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The map label for this gene is folK [H]

Identifier: 183219694

GI number: 183219694

Start: 264050

End: 264523

Strand: Direct

Name: folK [H]

Synonym: LEPBI_I0270

Alternate gene names: 183219694

Gene position: 264050-264523 (Clockwise)

Preceding gene: 183219693

Following gene: 183219695

Centisome position: 7.34

GC content: 39.03

Gene sequence:

>474_bases
ATGAAATATTCCAATATTGCCTTTTTGTCTTTAGGATCCAACATAGGTGACAGACACCATTTTATGGACCAGGCAATTTG
GGAAATATCCACCTTACCTGAATTACAGATTCTGAAACAATCAGAACGGTTGGAAACTGCACCACTCGAAAATACCAACC
AACCTTATTTTTTAAATCAAATCCTAAAGGTGATGGTGTCCTCTGCTTTCACACTGCCATGTTTATTAGATTCTTTGCAA
GGGATCGAAGACAAATTGGGACGCAAACGTAGGTCTTGGAAAGGACCACGCGAAATTGATATCGATATTCTCACTTACGA
AGCCGTGGTGATGAAAACAGATTTTTTACATTTACCCCACCATTCCCTGTATTCCAGACCATTCATTAAGCAGTTGTTAA
CTGACATGGGTGAGATTGGTGTGTATGCCCTCTATACGGAACTGAACCATGAAAAACATTATTCTACAGTATAA

Upstream 100 bases:

>100_bases
CGTGGCCAAGGCCGGATTTATTCCAGGCTTATGGAAATGACAAAAGAAATTGAATTAAAATGTCCTGATTATCGAACGAA
GTTTGTGAAGAGGTAAGTGT

Downstream 100 bases:

>100_bases
AAAAAAATACGACGCGGGCGAACCCATCTCTGTTGTCACTTGTTATGATTACACGTTTGCGACACTTTTTAATCGCACAG
ATGTAGATTGCCTTCTTGTG

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MKYSNIAFLSLGSNIGDRHHFMDQAIWEISTLPELQILKQSERLETAPLENTNQPYFLNQILKVMVSSAFTLPCLLDSLQ
GIEDKLGRKRRSWKGPREIDIDILTYEAVVMKTDFLHLPHHSLYSRPFIKQLLTDMGEIGVYALYTELNHEKHYSTV

Sequences:

>Translated_157_residues
MKYSNIAFLSLGSNIGDRHHFMDQAIWEISTLPELQILKQSERLETAPLENTNQPYFLNQILKVMVSSAFTLPCLLDSLQ
GIEDKLGRKRRSWKGPREIDIDILTYEAVVMKTDFLHLPHHSLYSRPFIKQLLTDMGEIGVYALYTELNHEKHYSTV
>Mature_157_residues
MKYSNIAFLSLGSNIGDRHHFMDQAIWEISTLPELQILKQSERLETAPLENTNQPYFLNQILKVMVSSAFTLPCLLDSLQ
GIEDKLGRKRRSWKGPREIDIDILTYEAVVMKTDFLHLPHHSLYSRPFIKQLLTDMGEIGVYALYTELNHEKHYSTV

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=125, Percent_Identity=31.2, Blast_Score=66, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18207; Mature: 18207

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYSNIAFLSLGSNIGDRHHFMDQAIWEISTLPELQILKQSERLETAPLENTNQPYFLNQ
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHH
ILKVMVSSAFTLPCLLDSLQGIEDKLGRKRRSWKGPREIDIDILTYEAVVMKTDFLHLPH
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEHHHHHHHHHHHCCCC
HSLYSRPFIKQLLTDMGEIGVYALYTELNHEKHYSTV
HHHHCCHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKYSNIAFLSLGSNIGDRHHFMDQAIWEISTLPELQILKQSERLETAPLENTNQPYFLNQ
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHH
ILKVMVSSAFTLPCLLDSLQGIEDKLGRKRRSWKGPREIDIDILTYEAVVMKTDFLHLPH
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEHHHHHHHHHHHCCCC
HSLYSRPFIKQLLTDMGEIGVYALYTELNHEKHYSTV
HHHHCCHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9168622 [H]