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The map label for this gene is cyaB [H]

Identifier: 183221965

GI number: 183221965

Start: 2694263

End: 2696590

Strand: Reverse

Name: cyaB [H]

Synonym: LEPBI_I2606

Alternate gene names: 183221965

Gene position: 2696590-2694263 (Counterclockwise)

Preceding gene: 183221966

Following gene: 183221964

Centisome position: 74.91

GC content: 40.42

Gene sequence:

>2328_bases
ATGTCCGACAAAGAATCAAAATCGCTTTCGATTTTAGATTACCTCAGTGTTGCAGTTGCCACCCTTGGGTCACTTGGTGT
GATCGTTTCTGTCGTCATGACAGGATGGGTATATGAGTATTCCTTCCTAGTTGGTGGGATGCTCGTACTGCTATCTTCAT
CTTACTTTGTTTACAAAATCATTGAAAAAGTTTCTAAAGACAAACAAAGATCAGGGGCTATCTGGTTATCATATGTAATT
GCAATTTTTATGTATACCATGGTAAATACCTTCCAACCTCTTAAGGAGTTGGAAGAAAATTCCATTTCATTTCGGTTTCA
ATTTTTACGAGGTACCAATACAAAAACAGAAAGTGAAGGGGACACGGGTAGGATTGAATACATCCAATACCAACCACCCG
CAAAAGCCAGAAAGGATATCAATATCATTGGTATCACAACAGAATCTTTAGAAAAACTACAAGGAACTTGGCCACTTCCA
TGGAGCTATTATTCTGATATCATTGAAACATTCAAAGATTCAAACAACATTCTGATGTTCGATATTTTCTTCGTTGATTA
TAAACCCGGCCAAACGGAAGAGATGGTCACTGCATTGCAAAAAAATCGCAATGTTTTATTTGACTACCCTATGGAAGTCA
GTGCGGAATCCAAAGAAGCAGTTCTCAATTTAGAAAAACGAATTGATATCTTAAGAAAGTTTCAAATTAAAAATGTCATC
GATGAAAACGATGGTGGTATCTCTTGGGTTAAATTCCCACAACCACCCATCGAACCGATCGGTGAGTTATCAGCTGGTCT
TGGTTTTGCGAACGTAAAAAAAGATGAGTCTGGTCTCAACAGAAAGATGCCACTTGTTGTTAAGGTTTATAACTCTGGAC
GTGACAGAGAAACTGAATATTTCCCTTCCATCGACTTACTCATTGTTTGCCAATACTACGGTATCAACGTACAAAATGAT
GTAGAAGTGAATATGGGCCATTATGTTAAACTCAAAAACATTCCAAACAAAATCATTCGAGAGTTTAATGTAAAAGCACG
TAAATTTGAAGAACGTGATGTGATGCATATCCCGAATGAAAATAGGGAAGTGGTCATACCTATCGACTGGGAAGGGCAAA
TGGAAATCAATTTTGTGGGAGGAAGGTATTCTTTCAAACAAAATGAGATCTTTGAAGTGACAAACGATTGGAATCAAGAA
TTACTCGAAGCAAACCAAATTAATAACAAAATTTTCCTAGTTGCGATGTATTATGCAACTGGTCGCGGGGCTTCCAAAGA
CTCCCACTTATCTCCGTTTGGTGATATGTCAGGGATTGAACACCACGCACATGCTGTAAACACCATTCTAAACCAAGACT
TTTTGTCCACAGTTCCGAATTGGGGGATCTTTCTCATTTATGTAGCTCTTGGTGTTATGATTGGATTTTTACAACCACGT
GTGAAAACCCATATTGGTTTTGCGATCATGTTAACTCAGTTATTACTTTATGTGATAGCCGCTCTTTATATTTTCCAAGC
TTTCAACCTGATCACCGTTTTACCATCAGTCACCATCGAACAGATTGTGGTCTTTGTGGCCATCATCGGATTTAGGATCT
TAACAGAAGAAGAGAACGTAAAATACATCCGACAAACCTTTTCCAAATTCGTATCCAAAGACGTTGTGGATGAACTCCTC
AAACACCCGGACAATTTGGCACTTGGTGGGTCCAAACGAGAGATCACCATTTTTTTCTCTGACGTTCGTGGGTTCACGAC
CATTTCCGAACAATTGGGACCGGAAGACCTCGTGAAGTTACTGAACGAATACCTTTCTGCCATGACGGACATCATCATTG
AATACAAAGGAACCATCGATAAGTACATGGGTGATGCCATCATGGCATTCTGGGGAGCTCCAGTACCGTTGGAAGACCAT
GCTTATTATGCTTGCGTCGCTGCATTAGCACAGCTTGACCACTTAAAAGTACTCCAACAAAAGTGGGCTGAACGGCATGT
CCCAGTGATCGACATTGGTTGTGGGCTCAACTCAGGCCCTGCAGTTGTTGGGAACATGGGTTCATCTCATAGGATGGAAT
ACACTTGTATGGGAGATACGATCAACCTCGGATCTCGCTTGGAAGGTTCGAATAAGATGTACACGACAAATATCATCATC
TCGGAATACACCTATGAAAAAGTAAAAGACCGAGTGGTGACACGAGAGCTTGATTTGGTGCGTGTAAAAGGAAAAACCCA
ACCTGTTCGGATTTACGAATTGCTTGGAATCACAAACCCAGAAGATATGGAGAAAATGAAGCGGCCACTCCAAAAGGCGG
CAACATGA

Upstream 100 bases:

>100_bases
AATTTCCTAAATTTTTTTCCGAAATCACTCAAAAACATTTGAGTCTCTTTAAAAAATCCGAGAGAATGGTCGGAAATTCC
TTAACGAATAAAGAGGCTCT

Downstream 100 bases:

>100_bases
AGTTTCAATGCCATCGTATCCATATCTCGACAAAATCAATTTCCCACAAGACCTTAGAAACCTAAAGGAAGCGGATCTCC
CTGCGGTCTGCCATGACCTC

Product: putative adenylate/guanylate cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 2; Adenylyl cyclase 2; AC2 [H]

Number of amino acids: Translated: 775; Mature: 774

Protein sequence:

>775_residues
MSDKESKSLSILDYLSVAVATLGSLGVIVSVVMTGWVYEYSFLVGGMLVLLSSSYFVYKIIEKVSKDKQRSGAIWLSYVI
AIFMYTMVNTFQPLKELEENSISFRFQFLRGTNTKTESEGDTGRIEYIQYQPPAKARKDINIIGITTESLEKLQGTWPLP
WSYYSDIIETFKDSNNILMFDIFFVDYKPGQTEEMVTALQKNRNVLFDYPMEVSAESKEAVLNLEKRIDILRKFQIKNVI
DENDGGISWVKFPQPPIEPIGELSAGLGFANVKKDESGLNRKMPLVVKVYNSGRDRETEYFPSIDLLIVCQYYGINVQND
VEVNMGHYVKLKNIPNKIIREFNVKARKFEERDVMHIPNENREVVIPIDWEGQMEINFVGGRYSFKQNEIFEVTNDWNQE
LLEANQINNKIFLVAMYYATGRGASKDSHLSPFGDMSGIEHHAHAVNTILNQDFLSTVPNWGIFLIYVALGVMIGFLQPR
VKTHIGFAIMLTQLLLYVIAALYIFQAFNLITVLPSVTIEQIVVFVAIIGFRILTEEENVKYIRQTFSKFVSKDVVDELL
KHPDNLALGGSKREITIFFSDVRGFTTISEQLGPEDLVKLLNEYLSAMTDIIIEYKGTIDKYMGDAIMAFWGAPVPLEDH
AYYACVAALAQLDHLKVLQQKWAERHVPVIDIGCGLNSGPAVVGNMGSSHRMEYTCMGDTINLGSRLEGSNKMYTTNIII
SEYTYEKVKDRVVTRELDLVRVKGKTQPVRIYELLGITNPEDMEKMKRPLQKAAT

Sequences:

>Translated_775_residues
MSDKESKSLSILDYLSVAVATLGSLGVIVSVVMTGWVYEYSFLVGGMLVLLSSSYFVYKIIEKVSKDKQRSGAIWLSYVI
AIFMYTMVNTFQPLKELEENSISFRFQFLRGTNTKTESEGDTGRIEYIQYQPPAKARKDINIIGITTESLEKLQGTWPLP
WSYYSDIIETFKDSNNILMFDIFFVDYKPGQTEEMVTALQKNRNVLFDYPMEVSAESKEAVLNLEKRIDILRKFQIKNVI
DENDGGISWVKFPQPPIEPIGELSAGLGFANVKKDESGLNRKMPLVVKVYNSGRDRETEYFPSIDLLIVCQYYGINVQND
VEVNMGHYVKLKNIPNKIIREFNVKARKFEERDVMHIPNENREVVIPIDWEGQMEINFVGGRYSFKQNEIFEVTNDWNQE
LLEANQINNKIFLVAMYYATGRGASKDSHLSPFGDMSGIEHHAHAVNTILNQDFLSTVPNWGIFLIYVALGVMIGFLQPR
VKTHIGFAIMLTQLLLYVIAALYIFQAFNLITVLPSVTIEQIVVFVAIIGFRILTEEENVKYIRQTFSKFVSKDVVDELL
KHPDNLALGGSKREITIFFSDVRGFTTISEQLGPEDLVKLLNEYLSAMTDIIIEYKGTIDKYMGDAIMAFWGAPVPLEDH
AYYACVAALAQLDHLKVLQQKWAERHVPVIDIGCGLNSGPAVVGNMGSSHRMEYTCMGDTINLGSRLEGSNKMYTTNIII
SEYTYEKVKDRVVTRELDLVRVKGKTQPVRIYELLGITNPEDMEKMKRPLQKAAT
>Mature_774_residues
SDKESKSLSILDYLSVAVATLGSLGVIVSVVMTGWVYEYSFLVGGMLVLLSSSYFVYKIIEKVSKDKQRSGAIWLSYVIA
IFMYTMVNTFQPLKELEENSISFRFQFLRGTNTKTESEGDTGRIEYIQYQPPAKARKDINIIGITTESLEKLQGTWPLPW
SYYSDIIETFKDSNNILMFDIFFVDYKPGQTEEMVTALQKNRNVLFDYPMEVSAESKEAVLNLEKRIDILRKFQIKNVID
ENDGGISWVKFPQPPIEPIGELSAGLGFANVKKDESGLNRKMPLVVKVYNSGRDRETEYFPSIDLLIVCQYYGINVQNDV
EVNMGHYVKLKNIPNKIIREFNVKARKFEERDVMHIPNENREVVIPIDWEGQMEINFVGGRYSFKQNEIFEVTNDWNQEL
LEANQINNKIFLVAMYYATGRGASKDSHLSPFGDMSGIEHHAHAVNTILNQDFLSTVPNWGIFLIYVALGVMIGFLQPRV
KTHIGFAIMLTQLLLYVIAALYIFQAFNLITVLPSVTIEQIVVFVAIIGFRILTEEENVKYIRQTFSKFVSKDVVDELLK
HPDNLALGGSKREITIFFSDVRGFTTISEQLGPEDLVKLLNEYLSAMTDIIIEYKGTIDKYMGDAIMAFWGAPVPLEDHA
YYACVAALAQLDHLKVLQQKWAERHVPVIDIGCGLNSGPAVVGNMGSSHRMEYTCMGDTINLGSRLEGSNKMYTTNIIIS
EYTYEKVKDRVVTRELDLVRVKGKTQPVRIYELLGITNPEDMEKMKRPLQKAAT

Specific function: Unknown

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Homo sapiens, GI134152694, Length=156, Percent_Identity=35.8974358974359, Blast_Score=70, Evalue=1e-11,
Organism=Homo sapiens, GI167830411, Length=191, Percent_Identity=34.0314136125654, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI4504217, Length=180, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17508769, Length=171, Percent_Identity=31.5789473684211, Blast_Score=76, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71989805, Length=155, Percent_Identity=34.8387096774194, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71989822, Length=155, Percent_Identity=34.8387096774194, Blast_Score=75, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17534665, Length=216, Percent_Identity=30.5555555555556, Blast_Score=73, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI212645647, Length=178, Percent_Identity=32.5842696629214, Blast_Score=72, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17534659, Length=140, Percent_Identity=32.8571428571429, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI161078020, Length=178, Percent_Identity=31.4606741573034, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI28574512, Length=212, Percent_Identity=33.0188679245283, Blast_Score=76, Evalue=7e-14,
Organism=Drosophila melanogaster, GI161076872, Length=212, Percent_Identity=33.0188679245283, Blast_Score=76, Evalue=7e-14,
Organism=Drosophila melanogaster, GI281366459, Length=173, Percent_Identity=31.2138728323699, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI281366457, Length=173, Percent_Identity=31.2138728323699, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI281366455, Length=173, Percent_Identity=31.2138728323699, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI56292422, Length=173, Percent_Identity=31.2138728323699, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI56292424, Length=173, Percent_Identity=31.2138728323699, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24666940, Length=173, Percent_Identity=31.2138728323699, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI62484477, Length=218, Percent_Identity=28.4403669724771, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI62484298, Length=218, Percent_Identity=28.4403669724771, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI116008008, Length=218, Percent_Identity=28.4403669724771, Blast_Score=69, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221330470, Length=141, Percent_Identity=34.7517730496454, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221330468, Length=141, Percent_Identity=34.7517730496454, Blast_Score=68, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR011006
- InterPro:   IPR001789 [H]

Pfam domain/function: PF00211 Guanylate_cyc; PF00072 Response_reg [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 88148; Mature: 88017

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDKESKSLSILDYLSVAVATLGSLGVIVSVVMTGWVYEYSFLVGGMLVLLSSSYFVYKI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
IEKVSKDKQRSGAIWLSYVIAIFMYTMVNTFQPLKELEENSISFRFQFLRGTNTKTESEG
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCC
DTGRIEYIQYQPPAKARKDINIIGITTESLEKLQGTWPLPWSYYSDIIETFKDSNNILMF
CCCCEEEEEECCCCHHHCCCEEEEECHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEE
DIFFVDYKPGQTEEMVTALQKNRNVLFDYPMEVSAESKEAVLNLEKRIDILRKFQIKNVI
EEEEEECCCCCHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DENDGGISWVKFPQPPIEPIGELSAGLGFANVKKDESGLNRKMPLVVKVYNSGRDRETEY
CCCCCCEEEEECCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCC
FPSIDLLIVCQYYGINVQNDVEVNMGHYVKLKNIPNKIIREFNVKARKFEERDVMHIPNE
CCCCCEEEEEEECCCCCCCCEEECCCCEEEECCCCHHHHHHHCCHHHHHCCCCCEECCCC
NREVVIPIDWEGQMEINFVGGRYSFKQNEIFEVTNDWNQELLEANQINNKIFLVAMYYAT
CCEEEEEECCCCEEEEEEECCEEECCCCCCEEECCHHHHHHHHHHHCCCEEEEEEEEEEC
GRGASKDSHLSPFGDMSGIEHHAHAVNTILNQDFLSTVPNWGIFLIYVALGVMIGFLQPR
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCHH
VKTHIGFAIMLTQLLLYVIAALYIFQAFNLITVLPSVTIEQIVVFVAIIGFRILTEEENV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHEEECCCHH
KYIRQTFSKFVSKDVVDELLKHPDNLALGGSKREITIFFSDVRGFTTISEQLGPEDLVKL
HHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEEEECCCCHHHHHHHCCHHHHHHH
LNEYLSAMTDIIIEYKGTIDKYMGDAIMAFWGAPVPLEDHAYYACVAALAQLDHLKVLQQ
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
KWAERHVPVIDIGCGLNSGPAVVGNMGSSHRMEYTCMGDTINLGSRLEGSNKMYTTNIII
HHHHCCCCEEEECCCCCCCCEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEEEEE
SEYTYEKVKDRVVTRELDLVRVKGKTQPVRIYELLGITNPEDMEKMKRPLQKAAT
EHHHHHHHHHHHHHHHCCEEEECCCCCCEEEEHHHCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SDKESKSLSILDYLSVAVATLGSLGVIVSVVMTGWVYEYSFLVGGMLVLLSSSYFVYKI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
IEKVSKDKQRSGAIWLSYVIAIFMYTMVNTFQPLKELEENSISFRFQFLRGTNTKTESEG
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCC
DTGRIEYIQYQPPAKARKDINIIGITTESLEKLQGTWPLPWSYYSDIIETFKDSNNILMF
CCCCEEEEEECCCCHHHCCCEEEEECHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEE
DIFFVDYKPGQTEEMVTALQKNRNVLFDYPMEVSAESKEAVLNLEKRIDILRKFQIKNVI
EEEEEECCCCCHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DENDGGISWVKFPQPPIEPIGELSAGLGFANVKKDESGLNRKMPLVVKVYNSGRDRETEY
CCCCCCEEEEECCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCC
FPSIDLLIVCQYYGINVQNDVEVNMGHYVKLKNIPNKIIREFNVKARKFEERDVMHIPNE
CCCCCEEEEEEECCCCCCCCEEECCCCEEEECCCCHHHHHHHCCHHHHHCCCCCEECCCC
NREVVIPIDWEGQMEINFVGGRYSFKQNEIFEVTNDWNQELLEANQINNKIFLVAMYYAT
CCEEEEEECCCCEEEEEEECCEEECCCCCCEEECCHHHHHHHHHHHCCCEEEEEEEEEEC
GRGASKDSHLSPFGDMSGIEHHAHAVNTILNQDFLSTVPNWGIFLIYVALGVMIGFLQPR
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCHH
VKTHIGFAIMLTQLLLYVIAALYIFQAFNLITVLPSVTIEQIVVFVAIIGFRILTEEENV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHEEECCCHH
KYIRQTFSKFVSKDVVDELLKHPDNLALGGSKREITIFFSDVRGFTTISEQLGPEDLVKL
HHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEEEECCCCHHHHHHHCCHHHHHHH
LNEYLSAMTDIIIEYKGTIDKYMGDAIMAFWGAPVPLEDHAYYACVAALAQLDHLKVLQQ
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
KWAERHVPVIDIGCGLNSGPAVVGNMGSSHRMEYTCMGDTINLGSRLEGSNKMYTTNIII
HHHHCCCCEEEECCCCCCCCEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEEEEE
SEYTYEKVKDRVVTRELDLVRVKGKTQPVRIYELLGITNPEDMEKMKRPLQKAAT
EHHHHHHHHHHHHHHHCCEEEECCCCCCEEEEHHHCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9523018; 8418825 [H]