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The map label for this gene is moaC [H]

Identifier: 183222126

GI number: 183222126

Start: 2867495

End: 2868409

Strand: Direct

Name: moaC [H]

Synonym: LEPBI_I2769

Alternate gene names: 183222126

Gene position: 2867495-2868409 (Clockwise)

Preceding gene: 183222125

Following gene: 183222127

Centisome position: 79.66

GC content: 41.53

Gene sequence:

>915_bases
ATGAACGATATCACGGGAAAAAGAACCACGCTCCGTTACGCGGAAGCGGAAGGCTTTGTATACTGCCAAAAAGAAACCAT
TCAAAGGATCAAAACAAATACACTCCCGAAAGGGGATTTGTTTGAAGTTGCAAAAGCATCAGCGCTGTTAGGTGCAAAAA
AAACGTCAGACCTAATTCCACACTGTCATCCTGTGCCTATCGATTCCTTCTCCATTCAATTTGAAATCATCGATGAAAAA
AATGCCGTCCGTATACTCACTCAAGCAAAATCCATTGGGAAAACAGGCATTGAAATGGAAGCATTGACTGGCGTCACAGT
TGCCGCACTTGTGATTTATGATCTTTTAAAACCGATTGATAAGTCCTTAGAAATTTCATCTATCCGCCTCTTGGAAAAAA
AAGGAGGCAAAACGGACAAACACATTGCAAAATTTGCAGATGGCGCAAAAGCCAAAATTTTGGTTTGTTCCGATTCCTGT
TTTGCTGGAAAAAAGCAAGACGGTTCTGGTAAAATCATCGCCGAACTTCTCTCAAACGAGGGTGTGGAAGTTTTAGAAAT
TAAAATTGTACCAGATGAACCAAAAGAGATAGAACAAACCATTTCCAATTGGGCAAACGAAAAAATTGATCTGATCATCA
CTACAGGTGGGACAGGACTTGGTCCAAGAGATAACACTACTGATACCATCAAACCCATGTTAGAGAAAGAAATTCCGGGC
ATTGCAGAAGTGATGAGGTCTTTTGGCCAAGATCGAACCCCATTTGCTATGTTATCTAGATCGATTGCGGGAAGCATCGG
AAAGTCCATCATCATCGCAGTACCTGGAAGTAGCAATGGTTCCAAAGAAAGTATGACGGCAATACTACCTGCTGTCTTCC
ATGCAAAAAAAATGATGAGAGGCGAAGGGCATTGA

Upstream 100 bases:

>100_bases
TGCCATCATCGTGGTTGGGGAAATTGTGCGTTTTTATGAAGAGATGAAATTTTTGAAAAATAGCTGTGCTTCCATTCTAT
CTCCTATATAAGGGATAGGA

Downstream 100 bases:

>100_bases
TTTCCTATACCGAAGCCTTAAACTTGGTATTGAAGGAAACAAAATCTTATGGAACTGAATTCATTCCACTCAGCCAATCC
ATGGGTAGAGTTTTATCAGA

Product: bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA

Products: NA

Alternate protein names: Molybdenum cofactor biosynthesis protein C; Molybdenum cofactor biosynthesis protein B [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MNDITGKRTTLRYAEAEGFVYCQKETIQRIKTNTLPKGDLFEVAKASALLGAKKTSDLIPHCHPVPIDSFSIQFEIIDEK
NAVRILTQAKSIGKTGIEMEALTGVTVAALVIYDLLKPIDKSLEISSIRLLEKKGGKTDKHIAKFADGAKAKILVCSDSC
FAGKKQDGSGKIIAELLSNEGVEVLEIKIVPDEPKEIEQTISNWANEKIDLIITTGGTGLGPRDNTTDTIKPMLEKEIPG
IAEVMRSFGQDRTPFAMLSRSIAGSIGKSIIIAVPGSSNGSKESMTAILPAVFHAKKMMRGEGH

Sequences:

>Translated_304_residues
MNDITGKRTTLRYAEAEGFVYCQKETIQRIKTNTLPKGDLFEVAKASALLGAKKTSDLIPHCHPVPIDSFSIQFEIIDEK
NAVRILTQAKSIGKTGIEMEALTGVTVAALVIYDLLKPIDKSLEISSIRLLEKKGGKTDKHIAKFADGAKAKILVCSDSC
FAGKKQDGSGKIIAELLSNEGVEVLEIKIVPDEPKEIEQTISNWANEKIDLIITTGGTGLGPRDNTTDTIKPMLEKEIPG
IAEVMRSFGQDRTPFAMLSRSIAGSIGKSIIIAVPGSSNGSKESMTAILPAVFHAKKMMRGEGH
>Mature_304_residues
MNDITGKRTTLRYAEAEGFVYCQKETIQRIKTNTLPKGDLFEVAKASALLGAKKTSDLIPHCHPVPIDSFSIQFEIIDEK
NAVRILTQAKSIGKTGIEMEALTGVTVAALVIYDLLKPIDKSLEISSIRLLEKKGGKTDKHIAKFADGAKAKILVCSDSC
FAGKKQDGSGKIIAELLSNEGVEVLEIKIVPDEPKEIEQTISNWANEKIDLIITTGGTGLGPRDNTTDTIKPMLEKEIPG
IAEVMRSFGQDRTPFAMLSRSIAGSIGKSIIIAVPGSSNGSKESMTAILPAVFHAKKMMRGEGH

Specific function: Together with moaA, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG0315

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the moaB/mog family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=155, Percent_Identity=42.5806451612903, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI66932975, Length=155, Percent_Identity=42.5806451612903, Blast_Score=122, Evalue=3e-28,
Organism=Escherichia coli, GI1787001, Length=138, Percent_Identity=44.2028985507246, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1786190, Length=135, Percent_Identity=32.5925925925926, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787000, Length=147, Percent_Identity=27.2108843537415, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI32566331, Length=136, Percent_Identity=39.7058823529412, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17564954, Length=156, Percent_Identity=28.2051282051282, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28574492, Length=139, Percent_Identity=40.2877697841727, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI28574490, Length=139, Percent_Identity=40.2877697841727, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI17136978, Length=147, Percent_Identity=35.3741496598639, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24638841, Length=147, Percent_Identity=35.3741496598639, Blast_Score=92, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023045
- InterPro:   IPR023046
- InterPro:   IPR020817
- InterPro:   IPR012247
- InterPro:   IPR001453
- InterPro:   IPR002820 [H]

Pfam domain/function: PF01967 MoaC; PF00994 MoCF_biosynth [H]

EC number: NA

Molecular weight: Translated: 32836; Mature: 32836

Theoretical pI: Translated: 8.32; Mature: 8.32

Prosite motif: PS01078 MOCF_BIOSYNTHESIS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDITGKRTTLRYAEAEGFVYCQKETIQRIKTNTLPKGDLFEVAKASALLGAKKTSDLIP
CCCCCCCCEEEEEECCCCEEEECHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHCCCC
HCHPVPIDSFSIQFEIIDEKNAVRILTQAKSIGKTGIEMEALTGVTVAALVIYDLLKPID
CCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHC
KSLEISSIRLLEKKGGKTDKHIAKFADGAKAKILVCSDSCFAGKKQDGSGKIIAELLSNE
CCCCHHHHHHHHHCCCCCHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHCCC
GVEVLEIKIVPDEPKEIEQTISNWANEKIDLIITTGGTGLGPRDNTTDTIKPMLEKEIPG
CCEEEEEEECCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCC
IAEVMRSFGQDRTPFAMLSRSIAGSIGKSIIIAVPGSSNGSKESMTAILPAVFHAKKMMR
HHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHC
GEGH
CCCC
>Mature Secondary Structure
MNDITGKRTTLRYAEAEGFVYCQKETIQRIKTNTLPKGDLFEVAKASALLGAKKTSDLIP
CCCCCCCCEEEEEECCCCEEEECHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHCCCC
HCHPVPIDSFSIQFEIIDEKNAVRILTQAKSIGKTGIEMEALTGVTVAALVIYDLLKPID
CCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHC
KSLEISSIRLLEKKGGKTDKHIAKFADGAKAKILVCSDSCFAGKKQDGSGKIIAELLSNE
CCCCHHHHHHHHHCCCCCHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHCCC
GVEVLEIKIVPDEPKEIEQTISNWANEKIDLIITTGGTGLGPRDNTTDTIKPMLEKEIPG
CCEEEEEEECCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCC
IAEVMRSFGQDRTPFAMLSRSIAGSIGKSIIIAVPGSSNGSKESMTAILPAVFHAKKMMR
HHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHC
GEGH
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Involved in molybdopterin biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]