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The map label for this gene is yrkA [H]

Identifier: 183220129

GI number: 183220129

Start: 732192

End: 733562

Strand: Direct

Name: yrkA [H]

Synonym: LEPBI_I0717

Alternate gene names: 183220129

Gene position: 732192-733562 (Clockwise)

Preceding gene: 183220128

Following gene: 183220130

Centisome position: 20.34

GC content: 40.77

Gene sequence:

>1371_bases
ATGGAAATAATCGGCATCTTTCTTATCTTCCTCCTTGTCTTTGTCAATGGTTTCTTCGTCGCTGCAGAGTTTGCGATGGT
ATCAATTCGCCCCTCTCGACTCGAGGAGCTTGTCAAAGAAAACCGGGCCATGTCCCATATCACCAAAAAAGCCATCTCCA
AAATCGACGATATGTTGTCGGTATGCCAAGTGGGGATCACCGTTGCGAGTTTACTCCTTGGTTGGATTGGTGAAGCATTA
TTTGCAAGTGTTGTCTCTGGCTCCTTACGAATGTTGCAAATCGAATTGGATGTTGTCACCATTCATAGTATCTCCATTGG
AGTTTCGTTTACACTCATCACTCTCCTTCATGTGATTTTAGGAGAGTTGGTTCCAAAAACGTTAGCGATTCAAAATACCG
AAGCGATTGCGTTAGGTGTTTCGGCACCCATGTGGTTGTTCTACTATTTATTTTTCCCAGTTACGTTTATCATGAATCGA
TTGGCTGGTGGAATCCTCACACTCTTTCGTTTGCAACGAACAGGTGATAAATATGTTCATTCAGCCGAAGAGTTGATGAT
CATCATTGAGGAACAAAGGAAACAAGGTCGGATTGATAATGCAGAAATGCAACTCATCCAAAAGACGTTTGATTTTTCCG
AACATACAGCCAAAGACGTGATGACACATCGATTGTCCATCATTGGAATCCCACAAGAATCAACGATCGATAAACTCCTT
CCCCTCATTGCCGAACATAGTTTTTCCAGATACCCAGTGTATCACCAAACTTTGGATAAAATTGTGGGGATTGTCCATGT
CCAAAAGTATTTAAAATGGCAAGCCGAGCATCTTTCCGCCAAAGGCAAAAAGGAAAAAATCACTGTCATCATGGAAAAGG
ATTTTGTAAAGGTTCCGGAATCCATGTCCATCGAACGTGTGATGACAAAACTCCGAGAGAAAAAACAACATATGGCAATT
GTTATTGATGAATATGGTGGAGTCTCCGGCTTACTCACGTTAGAAGATATTATCGAGGAATTTTTTGGTGAAATCCGAGA
TGAAACGGATACCGATGAAGTGGATGTTACATCCAAAAATAAAAAAACGAAAACCATTACCTTAGATGGTGAAACCGAAC
TCTCTAGCCTAACAGATATTTTAGAAGGGGAAGAACCTTCGGATATGGAAGAAGTTCGGACGATTGCTGGTTACTTCATG
GAAAAAAACGAAGATATGCCCAAAGAAGGTAGCATCGTTCAAATCAAAAAAGGTAGTTTAAAAGTGAAAAAAATGGAAGG
AAACAAAATCATTTCCATCCTTTTCACGCCGAAATTAGAAGAAGACCATGATTCCGAAATGGAACGGGAACTCTCTTACG
AGGATCGGTAA

Upstream 100 bases:

>100_bases
AATTGTAGGCGACACTAGAAGATCGGTCCAAAATACTTAATTCTGTTCCTCATTATACAATGGACCCTGATTTTAAAACT
TTAGTGGTGTTGAAGTTCCT

Downstream 100 bases:

>100_bases
ATGAAAGAAATCATCATCGCAGTCTCAGGTTCCATTGCTTCTTACAAGGCATGTGATTTGGTAAGAGGGCTTACCAAAAC
TGGTTACCCTGTGCGAGTGA

Product: hemolysin-related CBS regulatory domain

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MEIIGIFLIFLLVFVNGFFVAAEFAMVSIRPSRLEELVKENRAMSHITKKAISKIDDMLSVCQVGITVASLLLGWIGEAL
FASVVSGSLRMLQIELDVVTIHSISIGVSFTLITLLHVILGELVPKTLAIQNTEAIALGVSAPMWLFYYLFFPVTFIMNR
LAGGILTLFRLQRTGDKYVHSAEELMIIIEEQRKQGRIDNAEMQLIQKTFDFSEHTAKDVMTHRLSIIGIPQESTIDKLL
PLIAEHSFSRYPVYHQTLDKIVGIVHVQKYLKWQAEHLSAKGKKEKITVIMEKDFVKVPESMSIERVMTKLREKKQHMAI
VIDEYGGVSGLLTLEDIIEEFFGEIRDETDTDEVDVTSKNKKTKTITLDGETELSSLTDILEGEEPSDMEEVRTIAGYFM
EKNEDMPKEGSIVQIKKGSLKVKKMEGNKIISILFTPKLEEDHDSEMERELSYEDR

Sequences:

>Translated_456_residues
MEIIGIFLIFLLVFVNGFFVAAEFAMVSIRPSRLEELVKENRAMSHITKKAISKIDDMLSVCQVGITVASLLLGWIGEAL
FASVVSGSLRMLQIELDVVTIHSISIGVSFTLITLLHVILGELVPKTLAIQNTEAIALGVSAPMWLFYYLFFPVTFIMNR
LAGGILTLFRLQRTGDKYVHSAEELMIIIEEQRKQGRIDNAEMQLIQKTFDFSEHTAKDVMTHRLSIIGIPQESTIDKLL
PLIAEHSFSRYPVYHQTLDKIVGIVHVQKYLKWQAEHLSAKGKKEKITVIMEKDFVKVPESMSIERVMTKLREKKQHMAI
VIDEYGGVSGLLTLEDIIEEFFGEIRDETDTDEVDVTSKNKKTKTITLDGETELSSLTDILEGEEPSDMEEVRTIAGYFM
EKNEDMPKEGSIVQIKKGSLKVKKMEGNKIISILFTPKLEEDHDSEMERELSYEDR
>Mature_456_residues
MEIIGIFLIFLLVFVNGFFVAAEFAMVSIRPSRLEELVKENRAMSHITKKAISKIDDMLSVCQVGITVASLLLGWIGEAL
FASVVSGSLRMLQIELDVVTIHSISIGVSFTLITLLHVILGELVPKTLAIQNTEAIALGVSAPMWLFYYLFFPVTFIMNR
LAGGILTLFRLQRTGDKYVHSAEELMIIIEEQRKQGRIDNAEMQLIQKTFDFSEHTAKDVMTHRLSIIGIPQESTIDKLL
PLIAEHSFSRYPVYHQTLDKIVGIVHVQKYLKWQAEHLSAKGKKEKITVIMEKDFVKVPESMSIERVMTKLREKKQHMAI
VIDEYGGVSGLLTLEDIIEEFFGEIRDETDTDEVDVTSKNKKTKTITLDGETELSSLTDILEGEEPSDMEEVRTIAGYFM
EKNEDMPKEGSIVQIKKGSLKVKKMEGNKIISILFTPKLEEDHDSEMERELSYEDR

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=395, Percent_Identity=36.2025316455696, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI94681046, Length=325, Percent_Identity=25.8461538461538, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1790664, Length=456, Percent_Identity=23.0263157894737, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI145693175, Length=426, Percent_Identity=22.7699530516432, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1786879, Length=272, Percent_Identity=31.6176470588235, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI87082033, Length=256, Percent_Identity=26.171875, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788119, Length=269, Percent_Identity=24.5353159851301, Blast_Score=79, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR002550
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF01595 DUF21 [H]

EC number: NA

Molecular weight: Translated: 51724; Mature: 51724

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIIGIFLIFLLVFVNGFFVAAEFAMVSIRPSRLEELVKENRAMSHITKKAISKIDDMLS
CHHHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VCQVGITVASLLLGWIGEALFASVVSGSLRMLQIELDVVTIHSISIGVSFTLITLLHVIL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEEEEEEEHHHHHHHHHHHHHHHH
GELVPKTLAIQNTEAIALGVSAPMWLFYYLFFPVTFIMNRLAGGILTLFRLQRTGDKYVH
HHHCCHHHEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
SAEELMIIIEEQRKQGRIDNAEMQLIQKTFDFSEHTAKDVMTHRLSIIGIPQESTIDKLL
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHEEECCCHHHHHHHH
PLIAEHSFSRYPVYHQTLDKIVGIVHVQKYLKWQAEHLSAKGKKEKITVIMEKDFVKVPE
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHCCC
SMSIERVMTKLREKKQHMAIVIDEYGGVSGLLTLEDIIEEFFGEIRDETDTDEVDVTSKN
CCCHHHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECCCC
KKTKTITLDGETELSSLTDILEGEEPSDMEEVRTIAGYFMEKNEDMPKEGSIVQIKKGSL
CCEEEEEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCE
KVKKMEGNKIISILFTPKLEEDHDSEMERELSYEDR
EEEEECCCEEEEEEECCCCCCCCHHHHHHHCCCCCC
>Mature Secondary Structure
MEIIGIFLIFLLVFVNGFFVAAEFAMVSIRPSRLEELVKENRAMSHITKKAISKIDDMLS
CHHHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VCQVGITVASLLLGWIGEALFASVVSGSLRMLQIELDVVTIHSISIGVSFTLITLLHVIL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEEEEEEEHHHHHHHHHHHHHHHH
GELVPKTLAIQNTEAIALGVSAPMWLFYYLFFPVTFIMNRLAGGILTLFRLQRTGDKYVH
HHHCCHHHEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
SAEELMIIIEEQRKQGRIDNAEMQLIQKTFDFSEHTAKDVMTHRLSIIGIPQESTIDKLL
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHEEECCCHHHHHHHH
PLIAEHSFSRYPVYHQTLDKIVGIVHVQKYLKWQAEHLSAKGKKEKITVIMEKDFVKVPE
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHCCC
SMSIERVMTKLREKKQHMAIVIDEYGGVSGLLTLEDIIEEFFGEIRDETDTDEVDVTSKN
CCCHHHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECCCC
KKTKTITLDGETELSSLTDILEGEEPSDMEEVRTIAGYFMEKNEDMPKEGSIVQIKKGSL
CCEEEEEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCE
KVKKMEGNKIISILFTPKLEEDHDSEMERELSYEDR
EEEEECCCEEEEEEECCCCCCCCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 8969508; 7608059 [H]