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The map label for this gene is trxA1 [H]

Identifier: 183222519

GI number: 183222519

Start: 3287096

End: 3287410

Strand: Reverse

Name: trxA1 [H]

Synonym: LEPBI_I3174

Alternate gene names: 183222519

Gene position: 3287410-3287096 (Counterclockwise)

Preceding gene: 183222521

Following gene: 183222518

Centisome position: 91.33

GC content: 40.32

Gene sequence:

>315_bases
ATGTCTGACATATACCCCAAAAGTTTTGAAACCTTACTCCAAACACATGACAAACCGATCCTCGTCGATTTTTGGGCACC
ATGGTGTGGACCTTGCAAAATGGTGGCACCTGAGTTGGAAAAACTTGCCAAAGACTGGAAGGGAAAAGTTTCCATCATCA
AAGTGAATACCGATGAAAAACAAGAGATCGCAGGCAAGTATGGAATATCAGGGATTCCGACGTTTATCTTATTTAAAAAT
GGGAAAGAGGTCCATCGTATTTCTGGTGCTATGCGAAGTGAAGAATTTAAGATAGTATTTGGTAGTTACCTTTAG

Upstream 100 bases:

>100_bases
GACCAGGAAATGAGACAGAAAACTACACACTTCTCATATTTTTTTACTGTTTTTCCATATACCCTGGTGGGTATATGGTC
TAATGGATAGGAGAGAGAAT

Downstream 100 bases:

>100_bases
CTATTAATTTTTTACTTGAACCATCCAAAAGAGTATTGGATTCTTTGTTTCTCTGAGGTGAACCTTCTTGAAAAAAACAA
TCTTAGCTCTTTTGTCATTT

Product: thioredoxin 1

Products: NA

Alternate protein names: Trx-1; Thioredoxin-M [H]

Number of amino acids: Translated: 104; Mature: 103

Protein sequence:

>104_residues
MSDIYPKSFETLLQTHDKPILVDFWAPWCGPCKMVAPELEKLAKDWKGKVSIIKVNTDEKQEIAGKYGISGIPTFILFKN
GKEVHRISGAMRSEEFKIVFGSYL

Sequences:

>Translated_104_residues
MSDIYPKSFETLLQTHDKPILVDFWAPWCGPCKMVAPELEKLAKDWKGKVSIIKVNTDEKQEIAGKYGISGIPTFILFKN
GKEVHRISGAMRSEEFKIVFGSYL
>Mature_103_residues
SDIYPKSFETLLQTHDKPILVDFWAPWCGPCKMVAPELEKLAKDWKGKVSIIKVNTDEKQEIAGKYGISGIPTFILFKNG
KEVHRISGAMRSEEFKIVFGSYL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=89, Percent_Identity=35.9550561797753, Blast_Score=76, Evalue=7e-15,
Organism=Homo sapiens, GI21361657, Length=70, Percent_Identity=44.2857142857143, Blast_Score=70, Evalue=4e-13,
Organism=Homo sapiens, GI50592994, Length=83, Percent_Identity=38.5542168674699, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI20070125, Length=77, Percent_Identity=41.5584415584416, Blast_Score=67, Evalue=4e-12,
Organism=Homo sapiens, GI95113651, Length=93, Percent_Identity=38.7096774193548, Blast_Score=65, Evalue=1e-11,
Organism=Homo sapiens, GI4758304, Length=66, Percent_Identity=40.9090909090909, Blast_Score=63, Evalue=5e-11,
Organism=Homo sapiens, GI5031973, Length=80, Percent_Identity=35, Blast_Score=63, Evalue=5e-11,
Organism=Escherichia coli, GI87082331, Length=90, Percent_Identity=48.8888888888889, Blast_Score=99, Evalue=8e-23,
Organism=Escherichia coli, GI1788936, Length=89, Percent_Identity=46.0674157303371, Blast_Score=93, Evalue=4e-21,
Organism=Escherichia coli, GI87081747, Length=95, Percent_Identity=31.5789473684211, Blast_Score=62, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI212646193, Length=78, Percent_Identity=42.3076923076923, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71980562, Length=91, Percent_Identity=39.5604395604396, Blast_Score=79, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71980565, Length=88, Percent_Identity=40.9090909090909, Blast_Score=78, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI71998175, Length=78, Percent_Identity=44.8717948717949, Blast_Score=75, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17507705, Length=74, Percent_Identity=40.5405405405405, Blast_Score=75, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17509965, Length=76, Percent_Identity=38.1578947368421, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17507915, Length=90, Percent_Identity=36.6666666666667, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17510299, Length=73, Percent_Identity=39.7260273972603, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI25144092, Length=71, Percent_Identity=42.2535211267606, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6321648, Length=82, Percent_Identity=43.9024390243902, Blast_Score=84, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6323072, Length=76, Percent_Identity=46.0526315789474, Blast_Score=82, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319925, Length=82, Percent_Identity=40.2439024390244, Blast_Score=72, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324862, Length=81, Percent_Identity=35.8024691358025, Blast_Score=66, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6319806, Length=74, Percent_Identity=37.8378378378378, Blast_Score=60, Evalue=6e-11,
Organism=Drosophila melanogaster, GI28573567, Length=91, Percent_Identity=38.4615384615385, Blast_Score=86, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24639826, Length=73, Percent_Identity=41.0958904109589, Blast_Score=84, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17648013, Length=79, Percent_Identity=43.0379746835443, Blast_Score=83, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24583090, Length=79, Percent_Identity=43.0379746835443, Blast_Score=83, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24664269, Length=64, Percent_Identity=43.75, Blast_Score=79, Evalue=6e-16,
Organism=Drosophila melanogaster, GI17530795, Length=74, Percent_Identity=32.4324324324324, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21358065, Length=91, Percent_Identity=31.8681318681319, Blast_Score=69, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24658597, Length=79, Percent_Identity=39.2405063291139, Blast_Score=69, Evalue=7e-13,
Organism=Drosophila melanogaster, GI19921434, Length=81, Percent_Identity=37.037037037037, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11822; Mature: 11691

Theoretical pI: Translated: 8.70; Mature: 8.70

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDIYPKSFETLLQTHDKPILVDFWAPWCGPCKMVAPELEKLAKDWKGKVSIIKVNTDEK
CCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCH
QEIAGKYGISGIPTFILFKNGKEVHRISGAMRSEEFKIVFGSYL
HHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCEEEEECCCC
>Mature Secondary Structure 
SDIYPKSFETLLQTHDKPILVDFWAPWCGPCKMVAPELEKLAKDWKGKVSIIKVNTDEK
CCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCCCH
QEIAGKYGISGIPTFILFKNGKEVHRISGAMRSEEFKIVFGSYL
HHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3096973; 3926769 [H]