| Definition | Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)' chromosome chromosome I, complete sequence. |
|---|---|
| Accession | NC_010602 |
| Length | 3,599,677 |
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The map label for this gene is murF [H]
Identifier: 183221139
GI number: 183221139
Start: 1830833
End: 1832212
Strand: Direct
Name: murF [H]
Synonym: LEPBI_I1753
Alternate gene names: 183221139
Gene position: 1830833-1832212 (Clockwise)
Preceding gene: 183221135
Following gene: 183221140
Centisome position: 50.86
GC content: 35.87
Gene sequence:
>1380_bases ATGATCGCACCATTTGAATATTCCCTGTCAACTATTCTAAGTTTGTTTTCTTTGAAACCAGTTTGGGAGAATCCAATGAA TCCAAAATTCTTTTGGATTTCGACTTCTTCTAAAGAAATTCAAAAAAACACTCTCTTTGTCCCCCTTCGTGGAGAACGAG ATGGCCATGAGTATATTGCCGATGCGTTAAAAGCTGGTGCCACAGGTTTTTTATGCGAAAAAAATCACCCGATCCTAAAA AACCTTTCGAATGAAGACCAGAAAAAAGCCATCTTCGTAAAAGATACTTTGATCGCCCTTGGAACTTTAGCGAACTTTCA TCGAAACCGATTTTGTCCCATCGTCATTGCCATCACTGGTTCTTCTGGGAAAACATCTACAAAAGATCTGTTAGGTGGAC TTTTTTCATTTTTAGGATCAAAGTCTCTTGTGGTTACGGAAAAAAACTACAATAATGAAATCGGAGTTCCTTTCACTCTC TTTCGTATCACGGAGCGAACACAAGTTGTGATCTGTGAAATGGGAATGAACCATAGAGGCGAAATAAATCGGTTATCAAA AATGGCTGAACCCACACATGCTTTGATAACGAACATTGGCTCCGCACATATAGAAAATTTAAAATCAAGGGAAAACATCG CGGAAGAAAAAATTGATATCATCAATGGTTTACGCCCAAATGGAGTTCTGTTTGTGCCAGATGATTTGGATTTTTTAGGA CGAGCAAAACAAAGGACCAAAAAATCAAATGTGAACTTGAAGATATGGAAACATTCAAAAAATCCGGAACTGAAGGTGAA TATAGTCCAAAAGAACGGATTTTTGTTAGAATGGAGAATGGAAAAGATTCAATGGAATATCCCTGGTTCTAAATTATTGA GTAATGTTCGAGGAATGATCGCCGTTGGAAATTTCTTTCAAATTCCCGATGTAGAAATGAAAAAAACAATTCGGACTTAC AAAAGCCCAAACAAACGACTCAATATTAAAAAAGGATTTTATACCATCATTGATGATAGTTACAATGCTAATCCTGAATC GATGTTGTCGAGTATTGATGCAAGTATACAATATGCACAAAACAAACCCATCGTCTGGGTCCTTGGAACAATGAAGGAAC TTGGAAAGTTTTCAAAATTCTATCATGAAGAAATCGGAAAAAATTTGAAAAAATACCCAAAAGGAACCTTACTTGGATTT GGTGATGATACATTACCAATGGTCAAACAAGTATCCAATGGAAAACACTTTCAATCAAAAGTGGATTTAGTTGAATTCAT TAAAAAAGAAATTCCAAAACAAGCAGTGATTCTCGTAAAAGGATCTCGCTCTATGAAAATGGAAGAAATTGTCTCGGAAC TAGTTTCATTTAAAGGTTGA
Upstream 100 bases:
>100_bases GATTCGTCCAAGACCAATGAGAATCGTTTTGATTTTAGTTGGTTTCATCTAAGTTTTTCTTTATAATCTATCTTTCTGGG AGAATCTGGTTCAAGAAGCT
Downstream 100 bases:
>100_bases TCGAGAATGAGGTTTTTTTAGATTCTACGTATGACAAACCCTTTACCGAAAGTTGCTGTAATTATGGGATCATATTCCGA TTGGGACACCATGAAGGAAG
Product: UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase
Products: NA
Alternate protein names: D-alanyl-D-alanine-adding enzyme; UDP-MurNAc-pentapeptide synthetase [H]
Number of amino acids: Translated: 459; Mature: 459
Protein sequence:
>459_residues MIAPFEYSLSTILSLFSLKPVWENPMNPKFFWISTSSKEIQKNTLFVPLRGERDGHEYIADALKAGATGFLCEKNHPILK NLSNEDQKKAIFVKDTLIALGTLANFHRNRFCPIVIAITGSSGKTSTKDLLGGLFSFLGSKSLVVTEKNYNNEIGVPFTL FRITERTQVVICEMGMNHRGEINRLSKMAEPTHALITNIGSAHIENLKSRENIAEEKIDIINGLRPNGVLFVPDDLDFLG RAKQRTKKSNVNLKIWKHSKNPELKVNIVQKNGFLLEWRMEKIQWNIPGSKLLSNVRGMIAVGNFFQIPDVEMKKTIRTY KSPNKRLNIKKGFYTIIDDSYNANPESMLSSIDASIQYAQNKPIVWVLGTMKELGKFSKFYHEEIGKNLKKYPKGTLLGF GDDTLPMVKQVSNGKHFQSKVDLVEFIKKEIPKQAVILVKGSRSMKMEEIVSELVSFKG
Sequences:
>Translated_459_residues MIAPFEYSLSTILSLFSLKPVWENPMNPKFFWISTSSKEIQKNTLFVPLRGERDGHEYIADALKAGATGFLCEKNHPILK NLSNEDQKKAIFVKDTLIALGTLANFHRNRFCPIVIAITGSSGKTSTKDLLGGLFSFLGSKSLVVTEKNYNNEIGVPFTL FRITERTQVVICEMGMNHRGEINRLSKMAEPTHALITNIGSAHIENLKSRENIAEEKIDIINGLRPNGVLFVPDDLDFLG RAKQRTKKSNVNLKIWKHSKNPELKVNIVQKNGFLLEWRMEKIQWNIPGSKLLSNVRGMIAVGNFFQIPDVEMKKTIRTY KSPNKRLNIKKGFYTIIDDSYNANPESMLSSIDASIQYAQNKPIVWVLGTMKELGKFSKFYHEEIGKNLKKYPKGTLLGF GDDTLPMVKQVSNGKHFQSKVDLVEFIKKEIPKQAVILVKGSRSMKMEEIVSELVSFKG >Mature_459_residues MIAPFEYSLSTILSLFSLKPVWENPMNPKFFWISTSSKEIQKNTLFVPLRGERDGHEYIADALKAGATGFLCEKNHPILK NLSNEDQKKAIFVKDTLIALGTLANFHRNRFCPIVIAITGSSGKTSTKDLLGGLFSFLGSKSLVVTEKNYNNEIGVPFTL FRITERTQVVICEMGMNHRGEINRLSKMAEPTHALITNIGSAHIENLKSRENIAEEKIDIINGLRPNGVLFVPDDLDFLG RAKQRTKKSNVNLKIWKHSKNPELKVNIVQKNGFLLEWRMEKIQWNIPGSKLLSNVRGMIAVGNFFQIPDVEMKKTIRTY KSPNKRLNIKKGFYTIIDDSYNANPESMLSSIDASIQYAQNKPIVWVLGTMKELGKFSKFYHEEIGKNLKKYPKGTLLGF GDDTLPMVKQVSNGKHFQSKVDLVEFIKKEIPKQAVILVKGSRSMKMEEIVSELVSFKG
Specific function: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein [H]
COG id: COG0770
COG function: function code M; UDP-N-acetylmuramyl pentapeptide synthase
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the MurCDEF family [H]
Homologues:
Organism=Escherichia coli, GI1786274, Length=446, Percent_Identity=32.0627802690583, Blast_Score=162, Evalue=6e-41,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR004101 - InterPro: IPR013221 - InterPro: IPR000713 - InterPro: IPR005863 [H]
Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]
EC number: =6.3.2.10 [H]
Molecular weight: Translated: 51930; Mature: 51930
Theoretical pI: Translated: 10.28; Mature: 10.28
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 2.8 %Met (Translated Protein) 3.5 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 2.8 %Met (Mature Protein) 3.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MIAPFEYSLSTILSLFSLKPVWENPMNPKFFWISTSSKEIQKNTLFVPLRGERDGHEYIA CCCCCHHHHHHHHHHHHCCCHHCCCCCCEEEEEECCCCHHCCCEEEEEECCCCCCHHHHH DALKAGATGFLCEKNHPILKNLSNEDQKKAIFVKDTLIALGTLANFHRNRFCPIVIAITG HHHHCCCCEEEECCCCCHHHCCCCCCHHCEEEEHHHHHHHHHHHHHHCCCCCEEEEEEEC SSGKTSTKDLLGGLFSFLGSKSLVVTEKNYNNEIGVPFTLFRITERTQVVICEMGMNHRG CCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEEECCCCEEEEEECCCCCCC EINRLSKMAEPTHALITNIGSAHIENLKSRENIAEEKIDIINGLRPNGVLFVPDDLDFLG HHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHH RAKQRTKKSNVNLKIWKHSKNPELKVNIVQKNGFLLEWRMEKIQWNIPGSKLLSNVRGMI HHHHHHHHCCCEEEEEECCCCCCEEEEEEECCCEEEEEEEEEEEECCCHHHHHHHCCCCE AVGNFFQIPDVEMKKTIRTYKSPNKRLNIKKGFYTIIDDSYNANPESMLSSIDASIQYAQ EECCEEECCCHHHHHHHHHHCCCCCEEEEECCEEEEECCCCCCCHHHHHHHHHHHHEECC NKPIVWVLGTMKELGKFSKFYHEEIGKNLKKYPKGTLLGFGDDTLPMVKQVSNGKHFQSK CCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHCCCCHHHHH VDLVEFIKKEIPKQAVILVKGSRSMKMEEIVSELVSFKG HHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHCCC >Mature Secondary Structure MIAPFEYSLSTILSLFSLKPVWENPMNPKFFWISTSSKEIQKNTLFVPLRGERDGHEYIA CCCCCHHHHHHHHHHHHCCCHHCCCCCCEEEEEECCCCHHCCCEEEEEECCCCCCHHHHH DALKAGATGFLCEKNHPILKNLSNEDQKKAIFVKDTLIALGTLANFHRNRFCPIVIAITG HHHHCCCCEEEECCCCCHHHCCCCCCHHCEEEEHHHHHHHHHHHHHHCCCCCEEEEEEEC SSGKTSTKDLLGGLFSFLGSKSLVVTEKNYNNEIGVPFTLFRITERTQVVICEMGMNHRG CCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEEECCCCEEEEEECCCCCCC EINRLSKMAEPTHALITNIGSAHIENLKSRENIAEEKIDIINGLRPNGVLFVPDDLDFLG HHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHH RAKQRTKKSNVNLKIWKHSKNPELKVNIVQKNGFLLEWRMEKIQWNIPGSKLLSNVRGMI HHHHHHHHCCCEEEEEECCCCCCEEEEEEECCCEEEEEEEEEEEECCCHHHHHHHCCCCE AVGNFFQIPDVEMKKTIRTYKSPNKRLNIKKGFYTIIDDSYNANPESMLSSIDASIQYAQ EECCEEECCCHHHHHHHHHHCCCCCEEEEECCEEEEECCCCCCCHHHHHHHHHHHHEECC NKPIVWVLGTMKELGKFSKFYHEEIGKNLKKYPKGTLLGFGDDTLPMVKQVSNGKHFQSK CCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHCCCCHHHHH VDLVEFIKKEIPKQAVILVKGSRSMKMEEIVSELVSFKG HHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 9384377 [H]