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The map label for this gene is moeA [H]

Identifier: 183222127

GI number: 183222127

Start: 2868406

End: 2869596

Strand: Direct

Name: moeA [H]

Synonym: LEPBI_I2770

Alternate gene names: 183222127

Gene position: 2868406-2869596 (Clockwise)

Preceding gene: 183222126

Following gene: 183222128

Centisome position: 79.69

GC content: 38.46

Gene sequence:

>1191_bases
TTGATTTCCTATACCGAAGCCTTAAACTTGGTATTGAAGGAAACAAAATCTTATGGAACTGAATTCATTCCACTCAGCCA
ATCCATGGGTAGAGTTTTATCAGAAAATATTTTAGCAGATCGTGACTACCCACCATTCCATAGGTCCGCGATGGACGGAT
TTGCCATTTCCCATAAAGATTATGTGAAAGATCTCTCGTATTTTTACCAAAGAGAACTTCATGCAGGATCAACATTCACA
AAACTGCCTGGTGAAACGGTGATTCGAATCATGACAGGAGCGCCAGTCCCAGATGGCTTCGATGCAGTGATCAAAATTGA
AGATGCCATCCCTTCTGAGAAAAACGGAATTAAATCTGTATCCTTTCCTATGGATGGAATCTCTCTGTGGCAAAATATCG
CCAAACAAGGAGAAGATGCAAAACAAAATGATTCTCTTCTTCCTATAGGAACAAAACTTGATATCTCTGAAGTTTCGCTT
CTCGCAAGTTTAGGTAAATTTTCTGTCCCGGTTTTTTCTTTGCCAAAAGTAGGAATCATTTCGACAGGAAATGAAGTGGT
TCCGGTCGACTCCTCTCCTCTCCCCCACCAAATCCGTGATTCTAATTCCTATACGATTGCCTCTTCATTATTCAAATTTG
GTATCATACCAAATTTTATGATCCACGTACCTGATGATGAAGTTAAAATGAAAAGTATCATAAAACAAGGATTAGATTGT
GATATTTTGATTTTGTCAGGTGGTGTTTCCATGGGTGAAAAGGATTTGGTCCCTGATTTGCTAAACAAATTGGGTGTGAC
CAAAATCTTTCACAAAATCGCAATCAAACCTGGAAAACCAGTATGGTTTGGTAAAAATGAAACAACACTGGTCTTTGGAT
TGCCTGGAAATCCTTTTAGCACTCAAACATGTTTCCGAATTCTGATAGATCCATTGCTCAACTCTTCTTTTTCACAAAAA
ATCGAGCAACCATTGAAGTTCCCGTCACTCCATTCAAAAAAGAAAAAACATAAGCTAACAGAATTTTATCCAGTTCGATT
TGTTACGAAAGAGAAAACATATTTGGAACCCATTGAATGGAATGGAAGTGGTGATGTGAAGGCAGCTAGATTTTCCAATG
GGCTTGCCATCTTTCCAAGTGAAAAAAACCAACTGGAACCGGAAATGATGATCCAATTCTTAGCTTGGTAA

Upstream 100 bases:

>100_bases
TCATCGCAGTACCTGGAAGTAGCAATGGTTCCAAAGAAAGTATGACGGCAATACTACCTGCTGTCTTCCATGCAAAAAAA
ATGATGAGAGGCGAAGGGCA

Downstream 100 bases:

>100_bases
ATTATTTTTCAACAAATTGTACGATTCATACACATTTTATTCGTATTTTATGCGATTCTAATCTATTAAAAAATATCATC
TGATTTTCTGCGGAAAAAAT

Product: molybdopterin biosynthesis protein MoeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MISYTEALNLVLKETKSYGTEFIPLSQSMGRVLSENILADRDYPPFHRSAMDGFAISHKDYVKDLSYFYQRELHAGSTFT
KLPGETVIRIMTGAPVPDGFDAVIKIEDAIPSEKNGIKSVSFPMDGISLWQNIAKQGEDAKQNDSLLPIGTKLDISEVSL
LASLGKFSVPVFSLPKVGIISTGNEVVPVDSSPLPHQIRDSNSYTIASSLFKFGIIPNFMIHVPDDEVKMKSIIKQGLDC
DILILSGGVSMGEKDLVPDLLNKLGVTKIFHKIAIKPGKPVWFGKNETTLVFGLPGNPFSTQTCFRILIDPLLNSSFSQK
IEQPLKFPSLHSKKKKHKLTEFYPVRFVTKEKTYLEPIEWNGSGDVKAARFSNGLAIFPSEKNQLEPEMMIQFLAW

Sequences:

>Translated_396_residues
MISYTEALNLVLKETKSYGTEFIPLSQSMGRVLSENILADRDYPPFHRSAMDGFAISHKDYVKDLSYFYQRELHAGSTFT
KLPGETVIRIMTGAPVPDGFDAVIKIEDAIPSEKNGIKSVSFPMDGISLWQNIAKQGEDAKQNDSLLPIGTKLDISEVSL
LASLGKFSVPVFSLPKVGIISTGNEVVPVDSSPLPHQIRDSNSYTIASSLFKFGIIPNFMIHVPDDEVKMKSIIKQGLDC
DILILSGGVSMGEKDLVPDLLNKLGVTKIFHKIAIKPGKPVWFGKNETTLVFGLPGNPFSTQTCFRILIDPLLNSSFSQK
IEQPLKFPSLHSKKKKHKLTEFYPVRFVTKEKTYLEPIEWNGSGDVKAARFSNGLAIFPSEKNQLEPEMMIQFLAW
>Mature_396_residues
MISYTEALNLVLKETKSYGTEFIPLSQSMGRVLSENILADRDYPPFHRSAMDGFAISHKDYVKDLSYFYQRELHAGSTFT
KLPGETVIRIMTGAPVPDGFDAVIKIEDAIPSEKNGIKSVSFPMDGISLWQNIAKQGEDAKQNDSLLPIGTKLDISEVSL
LASLGKFSVPVFSLPKVGIISTGNEVVPVDSSPLPHQIRDSNSYTIASSLFKFGIIPNFMIHVPDDEVKMKSIIKQGLDC
DILILSGGVSMGEKDLVPDLLNKLGVTKIFHKIAIKPGKPVWFGKNETTLVFGLPGNPFSTQTCFRILIDPLLNSSFSQK
IEQPLKFPSLHSKKKKHKLTEFYPVRFVTKEKTYLEPIEWNGSGDVKAARFSNGLAIFPSEKNQLEPEMMIQFLAW

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=399, Percent_Identity=30.5764411027569, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI66932975, Length=399, Percent_Identity=30.5764411027569, Blast_Score=159, Evalue=3e-39,
Organism=Escherichia coli, GI1787049, Length=317, Percent_Identity=36.2776025236593, Blast_Score=169, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI25147659, Length=308, Percent_Identity=28.8961038961039, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17562606, Length=167, Percent_Identity=33.5329341317365, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17136978, Length=280, Percent_Identity=32.1428571428571, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24638841, Length=280, Percent_Identity=32.1428571428571, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44016; Mature: 44016

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISYTEALNLVLKETKSYGTEFIPLSQSMGRVLSENILADRDYPPFHRSAMDGFAISHKD
CCCHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHCCCCCCCHHHHHCCCCEECHHH
YVKDLSYFYQRELHAGSTFTKLPGETVIRIMTGAPVPDGFDAVIKIEDAIPSEKNGIKSV
HHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCCCEEE
SFPMDGISLWQNIAKQGEDAKQNDSLLPIGTKLDISEVSLLASLGKFSVPVFSLPKVGII
CCCCHHHHHHHHHHHCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHCCCEECCCCCCEE
STGNEVVPVDSSPLPHQIRDSNSYTIASSLFKFGIIPNFMIHVPDDEVKMKSIIKQGLDC
ECCCEEEECCCCCCCCHHCCCCCEEHHHHHHHHCCCCCEEEECCCCHHHHHHHHHCCCCE
DILILSGGVSMGEKDLVPDLLNKLGVTKIFHKIAIKPGKPVWFGKNETTLVFGLPGNPFS
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCEEEEECCCCCCC
TQTCFRILIDPLLNSSFSQKIEQPLKFPSLHSKKKKHKLTEFYPVRFVTKEKTYLEPIEW
HHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHCCHHEECEEEEECCCCCCCCEEE
NGSGDVKAARFSNGLAIFPSEKNQLEPEMMIQFLAW
CCCCCEEEEEECCCEEECCCCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MISYTEALNLVLKETKSYGTEFIPLSQSMGRVLSENILADRDYPPFHRSAMDGFAISHKD
CCCHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHCCCCCCCHHHHHCCCCEECHHH
YVKDLSYFYQRELHAGSTFTKLPGETVIRIMTGAPVPDGFDAVIKIEDAIPSEKNGIKSV
HHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCCCEEE
SFPMDGISLWQNIAKQGEDAKQNDSLLPIGTKLDISEVSLLASLGKFSVPVFSLPKVGII
CCCCHHHHHHHHHHHCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHCCCEECCCCCCEE
STGNEVVPVDSSPLPHQIRDSNSYTIASSLFKFGIIPNFMIHVPDDEVKMKSIIKQGLDC
ECCCEEEECCCCCCCCHHCCCCCEEHHHHHHHHCCCCCEEEECCCCHHHHHHHHHCCCCE
DILILSGGVSMGEKDLVPDLLNKLGVTKIFHKIAIKPGKPVWFGKNETTLVFGLPGNPFS
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCEEEEECCCCCCC
TQTCFRILIDPLLNSSFSQKIEQPLKFPSLHSKKKKHKLTEFYPVRFVTKEKTYLEPIEW
HHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHCCHHEECEEEEECCCCCCCCEEE
NGSGDVKAARFSNGLAIFPSEKNQLEPEMMIQFLAW
CCCCCEEEEEECCCEEECCCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9495759 [H]