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The map label for this gene is sdhA [H]

Identifier: 183222481

GI number: 183222481

Start: 3246980

End: 3248938

Strand: Reverse

Name: sdhA [H]

Synonym: LEPBI_I3136

Alternate gene names: 183222481

Gene position: 3248938-3246980 (Counterclockwise)

Preceding gene: 183222482

Following gene: 183222479

Centisome position: 90.26

GC content: 38.39

Gene sequence:

>1959_bases
TTGAGTATAGCTGAAATGGTTGGAAACGAGGGAAAGTCATTTCCTTGGAATGCTAAAATTCCAGATGGTCCATTGGAAGA
AAAATGGAATCTCTTTAAAAGGAATTCCAGATTAATTTCACCTAACAACAGAAAGAAGTTTAAAATCATTGTTGTGGGCA
CTGGCCTTTCTGGGAGTGCAGCAGCAGCAACACTCGCTGAACAAGGATACCAAGTTTCATCTTTTTGTTTTCATGAATCA
GCGAGGCGTGCCCATTCTATTGCCGCTCAAGGTGGAGTGAATGCGGCAAAAAATTATAAAAATGACGGGGACAGTGTCAT
CCGCATGTTTCGTGATACCTTAAAAGGTGGAGACTTTCGCTCGCGTGAGGCAAACGTTTATCGATTAGCAGAATGTTCGA
TCCCTTTTATCGATCTTGCGGTTTCACAAGGAGTTCCTTTTAATCGAGAGTATGGTGGTTATTTAGAGAATCGTTCTTTC
GGTGGAGTACAAGTGAGTCGAACCTTTTATTCGAAAGGTCAAACTGGTCAACAATTGTTACTTGGTGCCTACCAAACAAT
GATGCGACAAGTTCATCTCGGCAAAGTACAATTGTATACCAATGTTGAACTTTTGGATTACATCATCATTGATGGTCATG
CTAAGGGAATTGTTGTTAGAAATTTACTAAATGGAGAATTGGAAAAACATTCAGCTCATGCGATTGTTGTTGCATCTGGC
GGATTTGGTAAAATCTATTATCTTTCCACATTAGCTTTAGGTTGCAATGCAACAGCAGTTTGGCGAGCTCATAAAAAGGG
TGCTTTATTTGCAAATCCGAGTTGGACTCAAATCCATCCTACGTCCCTGCCACAAACCAACAGTTATCAATCCAAACTTA
CTTTAATGTCCGAATCATTACGAAATGATGGTAGGATTTGGGTACCCAAGTCAAAAGATGAGAAGAGACCTCCCGCAGAG
ATTCCGGAAGAAGAAAGGGATTACTATCTAGAAAGAAAATATCCTTCTTATGGTAATTTAGCGCCCAGGGACATCTCCTC
CCGTGCAGCAAAAGAGAGAATTGATTTGGGATTTGGTGTTGGCCCACTTAAGAATGCAGTCTATCTAGATTTTAAAGACG
CAAAAAAAACATTGGGAGAAGAAGTATTAAGGGCACGGTATGGCAATCTTTTTGATATGTACAAAAAAATAACCGATGTA
GATCCGTTAACCGAACCTATGTTAATTTCTCCATCTGCTCATTTTTCTATGGGCGGATTGTGGGTTGATTATGAGTTAAT
GACAAATGTTCCAGGACTTTATGCGATAGGAGAAGCAAATTTCGCTGATCATGGTGCGAATCGATTAGGAGCAAATTCAC
TATTACAAGCGTCAGTCGATGGTTATTTTATTCTACCGGCAACTCTTCCAAATTATCTTTATGACAAAGTAGATTCTAAT
CTTGTTTCCACTGATCACCCTAGTTTTAAAGAAGCAGAAGAAACGATCCAAAAAGAAATTCAATTTTATACAAATGCAAA
TGGGAAAAAGCTTATAGATGAATACCATAAAGAATTAGGCAAAATTCTATACGATTCGTGTGGTCTTAAACGTTCCAAAT
CTGAATTAGAATCGGCAGTTAAAACAATCCAAAATTTAAGAAATGAATTTTTATCCGGAAATATAAGGATTCCAAGTGAC
TCGTTTACAAAAAATGCAGAATTAGAGAAAGCGGGTAGAATGAAAGACTATCTGGAGTTAGCCGAACTTATGTGTTTGGA
TGCACTTCTGAGAGAAGAATCATGTGGTGCACATTTTCGGATCGAGCATCAAACAGAAGATGGCGAAGCCAAGAGAGATG
ACAAAAACTTTCAGTTTGTTTCTTGTTTTGAATGGTCGGGCGATGCATCAAGACCAATTTTACACAGAGAACCATTATCA
TTTGAATTTTTTTTACCACAAAACAGAGACTATCAATAA

Upstream 100 bases:

>100_bases
GATGTGGAAAATTTCCCAGCATTCATCGTAGTTGATGACAAAGGGAATGACTTTTTCCAGATGTTGCATTGATAGAAAAC
AACACAATTTATCTTCATGA

Downstream 100 bases:

>100_bases
TCAAAAAATCAATCATTCTGAAGTTTTTGATTCCCTAAAAATTCTTCTCTCCAATACGCGACACCACCATACCCAAGGCG
ACGGCTTTCTTTTTTCCAAT

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 652; Mature: 651

Protein sequence:

>652_residues
MSIAEMVGNEGKSFPWNAKIPDGPLEEKWNLFKRNSRLISPNNRKKFKIIVVGTGLSGSAAAATLAEQGYQVSSFCFHES
ARRAHSIAAQGGVNAAKNYKNDGDSVIRMFRDTLKGGDFRSREANVYRLAECSIPFIDLAVSQGVPFNREYGGYLENRSF
GGVQVSRTFYSKGQTGQQLLLGAYQTMMRQVHLGKVQLYTNVELLDYIIIDGHAKGIVVRNLLNGELEKHSAHAIVVASG
GFGKIYYLSTLALGCNATAVWRAHKKGALFANPSWTQIHPTSLPQTNSYQSKLTLMSESLRNDGRIWVPKSKDEKRPPAE
IPEEERDYYLERKYPSYGNLAPRDISSRAAKERIDLGFGVGPLKNAVYLDFKDAKKTLGEEVLRARYGNLFDMYKKITDV
DPLTEPMLISPSAHFSMGGLWVDYELMTNVPGLYAIGEANFADHGANRLGANSLLQASVDGYFILPATLPNYLYDKVDSN
LVSTDHPSFKEAEETIQKEIQFYTNANGKKLIDEYHKELGKILYDSCGLKRSKSELESAVKTIQNLRNEFLSGNIRIPSD
SFTKNAELEKAGRMKDYLELAELMCLDALLREESCGAHFRIEHQTEDGEAKRDDKNFQFVSCFEWSGDASRPILHREPLS
FEFFLPQNRDYQ

Sequences:

>Translated_652_residues
MSIAEMVGNEGKSFPWNAKIPDGPLEEKWNLFKRNSRLISPNNRKKFKIIVVGTGLSGSAAAATLAEQGYQVSSFCFHES
ARRAHSIAAQGGVNAAKNYKNDGDSVIRMFRDTLKGGDFRSREANVYRLAECSIPFIDLAVSQGVPFNREYGGYLENRSF
GGVQVSRTFYSKGQTGQQLLLGAYQTMMRQVHLGKVQLYTNVELLDYIIIDGHAKGIVVRNLLNGELEKHSAHAIVVASG
GFGKIYYLSTLALGCNATAVWRAHKKGALFANPSWTQIHPTSLPQTNSYQSKLTLMSESLRNDGRIWVPKSKDEKRPPAE
IPEEERDYYLERKYPSYGNLAPRDISSRAAKERIDLGFGVGPLKNAVYLDFKDAKKTLGEEVLRARYGNLFDMYKKITDV
DPLTEPMLISPSAHFSMGGLWVDYELMTNVPGLYAIGEANFADHGANRLGANSLLQASVDGYFILPATLPNYLYDKVDSN
LVSTDHPSFKEAEETIQKEIQFYTNANGKKLIDEYHKELGKILYDSCGLKRSKSELESAVKTIQNLRNEFLSGNIRIPSD
SFTKNAELEKAGRMKDYLELAELMCLDALLREESCGAHFRIEHQTEDGEAKRDDKNFQFVSCFEWSGDASRPILHREPLS
FEFFLPQNRDYQ
>Mature_651_residues
SIAEMVGNEGKSFPWNAKIPDGPLEEKWNLFKRNSRLISPNNRKKFKIIVVGTGLSGSAAAATLAEQGYQVSSFCFHESA
RRAHSIAAQGGVNAAKNYKNDGDSVIRMFRDTLKGGDFRSREANVYRLAECSIPFIDLAVSQGVPFNREYGGYLENRSFG
GVQVSRTFYSKGQTGQQLLLGAYQTMMRQVHLGKVQLYTNVELLDYIIIDGHAKGIVVRNLLNGELEKHSAHAIVVASGG
FGKIYYLSTLALGCNATAVWRAHKKGALFANPSWTQIHPTSLPQTNSYQSKLTLMSESLRNDGRIWVPKSKDEKRPPAEI
PEEERDYYLERKYPSYGNLAPRDISSRAAKERIDLGFGVGPLKNAVYLDFKDAKKTLGEEVLRARYGNLFDMYKKITDVD
PLTEPMLISPSAHFSMGGLWVDYELMTNVPGLYAIGEANFADHGANRLGANSLLQASVDGYFILPATLPNYLYDKVDSNL
VSTDHPSFKEAEETIQKEIQFYTNANGKKLIDEYHKELGKILYDSCGLKRSKSELESAVKTIQNLRNEFLSGNIRIPSDS
FTKNAELEKAGRMKDYLELAELMCLDALLREESCGAHFRIEHQTEDGEAKRDDKNFQFVSCFEWSGDASRPILHREPLSF
EFFLPQNRDYQ

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=586, Percent_Identity=26.6211604095563, Blast_Score=152, Evalue=1e-36,
Organism=Escherichia coli, GI1790597, Length=543, Percent_Identity=28.9134438305709, Blast_Score=213, Evalue=3e-56,
Organism=Escherichia coli, GI1786942, Length=632, Percent_Identity=26.1075949367089, Blast_Score=135, Evalue=7e-33,
Organism=Escherichia coli, GI1788928, Length=577, Percent_Identity=26.6897746967071, Blast_Score=133, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17505833, Length=558, Percent_Identity=27.9569892473118, Blast_Score=157, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17550100, Length=538, Percent_Identity=27.1375464684015, Blast_Score=152, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6322701, Length=612, Percent_Identity=28.2679738562091, Blast_Score=187, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6322416, Length=614, Percent_Identity=27.6872964169381, Blast_Score=179, Evalue=1e-45,
Organism=Drosophila melanogaster, GI17137288, Length=556, Percent_Identity=27.8776978417266, Blast_Score=171, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24655642, Length=556, Percent_Identity=27.8776978417266, Blast_Score=171, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24655647, Length=556, Percent_Identity=27.8776978417266, Blast_Score=171, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24663005, Length=590, Percent_Identity=26.9491525423729, Blast_Score=157, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 73208; Mature: 73076

Theoretical pI: Translated: 7.63; Mature: 7.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIAEMVGNEGKSFPWNAKIPDGPLEEKWNLFKRNSRLISPNNRKKFKIIVVGTGLSGSA
CCHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEECCCCCCEEEEEEEECCCCCCH
AAATLAEQGYQVSSFCFHESARRAHSIAAQGGVNAAKNYKNDGDSVIRMFRDTLKGGDFR
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHCCCCCC
SREANVYRLAECSIPFIDLAVSQGVPFNREYGGYLENRSFGGVQVSRTFYSKGQTGQQLL
CCCCCEEEEEECCCCEEEHHHHCCCCCCCCCCCCCCCCCCCCEEEEEHHHCCCCCHHHHH
LGAYQTMMRQVHLGKVQLYTNVELLDYIIIDGHAKGIVVRNLLNGELEKHSAHAIVVASG
HHHHHHHHHHHHCCEEEEEECCEEEEEEEECCCCCCEEEHHHHCCCHHCCCCCEEEEEEC
GFGKIYYLSTLALGCNATAVWRAHKKGALFANPSWTQIHPTSLPQTNSYQSKLTLMSESL
CCCEEEEEEHHHHCCCCCEEEECCCCCCEEECCCCCEECCCCCCCCCCHHHHHHHHHHHH
RNDGRIWVPKSKDEKRPPAEIPEEERDYYLERKYPSYGNLAPRDISSRAAKERIDLGFGV
CCCCEEECCCCCCCCCCCCCCCCHHHHHEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCC
GPLKNAVYLDFKDAKKTLGEEVLRARYGNLFDMYKKITDVDPLTEPMLISPSAHFSMGGL
CCCCCEEEEEEHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCEEECCCCCCCCCCE
WVDYELMTNVPGLYAIGEANFADHGANRLGANSLLQASVDGYFILPATLPNYLYDKVDSN
EEEEHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHCCCCEEEECCCCHHHHHHHHCCC
LVSTDHPSFKEAEETIQKEIQFYTNANGKKLIDEYHKELGKILYDSCGLKRSKSELESAV
CCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
KTIQNLRNEFLSGNIRIPSDSFTKNAELEKAGRMKDYLELAELMCLDALLREESCGAHFR
HHHHHHHHHHHCCCEECCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEE
IEHQTEDGEAKRDDKNFQFVSCFEWSGDASRPILHREPLSFEFFLPQNRDYQ
EEECCCCCCCCCCCCCCEEEEEEECCCCCCCCCEECCCCCEEEECCCCCCCC
>Mature Secondary Structure 
SIAEMVGNEGKSFPWNAKIPDGPLEEKWNLFKRNSRLISPNNRKKFKIIVVGTGLSGSA
CHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEECCCCCCEEEEEEEECCCCCCH
AAATLAEQGYQVSSFCFHESARRAHSIAAQGGVNAAKNYKNDGDSVIRMFRDTLKGGDFR
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHCCCCCC
SREANVYRLAECSIPFIDLAVSQGVPFNREYGGYLENRSFGGVQVSRTFYSKGQTGQQLL
CCCCCEEEEEECCCCEEEHHHHCCCCCCCCCCCCCCCCCCCCEEEEEHHHCCCCCHHHHH
LGAYQTMMRQVHLGKVQLYTNVELLDYIIIDGHAKGIVVRNLLNGELEKHSAHAIVVASG
HHHHHHHHHHHHCCEEEEEECCEEEEEEEECCCCCCEEEHHHHCCCHHCCCCCEEEEEEC
GFGKIYYLSTLALGCNATAVWRAHKKGALFANPSWTQIHPTSLPQTNSYQSKLTLMSESL
CCCEEEEEEHHHHCCCCCEEEECCCCCCEEECCCCCEECCCCCCCCCCHHHHHHHHHHHH
RNDGRIWVPKSKDEKRPPAEIPEEERDYYLERKYPSYGNLAPRDISSRAAKERIDLGFGV
CCCCEEECCCCCCCCCCCCCCCCHHHHHEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCC
GPLKNAVYLDFKDAKKTLGEEVLRARYGNLFDMYKKITDVDPLTEPMLISPSAHFSMGGL
CCCCCEEEEEEHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCEEECCCCCCCCCCE
WVDYELMTNVPGLYAIGEANFADHGANRLGANSLLQASVDGYFILPATLPNYLYDKVDSN
EEEEHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHCCCCEEEECCCCHHHHHHHHCCC
LVSTDHPSFKEAEETIQKEIQFYTNANGKKLIDEYHKELGKILYDSCGLKRSKSELESAV
CCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
KTIQNLRNEFLSGNIRIPSDSFTKNAELEKAGRMKDYLELAELMCLDALLREESCGAHFR
HHHHHHHHHHHCCCEECCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEE
IEHQTEDGEAKRDDKNFQFVSCFEWSGDASRPILHREPLSFEFFLPQNRDYQ
EEECCCCCCCCCCCCCCEEEEEEECCCCCCCCCEECCCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]