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The map label for this gene is fdhA [H]

Identifier: 183222129

GI number: 183222129

Start: 2871244

End: 2873400

Strand: Direct

Name: fdhA [H]

Synonym: LEPBI_I2772

Alternate gene names: 183222129

Gene position: 2871244-2873400 (Clockwise)

Preceding gene: 183222128

Following gene: 183222131

Centisome position: 79.76

GC content: 36.76

Gene sequence:

>2157_bases
ATGGACCAAACACATTTTCGATCATGCAATTTATGTGAGGCCATGTGCGGATTACAAATCGAAGTCAAAAATGATACCAT
CGTAGGCTTCAAAGGTGATTCTCTGGATTCATTCAGCAGAGGTCATATTTGTCCAAAAGGTCCTGAATTAAAAAGTTTAT
ATGAAGATCCAGACAGACTAAAATACCCAATCAAAAAAACAAAAAATGGATGGGAGAAAGTGACCTGGGTGAATGCCCTT
TCCGATATCGCTAATCAAATTGTAACAATACAATCAAAATACGGCAACGATGCAGTCGCCATTTATAATGGGAATCCAAC
GGTTCACAATTACGGATCAATGTTATTTGGTCAAAGATTTGTCAGTCGCATAAAATCTAAAAACAATTTTTCAGCTACGT
CGGTAGACCAACTTCCACACCAACTCCTCTCCTATTTGATGTTTGGTCATCAATTACTTGTTCCAATTCCAGACATAGAT
CGAACGCAATACTTTCTAATTTTGGGTGGGAACCCATTTGCTTCTAACGGAAGTCTGATGACAGTACCCGATGTCAAAAA
AAGATTAAAAGCCATCCAAGATAGAGGTGGTAAATATGTAGTGATTGACCCAAGGAAAACTGAAACCGCAGAACATGCAG
ACGAACACCTATTCATCAAACCAGGAACCGATGTTTTTCTTTTACTTTCACTATTAAACATCATTTTTGAAAACAAACTA
AACAAACCAAATTCGCTTTTAAAAGAAAATGACATCCAGTCGATTCAAATTCTTGTGAAAGAATTTTCACCAGAGGATGT
ATCGAAAATCACAGGTATATCTAAAGAATCAATAGAACGAATTGCATTTGAATTTGCAAACGCATCCTCTGCCGTCTGTT
ATGGGAGAGTTGGAGTTTCCACACAGGAATTTGGAGCTCTGTGTCAATGGCTCATCAACGTGATCAATATTGTCACAGGA
AATTTGGACAAAGAAGGCGGAGCTATGTTCACATTACCAGCTGTTGATTTGGTTGGTGAAGGTTCAGTCATGAGGTCTTC
ATCCGGCAGTTTTAATACTTTCCAATCACGGGTAAGAAAACTACCCGAATTCAATGACGAATTGCCTGTTTCTGCCCTCG
CAGAAGAGATTTTGACAGAAGGGGAAGGACAAATCCGAGTTTTGGTGACTTCAGCAGGGAATCCTGTTTTATCTACACCT
AACGGATCTAAACTGGAAAAAGCATTAACTCAATTAGATCTTATGGTTAGTTTTGATTTTTATTTGAATGAAACCACAAA
ACATGCACATTATATTCTACCACCAACATCTACATTAGAACATGATCATTATGATTTAATATTCAATGTATTTGCTGTAA
GAAATACAGCGCGCTACAACCAACCCTTGTTTCCACCTGAAGAAGGAATGTTACATGATTGGGAGATTTTTTCCGATTTA
ACAAAACGGATTGAACTACGACGGTCAGGAAAAGAATTACCTACCGAGTTAATCAAAACGAAACTAACGCCTGCGAGTAT
CATAGACCATGCATTAAAATCAGGACCATATGGTGCCAAAAATAATTCAGATATCCAAATGAGTTTGGAACTTCTTAAAA
ACAGCTCGCATGGAATCGATTTAGGTCCACTAAAAAAATCTTTTCCTGAAAGGCTTTATACGAATGATAAAAAAATTCAT
TTATATCCAGATATTTTAGAATCTGATATTCCAAGATTAAAAACAAAATTCAAAGAACAAATCAATGTTAGTCAGTCAAT
GTTTCCTTATTTGTTGATAGGAAGAAGGCATTTAAGAAATAATAATTCATGGATGCATAATTTACCCAAATTGATGACGG
GGAAACCGAGATGTACTATGATGGTGCATCCAGATGATGCAATACAATTGGGAATCACAAATAATGAAGAAGTCATTGTA
GAATCAAAAGTAGGACAGTTGAAAATACCTGTTGAAATCACGGATGAATTAATGAAAGGTGTTGTCAGCATTCCGCATGG
TTTTGGACACAACCGCAGTGGTACAAGTCAAACGATAGCAACACAATTCTCAGGAGTTAGTATCAATGACCTGACTGATG
ATCAAATCATTGATGAATTTTCTGGAAATGCTGCGTTCAGCGGCATTCAGGTAAAAATCATAAAGATTCCTTCATAA

Upstream 100 bases:

>100_bases
TTCCTAATCACAGAAACGAATACAATTTTCATTTGAGAGGCAATTTTACACTTGTCTCTCAAAAATTTCTTTTCTAAACT
TCTTGTTTTAGGAGAGAGAT

Downstream 100 bases:

>100_bases
GAATTGTTTACTCATTTTTGAATCGAGACAAAACCCTTCGACCACCAATCAATGAAAATTTGTTTTGAAAATTTGTGAGA
TAGGAAGTTGCCTTCAGTGA

Product: molybdopterin-binding oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 718; Mature: 718

Protein sequence:

>718_residues
MDQTHFRSCNLCEAMCGLQIEVKNDTIVGFKGDSLDSFSRGHICPKGPELKSLYEDPDRLKYPIKKTKNGWEKVTWVNAL
SDIANQIVTIQSKYGNDAVAIYNGNPTVHNYGSMLFGQRFVSRIKSKNNFSATSVDQLPHQLLSYLMFGHQLLVPIPDID
RTQYFLILGGNPFASNGSLMTVPDVKKRLKAIQDRGGKYVVIDPRKTETAEHADEHLFIKPGTDVFLLLSLLNIIFENKL
NKPNSLLKENDIQSIQILVKEFSPEDVSKITGISKESIERIAFEFANASSAVCYGRVGVSTQEFGALCQWLINVINIVTG
NLDKEGGAMFTLPAVDLVGEGSVMRSSSGSFNTFQSRVRKLPEFNDELPVSALAEEILTEGEGQIRVLVTSAGNPVLSTP
NGSKLEKALTQLDLMVSFDFYLNETTKHAHYILPPTSTLEHDHYDLIFNVFAVRNTARYNQPLFPPEEGMLHDWEIFSDL
TKRIELRRSGKELPTELIKTKLTPASIIDHALKSGPYGAKNNSDIQMSLELLKNSSHGIDLGPLKKSFPERLYTNDKKIH
LYPDILESDIPRLKTKFKEQINVSQSMFPYLLIGRRHLRNNNSWMHNLPKLMTGKPRCTMMVHPDDAIQLGITNNEEVIV
ESKVGQLKIPVEITDELMKGVVSIPHGFGHNRSGTSQTIATQFSGVSINDLTDDQIIDEFSGNAAFSGIQVKIIKIPS

Sequences:

>Translated_718_residues
MDQTHFRSCNLCEAMCGLQIEVKNDTIVGFKGDSLDSFSRGHICPKGPELKSLYEDPDRLKYPIKKTKNGWEKVTWVNAL
SDIANQIVTIQSKYGNDAVAIYNGNPTVHNYGSMLFGQRFVSRIKSKNNFSATSVDQLPHQLLSYLMFGHQLLVPIPDID
RTQYFLILGGNPFASNGSLMTVPDVKKRLKAIQDRGGKYVVIDPRKTETAEHADEHLFIKPGTDVFLLLSLLNIIFENKL
NKPNSLLKENDIQSIQILVKEFSPEDVSKITGISKESIERIAFEFANASSAVCYGRVGVSTQEFGALCQWLINVINIVTG
NLDKEGGAMFTLPAVDLVGEGSVMRSSSGSFNTFQSRVRKLPEFNDELPVSALAEEILTEGEGQIRVLVTSAGNPVLSTP
NGSKLEKALTQLDLMVSFDFYLNETTKHAHYILPPTSTLEHDHYDLIFNVFAVRNTARYNQPLFPPEEGMLHDWEIFSDL
TKRIELRRSGKELPTELIKTKLTPASIIDHALKSGPYGAKNNSDIQMSLELLKNSSHGIDLGPLKKSFPERLYTNDKKIH
LYPDILESDIPRLKTKFKEQINVSQSMFPYLLIGRRHLRNNNSWMHNLPKLMTGKPRCTMMVHPDDAIQLGITNNEEVIV
ESKVGQLKIPVEITDELMKGVVSIPHGFGHNRSGTSQTIATQFSGVSINDLTDDQIIDEFSGNAAFSGIQVKIIKIPS
>Mature_718_residues
MDQTHFRSCNLCEAMCGLQIEVKNDTIVGFKGDSLDSFSRGHICPKGPELKSLYEDPDRLKYPIKKTKNGWEKVTWVNAL
SDIANQIVTIQSKYGNDAVAIYNGNPTVHNYGSMLFGQRFVSRIKSKNNFSATSVDQLPHQLLSYLMFGHQLLVPIPDID
RTQYFLILGGNPFASNGSLMTVPDVKKRLKAIQDRGGKYVVIDPRKTETAEHADEHLFIKPGTDVFLLLSLLNIIFENKL
NKPNSLLKENDIQSIQILVKEFSPEDVSKITGISKESIERIAFEFANASSAVCYGRVGVSTQEFGALCQWLINVINIVTG
NLDKEGGAMFTLPAVDLVGEGSVMRSSSGSFNTFQSRVRKLPEFNDELPVSALAEEILTEGEGQIRVLVTSAGNPVLSTP
NGSKLEKALTQLDLMVSFDFYLNETTKHAHYILPPTSTLEHDHYDLIFNVFAVRNTARYNQPLFPPEEGMLHDWEIFSDL
TKRIELRRSGKELPTELIKTKLTPASIIDHALKSGPYGAKNNSDIQMSLELLKNSSHGIDLGPLKKSFPERLYTNDKKIH
LYPDILESDIPRLKTKFKEQINVSQSMFPYLLIGRRHLRNNNSWMHNLPKLMTGKPRCTMMVHPDDAIQLGITNNEEVIV
ESKVGQLKIPVEITDELMKGVVSIPHGFGHNRSGTSQTIATQFSGVSINDLTDDQIIDEFSGNAAFSGIQVKIIKIPS

Specific function: Catalyzes the oxidation of formate [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI3868721, Length=729, Percent_Identity=22.9080932784636, Blast_Score=132, Evalue=7e-32,
Organism=Escherichia coli, GI1787870, Length=762, Percent_Identity=22.9658792650919, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI171474008, Length=365, Percent_Identity=28.2191780821918, Blast_Score=100, Evalue=5e-22,
Organism=Escherichia coli, GI87081797, Length=741, Percent_Identity=21.3225371120108, Blast_Score=100, Evalue=5e-22,
Organism=Escherichia coli, GI145693196, Length=694, Percent_Identity=20.7492795389049, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI1787778, Length=424, Percent_Identity=23.5849056603774, Blast_Score=70, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006478
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 80194; Mature: 80194

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQTHFRSCNLCEAMCGLQIEVKNDTIVGFKGDSLDSFSRGHICPKGPELKSLYEDPDRL
CCCCCCCCCCHHHHHHCCEEEECCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHCCHHHH
KYPIKKTKNGWEKVTWVNALSDIANQIVTIQSKYGNDAVAIYNGNPTVHNYGSMLFGQRF
CCCHHHCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEECCCCCEEHHHHHHHHHHH
VSRIKSKNNFSATSVDQLPHQLLSYLMFGHQLLVPIPDIDRTQYFLILGGNPFASNGSLM
HHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCCCCCCEE
TVPDVKKRLKAIQDRGGKYVVIDPRKTETAEHADEHLFIKPGTDVFLLLSLLNIIFENKL
ECHHHHHHHHHHHHCCCEEEEECCCCCCCHHCCCCEEEECCCCHHHHHHHHHHHHHHHCC
NKPNSLLKENDIQSIQILVKEFSPEDVSKITGISKESIERIAFEFANASSAVCYGRVGVS
CCCHHHHHHCCHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEECCCC
TQEFGALCQWLINVINIVTGNLDKEGGAMFTLPAVDLVGEGSVMRSSSGSFNTFQSRVRK
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCEEECCCCCHHHHHHHHHH
LPEFNDELPVSALAEEILTEGEGQIRVLVTSAGNPVLSTPNGSKLEKALTQLDLMVSFDF
CCCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCEEECCCCHHHHHHHHHHHHHEEEEE
YLNETTKHAHYILPPTSTLEHDHYDLIFNVFAVRNTARYNQPLFPPEEGMLHDWEIFSDL
EECCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHH
TKRIELRRSGKELPTELIKTKLTPASIIDHALKSGPYGAKNNSDIQMSLELLKNSSHGID
HHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHEEHHHHHCCCCCCC
LGPLKKSFPERLYTNDKKIHLYPDILESDIPRLKTKFKEQINVSQSMFPYLLIGRRHLRN
CCCHHHHHHHHHHCCCCEEEEEHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
NNSWMHNLPKLMTGKPRCTMMVHPDDAIQLGITNNEEVIVESKVGQLKIPVEITDELMKG
CCCHHHHCHHHHCCCCCEEEEECCCCCEEEEECCCCEEEEEECCCCEEECHHHHHHHHHH
VVSIPHGFGHNRSGTSQTIATQFSGVSINDLTDDQIIDEFSGNAAFSGIQVKIIKIPS
HHHCCCCCCCCCCCCCCCHHHEECCCEECCCCCHHHHHHHCCCCEECCEEEEEEECCC
>Mature Secondary Structure
MDQTHFRSCNLCEAMCGLQIEVKNDTIVGFKGDSLDSFSRGHICPKGPELKSLYEDPDRL
CCCCCCCCCCHHHHHHCCEEEECCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHCCHHHH
KYPIKKTKNGWEKVTWVNALSDIANQIVTIQSKYGNDAVAIYNGNPTVHNYGSMLFGQRF
CCCHHHCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCEEEEECCCCCEEHHHHHHHHHHH
VSRIKSKNNFSATSVDQLPHQLLSYLMFGHQLLVPIPDIDRTQYFLILGGNPFASNGSLM
HHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCCCCCCEE
TVPDVKKRLKAIQDRGGKYVVIDPRKTETAEHADEHLFIKPGTDVFLLLSLLNIIFENKL
ECHHHHHHHHHHHHCCCEEEEECCCCCCCHHCCCCEEEECCCCHHHHHHHHHHHHHHHCC
NKPNSLLKENDIQSIQILVKEFSPEDVSKITGISKESIERIAFEFANASSAVCYGRVGVS
CCCHHHHHHCCHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEECCCC
TQEFGALCQWLINVINIVTGNLDKEGGAMFTLPAVDLVGEGSVMRSSSGSFNTFQSRVRK
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCEEECCCCCHHHHHHHHHH
LPEFNDELPVSALAEEILTEGEGQIRVLVTSAGNPVLSTPNGSKLEKALTQLDLMVSFDF
CCCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCEEECCCCHHHHHHHHHHHHHEEEEE
YLNETTKHAHYILPPTSTLEHDHYDLIFNVFAVRNTARYNQPLFPPEEGMLHDWEIFSDL
EECCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHH
TKRIELRRSGKELPTELIKTKLTPASIIDHALKSGPYGAKNNSDIQMSLELLKNSSHGID
HHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHEEHHHHHCCCCCCC
LGPLKKSFPERLYTNDKKIHLYPDILESDIPRLKTKFKEQINVSQSMFPYLLIGRRHLRN
CCCHHHHHHHHHHCCCCEEEEEHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
NNSWMHNLPKLMTGKPRCTMMVHPDDAIQLGITNNEEVIVESKVGQLKIPVEITDELMKG
CCCHHHHCHHHHCCCCCEEEEECCCCCEEEEECCCCEEEEEECCCCEEECHHHHHHHHHH
VVSIPHGFGHNRSGTSQTIATQFSGVSINDLTDDQIIDEFSGNAAFSGIQVKIIKIPS
HHHCCCCCCCCCCCCCCCHHHEECCCEECCCCCHHHHHHHCCCCEECCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]