| Definition | Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)' chromosome chromosome I, complete sequence. |
|---|---|
| Accession | NC_010602 |
| Length | 3,599,677 |
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The map label for this gene is fumA [H]
Identifier: 183222482
GI number: 183222482
Start: 3248967
End: 3250580
Strand: Reverse
Name: fumA [H]
Synonym: LEPBI_I3137
Alternate gene names: 183222482
Gene position: 3250580-3248967 (Counterclockwise)
Preceding gene: 183222484
Following gene: 183222481
Centisome position: 90.3
GC content: 43.74
Gene sequence:
>1614_bases ATGCCAGAATACTTTTACGCCGATCCGTTTCCACTCACAGAGGACACAACCGAATACAAACTTTTGACAAAAGATTATGT AAGCACAGTCCCATTTGGTGACAAAGAAATTCTGAAAGTGGAACCAGAAGGTCTCACCTTCCTTGCAGAAAAAGCAATGG AAGATGTATCTTTTTATTTAAGGACTGAACATCTCACAAAGGTGCGTAAAATTTTAGATGACCCTGAAGCAACGCCTAAT GACCGTTTTGTGGCAATGGCACTTCTTAAAAATGCTGTGATCGCTGCTGACAAACAATTACCATCCTGCCAAGATACGGG AACTGGGATTGTCATGGCAAAAAAAGGAGAGTATGTCATTACAGGTGGCAATGATGCGGAAGCACTCTCGAAAGGAATCT ATAATACCTATGTGAATCGGAACCTGCGTTATTCCCAAGTGTTACCTCTTACCATGTATGAGGAAGTGAATTCTGGATCC AATTTACCAGCGCAAATTGATATTTATGCAACACCTGGTGACAAATATAGTTTTCTCTTTTTGGCAAAAGGAGGTGGGTC AGCGAACAAAACCTATCTCTTCCAAGAAACAAAAGCACTTCTGAATCCTACTTCTCTCGAAAAGTTCATCGCAGACAAAG TTGCCAATTTAGGAACGGCGGCATGTCCTCCTTACCATATTGCTGTGGTGATTGGAGGAACATCAGCAGAAGCCAATCTA AAGACCGTAAAACTAGCGTCAGCTGGGTATTTAGACCATCTACCAACCAAAGGAGACAAATTTGGTTCGGCATTCCGTGA CACGGAACTCGAAGCCAAAATGTTGTTAGCCGCTCAAAAATCCGGTATCGGGGCACAGTTTGGTGGAAAGTATTTGGCTC ATGACTTTAAAGTGATCCGCCTTCCGCGTCACGGTGCCTCTTGCCCCGTAGGACTCGGTGTGAGTTGCAGTGCGGATCGG AACATCAAAGCAAAGATCACCAAAGATGGTATCTTCTTAGAAAAACTCGAGTACGATCCTTCCAAGTATTTGCCAACCAT CGATGAAGTGGATTCTAGTTCCGAATCGGTGCATATTGATCTCAACCAACCGATGCCCGAAATTTTAAAAGTACTCACAA AGTATCCTGTCAAAACACGTGTGATGCTCAGTGGCAAATTAATCGTGGCACGTGATATCGCTCATGCCAAATTGAAAGAG AAAATGGACAAAGGGGAGACTCTCCCTGAGTATTTCAAAAATCACCCTGTGTATTATGCGGGACCTGCGAAAACTCCAGA AGGGATGCCATCAGGATCTTTTGGACCCACCACTGCGGGTCGTATGGACAGTTATGTTCCTGTTTTCCAAGAGAAAGGGT ATTCCATGATCACTCTTGCGAAAGGGAATCGTTCCAAAGTTGTAACCGATAGCTGCAAAAAAAATGGTGGATTTTACCTC GGATCCATCGGTGGCCCTGCGGCCCTCCTTGCCAAAGAAAACATCAAAAAGGTGGAAGTATTAGATTTTCCAGAACTGGG AATGGAAGCAGTTTGGTCCATCGATGTGGAAAATTTCCCAGCATTCATCGTAGTTGATGACAAAGGGAATGACTTTTTCC AGATGTTGCATTGA
Upstream 100 bases:
>100_bases TTGGGAATCAATCGTAGGAGAATCTTGATTTTGTGTCGTGAAAAATTCATTTACGAAAGAAGGTTTCCTTTCAGATTAGA AGTACCAAATAGAGGTTTCT
Downstream 100 bases:
>100_bases TAGAAAACAACACAATTTATCTTCATGATTGAGTATAGCTGAAATGGTTGGAAACGAGGGAAAGTCATTTCCTTGGAATG CTAAAATTCCAGATGGTCCA
Product: fumarate hydratase
Products: NA
Alternate protein names: Fumarase [H]
Number of amino acids: Translated: 537; Mature: 536
Protein sequence:
>537_residues MPEYFYADPFPLTEDTTEYKLLTKDYVSTVPFGDKEILKVEPEGLTFLAEKAMEDVSFYLRTEHLTKVRKILDDPEATPN DRFVAMALLKNAVIAADKQLPSCQDTGTGIVMAKKGEYVITGGNDAEALSKGIYNTYVNRNLRYSQVLPLTMYEEVNSGS NLPAQIDIYATPGDKYSFLFLAKGGGSANKTYLFQETKALLNPTSLEKFIADKVANLGTAACPPYHIAVVIGGTSAEANL KTVKLASAGYLDHLPTKGDKFGSAFRDTELEAKMLLAAQKSGIGAQFGGKYLAHDFKVIRLPRHGASCPVGLGVSCSADR NIKAKITKDGIFLEKLEYDPSKYLPTIDEVDSSSESVHIDLNQPMPEILKVLTKYPVKTRVMLSGKLIVARDIAHAKLKE KMDKGETLPEYFKNHPVYYAGPAKTPEGMPSGSFGPTTAGRMDSYVPVFQEKGYSMITLAKGNRSKVVTDSCKKNGGFYL GSIGGPAALLAKENIKKVEVLDFPELGMEAVWSIDVENFPAFIVVDDKGNDFFQMLH
Sequences:
>Translated_537_residues MPEYFYADPFPLTEDTTEYKLLTKDYVSTVPFGDKEILKVEPEGLTFLAEKAMEDVSFYLRTEHLTKVRKILDDPEATPN DRFVAMALLKNAVIAADKQLPSCQDTGTGIVMAKKGEYVITGGNDAEALSKGIYNTYVNRNLRYSQVLPLTMYEEVNSGS NLPAQIDIYATPGDKYSFLFLAKGGGSANKTYLFQETKALLNPTSLEKFIADKVANLGTAACPPYHIAVVIGGTSAEANL KTVKLASAGYLDHLPTKGDKFGSAFRDTELEAKMLLAAQKSGIGAQFGGKYLAHDFKVIRLPRHGASCPVGLGVSCSADR NIKAKITKDGIFLEKLEYDPSKYLPTIDEVDSSSESVHIDLNQPMPEILKVLTKYPVKTRVMLSGKLIVARDIAHAKLKE KMDKGETLPEYFKNHPVYYAGPAKTPEGMPSGSFGPTTAGRMDSYVPVFQEKGYSMITLAKGNRSKVVTDSCKKNGGFYL GSIGGPAALLAKENIKKVEVLDFPELGMEAVWSIDVENFPAFIVVDDKGNDFFQMLH >Mature_536_residues PEYFYADPFPLTEDTTEYKLLTKDYVSTVPFGDKEILKVEPEGLTFLAEKAMEDVSFYLRTEHLTKVRKILDDPEATPND RFVAMALLKNAVIAADKQLPSCQDTGTGIVMAKKGEYVITGGNDAEALSKGIYNTYVNRNLRYSQVLPLTMYEEVNSGSN LPAQIDIYATPGDKYSFLFLAKGGGSANKTYLFQETKALLNPTSLEKFIADKVANLGTAACPPYHIAVVIGGTSAEANLK TVKLASAGYLDHLPTKGDKFGSAFRDTELEAKMLLAAQKSGIGAQFGGKYLAHDFKVIRLPRHGASCPVGLGVSCSADRN IKAKITKDGIFLEKLEYDPSKYLPTIDEVDSSSESVHIDLNQPMPEILKVLTKYPVKTRVMLSGKLIVARDIAHAKLKEK MDKGETLPEYFKNHPVYYAGPAKTPEGMPSGSFGPTTAGRMDSYVPVFQEKGYSMITLAKGNRSKVVTDSCKKNGGFYLG SIGGPAALLAKENIKKVEVLDFPELGMEAVWSIDVENFPAFIVVDDKGNDFFQMLH
Specific function: It functions as an aerobic enzyme in the citric acid cycle. It accounts for about 80% of the fumarase activity when the bacteria grows aerobically [H]
COG id: COG1951
COG function: function code C; Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the class-I fumarase family [H]
Homologues:
Organism=Escherichia coli, GI1787897, Length=534, Percent_Identity=65.1685393258427, Blast_Score=742, Evalue=0.0, Organism=Escherichia coli, GI1790564, Length=533, Percent_Identity=65.1031894934334, Blast_Score=739, Evalue=0.0, Organism=Escherichia coli, GI1789443, Length=157, Percent_Identity=27.3885350318471, Blast_Score=70, Evalue=4e-13,
Paralogues:
None
Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR004646 - InterPro: IPR004647 - InterPro: IPR011167 - InterPro: IPR020557 [H]
Pfam domain/function: PF05681 Fumerase; PF05683 Fumerase_C [H]
EC number: =4.2.1.2 [H]
Molecular weight: Translated: 58813; Mature: 58682
Theoretical pI: Translated: 6.61; Mature: 6.61
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.9 %Cys (Translated Protein) 2.6 %Met (Translated Protein) 3.5 %Cys+Met (Translated Protein) 0.9 %Cys (Mature Protein) 2.4 %Met (Mature Protein) 3.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MPEYFYADPFPLTEDTTEYKLLTKDYVSTVPFGDKEILKVEPEGLTFLAEKAMEDVSFYL CCCCCCCCCCCCCCCCCCEEEEEHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHH RTEHLTKVRKILDDPEATPNDRFVAMALLKNAVIAADKQLPSCQDTGTGIVMAKKGEYVI HHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHEECCCCCCCCCCCCCEEEEEECCCEEE TGGNDAEALSKGIYNTYVNRNLRYSQVLPLTMYEEVNSGSNLPAQIDIYATPGDKYSFLF ECCCCHHHHHHHHHHHHHCCCCCHHEECCEEEHHHHCCCCCCCEEEEEEECCCCCEEEEE LAKGGGSANKTYLFQETKALLNPTSLEKFIADKVANLGTAACPPYHIAVVIGGTSAEANL EECCCCCCCCEEEEEHHHHHCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCE KTVKLASAGYLDHLPTKGDKFGSAFRDTELEAKMLLAAQKSGIGAQFGGKYLAHDFKVIR EEEEEECCCCHHCCCCCCCHHCCHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEE LPRHGASCPVGLGVSCSADRNIKAKITKDGIFLEKLEYDPSKYLPTIDEVDSSSESVHID ECCCCCCCCCCCCEECCCCCCEEEEEECCCEEEEEECCCCHHCCCCHHHCCCCCCEEEEE LNQPMPEILKVLTKYPVKTRVMLSGKLIVARDIAHAKLKEKMDKGETLPEYFKNHPVYYA CCCCHHHHHHHHHCCCCEEEEEEECCEEEEEHHHHHHHHHHHHCCCCCHHHHHCCCEEEE GPAKTPEGMPSGSFGPTTAGRMDSYVPVFQEKGYSMITLAKGNRSKVVTDSCKKNGGFYL CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCEEEEEECCCCCCEEEHHHCCCCCEEE GSIGGPAALLAKENIKKVEVLDFPELGMEAVWSIDVENFPAFIVVDDKGNDFFQMLH ECCCCCEEEEECCCCCEEEEECCCCCCCEEEEEEECCCCCEEEEEECCCCHHHHHCC >Mature Secondary Structure PEYFYADPFPLTEDTTEYKLLTKDYVSTVPFGDKEILKVEPEGLTFLAEKAMEDVSFYL CCCCCCCCCCCCCCCCCEEEEEHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHH RTEHLTKVRKILDDPEATPNDRFVAMALLKNAVIAADKQLPSCQDTGTGIVMAKKGEYVI HHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHEECCCCCCCCCCCCCEEEEEECCCEEE TGGNDAEALSKGIYNTYVNRNLRYSQVLPLTMYEEVNSGSNLPAQIDIYATPGDKYSFLF ECCCCHHHHHHHHHHHHHCCCCCHHEECCEEEHHHHCCCCCCCEEEEEEECCCCCEEEEE LAKGGGSANKTYLFQETKALLNPTSLEKFIADKVANLGTAACPPYHIAVVIGGTSAEANL EECCCCCCCCEEEEEHHHHHCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCE KTVKLASAGYLDHLPTKGDKFGSAFRDTELEAKMLLAAQKSGIGAQFGGKYLAHDFKVIR EEEEEECCCCHHCCCCCCCHHCCHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEE LPRHGASCPVGLGVSCSADRNIKAKITKDGIFLEKLEYDPSKYLPTIDEVDSSSESVHID ECCCCCCCCCCCCEECCCCCCEEEEEECCCEEEEEECCCCHHCCCCHHHCCCCCCEEEEE LNQPMPEILKVLTKYPVKTRVMLSGKLIVARDIAHAKLKEKMDKGETLPEYFKNHPVYYA CCCCHHHHHHHHHCCCCEEEEEEECCEEEEEHHHHHHHHHHHHCCCCCHHHHHCCCEEEE GPAKTPEGMPSGSFGPTTAGRMDSYVPVFQEKGYSMITLAKGNRSKVVTDSCKKNGGFYL CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCEEEEEECCCCCCEEEHHHCCCCCEEE GSIGGPAALLAKENIKKVEVLDFPELGMEAVWSIDVENFPAFIVVDDKGNDFFQMLH ECCCCCEEEEECCCCCEEEEECCCCCCCEEEEEEECCCCCEEEEEECCCCHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11677609; 1879695 [H]