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The map label for this gene is galE [C]

Identifier: 183222606

GI number: 183222606

Start: 3374802

End: 3375722

Strand: Reverse

Name: galE [C]

Synonym: LEPBI_I3261

Alternate gene names: 183222606

Gene position: 3375722-3374802 (Counterclockwise)

Preceding gene: 183222611

Following gene: 183222603

Centisome position: 93.78

GC content: 38.22

Gene sequence:

>921_bases
ATGAAAAAAAAACAAACTTTAATCACCGGAGCCAGTGGATTTGTGGGAAGTTATCTCCTCCCTGCACTCAAAACCCATGG
TAGTTATGAAATTCATTGCTTTCAAGGTGACATTCGAAGCCGAGAAACCGTAGAGGATCAGTTAAAAAAAGTCCAACCAG
ATATTTTGATCCATTTAGCTGCCCAGGCATTTGTTCCCAATGCCATCGCGAATCCCTGGGAAACTGAAGAAATCAATGTT
GGCGGCACCTTAAATCTTTTAGAAATTTTACATCGATTACAAAAACCATGTAAGATGTTGTACGTTTCATCAGCTGATGT
TTACGGAAAACAAAACATGGATGTCCTTCCCTTGGAAGAGTCCTTATTGCCAAAACCAGTCAATCCTTATGCAGGAAGCA
AATTAGCAGCAGAATCATTTTGTCGGCAATACTCTGAATATAGTCCTTCTGTTTCCGTTGTGATCGCACGTCCCTTCAAT
CATATTGGGATCGGCCAAAGAAAAGAATTTGTGATTCCAAATTTTTGTTCGCAAATCATCGAAGCAAAATATGCGGGGAA
AAAAGAAATTTTAGTGGGTGATTTAGCACCGACTCGTGACTTTTCTCATGTGGAGGATATCGTTGCTGGTTATCTGACTC
TGATCGAAAGGGGAGAATCGGGAGAAATATATAACATTTGTTCTGGAGAAGAACGTAGCATCCGTTATATGGTAGAAGAA
CTCGTAAAATTTTCTGGCGAAAATATTAAATTTTTAGTAGATGAAAGCAGAGTTCGTTCCTCCGAAACATCTCGGGTGTA
TGGTAACAATCAAAAACTAAAATCGTTAGGGTGGAAAAACAAACATAGTTTGAGTGAAACTCTAAAGGAAATTTATGATC
ATTTGGAATCCGAATTTTTTAAATTCAAACAAACCGTTTGA

Upstream 100 bases:

>100_bases
TGTTTGTCTTCCACAGTTTTCTTTCTTTTGTTGAGAGGATTTGAAAAATTGGAAGAATGGCAACTAAATCTTAGGGTCAG
ATCAGAAAATTCCCTTTTCT

Downstream 100 bases:

>100_bases
ACTTCATTCCAAGTCTTATCAGAAACCACTTTTTTGATGTTCCCTTTTTTACCTTTCTGAATCAAAGTCTCTAATGTTTT
CATCCTTTCTTTTGTCGCGG

Product: putative epimerase/dehydratase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MKKKQTLITGASGFVGSYLLPALKTHGSYEIHCFQGDIRSRETVEDQLKKVQPDILIHLAAQAFVPNAIANPWETEEINV
GGTLNLLEILHRLQKPCKMLYVSSADVYGKQNMDVLPLEESLLPKPVNPYAGSKLAAESFCRQYSEYSPSVSVVIARPFN
HIGIGQRKEFVIPNFCSQIIEAKYAGKKEILVGDLAPTRDFSHVEDIVAGYLTLIERGESGEIYNICSGEERSIRYMVEE
LVKFSGENIKFLVDESRVRSSETSRVYGNNQKLKSLGWKNKHSLSETLKEIYDHLESEFFKFKQTV

Sequences:

>Translated_306_residues
MKKKQTLITGASGFVGSYLLPALKTHGSYEIHCFQGDIRSRETVEDQLKKVQPDILIHLAAQAFVPNAIANPWETEEINV
GGTLNLLEILHRLQKPCKMLYVSSADVYGKQNMDVLPLEESLLPKPVNPYAGSKLAAESFCRQYSEYSPSVSVVIARPFN
HIGIGQRKEFVIPNFCSQIIEAKYAGKKEILVGDLAPTRDFSHVEDIVAGYLTLIERGESGEIYNICSGEERSIRYMVEE
LVKFSGENIKFLVDESRVRSSETSRVYGNNQKLKSLGWKNKHSLSETLKEIYDHLESEFFKFKQTV
>Mature_306_residues
MKKKQTLITGASGFVGSYLLPALKTHGSYEIHCFQGDIRSRETVEDQLKKVQPDILIHLAAQAFVPNAIANPWETEEINV
GGTLNLLEILHRLQKPCKMLYVSSADVYGKQNMDVLPLEESLLPKPVNPYAGSKLAAESFCRQYSEYSPSVSVVIARPFN
HIGIGQRKEFVIPNFCSQIIEAKYAGKKEILVGDLAPTRDFSHVEDIVAGYLTLIERGESGEIYNICSGEERSIRYMVEE
LVKFSGENIKFLVDESRVRSSETSRVYGNNQKLKSLGWKNKHSLSETLKEIYDHLESEFFKFKQTV

Specific function: Galactose metabolism; third step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=332, Percent_Identity=30.1204819277108, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI42516563, Length=326, Percent_Identity=29.4478527607362, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI56237023, Length=338, Percent_Identity=25.4437869822485, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI56118217, Length=338, Percent_Identity=25.4437869822485, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI189083684, Length=338, Percent_Identity=25.4437869822485, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4504031, Length=349, Percent_Identity=24.3553008595989, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1786974, Length=336, Percent_Identity=25.5952380952381, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI1788366, Length=349, Percent_Identity=24.3553008595989, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788353, Length=337, Percent_Identity=23.7388724035608, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI48994969, Length=273, Percent_Identity=25.6410256410256, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788365, Length=318, Percent_Identity=25.7861635220126, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI133901786, Length=342, Percent_Identity=24.8538011695906, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17539422, Length=342, Percent_Identity=24.8538011695906, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI133901790, Length=342, Percent_Identity=24.8538011695906, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI133901788, Length=342, Percent_Identity=24.8538011695906, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17539424, Length=342, Percent_Identity=24.8538011695906, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71982035, Length=340, Percent_Identity=27.3529411764706, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71982038, Length=342, Percent_Identity=27.1929824561404, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17568069, Length=326, Percent_Identity=28.8343558282209, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17507723, Length=343, Percent_Identity=23.9067055393586, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17539532, Length=331, Percent_Identity=25.9818731117825, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI115532424, Length=261, Percent_Identity=27.2030651340996, Blast_Score=68, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6319493, Length=348, Percent_Identity=22.9885057471264, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21356223, Length=324, Percent_Identity=25.6172839506173, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19923002, Length=344, Percent_Identity=24.4186046511628, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 34542; Mature: 34542

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKQTLITGASGFVGSYLLPALKTHGSYEIHCFQGDIRSRETVEDQLKKVQPDILIHLA
CCCCCEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCHHHHHHHH
AQAFVPNAIANPWETEEINVGGTLNLLEILHRLQKPCKMLYVSSADVYGKQNMDVLPLEE
HHHHCCHHHCCCCCCCEECCCCCHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCEECCHH
SLLPKPVNPYAGSKLAAESFCRQYSEYSPSVSVVIARPFNHIGIGQRKEFVIPNFCSQII
HCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEECHHHHHHHH
EAKYAGKKEILVGDLAPTRDFSHVEDIVAGYLTLIERGESGEIYNICSGEERSIRYMVEE
HHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHH
LVKFSGENIKFLVDESRVRSSETSRVYGNNQKLKSLGWKNKHSLSETLKEIYDHLESEFF
HHHHCCCCEEEEEEHHHHCCCCCCHHCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
KFKQTV
HHHHCC
>Mature Secondary Structure
MKKKQTLITGASGFVGSYLLPALKTHGSYEIHCFQGDIRSRETVEDQLKKVQPDILIHLA
CCCCCEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCHHHHHHHH
AQAFVPNAIANPWETEEINVGGTLNLLEILHRLQKPCKMLYVSSADVYGKQNMDVLPLEE
HHHHCCHHHCCCCCCCEECCCCCHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCEECCHH
SLLPKPVNPYAGSKLAAESFCRQYSEYSPSVSVVIARPFNHIGIGQRKEFVIPNFCSQII
HCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCEECHHHHHHHH
EAKYAGKKEILVGDLAPTRDFSHVEDIVAGYLTLIERGESGEIYNICSGEERSIRYMVEE
HHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHH
LVKFSGENIKFLVDESRVRSSETSRVYGNNQKLKSLGWKNKHSLSETLKEIYDHLESEFF
HHHHCCCCEEEEEEHHHHCCCCCCHHCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
KFKQTV
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]