| Definition | Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)' chromosome chromosome I, complete sequence. |
|---|---|
| Accession | NC_010602 |
| Length | 3,599,677 |
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The map label for this gene is dxs [H]
Identifier: 183221964
GI number: 183221964
Start: 2692366
End: 2694255
Strand: Reverse
Name: dxs [H]
Synonym: LEPBI_I2605
Alternate gene names: 183221964
Gene position: 2694255-2692366 (Counterclockwise)
Preceding gene: 183221965
Following gene: 183221963
Centisome position: 74.85
GC content: 43.92
Gene sequence:
>1890_bases ATGCCATCGTATCCATATCTCGACAAAATCAATTTCCCACAAGACCTTAGAAACCTAAAGGAAGCGGATCTCCCTGCGGT CTGCCATGACCTCAGGGAATACATCATCGACACCCTCTCCGACGTGGGAGGGCATTTCGCCAGTAACCTAGGAGTCGTGG AACTTACCGTTGCCCTTCACTACGTTTTCCAAACACCGAAAGACAAAATCATCTGGGACGTTGGCCACCAAACCTATCCT CATAAAATCCTGACAGGTCGAAAAAAAGAACTGCCAACGGTTCGTAAATGGTTGGGCCTTTCTGGATTTCCCAAACGAGA AGAATCTGAATATGATTTGTACAATACAGGCCATGCGGGAACTTCTATCTCCCAAGCCTTAGGTGAAGCCTGTGCCAGGG ACTTAATGGGTGAATCCTACAAAGTGGCGGCAGTGATTGGAGACGCCTCCATTGCCACGGGTATGGCACTGGAAGCCATG AACCATGGAGGGCATATCAAACCCAACATGTTAGTCATCTTAAATGACAACTACATGTCCATCTCCAAAAATGTCGGGTC CATTTCTAATTATTTGAATCGAATCATTTCTTCTCAAGTGTACAATAAGGGAAAAACTGCTATTTACAGTTTTTTAAAAT GGATTCCGCTGATTGGTCCCGCCTTGCAGGCATTAGCTCATAACATGGAAACATCGTTTAAACATTTTATGATGCGCCCT GGTGGACTCTTCGAAGATTTGGGATTTACTTATTTTGGTCCCATTGATGGACACGACGTAAACCGCGTGGTCCAAATGTT ACAAAACCTTTCCAAAATCCAAGGTCCCATTCTGCTCCATGTCCTCACTCAAAAAGGCAAAGGATACAAACCAGCGGAAG CTGACCCTATCAAATACCATGGAGTCACACCGTTTAACAAAGAATCAGGGAAAATGACTTCGGCTGATGCCAATAAAATT GGACTCTCTAAAATTGTGGGAAAAACTCTGATGGATCTCACAAACAAAGACAAACGAATTGCGGTGATCACTCCTGCCAT GATTGAAGGGTCAGGACTACGTGATTTTCAGGAGGCATATCCAAATCATACATTTGATGTAGGGATCGCCGAACAACACT CCGTTGCCTTTGCTGGTGCCATGACAAATGGTGGTGCCATCCCATTTATGTGTATTTATTCTACCTTTCTCACAAGAGCA ATGGACCAATTGGTAGAAGATGTATCCCTTATGAATTTGCCAGTTCGGTTTGTCATTGATCGAGCAGGGATTGTGGGACC CGATGGAGAAACCCACCAAGGTTTGTCTGATTTAGGGTATCTGGCAGGGCTTCCCAATATGGACATCATCGTTCCCAGTT CCGCGCAAGACATCATCGATAGCCTTCATTTTATGAAGGATTATTCGGAGCATCCGATCGCAATTCGATTCCCAAAAGAC AATGGCGACTTACGAGAATTAAAGTTCGAGAAACCGAACCAAATCACGAAAGCAAAAGCAAGAGTGGTGACGGAAGGAGA AGATTTACTAATCCTTTCCCTTGGATTTATGTTACCCATCGCGGGACAAGTCGCCGAAATTTTAAAAACAAAAGGAATCT CGGTTTCTGTGATTGATTTGTTTTGGCTACGACCTTATGATAAGGATCTTGTCCACACCTACATTGCAAAAACCAAACGG TTTGTGATTTTAGATGAAAGTTACCTCCATGCGGGTGCATCCGGTTACCTTTTGAATGAAATTCCAGGTTCACTCATTGG AAAGTTTCTAAAAACCTTTGCCCTTCCTTTGGAGCCGATCCACCACGGAGAAAGGAACCAAATCTTAGAACACTACCGAC TGACTGCGACTCAGATTGCCGAAGATTTACTTTCAGTTTTGCAAAAATAA
Upstream 100 bases:
>100_bases ACCCAACCTGTTCGGATTTACGAATTGCTTGGAATCACAAACCCAGAAGATATGGAGAAAATGAAGCGGCCACTCCAAAA GGCGGCAACATGAAGTTTCA
Downstream 100 bases:
>100_bases AAAATAAGTTTTCAAGGAGATTTTTAAGGCTTCCGAAAATGAAAGAAAACAGGTGAGGATCTCTTTGTCTTCAAGTTCTT TCCAACTTTCTTTAGATTTA
Product: 1-deoxy-D-xylulose-5-phosphate synthase
Products: NA
Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]
Number of amino acids: Translated: 629; Mature: 628
Protein sequence:
>629_residues MPSYPYLDKINFPQDLRNLKEADLPAVCHDLREYIIDTLSDVGGHFASNLGVVELTVALHYVFQTPKDKIIWDVGHQTYP HKILTGRKKELPTVRKWLGLSGFPKREESEYDLYNTGHAGTSISQALGEACARDLMGESYKVAAVIGDASIATGMALEAM NHGGHIKPNMLVILNDNYMSISKNVGSISNYLNRIISSQVYNKGKTAIYSFLKWIPLIGPALQALAHNMETSFKHFMMRP GGLFEDLGFTYFGPIDGHDVNRVVQMLQNLSKIQGPILLHVLTQKGKGYKPAEADPIKYHGVTPFNKESGKMTSADANKI GLSKIVGKTLMDLTNKDKRIAVITPAMIEGSGLRDFQEAYPNHTFDVGIAEQHSVAFAGAMTNGGAIPFMCIYSTFLTRA MDQLVEDVSLMNLPVRFVIDRAGIVGPDGETHQGLSDLGYLAGLPNMDIIVPSSAQDIIDSLHFMKDYSEHPIAIRFPKD NGDLRELKFEKPNQITKAKARVVTEGEDLLILSLGFMLPIAGQVAEILKTKGISVSVIDLFWLRPYDKDLVHTYIAKTKR FVILDESYLHAGASGYLLNEIPGSLIGKFLKTFALPLEPIHHGERNQILEHYRLTATQIAEDLLSVLQK
Sequences:
>Translated_629_residues MPSYPYLDKINFPQDLRNLKEADLPAVCHDLREYIIDTLSDVGGHFASNLGVVELTVALHYVFQTPKDKIIWDVGHQTYP HKILTGRKKELPTVRKWLGLSGFPKREESEYDLYNTGHAGTSISQALGEACARDLMGESYKVAAVIGDASIATGMALEAM NHGGHIKPNMLVILNDNYMSISKNVGSISNYLNRIISSQVYNKGKTAIYSFLKWIPLIGPALQALAHNMETSFKHFMMRP GGLFEDLGFTYFGPIDGHDVNRVVQMLQNLSKIQGPILLHVLTQKGKGYKPAEADPIKYHGVTPFNKESGKMTSADANKI GLSKIVGKTLMDLTNKDKRIAVITPAMIEGSGLRDFQEAYPNHTFDVGIAEQHSVAFAGAMTNGGAIPFMCIYSTFLTRA MDQLVEDVSLMNLPVRFVIDRAGIVGPDGETHQGLSDLGYLAGLPNMDIIVPSSAQDIIDSLHFMKDYSEHPIAIRFPKD NGDLRELKFEKPNQITKAKARVVTEGEDLLILSLGFMLPIAGQVAEILKTKGISVSVIDLFWLRPYDKDLVHTYIAKTKR FVILDESYLHAGASGYLLNEIPGSLIGKFLKTFALPLEPIHHGERNQILEHYRLTATQIAEDLLSVLQK >Mature_628_residues PSYPYLDKINFPQDLRNLKEADLPAVCHDLREYIIDTLSDVGGHFASNLGVVELTVALHYVFQTPKDKIIWDVGHQTYPH KILTGRKKELPTVRKWLGLSGFPKREESEYDLYNTGHAGTSISQALGEACARDLMGESYKVAAVIGDASIATGMALEAMN HGGHIKPNMLVILNDNYMSISKNVGSISNYLNRIISSQVYNKGKTAIYSFLKWIPLIGPALQALAHNMETSFKHFMMRPG GLFEDLGFTYFGPIDGHDVNRVVQMLQNLSKIQGPILLHVLTQKGKGYKPAEADPIKYHGVTPFNKESGKMTSADANKIG LSKIVGKTLMDLTNKDKRIAVITPAMIEGSGLRDFQEAYPNHTFDVGIAEQHSVAFAGAMTNGGAIPFMCIYSTFLTRAM DQLVEDVSLMNLPVRFVIDRAGIVGPDGETHQGLSDLGYLAGLPNMDIIVPSSAQDIIDSLHFMKDYSEHPIAIRFPKDN GDLRELKFEKPNQITKAKARVVTEGEDLLILSLGFMLPIAGQVAEILKTKGISVSVIDLFWLRPYDKDLVHTYIAKTKRF VILDESYLHAGASGYLLNEIPGSLIGKFLKTFALPLEPIHHGERNQILEHYRLTATQIAEDLLSVLQK
Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]
COG id: COG1154
COG function: function code HI; Deoxyxylulose-5-phosphate synthase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the transketolase family. DXPS subfamily [H]
Homologues:
Organism=Homo sapiens, GI205277463, Length=612, Percent_Identity=23.3660130718954, Blast_Score=86, Evalue=9e-17, Organism=Homo sapiens, GI4507521, Length=612, Percent_Identity=23.3660130718954, Blast_Score=86, Evalue=9e-17, Organism=Homo sapiens, GI133778974, Length=514, Percent_Identity=24.3190661478599, Blast_Score=81, Evalue=4e-15, Organism=Escherichia coli, GI1786622, Length=582, Percent_Identity=44.8453608247423, Blast_Score=499, Evalue=1e-142, Organism=Caenorhabditis elegans, GI17539652, Length=500, Percent_Identity=22.8, Blast_Score=78, Evalue=1e-14, Organism=Drosophila melanogaster, GI24645119, Length=528, Percent_Identity=22.9166666666667, Blast_Score=83, Evalue=6e-16, Organism=Drosophila melanogaster, GI45551847, Length=528, Percent_Identity=22.9166666666667, Blast_Score=82, Evalue=8e-16, Organism=Drosophila melanogaster, GI45550715, Length=528, Percent_Identity=22.9166666666667, Blast_Score=82, Evalue=8e-16,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005477 - InterPro: IPR009014 - InterPro: IPR015941 - InterPro: IPR005475 - InterPro: IPR005476 - InterPro: IPR005474 [H]
Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]
EC number: =2.2.1.7 [H]
Molecular weight: Translated: 69679; Mature: 69548
Theoretical pI: Translated: 6.95; Mature: 6.95
Prosite motif: PS00801 TRANSKETOLASE_1
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.5 %Cys (Translated Protein) 3.2 %Met (Translated Protein) 3.7 %Cys+Met (Translated Protein) 0.5 %Cys (Mature Protein) 3.0 %Met (Mature Protein) 3.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MPSYPYLDKINFPQDLRNLKEADLPAVCHDLREYIIDTLSDVGGHFASNLGVVELTVALH CCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH YVFQTPKDKIIWDVGHQTYPHKILTGRKKELPTVRKWLGLSGFPKREESEYDLYNTGHAG HHHCCCCCCEEEECCCCCCCHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCC TSISQALGEACARDLMGESYKVAAVIGDASIATGMALEAMNHGGHIKPNMLVILNDNYMS CHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCEE ISKNVGSISNYLNRIISSQVYNKGKTAIYSFLKWIPLIGPALQALAHNMETSFKHFMMRP ECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC GGLFEDLGFTYFGPIDGHDVNRVVQMLQNLSKIQGPILLHVLTQKGKGYKPAEADPIKYH CCCHHHCCCEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCEEEC GVTPFNKESGKMTSADANKIGLSKIVGKTLMDLTNKDKRIAVITPAMIEGSGLRDFQEAY CCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECHHCCCCCCCHHHHHC PNHTFDVGIAEQHSVAFAGAMTNGGAIPFMCIYSTFLTRAMDQLVEDVSLMNLPVRFVID CCCEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEE RAGIVGPDGETHQGLSDLGYLAGLPNMDIIVPSSAQDIIDSLHFMKDYSEHPIAIRFPKD CCCCCCCCCCCCCCHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHCCCCCEEEEECCC NGDLRELKFEKPNQITKAKARVVTEGEDLLILSLGFMLPIAGQVAEILKTKGISVSVIDL CCCHHHCCCCCCCHHHHHHHHEEECCCCEEEEEHHHHHHHHHHHHHHHHHCCCEEEEEEE FWLRPYDKDLVHTYIAKTKRFVILDESYLHAGASGYLLNEIPGSLIGKFLKTFALPLEPI EECCCCCHHHHHHHHHCCCEEEEEEHHHHHCCCCCCCHHHCCHHHHHHHHHHHCCCCCHH HHGERNQILEHYRLTATQIAEDLLSVLQK CCCCHHHHHHHHHHHHHHHHHHHHHHHCC >Mature Secondary Structure PSYPYLDKINFPQDLRNLKEADLPAVCHDLREYIIDTLSDVGGHFASNLGVVELTVALH CCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH YVFQTPKDKIIWDVGHQTYPHKILTGRKKELPTVRKWLGLSGFPKREESEYDLYNTGHAG HHHCCCCCCEEEECCCCCCCHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCC TSISQALGEACARDLMGESYKVAAVIGDASIATGMALEAMNHGGHIKPNMLVILNDNYMS CHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCEE ISKNVGSISNYLNRIISSQVYNKGKTAIYSFLKWIPLIGPALQALAHNMETSFKHFMMRP ECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC GGLFEDLGFTYFGPIDGHDVNRVVQMLQNLSKIQGPILLHVLTQKGKGYKPAEADPIKYH CCCHHHCCCEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCEEEC GVTPFNKESGKMTSADANKIGLSKIVGKTLMDLTNKDKRIAVITPAMIEGSGLRDFQEAY CCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECHHCCCCCCCHHHHHC PNHTFDVGIAEQHSVAFAGAMTNGGAIPFMCIYSTFLTRAMDQLVEDVSLMNLPVRFVID CCCEEEECCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEE RAGIVGPDGETHQGLSDLGYLAGLPNMDIIVPSSAQDIIDSLHFMKDYSEHPIAIRFPKD CCCCCCCCCCCCCCHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHCCCCCEEEEECCC NGDLRELKFEKPNQITKAKARVVTEGEDLLILSLGFMLPIAGQVAEILKTKGISVSVIDL CCCHHHCCCCCCCHHHHHHHHEEECCCCEEEEEHHHHHHHHHHHHHHHHHCCCEEEEEEE FWLRPYDKDLVHTYIAKTKRFVILDESYLHAGASGYLLNEIPGSLIGKFLKTFALPLEPI EECCCCCHHHHHHHHHCCCEEEEEEHHHHHCCCCCCCHHHCCHHHHHHHHHHHCCCCCHH HHGERNQILEHYRLTATQIAEDLLSVLQK CCCCHHHHHHHHHHHHHHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA