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The map label for this gene is moaA [H]

Identifier: 183222131

GI number: 183222131

Start: 2874603

End: 2875544

Strand: Direct

Name: moaA [H]

Synonym: LEPBI_I2774

Alternate gene names: 183222131

Gene position: 2874603-2875544 (Clockwise)

Preceding gene: 183222129

Following gene: 183222132

Centisome position: 79.86

GC content: 33.33

Gene sequence:

>942_bases
ATGTCCTTGGATACTAGAAAATTTGAAGTTTTAAGAATTAGTATTCTATCCCTATGTAATTTTGCCTGTGTTTATTGCGC
TCCAAAGGAAAAGGACAATCTCTCTTCATCAAATGCTTACAAACAATTTTTAAGCCCTTCCCTATTAGATCAAAATTTAA
AACAACTCATTCCACATATCCAAATCAAAGAAGTTCATCTAACTGGAGGTGAGCCAACCCTCCATCAAAACTTAATCCAA
TTGATTGAAATAGTAAAACAACATTCCATTGATGAGATTGCGATCACTTCCAATGGAAATTTTGAATCAGGACTTGTTAC
AAAAATGAAAGAAGCTGGACTCACAAGAATGAATTTTTCATTGGACAGCATGTCACAATCAGGATTTCAAAAATTAAGTG
ATCGGAATAAACCTGTGTCACAAATTTTAGAACAAATTTCTGAAGCAAAATCGATTGGGCTTGAAGTTAAAATTAATTCT
ACAATTTTACGAGGATTCAACGAATCAGAAATTTTAGATTTATTGGAGTGGTCTGGTAAACGATCAATTCCCATACGTTT
TTTAGAATTTATGAAAATGGGGCCACTGCATAAAGAACACCCAATGTATTTTTATTCCGCAGAGGAGATTCGAAATCAAA
TCAGCAAAAAATATAAATTTCTAAAACATCCAACAGCTTCTGATTCAACTGCCGAGTATTACATTACGGATGAAGGATAT
ATCTTTGGTTTGATCGCCAATCATACAGAACCTTTTTGTGAAGGATGTAATCGCTTACGAATGGATAGTAAAGGTCGAAT
CTATGGATGTCTAAGCGACGAAACTTCTTTTGAAATTCCCAATTCTTACGAAGATGTCCAATCCACATTACATCAAGCAA
TGTTAACAAAAAAAAAGAAATTCACTGGTTCTGAATTATCAATGAAATTTATCGGAGGTTAA

Upstream 100 bases:

>100_bases
ACTTTGGAAATGGATATTCATTAATTTTTATTTTAGTCATAAAGAAAAAATTCAATTTTGGTTTCCAACTCATAAATCTT
GTATAAAGTCGTTTTTAACG

Downstream 100 bases:

>100_bases
ATGAAGGTTGAAATATTATGTTTTGCTGCTTTAAAAGATTTTTTTCCAATCAAACAAACGATTGAAATTGAATTCAACTT
TAACGTTTCACAACTAAAAG

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MSLDTRKFEVLRISILSLCNFACVYCAPKEKDNLSSSNAYKQFLSPSLLDQNLKQLIPHIQIKEVHLTGGEPTLHQNLIQ
LIEIVKQHSIDEIAITSNGNFESGLVTKMKEAGLTRMNFSLDSMSQSGFQKLSDRNKPVSQILEQISEAKSIGLEVKINS
TILRGFNESEILDLLEWSGKRSIPIRFLEFMKMGPLHKEHPMYFYSAEEIRNQISKKYKFLKHPTASDSTAEYYITDEGY
IFGLIANHTEPFCEGCNRLRMDSKGRIYGCLSDETSFEIPNSYEDVQSTLHQAMLTKKKKFTGSELSMKFIGG

Sequences:

>Translated_313_residues
MSLDTRKFEVLRISILSLCNFACVYCAPKEKDNLSSSNAYKQFLSPSLLDQNLKQLIPHIQIKEVHLTGGEPTLHQNLIQ
LIEIVKQHSIDEIAITSNGNFESGLVTKMKEAGLTRMNFSLDSMSQSGFQKLSDRNKPVSQILEQISEAKSIGLEVKINS
TILRGFNESEILDLLEWSGKRSIPIRFLEFMKMGPLHKEHPMYFYSAEEIRNQISKKYKFLKHPTASDSTAEYYITDEGY
IFGLIANHTEPFCEGCNRLRMDSKGRIYGCLSDETSFEIPNSYEDVQSTLHQAMLTKKKKFTGSELSMKFIGG
>Mature_312_residues
SLDTRKFEVLRISILSLCNFACVYCAPKEKDNLSSSNAYKQFLSPSLLDQNLKQLIPHIQIKEVHLTGGEPTLHQNLIQL
IEIVKQHSIDEIAITSNGNFESGLVTKMKEAGLTRMNFSLDSMSQSGFQKLSDRNKPVSQILEQISEAKSIGLEVKINST
ILRGFNESEILDLLEWSGKRSIPIRFLEFMKMGPLHKEHPMYFYSAEEIRNQISKKYKFLKHPTASDSTAEYYITDEGYI
FGLIANHTEPFCEGCNRLRMDSKGRIYGCLSDETSFEIPNSYEDVQSTLHQAMLTKKKKFTGSELSMKFIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI22027536, Length=271, Percent_Identity=29.520295202952, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI116734668, Length=271, Percent_Identity=29.520295202952, Blast_Score=113, Evalue=2e-25,
Organism=Escherichia coli, GI1786999, Length=324, Percent_Identity=29.320987654321, Blast_Score=145, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17561210, Length=272, Percent_Identity=34.5588235294118, Blast_Score=145, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI32566329, Length=325, Percent_Identity=29.5384615384615, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI32566331, Length=307, Percent_Identity=29.9674267100977, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI28574488, Length=310, Percent_Identity=30, Blast_Score=141, Evalue=6e-34,
Organism=Drosophila melanogaster, GI28574490, Length=285, Percent_Identity=30.5263157894737, Blast_Score=140, Evalue=7e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 35587; Mature: 35456

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLDTRKFEVLRISILSLCNFACVYCAPKEKDNLSSSNAYKQFLSPSLLDQNLKQLIPHI
CCCCCHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHCCHHHHHHHHHHHCCCC
QIKEVHLTGGEPTLHQNLIQLIEIVKQHSIDEIAITSNGNFESGLVTKMKEAGLTRMNFS
EEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCCEEEECC
LDSMSQSGFQKLSDRNKPVSQILEQISEAKSIGLEVKINSTILRGFNESEILDLLEWSGK
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCEEEEECHHHHCCCCHHHHHHHHHCCCC
RSIPIRFLEFMKMGPLHKEHPMYFYSAEEIRNQISKKYKFLKHPTASDSTAEYYITDEGY
CCCHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCE
IFGLIANHTEPFCEGCNRLRMDSKGRIYGCLSDETSFEIPNSYEDVQSTLHQAMLTKKKK
EEEEEECCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHC
FTGSELSMKFIGG
CCCCCEEEEECCC
>Mature Secondary Structure 
SLDTRKFEVLRISILSLCNFACVYCAPKEKDNLSSSNAYKQFLSPSLLDQNLKQLIPHI
CCCCHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHCCHHHHHHHHHHHCCCC
QIKEVHLTGGEPTLHQNLIQLIEIVKQHSIDEIAITSNGNFESGLVTKMKEAGLTRMNFS
EEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCCEEEECC
LDSMSQSGFQKLSDRNKPVSQILEQISEAKSIGLEVKINSTILRGFNESEILDLLEWSGK
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCEEEEECHHHHCCCCHHHHHHHHHCCCC
RSIPIRFLEFMKMGPLHKEHPMYFYSAEEIRNQISKKYKFLKHPTASDSTAEYYITDEGY
CCCHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCE
IFGLIANHTEPFCEGCNRLRMDSKGRIYGCLSDETSFEIPNSYEDVQSTLHQAMLTKKKK
EEEEEECCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHC
FTGSELSMKFIGG
CCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]