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The map label for this gene is hemL1

Identifier: 183220564

GI number: 183220564

Start: 1216629

End: 1217906

Strand: Reverse

Name: hemL1

Synonym: LEPBI_I1168

Alternate gene names: 183220564

Gene position: 1217906-1216629 (Counterclockwise)

Preceding gene: 183220565

Following gene: 183220563

Centisome position: 33.83

GC content: 42.41

Gene sequence:

>1278_bases
ATGAATTCGGAAACATTATTCCAGAGATCAAAACAAGTGGTTCCAGGAGGAGTCCACAGTCCTGTCAGGTCATTCTCCTC
AGTAGGTGGGACTCCCATTTTTTTTAGTGAGGCGAGAGGCGCCTATCTTAAGTCAGTCGAAGGAAATGATTTCATCGATT
ATTGTTTGAGTTTTGGTCCACTTTTATTTGGACATCGACATCCTGAAATCCAAGAGGTGGTCGAAGATACGGTAAACAAA
GCTTGGTCTTTCGGTGCCTGTGAACCGTATTCTCTGGAACTAGCCGAGTTCATCACAGAACGAATCCCTTGGGTAGAAAA
AATTCGATTTGTGAATTCAGGAACTGAAGCTGTGATGAGTGCTCTAAGGGTAGCAAGAGCTGCAACTGGCCGAAATAAAA
TTTTAAAATTTGATGGATGTTATCACGGTCACTTGGATCAACTTTTAGTAAAATCCGGATCGGGCCTTGCAGGTCTCAGT
TCAAGTGATAGTAAAGGGATTGGTCCTGAAATCATCCAAAACACACTTGTCCTTCCATTAGATGATGAATCAAAACTGGA
AGAATTATTCCAAAGAGAAGGCTCAAATATCGCTTGTTTGGCGATCGAACCACTCCCCGCCAATTATGGACTCCTCCCGC
AAAGGATAGAATTTTTAAAGAAGTGTCGTGAGTTAACAACCAAATATGGAGTATTACTTCTTTTTGATGAAGTGATTTCG
GGTTTCAGAGTCTCCTTTCAAGGAATGGCTGGGATCACTGGTATCATTCCTGATTTAGTCTGTTACGGAAAGATCATAGG
AGGTGGATTTCCGGTGGGTGCTTATGCAGGGAAAAGAGAACTAATGGATTTAGTAGCACCGAGTGGGCCAGTTTACCAAG
CTGGTACACTATCTGCTAATCCAATTGGGATGCGTGCAGGACTCAAAACTCTCACCAAAGCTTGGACAGAAAATCCATAC
CCTGCTCTAGAATCTGCCACCAAACAACTCACAGATGGAATTCTAACCCTTCTATCCGAAAAAGGTGATACCAATTGGGA
GGCTGTCACCTTTGGAAGTTTGTTTTGGCTGAAAGGAAAAACAGAAAATCCGATCCGCCGAATAGACCAAATTCCTGGAA
CTCATAAATCCAATTTTGCCACCCTCTTCCACAAACTTCTTAAACAGGGAGTGTATCTTGCCCCAAGTGGATATGAGGTT
GGATTTTTATCGACTGCTCATACAAACGATATCATAAACCTCACCCTCGAAAAAACCAAAAAGGCATTAAAGGACTAA

Upstream 100 bases:

>100_bases
ATTTTGAAGATGGTTTAAGAGAAACATGGGACGTGTTTCGCAGAGCCGGATCTTCATTTTTAATCACGTATGGTGCAAGG
ATTGCACAAAGGTTGTATTC

Downstream 100 bases:

>100_bases
TCCATGATCACTACCAAATACCATAACGAAAGATTTGCCAATGCAATTCAATTAGTCCCCCAAGATGTTCCACCAATTTG
GTTTATGCGCCAAGCGGGAA

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MNSETLFQRSKQVVPGGVHSPVRSFSSVGGTPIFFSEARGAYLKSVEGNDFIDYCLSFGPLLFGHRHPEIQEVVEDTVNK
AWSFGACEPYSLELAEFITERIPWVEKIRFVNSGTEAVMSALRVARAATGRNKILKFDGCYHGHLDQLLVKSGSGLAGLS
SSDSKGIGPEIIQNTLVLPLDDESKLEELFQREGSNIACLAIEPLPANYGLLPQRIEFLKKCRELTTKYGVLLLFDEVIS
GFRVSFQGMAGITGIIPDLVCYGKIIGGGFPVGAYAGKRELMDLVAPSGPVYQAGTLSANPIGMRAGLKTLTKAWTENPY
PALESATKQLTDGILTLLSEKGDTNWEAVTFGSLFWLKGKTENPIRRIDQIPGTHKSNFATLFHKLLKQGVYLAPSGYEV
GFLSTAHTNDIINLTLEKTKKALKD

Sequences:

>Translated_425_residues
MNSETLFQRSKQVVPGGVHSPVRSFSSVGGTPIFFSEARGAYLKSVEGNDFIDYCLSFGPLLFGHRHPEIQEVVEDTVNK
AWSFGACEPYSLELAEFITERIPWVEKIRFVNSGTEAVMSALRVARAATGRNKILKFDGCYHGHLDQLLVKSGSGLAGLS
SSDSKGIGPEIIQNTLVLPLDDESKLEELFQREGSNIACLAIEPLPANYGLLPQRIEFLKKCRELTTKYGVLLLFDEVIS
GFRVSFQGMAGITGIIPDLVCYGKIIGGGFPVGAYAGKRELMDLVAPSGPVYQAGTLSANPIGMRAGLKTLTKAWTENPY
PALESATKQLTDGILTLLSEKGDTNWEAVTFGSLFWLKGKTENPIRRIDQIPGTHKSNFATLFHKLLKQGVYLAPSGYEV
GFLSTAHTNDIINLTLEKTKKALKD
>Mature_425_residues
MNSETLFQRSKQVVPGGVHSPVRSFSSVGGTPIFFSEARGAYLKSVEGNDFIDYCLSFGPLLFGHRHPEIQEVVEDTVNK
AWSFGACEPYSLELAEFITERIPWVEKIRFVNSGTEAVMSALRVARAATGRNKILKFDGCYHGHLDQLLVKSGSGLAGLS
SSDSKGIGPEIIQNTLVLPLDDESKLEELFQREGSNIACLAIEPLPANYGLLPQRIEFLKKCRELTTKYGVLLLFDEVIS
GFRVSFQGMAGITGIIPDLVCYGKIIGGGFPVGAYAGKRELMDLVAPSGPVYQAGTLSANPIGMRAGLKTLTKAWTENPY
PALESATKQLTDGILTLLSEKGDTNWEAVTFGSLFWLKGKTENPIRRIDQIPGTHKSNFATLFHKLLKQGVYLAPSGYEV
GFLSTAHTNDIINLTLEKTKKALKD

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=304, Percent_Identity=26.6447368421053, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI24119277, Length=303, Percent_Identity=26.7326732673267, Blast_Score=82, Evalue=7e-16,
Organism=Escherichia coli, GI1786349, Length=419, Percent_Identity=42.4821002386635, Blast_Score=371, Evalue=1e-104,
Organism=Escherichia coli, GI1789016, Length=356, Percent_Identity=32.0224719101124, Blast_Score=151, Evalue=7e-38,
Organism=Escherichia coli, GI1787560, Length=333, Percent_Identity=29.1291291291291, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1788044, Length=321, Percent_Identity=26.791277258567, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI145693181, Length=396, Percent_Identity=25.7575757575758, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1789759, Length=276, Percent_Identity=25.3623188405797, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI25144271, Length=319, Percent_Identity=24.4514106583072, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324432, Length=247, Percent_Identity=23.8866396761134, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21357415, Length=291, Percent_Identity=25.4295532646048, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GSA_LEPBA (B0SF64)

Other databases:

- EMBL:   CP000777
- RefSeq:   YP_001962229.1
- ProteinModelPortal:   B0SF64
- GeneID:   6388250
- GenomeReviews:   CP000777_GR
- KEGG:   lbf:LBF_1127
- HOGENOM:   HBG725944
- OMA:   DKVIKFE
- ProtClustDB:   PRK00062
- BioCyc:   LBIF355278:LBF_1127-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00375
- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =5.4.3.8

Molecular weight: Translated: 46413; Mature: 46413

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSETLFQRSKQVVPGGVHSPVRSFSSVGGTPIFFSEARGAYLKSVEGNDFIDYCLSFGP
CCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEECCCCCHHCCCCCCHHHHHHHHHHH
LLFGHRHPEIQEVVEDTVNKAWSFGACEPYSLELAEFITERIPWVEKIRFVNSGTEAVMS
HHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCHHHHHH
ALRVARAATGRNKILKFDGCYHGHLDQLLVKSGSGLAGLSSSDSKGIGPEIIQNTLVLPL
HHHHHHHHCCCCCEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCEEEEC
DDESKLEELFQREGSNIACLAIEPLPANYGLLPQRIEFLKKCRELTTKYGVLLLFDEVIS
CCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GFRVSFQGMAGITGIIPDLVCYGKIIGGGFPVGAYAGKRELMDLVAPSGPVYQAGTLSAN
CCEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEECCCCCCC
PIGMRAGLKTLTKAWTENPYPALESATKQLTDGILTLLSEKGDTNWEAVTFGSLFWLKGK
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECEEEEECCC
TENPIRRIDQIPGTHKSNFATLFHKLLKQGVYLAPSGYEVGFLSTAHTNDIINLTLEKTK
CCCHHHHHHHCCCCCCCHHHHHHHHHHHCCEEECCCCCCEEEEEECCCCCEEEEEHHHHH
KALKD
HHHCC
>Mature Secondary Structure
MNSETLFQRSKQVVPGGVHSPVRSFSSVGGTPIFFSEARGAYLKSVEGNDFIDYCLSFGP
CCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEECCCCCHHCCCCCCHHHHHHHHHHH
LLFGHRHPEIQEVVEDTVNKAWSFGACEPYSLELAEFITERIPWVEKIRFVNSGTEAVMS
HHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCHHHHHH
ALRVARAATGRNKILKFDGCYHGHLDQLLVKSGSGLAGLSSSDSKGIGPEIIQNTLVLPL
HHHHHHHHCCCCCEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCEEEEC
DDESKLEELFQREGSNIACLAIEPLPANYGLLPQRIEFLKKCRELTTKYGVLLLFDEVIS
CCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GFRVSFQGMAGITGIIPDLVCYGKIIGGGFPVGAYAGKRELMDLVAPSGPVYQAGTLSAN
CCEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEECCCCCCC
PIGMRAGLKTLTKAWTENPYPALESATKQLTDGILTLLSEKGDTNWEAVTFGSLFWLKGK
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECEEEEECCC
TENPIRRIDQIPGTHKSNFATLFHKLLKQGVYLAPSGYEVGFLSTAHTNDIINLTLEKTK
CCCHHHHHHHCCCCCCCHHHHHHHHHHHCCEEECCCCCCEEEEEECCCCCEEEEEHHHHH
KALKD
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA