVKRTGDEGNLNWKEGRDHWYHYL
EEEEECCCCCCCCCEEECCCCCHHHHHCEEEECEEEEEEECCCCCCCCCCCCCCHHHHHH
MKDPEVKKECPAVPMESEDPLFILYTSGSTGKPKGVLHTTAGYLLGANLTFATIFDYKDT
CCCCCHHHHCCCCCCCCCCCEEEEEECCCCCCCCCEEEECCCCEEECCCEEEEEEECCCC
DTYWCTADIGWITGHSYILYGPLSNGATSLMFEGVPSYPDMGRFWDVIDKYKVTVFYTAP
CCEEEEEECCEEECCCEEEEECCCCCCCEEEECCCCCCCCCHHHHHHHCCEEEEEEEECH
TAIRALMREGLEHIKKRSLASLRLLGSVGEPINPEAWEWYYANIGKSKCPIVDTWWQTET
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCEEECCCCCCC
GSIMISGIPGAIPQKPGSASWPFYGIQPVLVDNEGVELKGKGEISGNLCIAKPWPSMMRG
CCEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEECCCCCCCEEEECCCHHHHHC
VYGDPKRFFDTYFSQFKGYYFTGDGANRDKEGYFRITGRVDDVLNVSGHRIGSAEVESAL
CCCCHHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHH
VEHKSVAEAAVVGFPHDIKGQGIYAYVTVKQGVVTNDLLKKELIAMVEKVIGKIARPDVI
HHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCEE
HWAPGLPKTRSGKIMRRILRKIANNEFDTLGDISTLADPSVVQSLIDDKKKYHS
EECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PKERIVAPSKEFAKLANVSLKEYKSKYKESIEKPEKFWAEQAKRLTWFKKWTKVLRHDF
CCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AKAKVEWFVGGKLNVSYNCLDRHLDSPLKNKAALIWEGDNPDESKVLTYHDLHREVNHFA
HHCEEEEEECCEEEEEHHHHHHHCCCCCCCCEEEEECCCCCCCCCEEEHHHHHHHHHHHH
NVLKKFKVKKGDRVLIYLPMVPELAIATLACTRIGAVHSVVFGGFSPEALLGRIEDCKPT
HHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCE
LVITADGGYRGGKPIELKKNVDAALAETKFKVNDVIVVKRTGDEGNLNWKEGRDHWYHYL
EEEEECCCCCCCCCEEECCCCCHHHHHCEEEECEEEEEEECCCCCCCCCCCCCCHHHHHH
MKDPEVKKECPAVPMESEDPLFILYTSGSTGKPKGVLHTTAGYLLGANLTFATIFDYKDT
CCCCCHHHHCCCCCCCCCCCEEEEEECCCCCCCCCEEEECCCCEEECCCEEEEEEECCCC
DTYWCTADIGWITGHSYILYGPLSNGATSLMFEGVPSYPDMGRFWDVIDKYKVTVFYTAP
CCEEEEEECCEEECCCEEEEECCCCCCCEEEECCCCCCCCCHHHHHHHCCEEEEEEEECH
TAIRALMREGLEHIKKRSLASLRLLGSVGEPINPEAWEWYYANIGKSKCPIVDTWWQTET
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCEEECCCCCCC
GSIMISGIPGAIPQKPGSASWPFYGIQPVLVDNEGVELKGKGEISGNLCIAKPWPSMMRG
CCEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEECCCCCCCEEEECCCHHHHHC
VYGDPKRFFDTYFSQFKGYYFTGDGANRDKEGYFRITGRVDDVLNVSGHRIGSAEVESAL
CCCCHHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHH
VEHKSVAEAAVVGFPHDIKGQGIYAYVTVKQGVVTNDLLKKELIAMVEKVIGKIARPDVI
HHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCEE
HWAPGLPKTRSGKIMRRILRKIANNEFDTLGDISTLADPSVVQSLIDDKKKYHS
EECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA