Click here to switch to the map view.

The map label for this gene is trxB [H]

Identifier: 183221730

GI number: 183221730

Start: 2428292

End: 2429233

Strand: Direct

Name: trxB [H]

Synonym: LEPBI_I2359

Alternate gene names: 183221730

Gene position: 2428292-2429233 (Clockwise)

Preceding gene: 183221729

Following gene: 183221734

Centisome position: 67.46

GC content: 47.77

Gene sequence:

>942_bases
ATGAACCACAAAGTTGTCATCATTGGATCAGGACCAGCAGGTCATACGGCAGCCATCTACGCGGCAAGGGCCAATTTAAA
CCCAGTGATGTATGAAGGATTTATGGCGGGCGGAGTTGCCGCAGGGGGACAACTCACAACCACAACCGAAGTGGAAAATT
TTCCAGGTTTCCCAGAAGGAATCGATGGAACCAAACTCACCCAACTCTTCCGAGAACAATCGGCAAAATACGGAACGACC
ATCCACACCCAAACCATCACCAAAGTGGATTTTTCCAAACGACCTTTTACCATTTGGTCTGATGACGAAGAAATCAAAGC
AGATTCCATCATCATTGCAACTGGAGCGACCGCCAAACGAATGTTTGTAAAGGGTGAAGATGTGTTTTGGCAACGCGGGA
TTTCTGCTTGTGCGGTTTGTGATGGTGCCCTACCCATTTACCGAAACAAAGCATTGGCTGTTGTTGGTGGTGGTGACTCG
GCTGTAGAAGAAGCAAACCATCTCACGAAATTTGCATCCAAAGTGTATTTGGTCGTGAGACGTGACCAACTCAGAGCTTC
CCAAATCATGCAAAAACGAGCGATGGAACACCCAAAAATCGAAATCCTTTGGAACCAAACCGTGGTAGAAGCGAAAGGGG
GAGCCGGTGGCCTCACATCGATTGTCCTTGAAAGCACAAAGGACAAAACCCAAAAAGACTTAGAAGTGGGCGGACTCTTT
TATGCGATAGGGCATGTTCCGAACACTGAAATCTTTAAGGGTCAATTGAACTTAGATGAAACAGGTTACATCATCACAAA
ACCAGGAACCACTCAAACCAATGTGGAAGGTGTGTTTGCGGCAGGTGATGTACAGGACAAAGTGTACAGGCAAGCCATCA
CTGCAGCCGGCAGTGGTTGTATGGCTGCACTCGAAGCCGAACGATGGCTCGAAGGCCATTAG

Upstream 100 bases:

>100_bases
TTATTACGCTCCTTGGGTTCGGGCTTGTGAAACAAAATAAACGAGATTGATTTAGACCGAGTCTAAGAAATAACGAACTA
GATACAGGATAGGAGACATT

Downstream 100 bases:

>100_bases
AAAATCAGAAGAAACTTCCATCTTGGCATTAAGAAACCAGTTTGGTGGTAGATCCACTGGCTGGCTTTTTTTAGACCAAC
AAAAACAATTCTCTTTAAAA

Product: thioredoxin reductase 1

Products: NA

Alternate protein names: TRXR [H]

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MNHKVVIIGSGPAGHTAAIYAARANLNPVMYEGFMAGGVAAGGQLTTTTEVENFPGFPEGIDGTKLTQLFREQSAKYGTT
IHTQTITKVDFSKRPFTIWSDDEEIKADSIIIATGATAKRMFVKGEDVFWQRGISACAVCDGALPIYRNKALAVVGGGDS
AVEEANHLTKFASKVYLVVRRDQLRASQIMQKRAMEHPKIEILWNQTVVEAKGGAGGLTSIVLESTKDKTQKDLEVGGLF
YAIGHVPNTEIFKGQLNLDETGYIITKPGTTQTNVEGVFAAGDVQDKVYRQAITAAGSGCMAALEAERWLEGH

Sequences:

>Translated_313_residues
MNHKVVIIGSGPAGHTAAIYAARANLNPVMYEGFMAGGVAAGGQLTTTTEVENFPGFPEGIDGTKLTQLFREQSAKYGTT
IHTQTITKVDFSKRPFTIWSDDEEIKADSIIIATGATAKRMFVKGEDVFWQRGISACAVCDGALPIYRNKALAVVGGGDS
AVEEANHLTKFASKVYLVVRRDQLRASQIMQKRAMEHPKIEILWNQTVVEAKGGAGGLTSIVLESTKDKTQKDLEVGGLF
YAIGHVPNTEIFKGQLNLDETGYIITKPGTTQTNVEGVFAAGDVQDKVYRQAITAAGSGCMAALEAERWLEGH
>Mature_313_residues
MNHKVVIIGSGPAGHTAAIYAARANLNPVMYEGFMAGGVAAGGQLTTTTEVENFPGFPEGIDGTKLTQLFREQSAKYGTT
IHTQTITKVDFSKRPFTIWSDDEEIKADSIIIATGATAKRMFVKGEDVFWQRGISACAVCDGALPIYRNKALAVVGGGDS
AVEEANHLTKFASKVYLVVRRDQLRASQIMQKRAMEHPKIEILWNQTVVEAKGGAGGLTSIVLESTKDKTQKDLEVGGLF
YAIGHVPNTEIFKGQLNLDETGYIITKPGTTQTNVEGVFAAGDVQDKVYRQAITAAGSGCMAALEAERWLEGH

Specific function: Unknown

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787114, Length=317, Percent_Identity=50.788643533123, Blast_Score=298, Evalue=4e-82,
Organism=Escherichia coli, GI87081763, Length=317, Percent_Identity=33.4384858044164, Blast_Score=137, Evalue=7e-34,
Organism=Saccharomyces cerevisiae, GI6320560, Length=314, Percent_Identity=61.4649681528662, Blast_Score=412, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6321898, Length=317, Percent_Identity=60.2523659305994, Blast_Score=412, Evalue=1e-116,

Paralogues:

None

Copy number: 808 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103
- InterPro:   IPR005982 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.8.1.9 [H]

Molecular weight: Translated: 33700; Mature: 33700

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00573 PYRIDINE_REDOX_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHKVVIIGSGPAGHTAAIYAARANLNPVMYEGFMAGGVAAGGQLTTTTEVENFPGFPEG
CCCEEEEEECCCCCCEEEEEEEECCCCHHEEECCHHCCCCCCCEEEEEEECCCCCCCCCC
IDGTKLTQLFREQSAKYGTTIHTQTITKVDFSKRPFTIWSDDEEIKADSIIIATGATAKR
CCHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCCEEEECCCCCCCCCEEEEEECCCCEE
MFVKGEDVFWQRGISACAVCDGALPIYRNKALAVVGGGDSAVEEANHLTKFASKVYLVVR
EEECCCHHHHHCCCCEEEEECCCCEEECCCEEEEEECCCHHHHHHHHHHHHHHHEEEEEE
RDQLRASQIMQKRAMEHPKIEILWNQTVVEAKGGAGGLTSIVLESTKDKTQKDLEVGGLF
HHHHHHHHHHHHHHCCCCCEEEEECCEEEEECCCCCCHHHHEEECCCCHHHHHHHHCEEE
YAIGHVPNTEIFKGQLNLDETGYIITKPGTTQTNVEGVFAAGDVQDKVYRQAITAAGSGC
EEECCCCCCCEEEEEECCCCCCEEEECCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCH
MAALEAERWLEGH
HHHHHHHHHCCCC
>Mature Secondary Structure
MNHKVVIIGSGPAGHTAAIYAARANLNPVMYEGFMAGGVAAGGQLTTTTEVENFPGFPEG
CCCEEEEEECCCCCCEEEEEEEECCCCHHEEECCHHCCCCCCCEEEEEEECCCCCCCCCC
IDGTKLTQLFREQSAKYGTTIHTQTITKVDFSKRPFTIWSDDEEIKADSIIIATGATAKR
CCHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCCEEEECCCCCCCCCEEEEEECCCCEE
MFVKGEDVFWQRGISACAVCDGALPIYRNKALAVVGGGDSAVEEANHLTKFASKVYLVVR
EEECCCHHHHHCCCCEEEEECCCCEEECCCEEEEEECCCHHHHHHHHHHHHHHHEEEEEE
RDQLRASQIMQKRAMEHPKIEILWNQTVVEAKGGAGGLTSIVLESTKDKTQKDLEVGGLF
HHHHHHHHHHHHHHCCCCCEEEEECCEEEEECCCCCCHHHHEEECCCCHHHHHHHHCEEE
YAIGHVPNTEIFKGQLNLDETGYIITKPGTTQTNVEGVFAAGDVQDKVYRQAITAAGSGC
EEECCCCCCCEEEEEECCCCCCEEEECCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCH
MAALEAERWLEGH
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]