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The map label for this gene is hemE [H]

Identifier: 183220563

GI number: 183220563

Start: 1215582

End: 1216625

Strand: Reverse

Name: hemE [H]

Synonym: LEPBI_I1167

Alternate gene names: 183220563

Gene position: 1216625-1215582 (Counterclockwise)

Preceding gene: 183220564

Following gene: 183220562

Centisome position: 33.8

GC content: 38.31

Gene sequence:

>1044_bases
ATGATCACTACCAAATACCATAACGAAAGATTTGCCAATGCAATTCAATTAGTCCCCCAAGATGTTCCACCAATTTGGTT
TATGCGCCAAGCGGGAAGGTATCATTCACATTACCGTAAACTCAAAGAAACATACAGTTTTATGGAGTTATGTAAAGAAC
CAGAACTTGCTGCTGAGGTTGCCTTAGGTCCTGTCAAAGAATTTGGTTTTGACGTGAGTATTTTGTTCTCAGATTTACTC
TTTCCACTCGAAGCACTTGGGATGGGACTCACTTATGATCCAGGTCCCAAATTATCATTTTCTCTGACATCGATCACAGA
CCTAAACAAACTAAAACCAGTAGAGGAAGCAATCGAAGGATTGGTTTTCCAAAAACAAGCTGTGATTCGGACACGAGAAG
TTTTACCAAAAGATGTATCTCTCATTGGTTTTGTCGGTGGACCTTTTACACTTATGACATATGCCAGTATCGGAAAACAT
GATGGGAATCTATCGTTTATCAAAACCAATCAAAACTTTGTAGATGAATTCTATACAATCTTACTCCCATTACTCAAAAA
AAATATCGAATTACAATTACAAGGTGGCGCCGAAGTAGTAATGATGTTTGATACTGCTGCAGGAATGCTTGATCCAAATA
ATTTTCGCCGATACGTGGCAGAACCTATTGCCGAACTTACAAAAACGTTCCCGAATCAAATTGGATATTATGCTAAAAAT
TCCACAGAAGAGCATATACGCCAGATTCACAAAATTCCTGATTTAGTAGGATTTGGAGTTGACCATCGTTTTTCCATTCC
AAACGTCTTACATGAGTTTGGTGGCAAAGGATTCATCCAAGGGAATTTTGACCAAGAATTATTATTTGCAGATCCTGTGA
CTCTCAAACACAAAATAAAAGAGTATCTTTTACCGATAAAGGATATGGATCCAAAAGATCGAGTTGGTTGGGTTGCAGGC
CTTGGGCATGGAGTTTTACAATTCACTCCTGAAGCTTCTATCCACTCCCTAATCGAAGAAACAAGAAAGGTGTTTACTAA
ATGA

Upstream 100 bases:

>100_bases
CCCAAGTGGATATGAGGTTGGATTTTTATCGACTGCTCATACAAACGATATCATAAACCTCACCCTCGAAAAAACCAAAA
AGGCATTAAAGGACTAATCC

Downstream 100 bases:

>100_bases
AACAATTGCTAGAAAAATACGATACACCTGCCCCACGTTACACAAGTTACCCTACTGTTCCGTATTGGACAGATTCTCCA
ACGACGGAAGAATGTATCCA

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MITTKYHNERFANAIQLVPQDVPPIWFMRQAGRYHSHYRKLKETYSFMELCKEPELAAEVALGPVKEFGFDVSILFSDLL
FPLEALGMGLTYDPGPKLSFSLTSITDLNKLKPVEEAIEGLVFQKQAVIRTREVLPKDVSLIGFVGGPFTLMTYASIGKH
DGNLSFIKTNQNFVDEFYTILLPLLKKNIELQLQGGAEVVMMFDTAAGMLDPNNFRRYVAEPIAELTKTFPNQIGYYAKN
STEEHIRQIHKIPDLVGFGVDHRFSIPNVLHEFGGKGFIQGNFDQELLFADPVTLKHKIKEYLLPIKDMDPKDRVGWVAG
LGHGVLQFTPEASIHSLIEETRKVFTK

Sequences:

>Translated_347_residues
MITTKYHNERFANAIQLVPQDVPPIWFMRQAGRYHSHYRKLKETYSFMELCKEPELAAEVALGPVKEFGFDVSILFSDLL
FPLEALGMGLTYDPGPKLSFSLTSITDLNKLKPVEEAIEGLVFQKQAVIRTREVLPKDVSLIGFVGGPFTLMTYASIGKH
DGNLSFIKTNQNFVDEFYTILLPLLKKNIELQLQGGAEVVMMFDTAAGMLDPNNFRRYVAEPIAELTKTFPNQIGYYAKN
STEEHIRQIHKIPDLVGFGVDHRFSIPNVLHEFGGKGFIQGNFDQELLFADPVTLKHKIKEYLLPIKDMDPKDRVGWVAG
LGHGVLQFTPEASIHSLIEETRKVFTK
>Mature_347_residues
MITTKYHNERFANAIQLVPQDVPPIWFMRQAGRYHSHYRKLKETYSFMELCKEPELAAEVALGPVKEFGFDVSILFSDLL
FPLEALGMGLTYDPGPKLSFSLTSITDLNKLKPVEEAIEGLVFQKQAVIRTREVLPKDVSLIGFVGGPFTLMTYASIGKH
DGNLSFIKTNQNFVDEFYTILLPLLKKNIELQLQGGAEVVMMFDTAAGMLDPNNFRRYVAEPIAELTKTFPNQIGYYAKN
STEEHIRQIHKIPDLVGFGVDHRFSIPNVLHEFGGKGFIQGNFDQELLFADPVTLKHKIKEYLLPIKDMDPKDRVGWVAG
LGHGVLQFTPEASIHSLIEETRKVFTK

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=337, Percent_Identity=29.080118694362, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI2367337, Length=355, Percent_Identity=30.1408450704225, Blast_Score=152, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6320252, Length=345, Percent_Identity=24.3478260869565, Blast_Score=106, Evalue=6e-24,
Organism=Drosophila melanogaster, GI221330099, Length=341, Percent_Identity=30.791788856305, Blast_Score=134, Evalue=9e-32,
Organism=Drosophila melanogaster, GI19921920, Length=341, Percent_Identity=30.791788856305, Blast_Score=134, Evalue=9e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 39266; Mature: 39266

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00906 UROD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITTKYHNERFANAIQLVPQDVPPIWFMRQAGRYHSHYRKLKETYSFMELCKEPELAAEV
CCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
ALGPVKEFGFDVSILFSDLLFPLEALGMGLTYDPGPKLSFSLTSITDLNKLKPVEEAIEG
HHCCHHHHCCHHHHHHHHHHHHHHHHCCCCEECCCCCCEEEEHHHHHHHHCCCHHHHHHH
LVFQKQAVIRTREVLPKDVSLIGFVGGPFTLMTYASIGKHDGNLSFIKTNQNFVDEFYTI
HHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHH
LLPLLKKNIELQLQGGAEVVMMFDTAAGMLDPNNFRRYVAEPIAELTKTFPNQIGYYAKN
HHHHHHCCCEEEEECCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
STEEHIRQIHKIPDLVGFGVDHRFSIPNVLHEFGGKGFIQGNFDQELLFADPVTLKHKIK
CHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCEEEECCCCCCEEEECCHHHHHHHH
EYLLPIKDMDPKDRVGWVAGLGHGVLQFTPEASIHSLIEETRKVFTK
HHHCCCCCCCCCHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MITTKYHNERFANAIQLVPQDVPPIWFMRQAGRYHSHYRKLKETYSFMELCKEPELAAEV
CCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
ALGPVKEFGFDVSILFSDLLFPLEALGMGLTYDPGPKLSFSLTSITDLNKLKPVEEAIEG
HHCCHHHHCCHHHHHHHHHHHHHHHHCCCCEECCCCCCEEEEHHHHHHHHCCCHHHHHHH
LVFQKQAVIRTREVLPKDVSLIGFVGGPFTLMTYASIGKHDGNLSFIKTNQNFVDEFYTI
HHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHH
LLPLLKKNIELQLQGGAEVVMMFDTAAGMLDPNNFRRYVAEPIAELTKTFPNQIGYYAKN
HHHHHHCCCEEEEECCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
STEEHIRQIHKIPDLVGFGVDHRFSIPNVLHEFGGKGFIQGNFDQELLFADPVTLKHKIK
CHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCEEEECCCCCCEEEECCHHHHHHHH
EYLLPIKDMDPKDRVGWVAGLGHGVLQFTPEASIHSLIEETRKVFTK
HHHCCCCCCCCCHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA