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The map label for this gene is nuoH

Identifier: 183220692

GI number: 183220692

Start: 1355781

End: 1356851

Strand: Direct

Name: nuoH

Synonym: LEPBI_I1302

Alternate gene names: 183220692

Gene position: 1355781-1356851 (Clockwise)

Preceding gene: 183220691

Following gene: 183220693

Centisome position: 37.66

GC content: 43.98

Gene sequence:

>1071_bases
ATGGACTGGGCTTTAATTCTTGCTTGGGGGATCAAAATCCTCTCATTATTTTTTGTAATCCTTACTGGTGTTGCGTATTA
TACCCTCGCTGAACGTAAGTTTGCTGGTTTTATCCAAGATAGGCCAGGCCCAAACAGGGCAGGTCCTTTTGGAATTTTCC
AACCTTTGGCGGATGGGATTAAGTTTATCGCCAAAGAAGAAATTTTTCCAAAGAATGTATCCAAAGGGATGTATCTGCTT
GCTCCGACCATCTCCATGACTTGTGCGATTATGGCTTGGGCCGTGATTCCATTCGGGGGAACACTCCCTGCACCAGAATG
GCTTACGACGCTTACGGGTGTAGCCACAATCGACTTACAAATTGCAAACCCAGATTCTGGTGTTTTGTACATGCTTGCCA
TTTCATCCCTTTCTGTTTATGGAATCATGATTGCGGGTTGGTCGAGTAACAACAAATATTCGTTACTCGGTGGAGTTCGC
TCGACAGCACAGATGATCAGTTATGAACTTCCGATGGGCCTATCCATAGTCGCCATTGTGATCATGACGGGTTCACTCAA
ACTCACCGACATCAGTGACTCTCAAAAAGATATGTGGAATATCCTCTCTCCGCCTGGTTTTGTTGCCTTTTTTATTTATG
TGACTGCGATGTTTGCCGAAACCAATCGTCTGCCATTTGACCTTGCGGAAGCGGAGTCAGAGCTTGTGGTGGGTTTTCAT
ACAGAGTATGGCGCTTTTAAATTTGCACTCTTTTTTCTTGCGGAATACATGAATATGATCACCATGTCGTGCCTCACCAC
CTTACTGTTCTTTGGTGGATATAATGTACCGTTTCAGCTCGGGGCAGGGTCAGAATACCAAGCCTTCATCGGACTTGGGT
TTTTTATTCTAAAAGTATTGTTTTTTGCCTTTTTGTTCATTTGGGTGCGATGGACCTTACCTCGCTTCCGTTATGACCAA
CTCATGAAACTCGGTTGGAAAAAGATGATCCCTTGGGGCCTCTTTGTTGTGATGTTTGCCTCCATTTACACTGTGTATTG
GAAGGAAGGATGGATGAAATTATTTATATGA

Upstream 100 bases:

>100_bases
TGTGATGGCAGTTCGACCAACCATGACAAAATTTAAGGAAGAGTTTTCTCTTCGATTGAAAAAGGAAGTGAGTGTTTCTC
ACTAAAGGTCACCAAATACG

Downstream 100 bases:

>100_bases
ACCTAGAAACCTCTCCTTCCCTTTTGTTATTTGTATTTTTTGGCACAGTGACTGTGGTTACGGCCTTAAGTGTGGTCTTT
CAAAAAAATCCAGTGGTATC

Product: NADH-quinone oxidoreductase subunit H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MDWALILAWGIKILSLFFVILTGVAYYTLAERKFAGFIQDRPGPNRAGPFGIFQPLADGIKFIAKEEIFPKNVSKGMYLL
APTISMTCAIMAWAVIPFGGTLPAPEWLTTLTGVATIDLQIANPDSGVLYMLAISSLSVYGIMIAGWSSNNKYSLLGGVR
STAQMISYELPMGLSIVAIVIMTGSLKLTDISDSQKDMWNILSPPGFVAFFIYVTAMFAETNRLPFDLAEAESELVVGFH
TEYGAFKFALFFLAEYMNMITMSCLTTLLFFGGYNVPFQLGAGSEYQAFIGLGFFILKVLFFAFLFIWVRWTLPRFRYDQ
LMKLGWKKMIPWGLFVVMFASIYTVYWKEGWMKLFI

Sequences:

>Translated_356_residues
MDWALILAWGIKILSLFFVILTGVAYYTLAERKFAGFIQDRPGPNRAGPFGIFQPLADGIKFIAKEEIFPKNVSKGMYLL
APTISMTCAIMAWAVIPFGGTLPAPEWLTTLTGVATIDLQIANPDSGVLYMLAISSLSVYGIMIAGWSSNNKYSLLGGVR
STAQMISYELPMGLSIVAIVIMTGSLKLTDISDSQKDMWNILSPPGFVAFFIYVTAMFAETNRLPFDLAEAESELVVGFH
TEYGAFKFALFFLAEYMNMITMSCLTTLLFFGGYNVPFQLGAGSEYQAFIGLGFFILKVLFFAFLFIWVRWTLPRFRYDQ
LMKLGWKKMIPWGLFVVMFASIYTVYWKEGWMKLFI
>Mature_356_residues
MDWALILAWGIKILSLFFVILTGVAYYTLAERKFAGFIQDRPGPNRAGPFGIFQPLADGIKFIAKEEIFPKNVSKGMYLL
APTISMTCAIMAWAVIPFGGTLPAPEWLTTLTGVATIDLQIANPDSGVLYMLAISSLSVYGIMIAGWSSNNKYSLLGGVR
STAQMISYELPMGLSIVAIVIMTGSLKLTDISDSQKDMWNILSPPGFVAFFIYVTAMFAETNRLPFDLAEAESELVVGFH
TEYGAFKFALFFLAEYMNMITMSCLTTLLFFGGYNVPFQLGAGSEYQAFIGLGFFILKVLFFAFLFIWVRWTLPRFRYDQ
LMKLGWKKMIPWGLFVVMFASIYTVYWKEGWMKLFI

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=319, Percent_Identity=39.1849529780564, Blast_Score=219, Evalue=4e-57,
Organism=Escherichia coli, GI1788618, Length=321, Percent_Identity=40.1869158878505, Blast_Score=235, Evalue=4e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH_LEPBA (B0SFU0)

Other databases:

- EMBL:   CP000777
- RefSeq:   YP_001962348.1
- GeneID:   6388550
- GenomeReviews:   CP000777_GR
- KEGG:   lbf:LBF_1248
- HOGENOM:   HBG727670
- OMA:   QLMNLGW
- ProtClustDB:   CLSK573689
- BioCyc:   LBIF355278:LBF_1248-MONOMER
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 39991; Mature: 39991

Theoretical pI: Translated: 8.12; Mature: 8.12

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x19809b14)-; HASH(0x1a521618)-; HASH(0x1acbe180)-; HASH(0x1a4ee724)-; HASH(0x1a9479b0)-; HASH(0x1a899880)-; HASH(0x1a652888)-; HASH(0x1a20caa4)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDWALILAWGIKILSLFFVILTGVAYYTLAERKFAGFIQDRPGPNRAGPFGIFQPLADGI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
KFIAKEEIFPKNVSKGMYLLAPTISMTCAIMAWAVIPFGGTLPAPEWLTTLTGVATIDLQ
HHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCEEEEEEE
IANPDSGVLYMLAISSLSVYGIMIAGWSSNNKYSLLGGVRSTAQMISYELPMGLSIVAIV
EECCCCCEEEEEHHHHHHEEEEEEEEECCCCCEEEEHHHHHHHHHHHHCCCCCHHHHHHH
IMTGSLKLTDISDSQKDMWNILSPPGFVAFFIYVTAMFAETNRLPFDLAEAESELVVGFH
HHCCCEEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHCCCCCEEEEEE
TEYGAFKFALFFLAEYMNMITMSCLTTLLFFGGYNVPFQLGAGSEYQAFIGLGFFILKVL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHH
FFAFLFIWVRWTLPRFRYDQLMKLGWKKMIPWGLFVVMFASIYTVYWKEGWMKLFI
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCEEECH
>Mature Secondary Structure
MDWALILAWGIKILSLFFVILTGVAYYTLAERKFAGFIQDRPGPNRAGPFGIFQPLADGI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
KFIAKEEIFPKNVSKGMYLLAPTISMTCAIMAWAVIPFGGTLPAPEWLTTLTGVATIDLQ
HHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCEEEEEEE
IANPDSGVLYMLAISSLSVYGIMIAGWSSNNKYSLLGGVRSTAQMISYELPMGLSIVAIV
EECCCCCEEEEEHHHHHHEEEEEEEEECCCCCEEEEHHHHHHHHHHHHCCCCCHHHHHHH
IMTGSLKLTDISDSQKDMWNILSPPGFVAFFIYVTAMFAETNRLPFDLAEAESELVVGFH
HHCCCEEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHCCCCCEEEEEE
TEYGAFKFALFFLAEYMNMITMSCLTTLLFFGGYNVPFQLGAGSEYQAFIGLGFFILKVL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHH
FFAFLFIWVRWTLPRFRYDQLMKLGWKKMIPWGLFVVMFASIYTVYWKEGWMKLFI
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCEEECH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA