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The map label for this gene is ribH

Identifier: 183221522

GI number: 183221522

Start: 2233099

End: 2233566

Strand: Reverse

Name: ribH

Synonym: LEPBI_I2140

Alternate gene names: 183221522

Gene position: 2233566-2233099 (Counterclockwise)

Preceding gene: 183221523

Following gene: 183221521

Centisome position: 62.05

GC content: 47.86

Gene sequence:

>468_bases
ATGACAGCGCAATTGGAAGGCTTAAGGATCGGAAACGGACAAAAACATTGTGTCATCGTTTCAAAGTTCAATGAATTCAT
AACTGAGTCCCTATTAAAAGGGGCAAAAGATGCATACAGACAACATGGGGTAGCTGAATCCGATGTGACTGTGATCTATG
TCCCAGGTGCGTTTGAACTCCCGCAAACTGTCAAACGAGTCCTTGGGTCCAAAAAATACCAATTCTCTGCCATCGTTTGC
CTAGGGGCAGTGATCCGCGGGGCCACTTCCCATTATGATTTGGTTTCCGGGGAAGCCGCCAAAGTTGGATCCGTAGCAGA
CGGATCGGTTCCTGTGATTTTTGGTGTCATCACCACGGAGTCCATTGAACAAGCCATTGAGAGGGCAGGGACAAAAGCGG
GAAACAAGGGTTACGAAGCGGCCACCACAGCCATTGAAATGGCAAATCTTTTCAAAGAGATCGGATGA

Upstream 100 bases:

>100_bases
CACTGGAACGAGATGGTTTTGAAGTGGTCGAAAACCCAGACGGGAAAATTACCCTTGTCATTCGTCTTGCGAAATAACCC
CTCTTTTGGAACTTGGATAC

Downstream 100 bases:

>100_bases
GTTCCAGACACCGTGGGCGAAGTCTTGCCCTAATGTGCCTCTACCAAATTGATTTGGTGGGGACAGACCCAGACCGGGCT
ATGAAATTCGATTGGTATGA

Product: 6,7-dimethyl-8-ribityllumazine synthase

Products: NA

Alternate protein names: DMRL synthase; Lumazine synthase; Riboflavin synthase beta chain

Number of amino acids: Translated: 155; Mature: 154

Protein sequence:

>155_residues
MTAQLEGLRIGNGQKHCVIVSKFNEFITESLLKGAKDAYRQHGVAESDVTVIYVPGAFELPQTVKRVLGSKKYQFSAIVC
LGAVIRGATSHYDLVSGEAAKVGSVADGSVPVIFGVITTESIEQAIERAGTKAGNKGYEAATTAIEMANLFKEIG

Sequences:

>Translated_155_residues
MTAQLEGLRIGNGQKHCVIVSKFNEFITESLLKGAKDAYRQHGVAESDVTVIYVPGAFELPQTVKRVLGSKKYQFSAIVC
LGAVIRGATSHYDLVSGEAAKVGSVADGSVPVIFGVITTESIEQAIERAGTKAGNKGYEAATTAIEMANLFKEIG
>Mature_154_residues
TAQLEGLRIGNGQKHCVIVSKFNEFITESLLKGAKDAYRQHGVAESDVTVIYVPGAFELPQTVKRVLGSKKYQFSAIVCL
GAVIRGATSHYDLVSGEAAKVGSVADGSVPVIFGVITTESIEQAIERAGTKAGNKGYEAATTAIEMANLFKEIG

Specific function: Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit catalyzes

COG id: COG0054

COG function: function code H; Riboflavin synthase beta-chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DMRL synthase family

Homologues:

Organism=Escherichia coli, GI1786617, Length=141, Percent_Identity=52.4822695035461, Blast_Score=140, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6324429, Length=143, Percent_Identity=30.7692307692308, Blast_Score=74, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RISB_LEPBA (B0SB77)

Other databases:

- EMBL:   CP000777
- RefSeq:   YP_001963161.1
- ProteinModelPortal:   B0SB77
- SMR:   B0SB77
- GeneID:   6387770
- GenomeReviews:   CP000777_GR
- KEGG:   lbf:LBF_2086
- HOGENOM:   HBG311126
- OMA:   LGLQGAC
- ProtClustDB:   PRK00061
- BioCyc:   LBIF355278:LBF_2086-MONOMER
- HAMAP:   MF_00178
- InterPro:   IPR002180
- Gene3D:   G3DSA:3.40.50.960
- PANTHER:   PTHR21058
- TIGRFAMs:   TIGR00114

Pfam domain/function: PF00885 DMRL_synthase; SSF52121 DMRL_synthase

EC number: =2.5.1.9

Molecular weight: Translated: 16408; Mature: 16277

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAQLEGLRIGNGQKHCVIVSKFNEFITESLLKGAKDAYRQHGVAESDVTVIYVPGAFEL
CCCCCCCEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCC
PQTVKRVLGSKKYQFSAIVCLGAVIRGATSHYDLVSGEAAKVGSVADGSVPVIFGVITTE
HHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECHH
SIEQAIERAGTKAGNKGYEAATTAIEMANLFKEIG
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TAQLEGLRIGNGQKHCVIVSKFNEFITESLLKGAKDAYRQHGVAESDVTVIYVPGAFEL
CCCCCCEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCC
PQTVKRVLGSKKYQFSAIVCLGAVIRGATSHYDLVSGEAAKVGSVADGSVPVIFGVITTE
HHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECHH
SIEQAIERAGTKAGNKGYEAATTAIEMANLFKEIG
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA