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The map label for this gene is purE [H]

Identifier: 183221140

GI number: 183221140

Start: 1832243

End: 1832740

Strand: Direct

Name: purE [H]

Synonym: LEPBI_I1754

Alternate gene names: 183221140

Gene position: 1832243-1832740 (Clockwise)

Preceding gene: 183221139

Following gene: 183221141

Centisome position: 50.9

GC content: 42.37

Gene sequence:

>498_bases
ATGACAAACCCTTTACCGAAAGTTGCTGTAATTATGGGATCATATTCCGATTGGGACACCATGAAGGAAGCCTGCGAAAT
TTTAACTGAGTTTGGTGTACCTTTTGAAAAGGAAATTGTCTCCGCACATCGTTCTCCTGACAGAATGTTTCAATTTGCGA
AAAATGCAAAAAACAATGGTTTCGGTGTCATCATTGCAGGAGCGGGAGGAGCCGCACATTTGCCAGGTATGACGGCATCC
CTCACCACATTACCAGTTTTAGGTGTTCCAGTATTATCAAAAGCATTGAATGGAATGGATAGTTTATTATCAATCGTCCA
AATGCCAAAGGGAGTCCCTGTCGCAACCCTTGCGATTGGAACAAGTGGTGCTGCCAATGCAGGTTTACTTGCTGTTCGTA
TCTTATCCCTACTTGATTCCAGTCTTTCCAAAAAATTGGAAGACTATGCGGATCAAAATCGTGAACAAGCTCTTTCGAAA
AATGACCAACTGGTTTAG

Upstream 100 bases:

>100_bases
TCTCGTAAAAGGATCTCGCTCTATGAAAATGGAAGAAATTGTCTCGGAACTAGTTTCATTTAAAGGTTGATCGAGAATGA
GGTTTTTTTAGATTCTACGT

Downstream 100 bases:

>100_bases
GAATCATTGATGAAAATAGGTGTTTTGGGATCTGGTCAGCTCGGCCAAATGATGTGTTTGGAAGCGATTCCACTTGGACA
TGATTTCTATTGTTATTCGC

Product: phosphoribosylaminoimidazole carboxylase catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 165; Mature: 164

Protein sequence:

>165_residues
MTNPLPKVAVIMGSYSDWDTMKEACEILTEFGVPFEKEIVSAHRSPDRMFQFAKNAKNNGFGVIIAGAGGAAHLPGMTAS
LTTLPVLGVPVLSKALNGMDSLLSIVQMPKGVPVATLAIGTSGAANAGLLAVRILSLLDSSLSKKLEDYADQNREQALSK
NDQLV

Sequences:

>Translated_165_residues
MTNPLPKVAVIMGSYSDWDTMKEACEILTEFGVPFEKEIVSAHRSPDRMFQFAKNAKNNGFGVIIAGAGGAAHLPGMTAS
LTTLPVLGVPVLSKALNGMDSLLSIVQMPKGVPVATLAIGTSGAANAGLLAVRILSLLDSSLSKKLEDYADQNREQALSK
NDQLV
>Mature_164_residues
TNPLPKVAVIMGSYSDWDTMKEACEILTEFGVPFEKEIVSAHRSPDRMFQFAKNAKNNGFGVIIAGAGGAAHLPGMTASL
TTLPVLGVPVLSKALNGMDSLLSIVQMPKGVPVATLAIGTSGAANAGLLAVRILSLLDSSLSKKLEDYADQNREQALSKN
DQLV

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=156, Percent_Identity=57.6923076923077, Blast_Score=157, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6324702, Length=159, Percent_Identity=56.6037735849057, Blast_Score=173, Evalue=9e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17355; Mature: 17224

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNPLPKVAVIMGSYSDWDTMKEACEILTEFGVPFEKEIVSAHRSPDRMFQFAKNAKNNG
CCCCCCHHHHEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHCCCCCC
FGVIIAGAGGAAHLPGMTASLTTLPVLGVPVLSKALNGMDSLLSIVQMPKGVPVATLAIG
CEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEEC
TSGAANAGLLAVRILSLLDSSLSKKLEDYADQNREQALSKNDQLV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TNPLPKVAVIMGSYSDWDTMKEACEILTEFGVPFEKEIVSAHRSPDRMFQFAKNAKNNG
CCCCCHHHHEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHCCCCCC
FGVIIAGAGGAAHLPGMTASLTTLPVLGVPVLSKALNGMDSLLSIVQMPKGVPVATLAIG
CEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEEC
TSGAANAGLLAVRILSLLDSSLSKKLEDYADQNREQALSKNDQLV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3036807; 9384377 [H]