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The map label for this gene is 183220517

Identifier: 183220517

GI number: 183220517

Start: 1164780

End: 1166156

Strand: Reverse

Name: 183220517

Synonym: LEPBI_I1118

Alternate gene names: NA

Gene position: 1166156-1164780 (Counterclockwise)

Preceding gene: 183220519

Following gene: 183220515

Centisome position: 32.4

GC content: 40.38

Gene sequence:

>1377_bases
ATGAATCGAAAAACATTCCTTAAAAATTTGACTGCTACTGCCGCTGGAGTGAGCCTCCTTTCCCCCAAAAAATTCTACGG
ACAATCCACAGGAGTGGTCACTGCGGAAACGAAACCACGACCATCTGGACCCAAAAAAGCGATAGTGCTCGGTGGTGGTC
TATCTGGTCTTTATTCTGCTTATTTACTCAAACAAACAGGTTATGACGTCACTGTGATTGAAAGAGGAGATCGTTTCGGA
GGCAGGATCAGCACCTATTCCAATGCCGAATCGGGAATCGTACAAGACTTAGGTGGCGAATGGATCGGTGAAAACCAAAC
CGATATCAAAAGCCTTGTCAAACAACTTGGATTGGAACTCGTAAGTGCCAACATATCAGAGCGATTCCTTCTTTCCAAAA
CCAATTCTGACTCTCATAAAATTTCTAGCACCTCGATTGATACTTTAGATAAGGTGATCGACTTACACAAGTCACTTGGG
ACTTCACAAAAACAAGGATTAGACAAAATCAATTTTTCCTCTTATGCAAGATACCAAGGTTTATCCGAAGAAGAAATCCG
ATCCATGAACGAACTCTATCGGATCATTTTGGGAGCCGACTTAAACCAAATTTCCAGTGAATCTGTTCTCGATGATTTAT
CAGCATTACAATCTGCGCTCAAACCGAAATACTTAGTGAAAGGCGGTGCTGAACAAATCATACAATCGCTTGTCGCACAA
TTAAAAGGACAGGAATTATTATTGGGAGAAATGGCAACTAAGGTTTCCCAACAAAAAAACCAAGTGAGTGTCGAGTTATC
TTCAGGAAGGACCATCAAAGGGAATTTGGTAATTTGTACCCTCCCTTCTGCGGCTGTACTTGATATCAAATGGACACCAA
CATTGCCAAAAGATTTAATTTATTCCGCACTCAGAATGCAAACGGGTAAAATTTCGAAAAACATCTGTTTTGTGAAATCA
AATACAGGTTTATCAAATTTTTTCCAAAACACCAATACAGCAGCTGAAACTTTTTATGTTTCAGATCTTGCCATTGGCGC
AAACATTACAGCTGTCACATCCATAACAACAGGTGATAAAGCATCTCTGTTTGAGAAAGGGAGTGATCGCCAGAAAAAAA
TATTAATGGAATCCGCGCTCGAAGAGTTGGGTAATTTTGAAATCATAGCAGAAAAACCATTTCATTTTCATAGTTTTCAA
AAAACGACAGGTAGGTCCGGGTTTGTATCCTTATTTCCACCTGGAAGTTACGGAATCAAAGATGTTTGGAATGAACCATT
CGAAAGGGTATTTTTTGCAGGAGAACACCTCGCCTTACACACAGGAAGTATGGATTCAGCGGTTGCGTCGTCGATCCAAG
CGATTAGTAAAACCTAA

Upstream 100 bases:

>100_bases
GAATTTAGAATTTCGCATAAAAAAGCCAAAGCCAATAGAATCGATTTTTGTAATTTTTCTAGCCTTTTTTGTTTTGGATG
TTAAAATAGGGGAAAGTTCT

Downstream 100 bases:

>100_bases
TGAATTTTTAATCCGAACAAAAAGCGTAATGGTTTGCTCCTTCGGATCAAAAATTCATACATTAAAAAACTGAAACATAA
CACAACTACATTGTGAAAGA

Product: putative amine oxidase

Products: 2-oxo acid; NH3; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MNRKTFLKNLTATAAGVSLLSPKKFYGQSTGVVTAETKPRPSGPKKAIVLGGGLSGLYSAYLLKQTGYDVTVIERGDRFG
GRISTYSNAESGIVQDLGGEWIGENQTDIKSLVKQLGLELVSANISERFLLSKTNSDSHKISSTSIDTLDKVIDLHKSLG
TSQKQGLDKINFSSYARYQGLSEEEIRSMNELYRIILGADLNQISSESVLDDLSALQSALKPKYLVKGGAEQIIQSLVAQ
LKGQELLLGEMATKVSQQKNQVSVELSSGRTIKGNLVICTLPSAAVLDIKWTPTLPKDLIYSALRMQTGKISKNICFVKS
NTGLSNFFQNTNTAAETFYVSDLAIGANITAVTSITTGDKASLFEKGSDRQKKILMESALEELGNFEIIAEKPFHFHSFQ
KTTGRSGFVSLFPPGSYGIKDVWNEPFERVFFAGEHLALHTGSMDSAVASSIQAISKT

Sequences:

>Translated_458_residues
MNRKTFLKNLTATAAGVSLLSPKKFYGQSTGVVTAETKPRPSGPKKAIVLGGGLSGLYSAYLLKQTGYDVTVIERGDRFG
GRISTYSNAESGIVQDLGGEWIGENQTDIKSLVKQLGLELVSANISERFLLSKTNSDSHKISSTSIDTLDKVIDLHKSLG
TSQKQGLDKINFSSYARYQGLSEEEIRSMNELYRIILGADLNQISSESVLDDLSALQSALKPKYLVKGGAEQIIQSLVAQ
LKGQELLLGEMATKVSQQKNQVSVELSSGRTIKGNLVICTLPSAAVLDIKWTPTLPKDLIYSALRMQTGKISKNICFVKS
NTGLSNFFQNTNTAAETFYVSDLAIGANITAVTSITTGDKASLFEKGSDRQKKILMESALEELGNFEIIAEKPFHFHSFQ
KTTGRSGFVSLFPPGSYGIKDVWNEPFERVFFAGEHLALHTGSMDSAVASSIQAISKT
>Mature_458_residues
MNRKTFLKNLTATAAGVSLLSPKKFYGQSTGVVTAETKPRPSGPKKAIVLGGGLSGLYSAYLLKQTGYDVTVIERGDRFG
GRISTYSNAESGIVQDLGGEWIGENQTDIKSLVKQLGLELVSANISERFLLSKTNSDSHKISSTSIDTLDKVIDLHKSLG
TSQKQGLDKINFSSYARYQGLSEEEIRSMNELYRIILGADLNQISSESVLDDLSALQSALKPKYLVKGGAEQIIQSLVAQ
LKGQELLLGEMATKVSQQKNQVSVELSSGRTIKGNLVICTLPSAAVLDIKWTPTLPKDLIYSALRMQTGKISKNICFVKS
NTGLSNFFQNTNTAAETFYVSDLAIGANITAVTSITTGDKASLFEKGSDRQKKILMESALEELGNFEIIAEKPFHFHSFQ
KTTGRSGFVSLFPPGSYGIKDVWNEPFERVFFAGEHLALHTGSMDSAVASSIQAISKT

Specific function: Unknown

COG id: COG1231

COG function: function code E; Monoamine oxidase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the flavin monoamine oxidase family [H]

Homologues:

Organism=Homo sapiens, GI4557735, Length=447, Percent_Identity=24.8322147651007, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI38202207, Length=439, Percent_Identity=24.6013667425968, Blast_Score=88, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001613
- InterPro:   IPR002937 [H]

Pfam domain/function: PF01593 Amino_oxidase [H]

EC number: 1.4.3.2

Molecular weight: Translated: 49681; Mature: 49681

Theoretical pI: Translated: 9.25; Mature: 9.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRKTFLKNLTATAAGVSLLSPKKFYGQSTGVVTAETKPRPSGPKKAIVLGGGLSGLYSA
CCCHHHHHHHHHHHHCHHHCCCHHHCCCCCCEEEECCCCCCCCCCEEEEEECCHHHHHHH
YLLKQTGYDVTVIERGDRFGGRISTYSNAESGIVQDLGGEWIGENQTDIKSLVKQLGLEL
HHHHHCCCEEEEEECCCCCCCEEEECCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHH
VSANISERFLLSKTNSDSHKISSTSIDTLDKVIDLHKSLGTSQKQGLDKINFSSYARYQG
HHCCCCHHEEEECCCCCCCEECCCHHHHHHHHHHHHHHCCCHHHHCCCCCCHHHHHHHCC
LSEEEIRSMNELYRIILGADLNQISSESVLDDLSALQSALKPKYLVKGGAEQIIQSLVAQ
CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHH
LKGQELLLGEMATKVSQQKNQVSVELSSGRTIKGNLVICTLPSAAVLDIKWTPTLPKDLI
HCCCHHHHHHHHHHHHHCCCEEEEEECCCCEEECCEEEEECCCCEEEEEEECCCCCHHHH
YSALRMQTGKISKNICFVKSNTGLSNFFQNTNTAAETFYVSDLAIGANITAVTSITTGDK
HHHHHHHCCCCCCCEEEEECCCCHHHHHHCCCCHHHEEEEEHEEECCCEEEEEEECCCCH
ASLFEKGSDRQKKILMESALEELGNFEIIAEKPFHFHSFQKTTGRSGFVSLFPPGSYGIK
HHHHHCCCCHHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHCCCCCCEEEECCCCCCCHH
DVWNEPFERVFFAGEHLALHTGSMDSAVASSIQAISKT
HHHCCHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MNRKTFLKNLTATAAGVSLLSPKKFYGQSTGVVTAETKPRPSGPKKAIVLGGGLSGLYSA
CCCHHHHHHHHHHHHCHHHCCCHHHCCCCCCEEEECCCCCCCCCCEEEEEECCHHHHHHH
YLLKQTGYDVTVIERGDRFGGRISTYSNAESGIVQDLGGEWIGENQTDIKSLVKQLGLEL
HHHHHCCCEEEEEECCCCCCCEEEECCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHH
VSANISERFLLSKTNSDSHKISSTSIDTLDKVIDLHKSLGTSQKQGLDKINFSSYARYQG
HHCCCCHHEEEECCCCCCCEECCCHHHHHHHHHHHHHHCCCHHHHCCCCCCHHHHHHHCC
LSEEEIRSMNELYRIILGADLNQISSESVLDDLSALQSALKPKYLVKGGAEQIIQSLVAQ
CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHH
LKGQELLLGEMATKVSQQKNQVSVELSSGRTIKGNLVICTLPSAAVLDIKWTPTLPKDLI
HCCCHHHHHHHHHHHHHCCCEEEEEECCCCEEECCEEEEECCCCEEEEEEECCCCCHHHH
YSALRMQTGKISKNICFVKSNTGLSNFFQNTNTAAETFYVSDLAIGANITAVTSITTGDK
HHHHHHHCCCCCCCEEEEECCCCHHHHHHCCCCHHHEEEEEHEEECCCEEEEEEECCCCH
ASLFEKGSDRQKKILMESALEELGNFEIIAEKPFHFHSFQKTTGRSGFVSLFPPGSYGIK
HHHHHCCCCHHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHCCCCCCEEEECCCCCCCHH
DVWNEPFERVFFAGEHLALHTGSMDSAVASSIQAISKT
HHHCCHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-amino acid; H2O; O2

Specific reaction: an L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]