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The map label for this gene is manC [H]

Identifier: 183219898

GI number: 183219898

Start: 474657

End: 475727

Strand: Direct

Name: manC [H]

Synonym: LEPBI_I0480

Alternate gene names: 183219898

Gene position: 474657-475727 (Clockwise)

Preceding gene: 183219897

Following gene: 183219899

Centisome position: 13.19

GC content: 42.2

Gene sequence:

>1071_bases
ATGGCGAAATTACCAAAAGAAACCCCTGTGGTTCTGATTATGGCGGGAGGAAAGGGGGAGAGGTTCTGGCCTCGTTCCCG
CACCAACTCCCCAAAACAGCTCCAAAAAGTATATTCCAACAAAACTCTCTTACGTGAGACCATTGACCGGGCCCTTACTA
TCACGTCACTTGATCGCATTTACATTGGGACCAATGCCACACTTAAGGCTGAGATTCTAAAAAAAGACCCTAAGTTTCCC
TCGGGAAATTTTATCATCGAACCAGAAGGGAAAAACACAGCTCCCATCATTGCCCTCTCTGCTCTTTATTTCCAAAAAAA
ATATGGGAACCCCAATCTTATTGTCCTTTCTGCGGATGCCTTCATTGATCCCGTCAAAGAATTTACAAAAACCATCGAAC
AAGCATTGTATGAAACTGAAAATGGGATGGTTTTACTTGGCGTCAAACCTAACCGGCCAGAAGTAGGGTATGGTTATATC
AGTACTGGCAAACCAACTGATGTTGGTTATACGGTAAAAGCATTCTTTGAAAAACCAGATTTCAAAACGGCACTCAAATA
CATCAAAAAAAAGAATTTTTATTGGAACCCTGGGATCTTTCTTTTCCGAACCGAAACGATTTTATCCGAACTGGAACGAC
ATGCGCCACATATTTTGGGACCCCTCAAAAATGGATTTCCATTTAAGAGTTTTGGAGACTTGAAGTCGGCCTTCCAAATG
TTACCTTCGGAAGCCATCGACACTGCCATTATGGAAAAATCGAATCGCATTCGGATGGTGGAAGCCACATTCAATTGGGA
TGATGTGGGATCTTGGATGTCCCTTGAACGTATTTTACCTGGTGACAAAGAAAAAAACCACCACCAAGGAAAAGAAGTTC
TCTACCATAAAGCTTCGGGCAATATTTCTTCCGTGCAAAAAGAGCTCATTGCTTTCCTTGGTGTGAAAGATCTCATCGTA
GTAGAAGAACCTGATGTCCTCCTTGTGACTTCAAGAGAGGGTGTGAGTGAGATCAAAGCGATGTTATCCAATATGCGGAA
AAATAAAGTTTTACAAAAGTACCTCGACTAG

Upstream 100 bases:

>100_bases
ATCAAACTTCATAGCGAGGAAACTCCAAAGGAAGCGGGTGGAGTATAATTCTTTTCTAGTTTTCCTCTTTTTCCCTTTCT
AAATTCTGGTTCCAAACCCT

Downstream 100 bases:

>100_bases
AAATTTGACAGAACAGGCTTGATATAAGGAGGAAGGAATGCCTTCCGGAAAAAAGAGAAAGCGTAGAAAAATCGCAACAC
ACAAACGTAAGAAAAAACGC

Product: mannose-1-phosphate guanylyltransferase

Products: NA

Alternate protein names: GDP-mannose pyrophosphorylase; GMP; GMPP; GTP--mannose-1-phosphate guanylyltransferase [H]

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MAKLPKETPVVLIMAGGKGERFWPRSRTNSPKQLQKVYSNKTLLRETIDRALTITSLDRIYIGTNATLKAEILKKDPKFP
SGNFIIEPEGKNTAPIIALSALYFQKKYGNPNLIVLSADAFIDPVKEFTKTIEQALYETENGMVLLGVKPNRPEVGYGYI
STGKPTDVGYTVKAFFEKPDFKTALKYIKKKNFYWNPGIFLFRTETILSELERHAPHILGPLKNGFPFKSFGDLKSAFQM
LPSEAIDTAIMEKSNRIRMVEATFNWDDVGSWMSLERILPGDKEKNHHQGKEVLYHKASGNISSVQKELIAFLGVKDLIV
VEEPDVLLVTSREGVSEIKAMLSNMRKNKVLQKYLD

Sequences:

>Translated_356_residues
MAKLPKETPVVLIMAGGKGERFWPRSRTNSPKQLQKVYSNKTLLRETIDRALTITSLDRIYIGTNATLKAEILKKDPKFP
SGNFIIEPEGKNTAPIIALSALYFQKKYGNPNLIVLSADAFIDPVKEFTKTIEQALYETENGMVLLGVKPNRPEVGYGYI
STGKPTDVGYTVKAFFEKPDFKTALKYIKKKNFYWNPGIFLFRTETILSELERHAPHILGPLKNGFPFKSFGDLKSAFQM
LPSEAIDTAIMEKSNRIRMVEATFNWDDVGSWMSLERILPGDKEKNHHQGKEVLYHKASGNISSVQKELIAFLGVKDLIV
VEEPDVLLVTSREGVSEIKAMLSNMRKNKVLQKYLD
>Mature_355_residues
AKLPKETPVVLIMAGGKGERFWPRSRTNSPKQLQKVYSNKTLLRETIDRALTITSLDRIYIGTNATLKAEILKKDPKFPS
GNFIIEPEGKNTAPIIALSALYFQKKYGNPNLIVLSADAFIDPVKEFTKTIEQALYETENGMVLLGVKPNRPEVGYGYIS
TGKPTDVGYTVKAFFEKPDFKTALKYIKKKNFYWNPGIFLFRTETILSELERHAPHILGPLKNGFPFKSFGDLKSAFQML
PSEAIDTAIMEKSNRIRMVEATFNWDDVGSWMSLERILPGDKEKNHHQGKEVLYHKASGNISSVQKELIAFLGVKDLIVV
EEPDVLLVTSREGVSEIKAMLSNMRKNKVLQKYLD

Specific function: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS group C2 O antigen [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=352, Percent_Identity=34.375, Blast_Score=182, Evalue=3e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 40237; Mature: 40106

Theoretical pI: Translated: 9.97; Mature: 9.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLPKETPVVLIMAGGKGERFWPRSRTNSPKQLQKVYSNKTLLRETIDRALTITSLDRI
CCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHEEEEECCEE
YIGTNATLKAEILKKDPKFPSGNFIIEPEGKNTAPIIALSALYFQKKYGNPNLIVLSADA
EECCCCEEEHHHHHCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECHH
FIDPVKEFTKTIEQALYETENGMVLLGVKPNRPEVGYGYISTGKPTDVGYTVKAFFEKPD
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEECCCCCCCCCEEEEEECCCCC
FKTALKYIKKKNFYWNPGIFLFRTETILSELERHAPHILGPLKNGFPFKSFGDLKSAFQM
HHHHHHHHHHCCCEECCCEEEEEHHHHHHHHHHHCCHHCCCCCCCCCCCCHHHHHHHHHH
LPSEAIDTAIMEKSNRIRMVEATFNWDDVGSWMSLERILPGDKEKNHHQGKEVLYHKASG
CCHHHHHHHHHCCCCCEEEEEEECCHHHCCCHHHHHHHCCCCCCCCCCCCHHHEEECCCC
NISSVQKELIAFLGVKDLIVVEEPDVLLVTSREGVSEIKAMLSNMRKNKVLQKYLD
CHHHHHHHHHHHHCCCEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKLPKETPVVLIMAGGKGERFWPRSRTNSPKQLQKVYSNKTLLRETIDRALTITSLDRI
CCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHEEEEECCEE
YIGTNATLKAEILKKDPKFPSGNFIIEPEGKNTAPIIALSALYFQKKYGNPNLIVLSADA
EECCCCEEEHHHHHCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECHH
FIDPVKEFTKTIEQALYETENGMVLLGVKPNRPEVGYGYISTGKPTDVGYTVKAFFEKPD
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEECCCCCCCCCEEEEEECCCCC
FKTALKYIKKKNFYWNPGIFLFRTETILSELERHAPHILGPLKNGFPFKSFGDLKSAFQM
HHHHHHHHHHCCCEECCCEEEEEHHHHHHHHHHHCCHHCCCCCCCCCCCCHHHHHHHHHH
LPSEAIDTAIMEKSNRIRMVEATFNWDDVGSWMSLERILPGDKEKNHHQGKEVLYHKASG
CCHHHHHHHHHCCCCCEEEEEEECCHHHCCCHHHHHHHCCCCCCCCCCCCHHHEEECCCC
NISSVQKELIAFLGVKDLIVVEEPDVLLVTSREGVSEIKAMLSNMRKNKVLQKYLD
CHHHHHHHHHHHHCCCEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1379320 [H]